-
1
-
-
0011648510
-
The in vivo regulation of pulsatile insulin secretion
-
Pørksen N. The in vivo regulation of pulsatile insulin secretion. Diabetologia. 2002;45:3-20.
-
(2002)
Diabetologia
, vol.45
, pp. 3-20
-
-
Pørksen, N.1
-
2
-
-
72449148697
-
Pulsatility of insulin release - A clinically important phenomenon
-
Hellman B. Pulsatility of insulin release - a clinically important phenomenon. Ups J Med Sci. 2009;114:193-205.
-
(2009)
Ups J Med Sci
, vol.114
, pp. 193-205
-
-
Hellman, B.1
-
4
-
-
57649180449
-
Oscillatory control of insulin secretion
-
Tengholm A, Gylfe E. Oscillatory control of insulin secretion. Mol Cell Endocrinol. 2009;297:58-72.
-
(2009)
Mol Cell Endocrinol
, vol.297
, pp. 58-72
-
-
Tengholm, A.1
Gylfe, E.2
-
5
-
-
0036314998
-
Control mechanisms of the oscillations of insulin secretion in vitro and in vivo
-
Gilon P, Ravier MA, Jonas JC, Henquin JC. Control mechanisms of the oscillations of insulin secretion in vitro and in vivo. Diabetes. 2002;51:S144-51.
-
(2002)
Diabetes
, vol.51
-
-
Gilon, P.1
Ravier, M.A.2
Jonas, J.C.3
Henquin, J.C.4
-
6
-
-
0024917106
-
Electrophysiology of the pancreatic b-cell
-
Ashcroft FM, Rorsman P. Electrophysiology of the pancreatic b-cell. Prog Biophys Mol Biol. 1989;54:87-143.
-
(1989)
Prog Biophys Mol Biol
, vol.54
, pp. 87-143
-
-
Ashcroft, F.M.1
Rorsman, P.2
-
7
-
-
64149126546
-
Regulation of insulin secretion: A matter of phase control and amplitude modulation
-
Henquin JC. Regulation of insulin secretion: a matter of phase control and amplitude modulation. Diabetologia. 2009;52: 739-51.
-
(2009)
Diabetologia
, vol.52
, pp. 739-751
-
-
Henquin, J.C.1
-
8
-
-
35148816130
-
Metabolic and electrical oscillations: Partners in controlling pulsatile insulin secretion
-
Bertram R, Sherman A, Satin LS. Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion. Am J Physiol Endocrinol Metab. 2007;293:E890-900.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Bertram, R.1
Sherman, A.2
Satin, L.S.3
-
10
-
-
0001293564
-
Promotion of insulin secretion by glucagon
-
Samols E, Marri G, Marks V. Promotion of insulin secretion by glucagon. Lancet. 1965;2:415-16.
-
(1965)
Lancet
, vol.2
, pp. 415-416
-
-
Samols, E.1
Marri, G.2
Marks, V.3
-
11
-
-
0014104627
-
Insulin release after ACTH, glucagon and adenosine-3'-5'-phosphate (cyclic AMP) in the perfused isolated rat pancreas
-
Sussman KE, Vaughan GD. Insulin release after ACTH, glucagon and adenosine-3'-5'-phosphate (cyclic AMP) in the perfused isolated rat pancreas. Diabetes. 1967;16:449-54.
-
(1967)
Diabetes
, vol.16
, pp. 449-454
-
-
Sussman, K.E.1
Vaughan, G.D.2
-
12
-
-
0014151980
-
A possible role for the adenylcyclase system in insulin secretion
-
Malaisse WJ, Malaisse-Lagae F, Mayhew D. A possible role for the adenylcyclase system in insulin secretion. J Clin Invest. 1967;46:1724-34.
-
(1967)
J Clin Invest
, vol.46
, pp. 1724-1734
-
-
Malaisse, W.J.1
Malaisse-Lagae, F.2
Mayhew, D.3
-
13
-
-
0014209957
-
Stimulation of insulin secretion by theophylline
-
Turtle JR, Littleton GK, Kipnis DM. Stimulation of insulin secretion by theophylline. Nature. 1967;213:727-8.
-
(1967)
Nature
, vol.213
, pp. 727-728
-
-
Turtle, J.R.1
Littleton, G.K.2
Kipnis, D.M.3
-
14
-
-
0014195301
-
An adrenergic receptor mechanism for the control of cyclic 3'5' adenosine monophosphate synthesis in tissues
-
Turtle JR, Kipnis DM. An adrenergic receptor mechanism for the control of cyclic 3'5' adenosine monophosphate synthesis in tissues. Biochem Biophys Res Commun. 1967;28:797-802.
-
(1967)
Biochem Biophys Res Commun
, vol.28
, pp. 797-802
-
-
Turtle, J.R.1
Kipnis, D.M.2
-
15
-
-
25444520038
-
PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis
-
Seino S, Shibasaki T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol Rev. 2005; 85:1303-42.
-
(2005)
Physiol Rev
, vol.85
, pp. 1303-1342
-
-
Seino, S.1
Shibasaki, T.2
-
16
-
-
77953957372
-
Cyclic AMP signaling in pancreatic islets
-
Furman B, Ong WK, Pyne NJ. Cyclic AMP signaling in pancreatic islets. Adv Exp Med Biol. 2010;654:281-304.
-
(2010)
Adv Exp Med Biol
, vol.654
, pp. 281-304
-
-
Furman, B.1
Ong, W.K.2
Pyne, N.J.3
-
17
-
-
79951962147
-
CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals
-
Altarejos JY, Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol. 2011;12:141-51.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 141-151
-
-
Altarejos, J.Y.1
Montminy, M.2
-
18
-
-
0027473729
-
Pancreatic betacells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37)
-
4th
-
Holz GG 4th, Kuhtreiber WM, Habener JF. Pancreatic betacells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature. 1993;361: 362-5.
-
(1993)
Nature
, vol.361
, pp. 362-365
-
-
Holz, G.G.1
Kuhtreiber, W.M.2
Habener, J.F.3
-
19
-
-
0029781231
-
Factors determining the glucose sensitivity and glucose responsiveness of pancreatic beta cells
-
Schuit FC. Factors determining the glucose sensitivity and glucose responsiveness of pancreatic beta cells. Horm Res. 1996;46:99-106.
-
(1996)
Horm Res
, vol.46
, pp. 99-106
-
-
Schuit, F.C.1
-
20
-
-
64149095161
-
Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice
-
Fujimoto W, Miki T, Ogura T, Zhang M, Seino Y, Satin LS, et al. Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice. Diabetologia. 2009;52:863-72.
-
(2009)
Diabetologia
, vol.52
, pp. 863-872
-
-
Fujimoto, W.1
Miki, T.2
Ogura, T.3
Zhang, M.4
Seino, Y.5
Satin, L.S.6
-
21
-
-
77949538387
-
Epac: Defining a new mechanism for cAMP action
-
Gloerich M, Bos JL. Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol. 2010;50:355-75.
-
(2010)
Annu Rev Pharmacol Toxicol
, vol.50
, pp. 355-375
-
-
Gloerich, M.1
Bos, J.L.2
-
22
-
-
34447510936
-
Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains
-
Willoughby D, Cooper DM. Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains. Physiol Rev. 2007;87:965-1010.
-
(2007)
Physiol Rev
, vol.87
, pp. 965-1010
-
-
Willoughby, D.1
Cooper, D.M.2
-
24
-
-
0034105467
-
Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat islets
-
Guenifi A, Portela-Gomes GM, Grimelius L, Efendic S, Abdel-Halim SM. Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat islets. Histochem Cell Biol. 2000;113:81-9.
-
(2000)
Histochem Cell Biol
, vol.113
, pp. 81-89
-
-
Guenifi, A.1
Portela-Gomes, G.M.2
Grimelius, L.3
Efendic, S.4
Abdel-Halim, S.M.5
-
25
-
-
0142125207
-
Type VIII adenylyl cyclase in rat beta cells: Coincidence signal detector/generator for glucose and GLP-1
-
Delmeire D, Flamez D, Hinke SA, Cali JJ, Pipeleers D, Schuit F. Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1. Diabetologia. 2003;46:1383-93.
-
(2003)
Diabetologia
, vol.46
, pp. 1383-1393
-
-
Delmeire, D.1
Flamez, D.2
Hinke, S.A.3
Cali, J.J.4
Pipeleers, D.5
Schuit, F.6
-
26
-
-
0016791349
-
Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium
-
.Charles MA, Lawecki J, Pictet R, Grodsky GM. Insulin secretion. Interrelationships of glucose, cyclic adenosine 3:5-monophosphate, and calcium. J Biol Chem. 1975;250: 6134-40.
-
(1975)
J Biol Chem
, vol.250
, pp. 6134-6140
-
-
Charles, M.A.1
Lawecki, J.2
Pictet, R.3
Grodsky, G.M.4
-
28
-
-
0018906543
-
Stimulation of adenylate cyclase by Ca2+ and calmodulin in rat islets of Langerhans: Explanation for the glucose-induced increase in cyclic AMP levels
-
.Sharp GW, Wiedenkeller DE, Kaelin D, Siegel EG, Wollheim CB. Stimulation of adenylate cyclase by Ca2+ and calmodulin in rat islets of Langerhans: explanation for the glucose-induced increase in cyclic AMP levels. Diabetes. 1980;29:74-7.
