Factors determining the glucose sensitivity and glucose responsiveness of pancreatic beta cells

Hormone Research in Paediatrics

Volumn 46, Issue 3, 1996, Pages 99-106

  Schuit, Frans C ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

Author keywords

Beta cells; Cyclic AMP; Glucagon; Glucagon like peptide 1; Glucokinase; Glucose dependent insulinotrophic peptide; GLUT2; Insulin biosynthesis; Insulin release

Indexed keywords

CYCLIC AMP; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON RECEPTOR; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER; HEXOKINASE; PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL ACTIVITY; CELL FUNCTION; CELL SUBPOPULATION; GENE EXPRESSION; INSULIN RELEASE; INSULIN SYNTHESIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REVIEW; SIGNAL TRANSDUCTION;

EID: 0029781231     PISSN: 16632818     EISSN: 16632826     Source Type: Journal    
DOI: 10.1159/000185004     Document Type: Article

References (80)

1. Ijenquin JC: Cell biology of insulin secretion: in Kahn CR, Weir GC (eds): Joslin's Diabetes mellitus, Pennsylvania, Lea & Febiger, 1994, pp 56-78.
2. Wang RN, Klöppel G, Bouwens L: Duct to islet cell differentiation and islet growth in the pancreas of duct ligated adult rats, Diabetologia 1995:38:1405-1411.
3. Lacy PE, Kostianovsky M: Methods for the isolation of intact islets of Langerhans from the rat pancreas, Diabetes 1967;16:35-39.
4. Malaisse WJ, Scncr A, Herchuclz A, Hutton JC: Insulin release: The fuel hypothesis, Metabolism 1979;28:373-386.
5. Wolthcim CB, Sharp GWG: Regulation of insulin release by calcium, Physiol Rev 1981:61: 914-973.
6. 21, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion, Physiol Rev 1987;67:1185-1248.
7. MacDonald MJ: Elusive proximal signals of p-cells for insulin secretion, Diabetes 1990:39: 1461-1466.
8. Newgard CB, MaGarry DJ: Metabolic coupling factors in pancreatic ß-cell signal transduction, Ann Rev Biochem 1995:64:689-719.
9. Cerasi E: Mechanisms of glucose stimulated insulin secretion in health and in diabetes: Some re-evaluations and proposals, Diabelo-logia 1975;11:1-13.
10. Niki A, Niki H, Miwa I, Okuda J: Insulin secretion by anomers of glucose, Science 1974:186: 150-151.
11. Niki A, Niki H, Hashioka T: Effects of specific competitive inhibitors of sweet taste response on glucose-induced insulin release, Biomed Res 1993;14:13-18.
12. Malaisse WJ, Scner A, Herchuelz A, Hutton JC: Insulin release: The fuel hypothesis, Metabolism 1979;28:373-386.
13. Hcllcrslröm C: Effects of carbohydrates on the oxygen consumption of isolated pancreatic islets of mice, Endocrinology 1967;S1:105-112.
14. Ashcroft SJH: Glucoreceptor mechanisms and the control of insulin release and biosynthesis, Diabetologia 1980;18:5-15.
15. Dukes ID, McIntyre MS, Mertz RJ, Philipson LH, Roc MW, Spencer B, Worley JF III: Dependence on NADH produced during glycolysis for ß-cell glucose signalling, J Biol Chem 1994:269:10979-10982.
16. Sekine N, Cirulli V, Regazzi R, Brown LJ, Ginc E, Tamarit-Rodriguez J, Girotti M, Marie S, MacDonald MJ, Wollhcim CB, Rutter GA: Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase on pancreatic p-cclls: Potential role in nutrient sensing, J Biol Chem 1994;269:4895-4902.
17. Heimberg H, De Vos A, Vandercammen A, Van Schaftingcn E, Pipelcers D, Schuit F: Heterogeneity in glucose sensitivity among pancreatic ß-cells is correlated to differences in glucose phosphorylation rather than glucose transport, EMBO.I 1993:12:2873-2879.
18. De Vos A, Schuit FC, Malaisse WJ: Preferential stimulation by glucose of its oxidation relative to glycolysis in purified insulin-producing cells, Biochem Int 1991:24:117-121.
19. Heilman B, Sehlin J, Taljedal IB: Evidence for mediated transport of glucose in mammalian pancreatic β-cells, Biochim BiophysActa 1971: 241:147-154.
