Enhanced rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: Studies with 8-pCPT-2′-O-Me-cAMP-AM

Journal of Biological Chemistry

Volumn 284, Issue 16, 2009, Pages 10728-10736

  Chepurny, Oleg G ^a   Leech, Colin A ^a   Kelley, Grant G ^a   Dzhura, Igor ^a   Dzhura, Elvira ^a   Xiangquan, Li ^a   Rindler, Michael J ^b   Schwede, Frank ^c   Genieser, Hans G ^c   Holz, George G ^a,d  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BIOLOG Life Science Institute   (Germany)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOXYMETHYL ESTERS; ADDITIVE EFFECTS; BETA CELL; BINDING PROTEINS; BIOLOGICAL ACTIVITIES; CELL TYPES; CYCLIC NUCLEOTIDE; DOSE-DEPENDENT; EXCHANGE PROTEINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GLUCOSE METABOLISM; HIGH THROUGHPUT SCREENING; INSULIN SECRETION; LIVE-CELL IMAGING; MEMBRANE PERMEABILITY; PANCREATIC BETA CELLS; PROTEIN KINASE A; SATURATING CONCENTRATION;

AMPLITUDE MODULATION; BINDING ENERGY; BIOACTIVITY; CELL CULTURE; CELL MEMBRANES; CHEMICAL ACTIVATION; ENERGY TRANSFER; ESTERIFICATION; ESTERS; FLUORESCENCE; GENE EXPRESSION; GLUCOSE; INSULIN; NUCLEOTIDES; PHYSIOLOGY;

FETAL MONITORING;

8 (4 CHLOROPHENYLTHIOL) 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE ACETOXYMETHYL ESTER; CARRIER PROTEIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP; INSULIN; N6 2' O DIBUTYRYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE ACETOXYMETHYL ESTER; RAP1 PROTEIN; UNCLASSIFIED DRUG; 8 (4 CHLORO PHENYLTHIO) 2' O METHYLADENOSINE 3' 5' CYCLIC MONOPHOSPHATE; 8-(4-CHLORO-PHENYLTHIO)-2'-O-METHYLADENOSINE-3'-5'-CYCLIC MONOPHOSPHATE; CYCLIC AMP; DRUG DERIVATIVE; EPAC 1 PROTEIN, RAT; EPAC-1 PROTEIN, RAT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYBRID PROTEIN; ISOQUINOLINE DERIVATIVE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PROTEIN KINASE INHIBITOR; SULFONAMIDE;

ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE METABOLISM; INSULIN RELEASE; MEMBRANE PERMEABILITY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; METABOLISM; MOUSE; SECRETION;

RATTUS;

ANIMALS; CELL LINE; CYCLIC AMP; ENZYME ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INSULIN; INSULIN-SECRETING CELLS; ISOQUINOLINES; MICE; PROTEIN KINASE INHIBITORS; RAP1 GTP-BINDING PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; SULFONAMIDES;

EID: 67449092561     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M900166200     Document Type: Article

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