-
(1980)
Diabetes
, vol.29
, pp. 74-77
-
-
Sharp, G.W.1
Wiedenkeller, D.E.2
Kaelin, D.3
Siegel, E.G.4
Wollheim, C.B.5
-
29
-
-
78951478947
-
Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells
-
.Roger B, Papin J, Vacher P, Raoux M, Mulot A, Dubois M, et al. Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells. Diabetologia. 2011;54: 390-402.
-
(2011)
Diabetologia
, vol.54
, pp. 390-402
-
-
Roger, B.1
Papin, J.2
Vacher, P.3
Raoux, M.4
Mulot, A.5
Dubois, M.6
-
30
-
-
84859731273
-
Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling
-
.Willoughby D, Everett KL, Halls ML, Pacheco J, Skroblin P, Vaca L, et al. Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling. Sci Signal. 2012;5:ra29.
-
(2012)
Sci Signal
, pp. 5-29
-
-
Willoughby, D.1
Everett, K.L.2
Halls, M.L.3
Pacheco, J.4
Skroblin, P.5
Vaca, L.6
-
31
-
-
63849116225
-
Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8
-
.Martin AC, Willoughby D, Ciruela A, Ayling LJ, Pagano M, Wachten S, et al. Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8. Mol Pharmacol. 2009;75:830-42.
-
(2009)
Mol Pharmacol
, vol.75
, pp. 830-842
-
-
Martin, A.C.1
Willoughby, D.2
Ciruela, A.3
Ayling, L.J.4
Pagano, M.5
Wachten, S.6
-
32
-
-
77953732616
-
AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems
-
Willoughby D, Masada N, Wachten S, Pagano M, Halls ML, Everett KL, et al. AKAP79/150 interacts with AC8 and regulates Ca2+-dependent cAMP synthesis in pancreatic and neuronal systems. J Biol Chem. 2010;285:20328-42.
-
(2010)
J Biol Chem
, vol.285
, pp. 20328-20342
-
-
Willoughby, D.1
Masada, N.2
Wachten, S.3
Pagano, M.4
Halls, M.L.5
Everett, K.L.6
-
33
-
-
0030609153
-
Store-operated Ca2+ entry in insulin-releasing pancreatic b-cells
-
Liu YJ, Gylfe E. Store-operated Ca2+ entry in insulin-releasing pancreatic b-cells. Cell Calcium. 1997;22:277-86.
-
(1997)
Cell Calcium
, vol.22
, pp. 277-286
-
-
Liu, Y.J.1
Gylfe, E.2
-
34
-
-
0035511968
-
Protein kinase C and calcium regulation of adenylyl cyclase in isolated rat pancreatic islets
-
Tian Y, Laychock SG. Protein kinase C and calcium regulation of adenylyl cyclase in isolated rat pancreatic islets. Diabetes. 2001;50:2505-13.
-
(2001)
Diabetes
, vol.50
, pp. 2505-2513
-
-
Tian, Y.1
Laychock, S.G.2
-
35
-
-
0023695239
-
Stimulation by glucose of cyclic AMP accumulation in mouse pancreatic islets is mediated by protein kinase C
-
Thams P, Capito K, Hedeskov CJ. Stimulation by glucose of cyclic AMP accumulation in mouse pancreatic islets is mediated by protein kinase C. Biochem J. 1988;253: 229-34.
-
(1988)
Biochem J
, vol.253
, pp. 229-234
-
-
Thams, P.1
Capito, K.2
Hedeskov, C.J.3
-
36
-
-
0023269978
-
The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: Studies with a phorbol ester
-
Bozem M, Nenquin M, Henquin JC. The ionic, electrical, and secretory effects of protein kinase C activation in mouse pancreatic B-cells: studies with a phorbol ester. Endocrinology. 1987;121:1025-33.
-
(1987)
Endocrinology
, vol.121
, pp. 1025-1033
-
-
Bozem, M.1
Nenquin, M.2
Henquin, J.C.3
-
37
-
-
45549098329
-
Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
-
Dyachok O, Idevall-Hagren O, Sågetorp J, Tian G, Wuttke A, Arrieumerlou C, et al. Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion. Cell Metab. 2008;8: 26-37.
-
(2008)
Cell Metab
, vol.8
, pp. 26-37
-
-
Dyachok, O.1
Idevall-Hagren, O.2
Sågetorp, J.3
Tian, G.4
Wuttke, A.5
Arrieumerlou, C.6
-
38
-
-
50449094096
-
Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells
-
Ramos LS, Zippin JH, Kamenetsky M, Buck J, Levin LR. Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. J Gen Physiol. 2008;132:329-38.
-
(2008)
J Gen Physiol
, vol.132
, pp. 329-338
-
-
Ramos, L.S.1
Zippin, J.H.2
Kamenetsky, M.3
Buck, J.4
Levin, L.R.5
-
39
-
-
0034725748
-
Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor
-
Chen Y, Cann MJ, Litvin TN, Iourgenko V, Sinclair ML, Levin LR, et al. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science. 2000;289:625-8.
-
(2000)
Science
, vol.289
, pp. 625-628
-
-
Chen, Y.1
Cann, M.J.2
Litvin, T.N.3
Iourgenko, V.4
Sinclair, M.L.5
Levin, L.R.6
-
40
-
-
0037844844
-
Soluble adenylyl cyclase. Synergism between calcium and bicarbonate
-
Litvin TN, Kamenetsky M, Zarifyan A, Buck J, Levin LR. Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem. 2003;278: 15922-6.
-
(2003)
J Biol Chem
, vol.278
, pp. 15922-15926
-
-
Litvin, T.N.1
Kamenetsky, M.2
Zarifyan, A.3
Buck, J.4
Levin, L.R.5
-
41
-
-
0141703301
-
Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa
-
Jaiswal BS, Conti M. Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. Proc Natl Acad Sci USA. 2003;100:10676-81.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10676-10681
-
-
Jaiswal, B.S.1
Conti, M.2
-
42
-
-
79959390543
-
Glucose- and hormone-induced cAMP oscillations in a- and b-cells within intact pancreatic islets
-
Tian G, Sandler S, Gylfe E, Tengholm A. Glucose- and hormone-induced cAMP oscillations in a- and b-cells within intact pancreatic islets. Diabetes. 2011;60:1535-43.
-
(2011)
Diabetes
, vol.60
, pp. 1535-1543
-
-
Tian, G.1
Sandler, S.2
Gylfe, E.3
Tengholm, A.4
-
43
-
-
34447265905
-
Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling
-
Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem. 2007;76: 481-511.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 481-511
-
-
Conti, M.1
Beavo, J.2
-
44
-
-
0141594650
-
Cyclic nucleotide phosphodiesterases in pancreatic islets
-
Pyne NJ, Furman BL. Cyclic nucleotide phosphodiesterases in pancreatic islets. Diabetologia. 2003;46:1179-89.
-
(2003)
Diabetologia
, vol.46
, pp. 1179-1189
-
-
Pyne, N.J.1
Furman, B.L.2
-
45
-
-
82255192444
-
From PDE3B to the regulation of energy homeostasis
-
Degerman E, Ahmad F, Chung YW, Guirguis E, Omar B, Stenson L, et al. From PDE3B to the regulation of energy homeostasis. Curr Opin Pharmacol. 2011;11: 676-82.
-
(2011)
Curr Opin Pharmacol
, vol.11
, pp. 676-682
-
-
Degerman, E.1
Ahmad, F.2
Chung, Y.W.3
Guirguis, E.4
Omar, B.5
Stenson, L.6
-
46
-
-
0019494448
-
Cyclic nucleotide phosphodiesterase of rat pancreatic islets. Effects of Ca2+, calmodulin and trifluoperazine
-
Sugden MC, Ashcroft SJ. Cyclic nucleotide phosphodiesterase of rat pancreatic islets. Effects of Ca2+, calmodulin and trifluoperazine. Biochem J. 1981;197:459-64.
-
(1981)
Biochem J
, vol.197
, pp. 459-464
-
-
Sugden, M.C.1
Ashcroft, S.J.2
-
47
-
-
0020681907
-
The role of calmodulin in insulin secretion: The presence of a calmodulin-stimulatable phosphodiesterase in pancreatic islets of normal and pregnant rats
-
Lipson LG, Oldham SB. The role of calmodulin in insulin secretion: the presence of a calmodulin-stimulatable phosphodiesterase in pancreatic islets of normal and pregnant rats. Life Sci. 1983;32:775-80.
-
(1983)
Life Sci
, vol.32
, pp. 775-780
-
-
Lipson, L.G.1
Oldham, S.B.2
-
48
-
-
0022505064
-
Cyclic AMP phosphodiesterase activity in mouse pancreatic islets. Effects of calmodulin and phospholipids
-
Capito K, Hedeskov CJ, Thams P. Cyclic AMP phosphodiesterase activity in mouse pancreatic islets. Effects of calmodulin and phospholipids. Acta Endocrinol (Copenh). 1986; 111:533-8.
-
(1986)
Acta Endocrinol (Copenh)
, vol.111
, pp. 533-538
-
-
Capito, K.1
Hedeskov, C.J.2
Thams, P.3
-
49
-
-
0033529693
-
The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion
-
Han P, Werber J, Surana M, Fleischer N, Michaeli T. The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion. J Biol Chem. 1999;274:22337-44.
-
(1999)
J Biol Chem
, vol.274
, pp. 22337-22344
-
-
Han, P.1
Werber, J.2
Surana, M.3
Fleischer, N.4
Michaeli, T.5
-
50
-
-
38549127858
-
Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose
-
Dov A, Abramovitch E, Warwar N, Nesher R. Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose. Endocrinology. 2008;149:741-8.
