Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis

Gut

Volumn 53, Issue 10, 2004, Pages 1509-1515

  Frazer, D M ^b   Inglis, H R ^b   Wilkins, S J ^b   Millard, K N ^b   Steele, T M ^b   McLaren, G D ^c,d   McKie, A T ^e   Vulpe, C D ^f   Anderson, G J ^a,b  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA LONG BEACH HEALTHCARE SYSTEM   (United States)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME B; HEPCIDIN; IRON; METAL; PHENYLHYDRAZINE; TRANSFERRIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL MIGRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DUODENUM; ERYTHROPOIESIS; HEMOLYSIS; INTESTINE CELL; INTESTINE CRYPT; IRON ABSORPTION; IRON TRANSPORT; LIVER METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL DETECTION; STIMULUS RESPONSE;

ANALYSIS OF VARIANCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; HEMOLYSIS; INTESTINAL ABSORPTION; IRON; LIVER; MALE; PHENYLHYDRAZINES; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TRANSFERRIN;

EID: 4644301624     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.037416     Document Type: Article

References (44)

1. McCance RA, Widdowson EM. Absorption and excretion of iron. Lancet 1937;ii:680-4.
2. Lombard M, Chua E, O'Toole P. Regulation of intestinal non-haem iron absorption. Gut 1997;40:435-9.
3. Andrews NC. Disorders of iron metabolism. N Engl J Med 1999;341:1986-95.
4. Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol Dis 2003;30:288-97.
5. Conrad ME, Weintraub LR, Crosby WH. The role of the intestine in iron kinetics. J Clin Invest 1964;43:963-74.
6. Charlton RW, Jacobs P, Bothwell TH. The role of the intestinal mucosa in iron absorption. J Clin Invest 1965;44:543-54.
7. Krause A, Neitz S, Mägert H, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-50.
8. Park CH, Valore EV, Waring AJ, et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-10.
9. Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-19.
10. Ahmad KA, Ahmann JR, Migas, MC, et al. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol Dis 2002;29:361-6.
11. Mazur A, Feillet-Coudray C, Romier B, et al. Dietary iron regulates hepatic hepcidin 1 and 2 mRNAs in mice. Metabolism 2003;52:1229-31.
12. Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-44.
13. Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 2001;98:8780-5.
14. Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A 2002;99:4596-601.
15. Bridle KR, Frazer DM, Wilkins SJ, et al. Failure of hepcidin upregulation in HFE-associated haemochromatosis implicates the liver in the regulation of body iron homeostasis. Lancet 2003;361:669-73.
16. Roelto A, Paponikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-2.
17. Cortell S, Conrad ME. Effect of endotoxin on iron absorption. Am J Physiol 1967;213:43-7.
18. Anderson GJ, Frazer DM, Wilkins SJ, et al. Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption. Biochem Soc Trans 2002;30:724-6.
19. Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002;123:835-44.
20. Weintraub LR, Conrad ME, Crosby WH. The significance of iron turnover in the control of iron absorption. Blood 1964;24:19-24.
21. Anderson GJ, Powell LW, Halliday JW. The endocytosis of transferrin by rat intestinal epithelial cells. Gastroenterology 1994;106:414-22.
22. Dacie JV, Lewis SM. Practical haematalogy. Edinburgh: Churchill Livingstone, 1975.
23. Torrance JD, Bothwell TH. A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci 1968;33:9-11.
24. Wang XS, Ong WY, Connor JR. Increase in ferric and ferrous iron in the rat hippocampus with time after kainate-induced excitotoxic injury. Exp Brain Res 2002;143:137-48.
25. Makey DG, Seal US. The detection of four molecular forms of human transferrin during the iron binding process. Biochim Biophys Acta 1976;453:250-6.
26. Evans RW, Williams J. The electrophoresis of transferrins in urea/polyacrylamide gels. Biochem J 1980;189:541-6.
27. Davy P, Bingham D, Walters G, et al. Estimation of the saturation of serum transferrin by an electrophoretic technique. Ann Clin Biochem 1982;19:57-9.
28. Frazer DM, Vulpe CD, McKie AT, et al. Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins. Am J Physiol 2001;281:G931-9.
29. Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997;388:482-8.
30. Fleming MD, Trenor III CC, Su MA, et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 1997;16:383-6.
31. McKie AT, Barrow D, Latunde-Dada GO, et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 2001;291:1755-9.
32. McKie AT, Marciani P, Rolfs A, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 2000;5:299-309.
33. Donovan A, Brownlie A, Zhou Y, et al. Postional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 2000;403:776-81.
34. Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 2000;275:19906-12.
35. O'Riordan DK, Sharp P, Sykes RM, et al. Cellular mechanisms underlying the increased duodenal iron absorption in rats in response to phenylhydrazine-induced haemolytic anaemia. 1995;25:722-7.
36. Finch C. Regulators of iron balance in humans. Blood 1994;84:1697-702.
37. Enns CA, Shindelman JE, Tonik SE, et al. Radioimmunochemical measurement of the transferrin receptor in human trophoblast and reticulocyte membranes with a specific anti-receptor antibody. Proc Natl Acad Sci U S A 1981;78:4222-5.
38. Young SP, Bomford A, Williams R. The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes. Biochem J 1984;219:505-10.
39. Huebers H, Csiba E, Huebers E, et al. Molecular advantage of diferric transferrin in delivering iron to reticulocytes: a comparative study. Proc Soc Exp Biol Med 1985;179:222-6.
40. Camaschella C, Roetto A, De Gobbi M. Juvenile hemochromatosis. Semin Hematol 2002;39:242-8.
41. Erlandson ME, Waldon B, Stern G, et al. Studies on congenital hemolytic syndromes. IV. Gastrointestinal absorption of iron. Blood 1962;19:359-78.
42. Pootrakul P, Wattanasaree J, Anuwatanakulchai MS, et al. Increased red blood cell protoporphyrin in thalassemia: a result of relative iron deficiency. Am J Clin Pathol 1984;82:289-93.
43. Cazzola M, Pootrakul P, Bergamaschi G, et al. Adequacy of iron supply for erythropoiesis: in vivo observations in humans. J Lab Clin Med 1987;110:734-9.
44. Adamsky K, Weizer O, Amariglio N, et al. Decreased hepcidin mRNA expression in thalassemic mice. B J Haematol 2004;124:123-5.