Overexpression of Gs proteins and adenylyl cyclase in normal and diabetic islets

Pancreas

Volumn 25, Issue 2, 2002, Pages 176-181

  Portela Gomes, Guida M ^a   Abdel Halim, Samy M ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Adenylyl cyclase; Experimental diabetes; G protein; Hormones; Immunocytochemistry; Pancreas

Indexed keywords

ADENYLATE CYCLASE; GLUCAGON; INSULIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; GENE OVEREXPRESSION; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE; ANIMALS; DIABETES MELLITUS, TYPE 2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; MALE; RATS;

EID: 0036318731     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/00006676-200208000-00011     Document Type: Article

References (18)

1. Receptor-effector coupling by G proteins
2. Regulatory properties of the mammalian adenylyl cyclases
3. Impaired coupling of glucose signal to the exocytotic machinery in diabetic GK rats: A defect ameliorated by cAMP
4. Mutations in the promoter of adenylyl cyclase (AC)-III gene, overexpression of AC-III mRNA, and enhanced cAMP generation in islets from the spontaneously diabetic GK rat model of type-2 diabetes
5. Glucose enhances adenylyl cyclase responses in normal but not diabetic GK rat islets
6. Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakisaki (GK) rat pancreas: Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK islets
7. Mammalian adenylyl cyclases
8. G alpha olf: An olfactory neuron specific-G protein involved in odorant signal transduction
9. Interaction of Gs alpha with the cytosolic domains of mammalian adenylyl cyclase
10. Ultrastructural localization of olfactory transduction components: G protein subunit golf alpha and type III adenylyl cyclase
11. Cellular and subcellular expression of Golf/Gs and Gq/G11 alpha-subunits in rat pancreatic endocrine cells
12. Cell-specific localization of G protein alpha-subunits in the islets of Langerhans
13. Calcium signaling in rat pancreatic acinar cells: A role for G alpha q, G alpha 11, and G alpha 14
14. Expression of adenylyl cyclase subtypes in pancreatic beta-cells
15. G alpha olf identification by RT-PCR in purified normal pancreatic B cells and in islets from rat models of non-insulin-dependent diabetes
16. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled (PAP) procedures
17. Catalyzed reporter deposition, a novel method of signal amplification: Application to immunoassays
18. Synaptic vesicle protein2, a new neuroendocrine cell marker