-
(2008)
Endocrinology
, vol.149
, pp. 741-748
-
-
Dov, A.1
Abramovitch, E.2
Warwar, N.3
Nesher, R.4
-
51
-
-
51249111507
-
Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets
-
Waddleton D, Wu W, Feng Y, Thompson C, Wu M, Zhou YP, et al. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Biochem Pharmacol. 2008;76:884-93.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 884-893
-
-
Waddleton, D.1
Wu, W.2
Feng, Y.3
Thompson, C.4
Wu, M.5
Zhou, Y.P.6
-
52
-
-
0029562996
-
Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: Contributions of types III and IV to the modulation of insulin secretion
-
Parker JC, VanVolkenburg MA, Ketchum RJ, Brayman KL, Andrews KM. Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: contributions of types III and IV to the modulation of insulin secretion. Biochem Biophys Res Commun. 1995;217:916-23.
-
(1995)
Biochem Biophys Res Commun
, vol.217
, pp. 916-923
-
-
Parker, J.C.1
Vanvolkenburg, M.A.2
Ketchum, R.J.3
Brayman, K.L.4
Andrews, K.M.5
-
53
-
-
78649816005
-
Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets
-
Heimann E, Jones HA, Resjö S, Manganiello VC, Stenson L, Degerman E. Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets. PLoS One. 2010;5:e14191.
-
(2010)
PLoS One
, vol.5
-
-
Heimann, E.1
Jones, H.A.2
Resjö, S.3
Manganiello, V.C.4
Stenson, L.5
Degerman, E.6
-
54
-
-
0037020258
-
Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic b-cell exocytosis and release of insulin
-
Härndahl L, Jing XJ, Ivarsson R, Degerman E, Ahren B, Manganiello VC, et al. Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic b-cell exocytosis and release of insulin. J Biol Chem. 2002;277: 37446-55.
-
(2002)
J Biol Chem
, vol.277
, pp. 37446-37455
-
-
Härndahl, L.1
Jing, X.J.2
Ivarsson, R.3
Degerman, E.4
Ahren, B.5
Manganiello, V.C.6
-
55
-
-
2442423329
-
B-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology
-
Härndahl L, Wierup N, Enerbäck S, Mulder H, Manganiello VC, Sundler F, et al. b-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology. J Biol Chem. 2004;279:15214-22.
-
(2004)
J Biol Chem
, vol.279
, pp. 15214-15222
-
-
Härndahl, L.1
Wierup, N.2
Enerbäck, S.3
Mulder, H.4
Manganiello, V.C.5
Sundler, F.6
-
56
-
-
0031006544
-
Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B
-
Zhao AZ, Zhao H, Teague J, Fujimoto W, Beavo JA. Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B. Proc Natl Acad Sci USA. 1997;94:3223-8.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3223-3228
-
-
Zhao, A.Z.1
Zhao, H.2
Teague, J.3
Fujimoto, W.4
Beavo, J.A.5
-
57
-
-
33845348168
-
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice
-
Choi YH, Park S, Hockman S, Zmuda-Trzebiatowska E, Svennelid F, Haluzik M, et al. Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J Clin Invest. 2006;116:3240-51.
-
(2006)
J Clin Invest
, vol.116
, pp. 3240-3251
-
-
Choi, Y.H.1
Park, S.2
Hockman, S.3
Zmuda-Trzebiatowska, E.4
Svennelid, F.5
Haluzik, M.6
-
58
-
-
34249666189
-
B-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin
-
Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, et al. b-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin. Cell Signal. 2007;19: 1505-13.
-
(2007)
Cell Signal
, vol.19
, pp. 1505-1513
-
-
Walz, H.A.1
Wierup, N.2
Vikman, J.3
Manganiello, V.C.4
Degerman, E.5
Eliasson, L.6
-
59
-
-
0029122198
-
Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity
-
Shafiee-Nick R, Pyne NJ, Furman BL. Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity. Br J Pharmacol. 1995;115:1486-92.
-
(1995)
Br J Pharmacol
, vol.115
, pp. 1486-1492
-
-
Shafiee-Nick, R.1
Pyne, N.J.2
Furman, B.L.3
-
60
-
-
34247399168
-
PDE-10A inhibitors as insulin secretagogues
-
Cantin LD, Magnuson S, Gunn D, Barucci N, Breuhaus M, Bullock WH, et al. PDE-10A inhibitors as insulin secretagogues. Bioorg Med Chem Lett. 2007;17:2869-73.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 2869-2873
-
-
Cantin, L.D.1
Magnuson, S.2
Gunn, D.3
Barucci, N.4
Breuhaus, M.5
Bullock, W.H.6
-
61
-
-
84868241098
-
Role of phosphodiesterases in the shaping of sub-plasma membrane cAMP oscillations and pulsatile insulin secretion
-
in press, doi:10.1242/ jcs.107201
-
Tian G, Sagetorp J, Xu Y, Shuai H, Degerman E, Tengholm A. Role of phosphodiesterases in the shaping of sub-plasma membrane cAMP oscillations and pulsatile insulin secretion. J Cell Sci. 2012; in press, doi:10.1242/ jcs.107201.
-
(2012)
J Cell Sci
-
-
Tian, G.1
Sagetorp, J.2
Xu, Y.3
Shuai, H.4
Degerman, E.5
Tengholm, A.6
-
62
-
-
33644618433
-
The biology of incretin hormones
-
Drucker DJ. The biology of incretin hormones. Cell Metab. 2006;3:153-65.
-
(2006)
Cell Metab
, vol.3
, pp. 153-165
-
-
Drucker, D.J.1
-
63
-
-
0035461315
-
The neuropeptide pituitary adenylate cyclase-activating polypeptide and islet function
-
Filipsson K, Kvist-Reimer M, Ahren B. The neuropeptide pituitary adenylate cyclase-activating polypeptide and islet function. Diabetes. 2001;50:1959-69.
-
(2001)
Diabetes
, vol.50
, pp. 1959-1969
-
-
Filipsson, K.1
Kvist-Reimer, M.2
Ahren, B.3
-
64
-
-
0842346703
-
ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans
-
Al-Majed HT, Jones PM, Persaud SJ, Sugden D, Huang GC, Amiel S, et al. ACTH stimulates insulin secretion from MIN6 cells and primary mouse and human islets of Langerhans. J Endocrinol. 2004;180:155-66.
-
(2004)
J Endocrinol
, vol.180
, pp. 155-166
-
-
Al-Majed, H.T.1
Jones, P.M.2
Persaud, S.J.3
Sugden, D.4
Huang, G.C.5
Amiel, S.6
-
65
-
-
0030474003
-
Mechanisms of inhibition of insulin release
-
Sharp GW. Mechanisms of inhibition of insulin release. Am J Physiol. 1996;271:C1781-99.
-
(1996)
Am J Physiol
, vol.271
-
-
Sharp, G.W.1
-
66
-
-
80052878624
-
Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet b-cells
-
Dezaki K, Damdindorj B, Sone H, Dyachok O, Tengholm A, Gylfe E, et al. Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet b-cells. Diabetes. 2011;60: 2315-24.
-
(2011)
Diabetes
, vol.60
, pp. 2315-2324
-
-
Dezaki, K.1
Damdindorj, B.2
Sone, H.3
Dyachok, O.4
Tengholm, A.5
Gylfe, E.6
-
67
-
-
0030245732
-
Neurotransmitter-induced inhibition of exocytosis in insulin- secreting b cells by activation of calcineurin
-
Renström E, Ding WG, Bokvist K, Rorsman P. Neurotransmitter-induced inhibition of exocytosis in insulin- secreting b cells by activation of calcineurin. Neuron. 1996;17:513-22.
-
(1996)
Neuron
, vol.17
, pp. 513-522
-
-
Renström, E.1
Ding, W.G.2
Bokvist, K.3
Rorsman, P.4
-
69
-
-
31144458770
-
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting b-cells
-
Dyachok O, Isakov Y, Sågetorp J, TengholmA. Oscillations of cyclic AMP in hormone-stimulated insulin-secreting b-cells. Nature. 2006;439:349-52.
-
(2006)
Nature
, vol.439
, pp. 349-352
-
-
Dyachok, O.1
Isakov, Y.2
Sågetorp, J.3
Tengholm, A.4
-
70
-
-
80053180108
-
Systems analysis of GLP-1 receptor signaling in pancreatic b-cells
-
Takeda Y, Amano A, Noma A, Nakamura Y, Fujimoto S, Inagaki N. Systems analysis of GLP-1 receptor signaling in pancreatic b-cells. Am J Physiol Cell Physiol. 2011;301: C792-803.
-
(2011)
Am J Physiol Cell Physiol
, vol.301
-
-
Takeda, Y.1
Amano, A.2
Noma, A.3
Nakamura, Y.4
Fujimoto, S.5
Inagaki, N.6
-
71
-
-
37149054439
-
Regulation of cAMP dynamics by Ca2+ and G proteincoupled receptors in the pancreatic b-cell: A computational approach
-
Fridlyand LE, Harbeck MC, Roe MW, Philipson LH. Regulation of cAMP dynamics by Ca2+ and G proteincoupled receptors in the pancreatic b-cell: a computational approach. Am J Physiol Cell Physiol. 2007;293: C1924-33.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
-
-
Fridlyand, L.E.1
Harbeck, M.C.2
Roe, M.W.3
Philipson, L.H.4
-
72
-
-
20044389102
-
Loss of connexin36 channels alters b-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release
-
Ravier MA, Guldenagel M, Charollais A, Gjinovci A, Caille D, Sohl G, et al. Loss of connexin36 channels alters b-cell coupling, islet synchronization of glucose-induced Ca2+ and insulin oscillations, and basal insulin release. Diabetes. 2005;54:1798-807.
