-
1
-
-
0038312385
-
Decreased liver hepcidin expression in the Hfe knockout mouse
-
Ahmad KA, Ahmann JR, Migas MC, Waheed A, Britton RS, Bacon BR, Sly WS, Fleming RE. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis 29: 361-366, 2002.
-
(2002)
Blood Cells Mol Dis
, vol.29
, pp. 361-366
-
-
Ahmad, K.A.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Britton, R.S.5
Bacon, B.R.6
Sly, W.S.7
Fleming, R.E.8
-
2
-
-
0037460697
-
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
-
Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DH, Subramaniam VN, Powell LW, Anderson GJ, Ramm GA. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 361: 669-673, 2003.
-
(2003)
Lancet
, vol.361
, pp. 669-673
-
-
Bridle, K.R.1
Frazer, D.M.2
Wilkins, S.J.3
Dixon, J.L.4
Purdie, D.M.5
Crawford, D.H.6
Subramaniam, V.N.7
Powell, L.W.8
Anderson, G.J.9
Ramm, G.A.10
-
3
-
-
34250318957
-
The cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells
-
Chen J, Enns CA. The cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells. J Biol Chem 282: 6201-6209, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 6201-6209
-
-
Chen, J.1
Enns, C.A.2
-
4
-
-
0037174609
-
C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
-
Courselaud B, Pigeon C, Inoue Y, Inoue J, Gonzalez FJ, Leroyer P, Gilot D, Boudjema K, Guguen-Guillouzo C, Brissot P, Loreal O, Ilyin G. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 277: 41163-41170, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 41163-41170
-
-
Courselaud, B.1
Pigeon, C.2
Inoue, Y.3
Inoue, J.4
Gonzalez, F.J.5
Leroyer, P.6
Gilot, D.7
Boudjema, K.8
Guguen-Guillouzo, C.9
Brissot, P.10
Loreal, O.11
Ilyin, G.12
-
5
-
-
4644301624
-
Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis
-
Frazer DM, Inglis HR, Wilkins SJ, Millard KN, Steele TM, McLaren GD, McKie AT, Vulpe CD, Anderson GJ. Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. Gut 53: 1509-1515, 2004.
-
(2004)
Gut
, vol.53
, pp. 1509-1515
-
-
Frazer, D.M.1
Inglis, H.R.2
Wilkins, S.J.3
Millard, K.N.4
Steele, T.M.5
McLaren, G.D.6
McKie, A.T.7
Vulpe, C.D.8
Anderson, G.J.9
-
6
-
-
0036727925
-
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
-
Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, Anderson GJ. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123: 835-844, 2002.
-
(2002)
Gastroenterology
, vol.123
, pp. 835-844
-
-
Frazer, D.M.1
Wilkins, S.J.2
Becker, E.M.3
Vulpe, C.D.4
McKie, A.T.5
Trinder, D.6
Anderson, G.J.7
-
7
-
-
77951488966
-
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice
-
Gao J, Chen J, De Demenico I, Koeller DM, Harding CO, Fleming RE, Koeberl DD, Enns CA. Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. Blood 115: 3374-3381, 2010.
-
(2010)
Blood
, vol.115
, pp. 3374-3381
-
-
Gao, J.1
Chen, J.2
De Demenico, I.3
Koeller, D.M.4
Harding, C.O.5
Fleming, R.E.6
Koeberl, D.D.7
Enns, C.A.8
-
8
-
-
60649103774
-
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
-
Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab 9: 217-227, 2009.
-
(2009)
Cell Metab
, vol.9
, pp. 217-227
-
-
Gao, J.1
Chen, J.2
Kramer, M.3
Tsukamoto, H.4
Zhang, A.S.5
Enns, C.A.6
-
9
-
-
0037564038
-
Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
-
Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, Stremmel W. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 102: 371-376, 2003.
-
(2003)
Blood
, vol.102
, pp. 371-376
-
-
Gehrke, S.G.1
Kulaksiz, H.2
Herrmann, T.3
Riedel, H.D.4
Bents, K.5
Veltkamp, C.6
Stremmel, W.7
-
10
-
-
33749393565
-
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
-
Goswami T, Andrews NC. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem 281: 28494-28498, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 28494-28498
-
-
Goswami, T.1
Andrews, N.C.2
-
11
-
-
73449101157
-
The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells
-
Herbison CE, Thorstensen K, Chua AC, Graham RM, Leedman P, Olynyk JK, Trinder D. The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells. Am J Physiol Cell Physiol 297: C1567-C1575, 2009.
