Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

Journal of Cell Science

Volumn 125, Issue 21, 2012, Pages 5084-5095

  Tian, Geng ^a   Sågetorp, Jenny ^a   Xu, Yunjian ^a   Shuai, Hongyan ^a   Degerman, Eva ^b   Tengholm, Anders ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Adenylyl cyclase; Islets; Pancreatic cells; PDE1; PDE3; PDE4; PDE8

Indexed keywords

CYCLIC AMP; INSULIN; PHOSPHODIESTERASE; PHOSPHODIESTERASE I; PHOSPHODIESTERASE III; PHOSPHODIESTERASE VIIIB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSENSOR; CELL LEVEL; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; INSULIN RELEASE; INTRACELLULAR SIGNALING; MICROSCOPY; MOUSE; NONHUMAN; OSCILLATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PULSATILE FLOW;

3',5'-CYCLIC-AMP PHOSPHODIESTERASES; ANIMALS; CELL MEMBRANE; CELLS, CULTURED; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; FEMALE; GLUCOSE; INSULIN; ISLETS OF LANGERHANS; ISOENZYMES; KINETICS; MICE; MICE, INBRED C57BL; PERIODICITY; PHOSPHATIDYLINOSITOL PHOSPHATES; SECOND MESSENGER SYSTEMS; SINGLE-CELL ANALYSIS;

EID: 84868241098     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.107201     Document Type: Article

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