-
(2005)
Diabetes
, vol.54
, pp. 1798-1807
-
-
Ravier, M.A.1
Guldenagel, M.2
Charollais, A.3
Gjinovci, A.4
Caille, D.5
Sohl, G.6
-
73
-
-
51049110095
-
Cell coupling in mouse pancreatic b-cells measured in intact islets of Langerhans. Philos Transact A Math Phys
-
Zhang Q, Galvanovskis J, Abdulkader F, Partridge CJ, Göpel SO, Eliasson L, et al. Cell coupling in mouse pancreatic b-cells measured in intact islets of Langerhans. Philos Transact A Math Phys Eng Sci. 2008;366:3503-23.
-
(2008)
Eng Sci
, vol.366
, pp. 3503-3523
-
-
Zhang, Q.1
Galvanovskis, J.2
Abdulkader, F.3
Partridge, C.J.4
Göpel, S.O.5
Eliasson, L.6
-
74
-
-
0015800525
-
Activation by glucose of adenyl cyclase in pancreatic islets of the rat
-
Grill V, Cerasi E. Activation by glucose of adenyl cyclase in pancreatic islets of the rat. FEBS Lett. 1973;33: 311-14.
-
(1973)
FEBS Lett
, vol.33
, pp. 311-314
-
-
Grill, V.1
Cerasi, E.2
-
75
-
-
0018411266
-
The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release
-
Sharp GW. The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release. Diabetologia. 1979;16:287-96.
-
(1979)
Diabetologia
, vol.16
, pp. 287-296
-
-
Sharp, G.W.1
-
76
-
-
0016271918
-
The pancreatic b-cell recognition of insulin secretagogues: Does cyclic AMP mediate the effect of glucose?
-
Hellman B, Idahl LA, Lernmark A, Täljedal IB. The pancreatic b-cell recognition of insulin secretagogues: does cyclic AMP mediate the effect of glucose? Proc Natl Acad Sci USA. 1974;71:3405-9
-
(1974)
Proc Natl Acad Sci USA
, vol.71
, pp. 3405-3409
-
-
Hellman, B.1
Idahl, L.A.2
Lernmark, A.3
Täljedal, I.B.4
-
77
-
-
0021813422
-
Regulation of adenosine 3',5'-monophosphate levels in the pancreatic B cell
-
Schuit FC, Pipeleers DG. Regulation of adenosine 3',5'-monophosphate levels in the pancreatic B cell. Endocrinology. 1985;117:834-40.
-
(1985)
Endocrinology
, vol.117
, pp. 834-840
-
-
Schuit, F.C.1
Pipeleers, D.G.2
-
78
-
-
24744455039
-
Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 b-cell line
-
Landa LR Jr, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, et al. Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 b-cell line. J Biol Chem. 2005;280:31294-302.
-
(2005)
J Biol Chem
, vol.280
, pp. 31294-31302
-
-
Landa Jr., L.R.1
Harbeck, M.2
Kaihara, K.3
Chepurny, O.4
Kitiphongspattana, K.5
Graf, O.6
-
79
-
-
78650510151
-
Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit
-
Ni Q, Ganesan A, Aye-Han NN, Gao X, Allen MD, Levchenko A, et al. Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nat Chem Biol. 2011; 7:34-40.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 34-40
-
-
Ni, Q.1
Ganesan, A.2
Aye-Han, N.N.3
Gao, X.4
Allen, M.D.5
Levchenko, A.6
-
80
-
-
47749094308
-
Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice
-
Kim JW, Roberts CD, Berg SA, Caicedo A, Roper SD, Chaudhari N. Imaging cyclic AMP changes in pancreatic islets of transgenic reporter mice. PLoS One. 2008;3:e2127.
-
(2008)
PLoS One
, vol.3
-
-
Kim, J.W.1
Roberts, C.D.2
Berg, S.A.3
Caicedo, A.4
Roper, S.D.5
Chaudhari, N.6
-
81
-
-
0015391602
-
Insulin release from mouse islets. Effect of glucose and hormones on adenylate cyclase
-
Davis B, Lazarus NR. Insulin release from mouse islets. Effect of glucose and hormones on adenylate cyclase. Biochem J. 1972;129:373-9.
-
(1972)
Biochem J
, vol.129
, pp. 373-379
-
-
Davis, B.1
Lazarus, N.R.2
-
82
-
-
0033582196
-
Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells
-
Takahashi N, Kadowaki T, Yazaki Y, Ellis-Davies GC, Miyashita Y, Kasai H. Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells. Proc Natl Acad Sci USA. 1999;96:760-5.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 760-765
-
-
Takahashi, N.1
Kadowaki, T.2
Yazaki, Y.3
Ellis-Davies, G.C.4
Miyashita, Y.5
Kasai, H.6
-
83
-
-
0027531740
-
Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells
-
Gembal M, Detimary P, Gilon P, Gao ZY, Henquin JC. Mechanisms by which glucose can control insulin release independently from its action on adenosine triphosphate-sensitive K+ channels in mouse B cells. J Clin Invest. 1993; 91:871-80.
-
(1993)
J Clin Invest
, vol.91
, pp. 871-880
-
-
Gembal, M.1
Detimary, P.2
Gilon, P.3
Gao, Z.Y.4
Henquin, J.C.5
-
84
-
-
0032956241
-
CAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets
-
Yajima H, Komatsu M, Schermerhorn T, Aizawa T, Kaneko T, Nagai M, et al. cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets. Diabetes. 1999;48:1006-12.
-
(1999)
Diabetes
, vol.48
, pp. 1006-1012
-
-
Yajima, H.1
Komatsu, M.2
Schermerhorn, T.3
Aizawa, T.4
Kaneko, T.5
Nagai, M.6
-
85
-
-
0031712798
-
The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: In search of the underlying mechanism
-
Sato Y, Henquin JC. The K+-ATP channel-independent pathway of regulation of insulin secretion by glucose: in search of the underlying mechanism. Diabetes. 1998;47:1713-21.
-
(1998)
Diabetes
, vol.47
, pp. 1713-1721
-
-
Sato, Y.1
Henquin, J.C.2
-
86
-
-
37649002935
-
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP
-
Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, et al. Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci USA. 2007;104:19333-8.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19333-19338
-
-
Shibasaki, T.1
Takahashi, H.2
Miki, T.3
Sunaga, Y.4
Matsumura, K.5
Yamanaka, M.6
-
87
-
-
0032459512
-
Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic b-cells
-
Jones PM, Persaud SJ. Protein kinases, protein phosphorylation, and the regulation of insulin secretion from pancreatic b-cells. Endocr Rev. 1998;19:429-61.
-
(1998)
Endocr Rev
, vol.19
, pp. 429-461
-
-
Jones, P.M.1
Persaud, S.J.2
-
88
-
-
0031434473
-
Anchoring of protein kinase A facilitates hormone-mediated insulin secretion
-
Lester LB, Langeberg LK, Scott JD. Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proc Natl Acad Sci USA. 1997;94:14942-7.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 14942-14947
-
-
Lester, L.B.1
Langeberg, L.K.2
Scott, J.D.3
-
89
-
-
0035089841
-
Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation
-
Lester LB, Faux MC, Nauert JB, Scott JD. Targeted protein kinase A and PP-2B regulate insulin secretion through reversible phosphorylation. Endocrinology. 2001;142:1218-27.
-
(2001)
Endocrinology
, vol.142
, pp. 1218-1227
-
-
Lester, L.B.1
Faux, M.C.2
Nauert, J.B.3
Scott, J.D.4
-
90
-
-
2642705036
-
A novel lipid-anchored Akinase anchoring protein facilitates cAMP-responsive membrane events
-
Fraser ID, Tavalin SJ, Lester LB, Langeberg LK, Westphal AM, Dean RA, et al. A novel lipid-anchored Akinase anchoring protein facilitates cAMP-responsive membrane events. EMBO J. 1998;17:2261-72.
-
(1998)
EMBO J
, vol.17
, pp. 2261-2272
-
-
Fraser, I.D.1
Tavalin, S.J.2
Lester, L.B.3
Langeberg, L.K.4
Westphal, A.M.5
Dean, R.A.6
-
91
-
-
71549146561
-
AKAP 18 a and g have opposing effects on insulin release in INS-1E cells
-
Josefsen K, Lee YC, Thams P, Efendic S, Nielsen JH. AKAP 18 a and g have opposing effects on insulin release in INS-1E cells. FEBS Lett. 2010;584:81-5.
-
(2010)
FEBS Lett
, vol.584
, pp. 81-85
-
-
Josefsen, K.1
Lee, Y.C.2
Thams, P.3
Efendic, S.4
Nielsen, J.H.5
-
92
-
-
60849087354
-
Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: A tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring
-
Faruque OM, Le-Nguyen D, Lajoix AD, Vives E, Petit P, Bataille D, et al. Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring. Am J Physiol Cell Physiol. 2009; 296:C306-16.
-
(2009)
Am J Physiol Cell Physiol
, vol.296
-
-
Faruque, O.M.1
Le-Nguyen, D.2
Lajoix, A.D.3
Vives, E.4
Petit, P.5
Bataille, D.6
-
93
-
-
33747169050
-
CAMP oscillations restrict protein kinase A redistribution in insulin-secreting cells
-
Dyachok O, Sågetorp J, Isakov Y, Tengholm A. cAMP oscillations restrict protein kinase A redistribution in insulin-secreting cells. Biochem Soc Trans. 2006;34:498-501.
