Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 1, 2006, Pages 105-110

  Safran, Michal ^a   Kim, William Y ^a   O'Connell, Fionnuala ^a   Flippin, Lee ^b   Günzler, Volkmar ^b   Horner, James W ^a   DePinho, Ronald A ^a   Kaelin Jr , William G ^a,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b FIBROGEN INC   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Bioluminescence; Imaging; Von Hippel Lindau

Indexed keywords

ADENOSINE TRIPHOSPHATE; COMPLEMENTARY DNA; DEFEROXAMINE; ENZYME INHIBITOR; ERYTHROPOIETIN; FG 4383; GENOMIC DNA; HYBRID PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LUCIFERASE; MESSENGER RNA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; HELA CELL; HUMAN; HUMAN CELL; HYDROXYLATION; HYPOXIA; IMAGING SYSTEM; KIDNEY; LIVER; MOUSE; NEPHRECTOMY; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TREATMENT OUTCOME;

ANIMALS; CELL HYPOXIA; CELLS, CULTURED; DIOXYGENASES; DNA PRIMERS; DNA, COMPLEMENTARY; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROPOIETIN; HYPOXIA-INDUCIBLE FACTOR 1; LUCIFERASES; MICE; MODELS, ANIMAL; MOLECULAR PROBE TECHNIQUES; PLASMIDS; PROTEINS;

ANIMALIA;

EID: 30444445382     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509459103     Document Type: Article

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