-
(2009)
Am J Physiol Cell Physiol
, vol.297
-
-
Herbison, C.E.1
Thorstensen, K.2
Chua, A.C.3
Graham, R.M.4
Leedman, P.5
Olynyk, J.K.6
Trinder, D.7
-
12
-
-
10244265904
-
Diferric transferrin regulates transferrin receptor 2 protein stability
-
Johnson MB, Enns CA. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 104: 4287-4293, 2004.
-
(2004)
Blood
, vol.104
, pp. 4287-4293
-
-
Johnson, M.B.1
Enns, C.A.2
-
13
-
-
51649096725
-
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
-
Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, Wang RH, Deng C, Vaulont S, Mosser J, Coppin H, Roth MP. Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112: 1503-1509, 2008.
-
(2008)
Blood
, vol.112
, pp. 1503-1509
-
-
Kautz, L.1
Meynard, D.2
Monnier, A.3
Darnaud, V.4
Bouvet, R.5
Wang, R.H.6
Deng, C.7
Vaulont, S.8
Mosser, J.9
Coppin, H.10
Roth, M.P.11
-
14
-
-
0034284595
-
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
-
Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz- Knappe P, Adermann K. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 480: 147-150, 2000.
-
(2000)
FEBS Lett
, vol.480
, pp. 147-150
-
-
Krause, A.1
Neitz, S.2
Magert, H.J.3
Schulz, A.4
Forssmann, W.G.5
Schulz-Knappe, P.6
Adermann, K.7
-
15
-
-
34548825938
-
Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
-
Lin L, Valore EV, Nemeth E, Goodnough JB, Gabayan V, Ganz T. Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood 110: 2182-2189, 2007.
-
(2007)
Blood
, vol.110
, pp. 2182-2189
-
-
Lin, L.1
Valore, E.V.2
Nemeth, E.3
Goodnough, J.B.4
Gabayan, V.5
Ganz, T.6
-
16
-
-
0037244116
-
Human hepatocyte isolation and relationship of cell viability to early graft function
-
Mitry RR, Hughes RD, Aw MM, Terry C, Mieli-Vergani G, Girlanda R, Muiesan P, Rela M, Heaton ND, Dhawan A. Human hepatocyte isolation and relationship of cell viability to early graft function. Cell Transplant 12: 69-74, 2003.
-
(2003)
Cell Transplant
, vol.12
, pp. 69-74
-
-
Mitry, R.R.1
Hughes, R.D.2
Aw, M.M.3
Terry, C.4
Mieli-Vergani, G.5
Girlanda, R.6
Muiesan, P.7
Rela, M.8
Heaton, N.D.9
Dhawan, A.10
-
17
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113: 1271-1276, 2004.
-
(2004)
J Clin Invest
, vol.113
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
Keller, C.4
Taudorf, S.5
Pedersen, B.K.6
Ganz, T.7
-
18
-
-
13544250486
-
Hepcidin is decreased in TFR2 hemochromatosis
-
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood 105: 1803-1806, 2005.
-
(2005)
Blood
, vol.105
, pp. 1803-1806
-
-
Nemeth, E.1
Roetto, A.2
Garozzo, G.3
Ganz, T.4
Camaschella, C.5
-
19
-
-
0038662619
-
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
-
Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101: 2461-2463, 2003.
-
(2003)
Blood
, vol.101
, pp. 2461-2463
-
-
Nemeth, E.1
Valore, E.V.2
Territo, M.3
Schiller, G.4
Lichtenstein, A.5
Ganz, T.6
-
20
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110: 1037-1044, 2002.
-
(2002)
J Clin Invest
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
Danan, J.L.4
Bigard, X.5
Devaux, I.6
Beaumont, C.7
Kahn, A.8
Vaulont, S.9
-
21
-
-
23644444316
-
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
-
Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115: 2180-2186, 2005.