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 498-501
-
-
Dyachok, O.1
Sågetorp, J.2
Isakov, Y.3
Tengholm, A.4
-
94
-
-
0019834167
-
Calcium and pancreatic b-cell function: Modification of 45Ca fluxes by methylxanthines and dibutyryl cyclic-AMP
-
Gylfe E, Hellman B. Calcium and pancreatic b-cell function: modification of 45Ca fluxes by methylxanthines and dibutyryl cyclic-AMP. Biochem Med. 1981;26:365-76.
-
(1981)
Biochem Med
, vol.26
, pp. 365-376
-
-
Gylfe, E.1
Hellman, B.2
-
95
-
-
0021245129
-
The ionic, electrical, and secretory effects of endogenous cyclic adenosine monophosphate in mouse pancreatic B cells: Studies with forskolin
-
Henquin JC, Meissner HP. The ionic, electrical, and secretory effects of endogenous cyclic adenosine monophosphate in mouse pancreatic B cells: studies with forskolin. Endocrinology. 1984;115:1125-34.
-
(1984)
Endocrinology
, vol.115
, pp. 1125-1134
-
-
Henquin, J.C.1
Meissner, H.P.2
-
96
-
-
0021983028
-
Electrical activity, cAMP concentration, and insulin release in mouse islets of Langerhans
-
Eddlestone GT, Oldham SB, Lipson LG, Premdas FH, Beigelman PM. Electrical activity, cAMP concentration, and insulin release in mouse islets of Langerhans. Am J Physiol. 1985;248:C145-53.
-
(1985)
Am J Physiol
, vol.248
-
-
Eddlestone, G.T.1
Oldham, S.B.2
Lipson, L.G.3
Premdas, F.H.4
Beigelman, P.M.5
-
97
-
-
0023649945
-
Cyclic AMP raises cytosolic Ca2+ and promotes Ca2+ influx in a clonal pancreatic b-cell line (HIT T-15)
-
Prentki M, Glennon MC, Geschwind JF, Matschinsky FM, Corkey BE. Cyclic AMP raises cytosolic Ca2+ and promotes Ca2+ influx in a clonal pancreatic b-cell line (HIT T-15). FEBS Lett. 1987;220:103-7.
-
(1987)
FEBS Lett
, vol.220
, pp. 103-107
-
-
Prentki, M.1
Glennon, M.C.2
Geschwind, J.F.3
Matschinsky, F.M.4
Corkey, B.E.5
-
98
-
-
0023525741
-
Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion
-
Prentki M, Matschinsky FM. Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev. 1987;67:1185-248.
-
(1987)
Physiol Rev
, vol.67
, pp. 1185-1248
-
-
Prentki, M.1
Matschinsky, F.M.2
-
99
-
-
0024476904
-
Three types of cytoplasmic Ca2+ oscillations in stimulated pancreatic b-cells
-
Grapengiesser E, Gylfe E, Hellman B. Three types of cytoplasmic Ca2+ oscillations in stimulated pancreatic b-cells. Arch Biochem Biophys. 1989;268:404-7.
-
(1989)
Arch Biochem Biophys
, vol.268
, pp. 404-407
-
-
Grapengiesser, E.1
Gylfe, E.2
Hellman, B.3
-
100
-
-
0030588223
-
Crosstalk between the cAMP and inositol trisphosphate-signalling pathways in pancreatic b-cells
-
Liu YJ, Grapengiesser E, Gylfe E, Hellman B. Crosstalk between the cAMP and inositol trisphosphate-signalling pathways in pancreatic b-cells. Arch Biochem Biophys. 1996;334:295-302.
-
(1996)
Arch Biochem Biophys
, vol.334
, pp. 295-302
-
-
Liu, Y.J.1
Grapengiesser, E.2
Gylfe, E.3
Hellman, B.4
-
101
-
-
0027235323
-
Calcium-independent potentiation of insulin release by cyclic AMP in single b-cells
-
Ämmälä C, Ashcroft FM, Rorsman P. Calcium-independent potentiation of insulin release by cyclic AMP in single b-cells. Nature. 1993;363:356-8.
-
(1993)
Nature
, vol.363
, pp. 356-358
-
-
Ämmälä, C.1
Ashcroft, F.M.2
Rorsman, P.3
-
102
-
-
0031884567
-
Intracellular cAMP potentiates voltage-dependent activation of L-type Ca2+ channels in rat islet b-cells
-
Kanno T, Suga S, Wu J, Kimura M, Wakui M. Intracellular cAMP potentiates voltage-dependent activation of L-type Ca2+ channels in rat islet b-cells. Pflügers Arch. 1998;435: 578-80.
-
(1998)
Pflügers Arch
, vol.435
, pp. 578-580
-
-
Kanno, T.1
Suga, S.2
Wu, J.3
Kimura, M.4
Wakui, M.5
-
103
-
-
9444266572
-
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse a-cells
-
Gromada J, Ma X, Hoy M, Bokvist K, Salehi A, Berggren PO, et al. ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse a-cells. Diabetes. 2004;53:S181-9.
-
(2004)
Diabetes
, vol.53
-
-
Gromada, J.1
Ma, X.2
Hoy, M.3
Bokvist, K.4
Salehi, A.5
Berggren, P.O.6
-
104
-
-
8544271710
-
Ca2+-induced Ca2+ release via inositol 1,4,5-trisphosphate receptors is amplified by protein kinase A and triggers exocytosis in pancreatic b-cells
-
Dyachok O, Gylfe E. Ca2+-induced Ca2+ release via inositol 1,4,5-trisphosphate receptors is amplified by protein kinase A and triggers exocytosis in pancreatic b-cells. J Biol Chem. 2004;279:45455-61.
-
(2004)
J Biol Chem
, vol.279
, pp. 45455-45461
-
-
Dyachok, O.1
Gylfe, E.2
-
105
-
-
42449108189
-
Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagonlike peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets
-
Kim BJ, Park KH, Yim CY, Takasawa S, Okamoto H, Im MJ, et al. Generation of nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose by glucagonlike peptide-1 evokes Ca2+ signal that is essential for insulin secretion in mouse pancreatic islets. Diabetes. 2008;57:868-78.
-
(2008)
Diabetes
, vol.57
, pp. 868-878
-
-
Kim, B.J.1
Park, K.H.2
Yim, C.Y.3
Takasawa, S.4
Okamoto, H.5
Im, M.J.6
-
106
-
-
22144489495
-
A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic b cells
-
Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, et al. A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic b cells. J Physiol. 2005;566:173-88.
-
(2005)
J Physiol
, vol.566
, pp. 173-188
-
-
Kang, G.1
Chepurny, O.G.2
Rindler, M.J.3
Collis, L.4
Chepurny, Z.5
Li, W.H.6
-
107
-
-
0023020084
-
Regulation of insulin secretion by cAMP in rat islets of Langerhans permeabilised by high-voltage discharge
-
Jones PM, Fyles JM, Howell SL. Regulation of insulin secretion by cAMP in rat islets of Langerhans permeabilised by high-voltage discharge. FEBS Lett. 1986;205: 205-9.
-
(1986)
FEBS Lett
, vol.205
, pp. 205-209
-
-
Jones, P.M.1
Fyles, J.M.2
Howell, S.L.3
-
108
-
-
0027157517
-
Enhancers of cytosolic cAMP augment depolarization-induced exocytosis from pancreatic B-cells: Evidence for effects distal to Ca2+ entry
-
Gillis KD, Misler S. Enhancers of cytosolic cAMP augment depolarization-induced exocytosis from pancreatic B-cells: evidence for effects distal to Ca2+ entry. Pflugers Arch. 1993; 424:195-7.
-
(1993)
Pflugers Arch
, vol.424
, pp. 195-197
-
-
Gillis, K.D.1
Misler, S.2
-
109
-
-
0021871354
-
Insulin release independent of a rise in cytosolic free Ca2+ by forskolin and phorbol ester
-
Tamagawa T, Niki H, Niki A. Insulin release independent of a rise in cytosolic free Ca2+ by forskolin and phorbol ester. FEBS Lett. 1985;183:430-2.
-
(1985)
FEBS Lett
, vol.183
, pp. 430-432
-
-
Tamagawa, T.1
Niki, H.2
Niki, A.3
-
110
-
-
79952040814
-
CAMP increases the sensitivity of exocytosis to Ca2+ primarily through protein kinase A in mouse pancreatic beta cells
-
Skelin M, Rupnik M. cAMP increases the sensitivity of exocytosis to Ca2+ primarily through protein kinase A in mouse pancreatic beta cells. Cell Calcium. 2011;49:89-99.
-
(2011)
Cell Calcium
, vol.49
, pp. 89-99
-
-
Skelin, M.1
Rupnik, M.2
-
111
-
-
85047680153
-
Ca2+/calmodulin and cyclic 3,5' adenosine monophosphate control movement of secretory granules through protein phosphorylation/dephosphorylation in the pancreatic b-cell
-
Hisatomi M, Hidaka H, Niki I. Ca2+/calmodulin and cyclic 3,5' adenosine monophosphate control movement of secretory granules through protein phosphorylation/dephosphorylation in the pancreatic b-cell. Endocrinology. 1996;137: 4644-9.
