Direct activation of Epac by sulfonylurea is isoform selective

Chemistry and Biology

Volumn 18, Issue 2, 2011, Pages 243-251

  Herbst, Katie J ^a   Coltharp, Carla ^b   Amzel, L Mario ^a,b   Zhang, Jin ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTOR; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RAP1 PROTEIN; SULFONYLUREA DERIVATIVE;

ARTICLE; BINDING SITE; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME SPECIFICITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC PROCEDURES; HUMAN; METABOLISM; MOVEMENT (PHYSIOLOGY); PROTEIN CONFORMATION;

ARGININE; BINDING SITES; BIOSENSING TECHNIQUES; CYCLIC AMP; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; MOVEMENT; PROTEIN CONFORMATION; PROTEIN ISOFORMS; RAP1 GTP-BINDING PROTEINS; SUBSTRATE SPECIFICITY; SULFONYLUREA COMPOUNDS;

SUS;

EID: 79951816217     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2010.12.007     Document Type: Article

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