20. Mcglasson MD, Matschinsky FM: New perspectives on pancreatic islet glucokinase, Am J Physiol 1984;246:E1-E13.
21. Ashcroft FM, Harrison DE, Ashcroft SJH: Glucose induces closure of single potassium channels in isolated rat pancreatic p-cclls, Nature 1984:312:446-448.
22. Pipelcers D, Kickens R, Ling Z, Willikcns A, Schuit F: Physiologic relevance of heterogeneity in pancreatic beta-cell population, Diabetologia 1994:37:S57-S64.
23. Schuit FG, Int Veld PA, Pipelcers DG: Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells, Proc Natl Acad Sci USA 1988:85:3865-3869.
24. Salomon D, Meda P: Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells, Exp Cell Res 1986; 162:507-520.
25. Van Schravendijk CFH, Kiekens R, Pipelcers DG: Pancreatic p cell heterogeneity in glucose-induced insulin secretion, J Biol Chem 1992; 27:21344-21348.
26. Kiekens R, Int Veld P, Mahler T, Schuit F, Van de Winkel M, Pipelcers D: Differences in glucose recognition by individual rat pancreatic B-cells are associated with intercellular differences in glucose-induced biosynthetic activity, J Clin Invest 1992:89:117-125.
27. Thorens B, Sarkar HK, Kaback HR, Lodish HF: Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and p-panercatic islet cells, Cell 1988:55:281-290.
28. Meglasson MD, Burch PT, Berner DK, Najafi H, Vogin AP, Matschinskv FM: Chromatographic resolution and kinetic characterization of glucokinase from islets of Langerhans, Proc Natl Acad Sci USA 1983:80:85-89.
29. s cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion, J Biol Chem 1993;268:15205-15212.
30. Ferber S, BeltrandelRio H, Johnson J, Noel RJ, Cassidy LE, Clark S, Becker TC, Hughes S, Newgard CB: GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release, J Biol Chem 1994;269:11523-11529.
31. Valera A, Solanes G, Femandcz-Alvarez J, Pujol A, Ferrer J, Asins G, Gomis R, Bosch F: Expression of GLUT-2 antisense RNA in P cells of transgenic mice leads to diabetes, J Biol Chem 1994:269:28543-28546.
32. m glucose transporters in nonin-sulin-dcpcndcnt diabetes, Science 1990;250: 546-549.
33. Ogawa A, Johnson JH, Ohneda M, McAllister CT, Inman L, Alam T, Unger RH: Roles of insulin resistance and ß-cell dysfunction in dcxamethasonc-induced diabetes, J Clin Invest 1992:90:497-504.
34. Orci L, Unger RH, Ravazzola M, Ogawa A, Komiya I, Bactens D, Lodish HF, Thorens B: Reduced p-cell glucose transporter in new onset diabetic BB rats, J Clin Invest I990;86: 1615-1622.
35. German MS: Glucose sensing in pancreatic islet beta cells: The key role of glucokinase and the glycolytic intermediates, Proc Natl Acad Sci USA 1993;90:1781-1785.
36. Ishihara H, Asano T, Tsukuda K, Katagiri H, Inukai K, Anai M, Kikuchi M, Yazaki Y, Miyazaki JI, Oka Y: Overexpression ofhexokinasc 1 but not GLUT-1 glucose transporter alters concentration dependence of glucose-stimulated insulin secretion in pancreatic p-cell line MIN6. J Biol Chem 1994;269:3081-3087.
37. Ishihara FI, Asano T, Tsukuda K, Katagiri H, Inukai K, Anai M, Yazaki Y, Miyazaki JI, Kikuchi M, Oka Y: Human GLUT-2 ovcrex-prcssion does not affect glucose-stimulated insulin secretion in M1N6 cells, Am J Physiol 1995:289:E897-E902.
38. Heimberg H, De Vos A, Pipelcers D, Thorens B, Schuit F: Differences in glucose transporter gene expression between rat pancreatic u- and p-cells are correlated to differences in glucose transport but not in glucose utilisation, J Biol Chem 1995:270:8971-8975.
39. De Vos A, Hcimbcrg H, Quartier E, Huypens P, Bouwens L, Pipelcers D, Schuit F: Human and rat beta cells differ in glucose transporter but rot in glucokinase gene expression, J Clin Invest 1995:96:2489-2495.
40. Ferrer J, Benito C, Gomis R: Pancreatic islet GLUT2 glucose transporter mRNA and protein expression in humans with and without NIDDM, Diabetes 1995;44:1369-1374.