-
(1996)
Endocrinology
, vol.137
, pp. 4644-4649
-
-
Hisatomi, M.1
Hidaka, H.2
Niki, I.3
-
112
-
-
0030792753
-
Protein kinase Adependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells
-
Renström E, Eliasson L, Rorsman P. Protein kinase Adependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol. 1997;502: 105-18.
-
(1997)
J Physiol
, vol.502
, pp. 105-118
-
-
Renström, E.1
Eliasson, L.2
Rorsman, P.3
-
113
-
-
0037337832
-
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells
-
Eliasson L, Ma X, Renström E, Barg S, Berggren PO, Galvanovskis J, et al. SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells. J Gen Physiol. 2003;121:181-97.
-
(2003)
J Gen Physiol
, vol.121
, pp. 181-197
-
-
Eliasson, L.1
Ma, X.2
Renström, E.3
Barg, S.4
Berggren, P.O.5
Galvanovskis, J.6
-
114
-
-
10344258585
-
Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+
-
Wan QF, Dong Y, Yang H, Lou X, Ding J, Xu T. Protein kinase activation increases insulin secretion by sensitizing the secretory machinery to Ca2+. J Gen Physiol. 2004;124: 653-62.
-
(2004)
J Gen Physiol
, vol.124
, pp. 653-662
-
-
Wan, Q.F.1
Dong, Y.2
Yang, H.3
Lou, X.4
Ding, J.5
Xu, T.6
-
115
-
-
10344221040
-
A highly Ca2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells
-
Yang Y, Gillis KD. A highly Ca2+-sensitive pool of granules is regulated by glucose and protein kinases in insulin-secreting INS-1 cells. J Gen Physiol. 2004;124: 641-51.
-
(2004)
J Gen Physiol
, vol.124
, pp. 641-651
-
-
Yang, Y.1
Gillis, K.D.2
-
116
-
-
0025562585
-
Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A
-
Persaud SJ, Jones PM, Howell SL. Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A. Biochem Biophys Res Commun. 1990;173:833-9.
-
(1990)
Biochem Biophys Res Commun
, vol.173
, pp. 833-839
-
-
Persaud, S.J.1
Jones, P.M.2
Howell, S.L.3
-
117
-
-
0031587746
-
Pseudosubstrate inhibition of cyclic AMP-dependent protein kinase in intact pancreatic islets: Effects on cyclic AMP-dependent and glucose-dependent insulin secretion
-
Harris TE, Persaud SJ, Jones PM. Pseudosubstrate inhibition of cyclic AMP-dependent protein kinase in intact pancreatic islets: effects on cyclic AMP-dependent and glucose-dependent insulin secretion. Biochem Biophys Res Commun. 1997;232:648-51.
-
(1997)
Biochem Biophys Res Commun
, vol.232
, pp. 648-651
-
-
Harris, T.E.1
Persaud, S.J.2
Jones, P.M.3
-
118
-
-
33644538464
-
Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets
-
Hatakeyama H, Kishimoto T, Nemoto T, Kasai H, Takahashi N. Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets. J Physiol. 2006;570:271-82.
-
(2006)
J Physiol
, vol.570
, pp. 271-282
-
-
Hatakeyama, H.1
Kishimoto, T.2
Nemoto, T.3
Kasai, H.4
Takahashi, N.5
-
119
-
-
77954925625
-
CAMP mediators of pulsatile insulin secretion from glucosestimulated single b-cells
-
Idevall-Hagren O, Barg S, Gylfe E, Tengholm A. cAMP mediators of pulsatile insulin secretion from glucosestimulated single b-cells. J Biol Chem. 2010;285:23007-18.
-
(2010)
J Biol Chem
, vol.285
, pp. 23007-23018
-
-
Idevall-Hagren, O.1
Barg, S.2
Gylfe, E.3
Tengholm, A.4
-
120
-
-
0031884567
-
Intracellular cAMP potentiates voltage-dependent activation of L-type Ca2+ channels in rat islet b-cells
-
Kanno T, Suga S, Wu J, Kimura M, Wakui M. Intracellular cAMP potentiates voltage-dependent activation of L-type Ca2+ channels in rat islet b-cells. Pflügers Arch. 1998;435: 578-80.
-
(1998)
Pflügers Arch
, vol.435
, pp. 578-580
-
-
Kanno, T.1
Suga, S.2
Wu, J.3
Kimura, M.4
Wakui, M.5
-
121
-
-
0242467078
-
PKA-mediated phosphorylation of the human KATP channel: Separate roles of Kir6.2 and SUR1 subunit phosphorylation
-
Beguin P, Nagashima K, Nishimura M, Gonoi T, Seino S. PKA-mediated phosphorylation of the human KATP channel: separate roles of Kir6.2 and SUR1 subunit phosphorylation. EMBO J. 1999;18:4722-32.
-
(1999)
EMBO J
, vol.18
, pp. 4722-4732
-
-
Beguin, P.1
Nagashima, K.2
Nishimura, M.3
Gonoi, T.4
Seino, S.5
-
122
-
-
0034161609
-
Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells
-
Lin YF, Jan YN, Jan LY. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cells. EMBO J. 2000;19:942-55.
-
(2000)
EMBO J
, vol.19
, pp. 942-955
-
-
Lin, Y.F.1
Jan, Y.N.2
Jan, L.Y.3
-
123
-
-
0036718447
-
Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism
-
Light PE, Manning Fox JE, Riedel MJ, Wheeler MB. Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism. Mol Endocrinol. 2002;16: 2135-44.
-
(2002)
Mol Endocrinol
, vol.16
, pp. 2135-2144
-
-
Light, P.E.1
Manning Fox, J.E.2
Riedel, M.J.3
Wheeler, M.B.4
-
124
-
-
10644293820
-
Glucagonlike peptide-1: Regulation of insulin secretion and therapeutic potential
-
Gromada J, Brock B, Schmitz O, Rorsman P. Glucagonlike peptide-1: regulation of insulin secretion and therapeutic potential. Basic Clin Pharmacol Toxicol. 2004;95: 252-62.
-
(2004)
Basic Clin Pharmacol Toxicol
, vol.95
, pp. 252-262
-
-
Gromada, J.1
Brock, B.2
Schmitz, O.3
Rorsman, P.4
-
125
-
-
0033769693
-
CAMP-GEFII is a direct target of cAMP in regulated exocytosis
-
Ozaki N, Shibasaki T, Kashima Y, Miki T, Takahashi K, Ueno H, et al. cAMP-GEFII is a direct target of cAMP in regulated exocytosis. Nat Cell Biol. 2000;2:805-11.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 805-811
-
-
Ozaki, N.1
Shibasaki, T.2
Kashima, Y.3
Miki, T.4
Takahashi, K.5
Ueno, H.6
-
126
-
-
33750730215
-
Cell physiology of cAMP sensor Epac
-
Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG. Cell physiology of cAMP sensor Epac. J Physiol. 2006;577: 5-15.
-
(2006)
J Physiol
, vol.577
, pp. 5-15
-
-
Holz, G.G.1
Kang, G.2
Harbeck, M.3
Roe, M.W.4
Chepurny, O.G.5
-
127
-
-
78649358628
-
Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1
-
Leech CA, Chepurny OG, Holz GG. Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1.Vitam Horm. 2010;84:279-302.
-
(2010)
Vitam Horm
, vol.84
, pp. 279-302
-
-
Leech, C.A.1
Chepurny, O.G.2
Holz, G.G.3
-
128
-
-
0347990624
-
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic b-cell
-
.Holz GG. Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic b-cell. Diabetes. 2004;53: 5-13.
-
(2004)
Diabetes
, vol.53
, pp. 5-13
-
-
Holz, G.G.1
-
129
-
-
0034638602
-
Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic b-cells
-
.Leech CA, Holz GG, Chepurny O, Habener JF. Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic b-cells. Biochem Biophys Res Commun. 2000; 278:44-7.
-
(2000)
Biochem Biophys Res Commun
, vol.278
, pp. 44-47
-
-
Leech, C.A.1
Holz, G.G.2
Chepurny, O.3
Habener, J.F.4
-
130
-
-
77349114753
-
Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'- O-Me-cAMP-AM
-
.Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, et al. Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'- O-Me-cAMP-AM. Islets. 2009;1:260-5.
-
(2009)
Islets
, vol.1
, pp. 260-265
-
-
Kelley, G.G.1
Chepurny, O.G.2
Schwede, F.3
Genieser, H.G.4
Leech, C.A.5
Roe, M.W.6
-
131
-
-
77349096383
-
PKA-dependent potentiation of glucosestimulated insulin secretion by Epac activator 8-pCPT-2'-OMe- cAMP-AM in human islets of Langerhans
-
.Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, et al. PKA-dependent potentiation of glucosestimulated insulin secretion by Epac activator 8-pCPT-2'-OMe- cAMP-AM in human islets of Langerhans. Am J Physiol Endocrinol Metab. 2010;298:E622-33.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.298
-
-
Chepurny, O.G.1
Kelley, G.G.2
Dzhura, I.3
Leech, C.A.4
Roe, M.W.5
Dzhura, E.6
-
132
-
-
64549105338
-
Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function
-
.Niimura M, Miki T, Shibasaki T, Fujimoto W, Iwanaga T, Seino S. Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function. J Cell Physiol. 2009;219:652-8.
-
(2009)
J Cell Physiol
, vol.219
, pp. 652-658
-
-
Niimura, M.1
Miki, T.2
Shibasaki, T.3
Fujimoto, W.4
Iwanaga, T.5
Seino, S.6
-
133
-
-
67449092561
-
Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epacselective cyclic AMP analog in rat INS-1 cells: Studies with 8-pCPT-2'-O-Me-cAMP-AM
-
.Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, et al. Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epacselective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. J Biol Chem. 2009; 284:10728-36.
