Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor

Science

Volumn 289, Issue 5479, 2000, Pages 625-628

  Chen, Yanqiu ^a   Cann, Martin J ^a   Litvin, Tatiana N ^a   Iourgenko, Vadim ^a   Sinclair, Meeghan L ^a   Levin, Lonny R ^a   Buck, Jochen ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BICARBONATE; CYCLIC AMP;

ACROSOME REACTION; ARTICLE; CELL MEMBRANE POTENTIAL; CELL PH; CONTROLLED STUDY; CYANOBACTERIUM; EMBRYO; ENZYME ACTIVATION; ENZYME REGULATION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SENSOR; SIGNAL TRANSDUCTION; SPERMATOZOON CAPACITATION; SPERMATOZOON MOTILITY;

ADENYLATE CYCLASE; ANIMALS; BICARBONATES; CATALYTIC DOMAIN; CELL LINE; CYANOBACTERIA; CYCLIC AMP; ENZYME ACTIVATION; EVOLUTION, MOLECULAR; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; PHYLOGENY; RATS; RECOMBINANT PROTEINS; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION; SOLUBILITY; SPERM CAPACITATION; SPERMATOZOA; TESTIS;

CYANOBACTERIA; MAMMALIA;

EID: 0034725748     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.289.5479.625     Document Type: Article

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25. We thank R. B. Silver for assistance with in vivo pH measurement; R. Duvoisin, M. C. Gershengorn, C. Nathan, and M. R. Reidenberg for suggestions; J. Qiu for technical assistance; and M. Ohmori for the kind gift of Spirulina platensis CyaC in bacterial expression vector. Supported by Weill Medical College or Cornell University Research Associates, the Irma T. Hirschl Trust, The L. W. Frohlich Charitable Trust, Edith C. Blum Foundation, and NIH.