41. Matschinskv F, Liang Y, Kesavan P, Wang L, Froguel P, Velho G, Cohen D, Permutt MA, Tanizawa Y, Jetton TL, Niswender K, Magnu-son MA: Glucokinase as pancreatic ß cell glucose sensor and diabetes gene, J Clin Invest 1993;92:2092-2098.
42. Matchinsky FM: Glucokinase as glucose sensor and metabolic signal generator in pancreatic ß-cells and hepatocytes, Diabetes 1990:39:647-652.
43. Liang Y, Najafi H, Matschinsky FM: Glucose regulates glucokinase activity in cultured islets from rat pancreas, J Biol Client 1990:265: 16863-16866.
44. Efrat S, Leiser M, Wu YJ, Fusco-Dcmanc D, Emran OB, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N: Ribozyme-mediated attenuation of pancreatic ß-cell glucokinasc expression in transgenic mice results in impaired glucose-induced insulin secretion, Proc Nall Acad Sei USA 1994:91:2051-2055.
45. Bali D, Svetlanov A, Lee HW, Fusco-DcMane F, Leiser M, Li B, Barzilai N, Surana M, Hou H, Fleischer N, DePinho R, Rossetti L, Efrat S: Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinasc gene, J Biol Chem 1995:270: 21464-21467.
46. Grupc A, Uultgrcn B, Ryan A, Ma YH, Bauer M, Stewart TA: Transgenic knockouts reveal a critical requirement for pancreatic ß-cell gluco-kinase in maintaining glucose homeostasis, Cell 1995:83:69-78.
47. Tcrauchi Y, Sakura H, Iwamoto K, Yasuda K, Yazaki Y, Kadowaki T: Targeted disruption of pancreatic ß-cell glucokinasegene results in impaired insulin secretion and diabetes (abstract), Diabetologia 1995;38:A15.
48. Vionnet N, Stoffel M, Takeda J, Yasuda K, Bell GL, Zouali H, Lesage S, Velho G, Iris F, Passa P, Frogucl P, Cohen D: Nonsense mutation in the glucokinasc gene causes early-onsel non-insulin-dependent diabetes mellitus, Nature 1992;356:721-722.
49. Chiu KC, Province MA, Pcrmutt MA: Gluco-kinase gene is genetic marker for NIDDM in American blacks, Diabetes 1992:41:843-849.
50. Velho G, Froguel P, Clement K, Pueyo ME, Rakotoambinina B, Zouali H, Passa P, Cohen D, Robert JJ: Primary pancreatic beta-cell secretory defect caused by mutations in glucoki-nase gene in kindreds of maturity onset diabetes of the young, Lancet 1992:340:444-448.
51. Epstein PN, Boschcro AC, Atwater I, Cai X, Overbeek PA: Expression of yeast hexokinasc in pancreatic ß-cells of transgenic mice reduces blood glucose, enhances insulin secretion, and decreases diabetes, Proc Natl Acad Sei USA 1992;89:12038-12042.
52. Voss-McCowan ME, Xu B, Epstein PN: Insulin synthesis, secretory competence, and glucose utilization are sensitized by transgenic yeast hexokinase, J Biol Chem 1994:269: 15814-15818.
53. Pipeleers DG, Schuil FC, In't Veld PA, Maes E, Hooghe-Peters EL, Van De Winkel M, Gepts W: Interplay of nutrients and hormones in the regulation of insulin release, Endocrinology 1985:117:824-833.
54. Schuit FC, Pipeleers DG: Regulation of adenosine 3',5'-monophosphatc levels in the pancreatic ß cell, Endocrinology 1985; 117:834-840.
55. Pipeleers D, In’t Veld P, Maes E, Van De Winkel M: Glucose-induced insulin release depends on functional cooperation between islet cells, Proc Natl Acad Sei USA 1982.79:7322-7325.
56. Schuit FC, Pipeleers DG: Differences in adrenergic recognition by pancreatic A- and B-cells, Science 1986:232:875-877.
57. Schuit FC, Derde MP, Pipeleers DG: Sensitivity of rat pancreatic A and B cells to somatostatin, Diabetologia 1989:32:207-212.
58. Wang JL, Corbett JA, Marshall CA, McDaniel M: Glucose-induced insulin secretion from purified ß-cells, A role for modulation of Ca-* influx by cAMP- and protein kinase C-depen-dent signal transduction pathways, J Biol Chem 1993:268:7785-7791.
59. Bonner-Weir S, Orci L: New perspective on the microvasculature of the islets of Langcrhans in the rat, Diabetes 1982:31:883-889.