-
(2009)
J Biol Chem
, vol.284
, pp. 10728-10736
-
-
Chepurny, O.G.1
Leech, C.A.2
Kelley, G.G.3
Dzhura, I.4
Dzhura, E.5
Li, X.6
-
134
-
-
34748859183
-
Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells
-
.Kwan EP, Gao X, Leung YM, Gaisano HY. Activation of exchange protein directly activated by cyclic adenosine monophosphate and protein kinase A regulate common and distinct steps in promoting plasma membrane exocytic and granule-to-granule fusions in rat islet beta cells. Pancreas. 2007;35:e45-54.
-
(2007)
Pancreas
, vol.35
-
-
Kwan, E.P.1
Gao, X.2
Leung, Y.M.3
Gaisano, H.Y.4
-
135
-
-
66849115296
-
Mechanisms of biphasic insulingranule exocytosis - Roles of the cytoskeleton, small GTPases and SNARE proteins
-
.Wang Z, Thurmond DC. Mechanisms of biphasic insulingranule exocytosis - roles of the cytoskeleton, small GTPases and SNARE proteins. J Cell Sci. 2009;122:893- 903.
-
(2009)
J Cell Sci
, vol.122
, pp. 893-903
-
-
Wang, Z.1
Thurmond, D.C.2
-
136
-
-
76149107841
-
Small G proteins in islet b-cell function
-
.Kowluru A. Small G proteins in islet b-cell function. Endocr Rev. 2010;31:52-78.
-
(2010)
Endocr Rev
, vol.31
, pp. 52-78
-
-
Kowluru, A.1
-
137
-
-
78650090455
-
Epac2-dependent mobilization of intracellular Ca2+ by GLP-1 receptor agonist Exendin-4 is disrupted in b-cells of PLC-e knockout mice
-
.Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, et al. Epac2-dependent mobilization of intracellular Ca2+ by GLP-1 receptor agonist Exendin-4 is disrupted in b-cells of PLC-e knockout mice. J Physiol. 2010;588: 4871-89.
-
(2010)
J Physiol
, vol.588
, pp. 4871-4889
-
-
Dzhura, I.1
Chepurny, O.G.2
Kelley, G.G.3
Leech, C.A.4
Roe, M.W.5
Dzhura, E.6
-
138
-
-
79955793555
-
Phospholipase C-e links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans
-
.Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, et al. Phospholipase C-e links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. 2011;3:121-8.
-
(2011)
Islets
, vol.3
, pp. 121-128
-
-
Dzhura, I.1
Chepurny, O.G.2
Leech, C.A.3
Roe, M.W.4
Dzhura, E.5
Xu, X.6
-
139
-
-
0035886966
-
CAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic b-cells
-
.Kang G, Chepurny OG, Holz GG. cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic b-cells. J Physiol. 2001;536:375-85.
-
(2001)
J Physiol
, vol.536
, pp. 375-385
-
-
Kang, G.1
Chepurny, O.G.2
Holz, G.G.3
-
140
-
-
0037424363
-
Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic b-cells
-
.Kang G, Joseph JW, Chepurny OG, Monaco M, Wheeler MB, Bos JL, et al. Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic b-cells. J Biol Chem. 2003;278:8279-85.
-
(2003)
J Biol Chem
, vol.278
, pp. 8279-8285
-
-
Kang, G.1
Joseph, J.W.2
Chepurny, O.G.3
Monaco, M.4
Wheeler, M.B.5
Bos, J.L.6
-
141
-
-
40049101849
-
Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic b-cells and rat INS-1 cells
-
.Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG. Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic b-cells and rat INS-1 cells. J Physiol. 2008;586:1307-19.
-
(2008)
J Physiol
, vol.586
, pp. 1307-1319
-
-
Kang, G.1
Leech, C.A.2
Chepurny, O.G.3
Coetzee, W.A.4
Holz, G.G.5
-
142
-
-
79957904659
-
Rim2a determines docking and priming states in insulin granule exocytosis
-
.Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, et al. Rim2a determines docking and priming states in insulin granule exocytosis. Cell Metab. 2010;12:117-29.
-
(2010)
Cell Metab
, vol.12
, pp. 117-129
-
-
Yasuda, T.1
Shibasaki, T.2
Minami, K.3
Takahashi, H.4
Mizoguchi, A.5
Uriu, Y.6
-
143
-
-
0035824548
-
Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion
-
.Kashima Y, Miki T, Shibasaki T, Ozaki N, Miyazaki M, Yano H, et al. Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem. 2001; 276:46046-53.
-
(2001)
J Biol Chem
, vol.276
, pp. 46046-46053
-
-
Kashima, Y.1
Miki, T.2
Shibasaki, T.3
Ozaki, N.4
Miyazaki, M.5
Yano, H.6
-
144
-
-
0037184610
-
Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis
-
.Fujimoto K, Shibasaki T, Yokoi N, Kashima Y, Matsumoto M, Sasaki T, et al. Piccolo, a Ca2+ sensor in pancreatic beta-cells. Involvement of cAMP-GEFII.Rim2. Piccolo complex in cAMP-dependent exocytosis. J Biol Chem. 2002;277:50497-502.
-
(2002)
J Biol Chem
, vol.277
, pp. 50497-50502
-
-
Fujimoto, K.1
Shibasaki, T.2
Yokoi, N.3
Kashima, Y.4
Matsumoto, M.5
Sasaki, T.6
-
145
-
-
1542289732
-
Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis
-
Shibasaki T, Sunaga Y, Fujimoto K, Kashima Y, Seino S. Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis. J Biol Chem. 2004;279:7956-61.
-
(2004)
J Biol Chem
, vol.279
, pp. 7956-7961
-
-
Shibasaki, T.1
Sunaga, Y.2
Fujimoto, K.3
Kashima, Y.4
Seino, S.5
-
146
-
-
68049096966
-
Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulinsecreting cells
-
Vikman J, Svensson H, Huang YC, Kang Y, Andersson SA, Gaisano HY, et al. Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulinsecreting cells. Am J Physiol Endocrinol Metab. 2009;297: E452-61.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
-
-
Vikman, J.1
Svensson, H.2
Huang, Y.C.3
Kang, Y.4
Andersson, S.A.5
Gaisano, H.Y.6
-
147
-
-
68149136367
-
The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs
-
Zhang CL, Katoh M, Shibasaki T, Minami K, Sunaga Y, Takahashi H, et al. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science. 2009;325: 607-10.
-
(2009)
Science
, vol.325
, pp. 607-610
-
-
Zhang, C.L.1
Katoh, M.2
Shibasaki, T.3
Minami, K.4
Sunaga, Y.5
Takahashi, H.6
-
148
-
-
34547114234
-
Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse b-cells
-
Hatakeyama H, Takahashi N, Kishimoto T, Nemoto T, Kasai H. Two cAMP-dependent pathways differentially regulate exocytosis of large dense-core and small vesicles in mouse b-cells. J Physiol. 2007;582:1087-98.
-
(2007)
J Physiol
, vol.582
, pp. 1087-1098
-
-
Hatakeyama, H.1
Takahashi, N.2
Kishimoto, T.3
Nemoto, T.4
Kasai, H.5
-
149
-
-
79951816217
-
Direct activation of Epac by sulfonylurea is isoform selective
-
Herbst KJ, Coltharp C, Amzel LM, Zhang J. Direct activation of Epac by sulfonylurea is isoform selective. Chem Biol. 2011;18:243-51.
-
(2011)
Chem Biol
, vol.18
, pp. 243-251
-
-
Herbst, K.J.1
Coltharp, C.2
Amzel, L.M.3
Zhang, J.4
-
150
-
-
79951696645
-
Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs
-
Tsalkova T, Gribenko AV, Cheng X. Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs. Assay Drug Dev Technol. 2011; 9:88-91.
-
(2011)
Assay Drug Dev Technol
, vol.9
, pp. 88-91
-
-
Tsalkova, T.1
Gribenko, A.V.2
Cheng, X.3
-
151
-
-
84856285651
-
Epac2: A sulfonylurea receptor?
-
Rehmann H. Epac2: a sulfonylurea receptor? Biochem Soc Trans. 2012;40:6-10.
-
(2012)
Biochem Soc Trans
, vol.40
, pp. 6-10
-
-
Rehmann, H.1
-
152
-
-
0015211390
-
Chlorpropamide and tolbutamide inhibition of adenosine 3'5' cyclic monophosphate phosphodiesterase
-
Brooker G, Fichman M. Chlorpropamide and tolbutamide inhibition of adenosine 3'5' cyclic monophosphate phosphodiesterase. Biochem Biophys Res Commun. 1971;42: 824-8.
-
(1971)
Biochem Biophys Res Commun
, vol.42
, pp. 824-828
-
-
Brooker, G.1
Fichman, M.2
-
153
-
-
0015209607
-
Inhibition of cyclic 3',5'-AMP phosphodiesterase in islet cells and other tissues by tolbutamide
-
Goldfine ID, Perlman R, Roth J. Inhibition of cyclic 3',5'-AMP phosphodiesterase in islet cells and other tissues by tolbutamide. Nature. 1971;234:295-7.