-
(2005)
J Clin Invest
, vol.115
, pp. 2180-2186
-
-
Niederkofler, V.1
Salie, R.2
Arber, S.3
-
22
-
-
9144252017
-
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
-
Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dube MP, Andres L, MacFarlane J, Sakellaropoulos N, Politou M, Nemeth E, Thompson J, Risler JK, Zaborowska C, Babakaiff R, Radomski CC, Pape TD, Davidas O, Christakis J, Brissot P, Lockitch G, Ganz T, Hayden MR, Goldberg YP. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 36: 77-82, 2004.
-
(2004)
Nat Genet
, vol.36
, pp. 77-82
-
-
Papanikolaou, G.1
Samuels, M.E.2
Ludwig, E.H.3
MacDonald, M.L.4
Franchini, P.L.5
Dube, M.P.6
Andres, L.7
MacFarlane, J.8
Sakellaropoulos, N.9
Politou, M.10
Nemeth, E.11
Thompson, J.12
Risler, J.K.13
Zaborowska, C.14
Babakaiff, R.15
Radomski, C.C.16
Pape, T.D.17
Davidas, O.18
Christakis, J.19
Brissot, P.20
Lockitch, G.21
Ganz, T.22
Hayden, M.R.23
Goldberg, Y.P.24
more..
-
23
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276: 7806-7810, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
Valore, E.V.2
Waring, A.J.3
Ganz, T.4
-
24
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
Brissot, P.6
Loreal, O.7
-
25
-
-
37049024131
-
Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis
-
Piperno A, Girelli D, Nemeth E, Trombini P, Bozzini C, Poggiali E, Phung Y, Ganz T, Camaschella C. Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis. Blood 110: 4096-4100, 2007.
-
(2007)
Blood
, vol.110
, pp. 4096-4100
-
-
Piperno, A.1
Girelli, D.2
Nemeth, E.3
Trombini, P.4
Bozzini, C.5
Poggiali, E.6
Phung, Y.7
Ganz, T.8
Camaschella, C.9
-
26
-
-
66749183353
-
Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
-
Ramey G, Deschemin JC, Vaulont S. Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica 94: 765-772, 2009.
-
(2009)
Haematologica
, vol.94
, pp. 765-772
-
-
Ramey, G.1
Deschemin, J.C.2
Vaulont, S.3
-
27
-
-
10244255021
-
Regulation of transferrin receptor 2 protein levels by transferrin
-
Robb A, Wessling-Resnick M. Regulation of transferrin receptor 2 protein levels by transferrin. Blood 104: 4294-4299, 2004.
-
(2004)
Blood
, vol.104
, pp. 4294-4299
-
-
Robb, A.1
Wessling-Resnick, M.2
-
28
-
-
28444432294
-
The effects of cryopreservation on human hepatocytes obtained from different sources of liver tissue
-
Terry C, Mitry RR, Lehec SC, Muiesan P, Rela M, Heaton ND, Hughes RD, Dhawan A. The effects of cryopreservation on human hepatocytes obtained from different sources of liver tissue. Cell Transplant 14: 585-594, 2005.
-
(2005)
Cell Transplant
, vol.14
, pp. 585-594
-
-
Terry, C.1
Mitry, R.R.2
Lehec, S.C.3
Muiesan, P.4
Rela, M.5
Heaton, N.D.6
Hughes, R.D.7
Dhawan, A.8
-
29
-
-
75449097854
-
Huh-7: A human "hemochromatotic" cell line
-
Vecchi C, Montosi G, Pietrangelo A. Huh-7: a human " hemochromatotic" cell line. Hepatology 51: 654-659, 2010.
-
(2010)
Hepatology
, vol.51
, pp. 654-659
-
-
Vecchi, C.1
Montosi, G.2
Pietrangelo, A.3
-
30
-
-
73149083742
-
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
-
Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology 50: 1992-2000, 2009.
-
(2009)
Hepatology
, vol.50
, pp. 1992-2000
-
-
Wallace, D.F.1
Summerville, L.2
Crampton, E.M.3
Frazer, D.M.4
Anderson, G.J.5
Subramaniam, V.N.6
-
31
-
-
0037111732
-
Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
-
Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100: 3776-3781, 2002.
-
(2002)
Blood
, vol.100
, pp. 3776-3781
-
-
Weinstein, D.A.1
Roy, C.N.2
Fleming, M.D.3
Loda, M.F.4
Wolfsdorf, J.I.5
Andrews, N.C.6
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