60. Meda P, Perrelet A, Orci L: Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion, J Cell Biol 1979;82:441-448.
61. Van Schravendijk CFH, Foriers A, Hooghe-Peters EL, Rogiers V, De Meyts P, Sodoycz JC, Pipeleers DG: Pancreatic hormone receptors on islet cells, Endocrinology 1985; 117:841-848.
62. Jelinek U, Lok S, Rosenberg GB, Smith RA, Grant FJ, Biggs S, Bensch PA, Kuijper JL, Sheppard PO, Sprecher CA, O’Hara PJ, Foster D, Walker KM, Chen LHJ, McKcman PA, Kindsvogel W: Expression cloning and signaling properties of the rat glucagon receptor, Science 1993;259:1614-1616.
63. Moens K, Heimberg H, Flamez D, Huypens P, Quartier E, Ling Z, Pipeleers D, Gremlich S, Thorens B, Schuit F: Expression and functional activity of glucagon-, GLP-1 and GIP-recep-tors in rat pancreatic islet cells, Diabetes 1996: 45:257-261.
64. Abrahamsen N, Nishimura E: Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3'.5'-monophosphate, and glucocorticoids Endocrinology 1995; 136:1572-1578.
65. Kreymann B, Williams G, Ghatci MA, Bloom SR: Glucagon-like peptide-1 7-36: A physiological incretin in man, Lancet 1987:1300-1303.
66. Weir GC, Mojsov S, Hendrick GK, Habencr JF: Glucagonlike peptide I (7-37) actions on endocrine pancreas, Diabetes 1989:38:338-342.
67. Gutniak M, Orskov C, Holst JJ, Ahrcn B, Efcn-dic S: Anlidiabctogenic effects of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus, N Engl J Med 1992;326:1316-1322.
68. Kölligs F, Fchmann H-C, Gökc R, Göke B: Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist ex-endin (9-39) amide, Diabetes 1995:44:16-19.
69. Holz IV GG, Kühtreibcr WM, Habencr JF: Pancreatic beta-cells are rendered glucose-competent by insulinotropic hormone glucagonlike peptide-1(7-37), Nature 1993:361:362-365.
70. Fehmann HC, Göke R, Göke B: Cell and molecular biology of the incretin hormones gluca-gon-like peptide-l and glucose-dependent insulin releasing polypcpt ide, EndocrRev 1995,16: 390-410.
71. Chan CB, Pederson RA, Buchan AMJ, Tubes-ing KB, Brown JC: Gastric inhibitory polypeptide (GIP) and insulin release in the obese Zucker rat, Diabetes 1984:33:536-542.
72. Kato I, Suzuki Y, Akabane A, Yonekura H, Tanaka O, Kondo H, Takasawa S, Yoshimoto T, Okamoto H: Transgenic mice overcxpress-ing human vasoactive intestinal peptide (VIP) gene in pancreatic ß cells, J Biol Chem 1994; 269:21223-21228.
73. Yada T, Sakurada M, Ihida K, Nakata M, Murata F, Arimura A, Kikuchi M: Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet ß-cells, J Biol Chem 1994:269:1290-1293.
74. Creutzfeldt W: The incretin concept today, Diabetologia 1979;16:15-85.
75. Thorens B: Expression cloning of the pancreatic B-cell receptor for the gluco-incretin hormone glucagon-like peptide I, Proc Natl Acad Sei USA 1992;89:8641-8645.
76. Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI: Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain, Endocrinology 1993:133:2861-2870.
77. Christie MR, Ashcroft SJH: Substrates for cyclic AMP-dependent protein kinase in islets of Langcrhans: Studies with forskolin and catalytic subunit, Biochem J 1985:227:727-736.
78. Ämmälä C, Eliason L, Bokvist K, Berggren P-O, Honkanen RE, Rorsman P: Activation of proticn kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic ß-cells, Proc Natl Acad Sei USA 1994:91:4343-4347.
79. Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CMB, Mccran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JPH, Smith DM, Ghalei MA, Herbert J, Bloom SR: A role for glucagon-like peptide-1 in the central regulation of feeding, Nature 1996:379:69-72.
80. Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, Poller W, Velho G, Carcassi C, Contu L, Julier C, Cambien F, Passa P, Lathrop M, Kindsvogcl W, Demenais F, Nishimura E, Froguel P: A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus, Nature Genet 1995:9:299-304.