-
(1971)
Nature
, vol.234
, pp. 295-297
-
-
Goldfine, I.D.1
Perlman, R.2
Roth, J.3
-
154
-
-
0024354876
-
Similar reduction of first- and second-phase B-cell responses at three different glucose levels in type II diabetes and the effect of glicazide therapy
-
Hosker JP, Rudenski AS, Burnett MA, Matthews DR, Turner RC. Similar reduction of first- and second-phase B-cell responses at three different glucose levels in type II diabetes and the effect of glicazide therapy. Metabolism. 1989;38:767-72.
-
(1989)
Metabolism
, vol.38
, pp. 767-772
-
-
Hosker, J.P.1
Rudenski, A.S.2
Burnett, M.A.3
Matthews, D.R.4
Turner, R.C.5
-
155
-
-
0019415621
-
Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man
-
Lang DA, Matthews DR, Burnett M, Turner RC. Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. Diabetes. 1981;30:435-9.
-
(1981)
Diabetes
, vol.30
, pp. 435-439
-
-
Lang, D.A.1
Matthews, D.R.2
Burnett, M.3
Turner, R.C.4
-
156
-
-
77949268922
-
Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance
-
Mari A, Tura A, Natali A, Laville M, Laakso M, Gabriel R, et al. Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance. Diabetologia. 2010; 53:749-56.
-
(2010)
Diabetologia
, vol.53
, pp. 749-756
-
-
Mari, A.1
Tura, A.2
Natali, A.3
Laville, M.4
Laakso, M.5
Gabriel, R.6
-
157
-
-
67349228410
-
The beta cell lesion in type 2 diabetes: There has to be a primary functional abnormality
-
Kahn SE, Zraika S, Utzschneider KM, Hull RL. The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. Diabetologia. 2009;52:1003-12.
-
(2009)
Diabetologia
, vol.52
, pp. 1003-1012
-
-
Kahn, S.E.1
Zraika, S.2
Utzschneider, K.M.3
Hull, R.L.4
-
158
-
-
0022617246
-
Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
-
Nauck M, Stockmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1986;29:46-52.
-
(1986)
Diabetologia
, vol.29
, pp. 46-52
-
-
Nauck, M.1
Stockmann, F.2
Ebert, R.3
Creutzfeldt, W.4
-
159
-
-
0021864131
-
Glucagon physiology and pathophysiology in the light of new advances
-
Unger RH. Glucagon physiology and pathophysiology in the light of new advances. Diabetologia. 1985;28:574-8.
-
(1985)
Diabetologia
, vol.28
, pp. 574-578
-
-
Unger, R.H.1
-
160
-
-
74249123937
-
Overexpression of alpha2Aadrenergic receptors contributes to type 2 diabetes
-
Rosengren AH, Jokubka R, Tojjar D, Granhall C, Hansson O, Li DQ, et al. Overexpression of alpha2Aadrenergic receptors contributes to type 2 diabetes. Science. 2010;327:217-20.
-
(2010)
Science
, vol.327
, pp. 217-220
-
-
Rosengren, A.H.1
Jokubka, R.2
Tojjar, D.3
Granhall, C.4
Hansson, O.5
Li, D.Q.6
-
161
-
-
75749091912
-
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
-
Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010;42:142-8.
-
(2010)
Nat Genet
, vol.42
, pp. 142-148
-
-
Saxena, R.1
Hivert, M.F.2
Langenberg, C.3
Tanaka, T.4
Pankow, J.S.5
Vollenweider, P.6
-
162
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105-16.
-
(2010)
Nat Genet
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
Langenberg, C.2
Prokopenko, I.3
Saxena, R.4
Soranzo, N.5
Jackson, A.U.6
-
163
-
-
0017193626
-
Decreased cyclic AMP and insulin responses to glucose in pancreatic islets of diabetic Chinese hamsters
-
Rabinovitch A, Renold AE, Cerasi E. Decreased cyclic AMP and insulin responses to glucose in pancreatic islets of diabetic Chinese hamsters. Diabetologia. 1976;12:581-7.
-
(1976)
Diabetologia
, vol.12
, pp. 581-587
-
-
Rabinovitch, A.1
Renold, A.E.2
Cerasi, E.3
-
164
-
-
0029859599
-
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: Reversal by IBMX, glucagon, GIP
-
Dachicourt N, Serradas P, Giroix MH, Gangnerau MN, Portha B. Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP. Am J Physiol. 1996;271:E725-32.
-
(1996)
Am J Physiol
, vol.1
-
-
Dachicourt, N.1
Serradas, P.2
Giroix, M.H.3
Gangnerau, M.N.4
Portha, B.5
-
165
-
-
80054965549
-
CAMP-secretion coupling is impaired in diabetic GK/Par rat beta-cells: A defect counteracted by GLP-1
-
Dolz M, Movassat J, Bailbe D, Le Stunff H, Giroix MH, Fradet M, et al. cAMP-secretion coupling is impaired in diabetic GK/Par rat beta-cells: a defect counteracted by GLP-1.Am J Physiol Endocrinol Metab. 2011;301: E797-806.
-
(2011)
Am J Physiol Endocrinol Metab
, vol.301
-
-
Dolz, M.1
Movassat, J.2
Bailbe, D.3
Le Stunff, H.4
Giroix, M.H.5
Fradet, M.6
-
166
-
-
0029900592
-
Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: A defect ameliorated by cAMP
-
.Abdel-Halim SM, Guenifi A, Khan A, Larsson O, Berggren PO, Östenson CG, et al. Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: a defect ameliorated by cAMP. Diabetes. 1996;45: 934-40.
-
(1996)
Diabetes
, vol.45
, pp. 934-940
-
-
Abdel-Halim, S.M.1
Guenifi, A.2
Khan, A.3
Larsson, O.4
Berggren, P.O.5
Östenson, C.G.6
-
167
-
-
0031914387
-
Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes
-
.Abdel-Halim SM, Guenifi A, He B, Yang B, Mustafa M, Hojeberg B, et al. Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type 2 diabetes. Diabetes. 1998;47: 498-504.
-
(1998)
Diabetes
, vol.47
, pp. 498-504
-
-
Abdel-Halim, S.M.1
Guenifi, A.2
He, B.3
Yang, B.4
Mustafa, M.5
Hojeberg, B.6
-
168
-
-
0033534205
-
Gaolf identification by RT-PCR in purified normal pancreatic B cells and in islets from rat models of non-insulin-dependent diabetes
-
.Frayon S, Pessah M, Giroix MH, Mercan D, Boissard C, Malaisse WJ, et al. Gaolf identification by RT-PCR in purified normal pancreatic B cells and in islets from rat models of non-insulin-dependent diabetes. Biochem Biophys Res Commun. 1999;254:269-72.
-
(1999)
Biochem Biophys Res Commun
, vol.254
, pp. 269-272
-
-
Frayon, S.1
Pessah, M.2
Giroix, M.H.3
Mercan, D.4
Boissard, C.5
Malaisse, W.J.6
-
169
-
-
0036318731
-
Overexpression of Gs proteins and adenylyl cyclase in normal and diabetic islets
-
.Portela-Gomes GM, Abdel-Halim SM. Overexpression of Gs proteins and adenylyl cyclase in normal and diabetic islets. Pancreas. 2002;25:176-81.
-
(2002)
Pancreas
, vol.25
, pp. 176-181
-
-
Portela-Gomes, G.M.1
Abdel-Halim, S.M.2
-
170
-
-
33947373424
-
Glucotoxicity inhibits late steps of insulin exocytosis
-
.Dubois M, Vacher P, Roger B, Huyghe D, Vandewalle B, Kerr-Conte J, et al. Glucotoxicity inhibits late steps of insulin exocytosis. Endocrinology. 2007;148:1605-14.
-
(2007)
Endocrinology
, vol.148
, pp. 1605-1614
-
-
Dubois, M.1
Vacher, P.2
Roger, B.3
Huyghe, D.4
Vandewalle, B.5
Kerr-Conte, J.6
-
171
-
-
10044294739
-
Targeting b-cell cyclic 3'5' adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review
-
.Furman B, Pyne N, Flatt P, O'Harte F. Targeting b-cell cyclic 3'5' adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A review. J Pharm Pharmacol. 2004;56:1477-92.
-
(2004)
J Pharm Pharmacol
, vol.56
, pp. 1477-1492
-
-
Furman, B.1
Pyne, N.2
Flatt, P.3
O'Harte, F.4
-
172
-
-
33847672708
-
Re-discovering PDE3 inhibitors - New opportunities for a long neglected target
-
.Thompson PE, Manganiello V, Degerman E. Re-discovering PDE3 inhibitors - new opportunities for a long neglected target. Curr Top Med Chem. 2007;7:421-36.
-
(2007)
Curr Top Med Chem
, vol.7
, pp. 421-436
-
-
Thompson, P.E.1
Manganiello, V.2
Degerman, E.3
-
173
-
-
67349176115
-
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
-
.Ahrén B. Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov. 2009;8:369-85.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 369-385
-
-
Ahrén, B.1
-
174
-
-
67651173077
-
Incretin-based therapies for type 2 diabetes mellitus
-
.Lovshin JA, Drucker DJ. Incretin-based therapies for type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5:262-9.
-
(2009)
Nat Rev Endocrinol
, vol.5
, pp. 262-269
-
-
Lovshin, J.A.1
Drucker, D.J.2
-
176
-
-
84856918822
-
The therapeutic potential of GPR119 agonists for type 2 diabetes
-
.Ohishi T, Yoshida S. The therapeutic potential of GPR119 agonists for type 2 diabetes. Expert Opin Investig Drugs. 2012;21:321-8.
-
(2012)
Expert Opin Investig Drugs
, vol.21
, pp. 321-328
-
-
Ohishi, T.1
Yoshida, S.2
|