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Volumn 60, Issue 9, 2011, Pages 2315-2324

Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GHRELIN; GLUCOSE; INSULIN;

EID: 80052878624     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0368     Document Type: Article
Times cited : (56)

References (50)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-660 (Pubitemid 129516334)
    • (1999) Nature , vol.402 , Issue.6762 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 3
    • 33748664379 scopus 로고    scopus 로고
    • Drug Insight: The functions of ghrelin and its potential as a multitherapeutic hormone
    • DOI 10.1038/ncpendmet0080, PII NCPENDMET0080
    • Kojima M, Kangawa K. Drug insight: the functions of ghrelin and its potential as a multitherapeutic hormone. Nat Clin Pract Endocrinol Metab 2006;2:80-88 (Pubitemid 44446932)
    • (2006) Nature Clinical Practice Endocrinology and Metabolism , vol.2 , Issue.2 , pp. 80-88
    • Kojima, M.1    Kangawa, K.2
  • 5
    • 9444264700 scopus 로고    scopus 로고
    • 2+ signaling in β-cells: Implication in the glycemic control in rodents
    • 2+ signaling in β-cells: implication in the glycemic control in rodents. Diabetes 2004;53:3142-3151
    • (2004) Diabetes , vol.53 , pp. 3142-3151
    • Dezaki, K.1    Hosoda, H.2    Kakei, M.3
  • 8
    • 38849090670 scopus 로고    scopus 로고
    • Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
    • DOI 10.1016/j.cell.2008.01.017, PII S0092867408001177
    • Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 2008;132:387-396 (Pubitemid 351192001)
    • (2008) Cell , vol.132 , Issue.3 , pp. 387-396
    • Yang, J.1    Brown, M.S.2    Liang, G.3    Grishin, N.V.4    Goldstein, J.L.5
  • 9
    • 78149450776 scopus 로고    scopus 로고
    • Modulation of ghrelin O-acyltransferase expression in pancreatic islets
    • An W, Li Y, Xu G, et al. Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cell Physiol Biochem 2010;26:707-716
    • (2010) Cell Physiol Biochem , vol.26 , pp. 707-716
    • An, W.1    Li, Y.2    Xu, G.3
  • 10
    • 0037372044 scopus 로고    scopus 로고
    • Dose-dependent inhibition by ghrelin of insulin secretion in the mouse
    • DOI 10.1210/en.2002-220819
    • Reimer MK, Pacini G, Ahrén B. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology 2003;144:916-921 (Pubitemid 36262858)
    • (2003) Endocrinology , vol.144 , Issue.3 , pp. 916-921
    • Reimer, M.K.1    Pacini, G.2    Ahren, B.3
  • 11
    • 77956357163 scopus 로고    scopus 로고
    • Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans
    • Tong J, Prigeon RL, Davis HW, et al. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes 2010;59:2145-2151
    • (2010) Diabetes , vol.59 , pp. 2145-2151
    • Tong, J.1    Prigeon, R.L.2    Davis, H.W.3
  • 12
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance
    • DOI 10.2337/db06-0878
    • Dezaki K, Sone H, Koizumi M, et al. Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-induced glucose intolerance. Diabetes 2006;55:3486-3493 (Pubitemid 44923609)
    • (2006) Diabetes , vol.55 , Issue.12 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3    Nakata, M.4    Kakei, M.5    Nagai, H.6    Hosoda, H.7    Kangawa, K.8    Yada, T.9
  • 14
    • 43049170316 scopus 로고    scopus 로고
    • Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
    • Dezaki K, Sone H, Yada T. Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis. Pharmacol Ther 2008;118:239-249
    • (2008) Pharmacol Ther , vol.118 , pp. 239-249
    • Dezaki, K.1    Sone, H.2    Yada, T.3
  • 15
    • 34548436635 scopus 로고    scopus 로고
    • 2+ signaling and insulin release in islet β-cells: Novel signal transduction of ghrelin
    • 2+ signaling and insulin release in islet β-cells: novel signal transduction of ghrelin. Diabetes 2007;56:2319-2327
    • (2007) Diabetes , vol.56 , pp. 2319-2327
    • Dezaki, K.1    Kakei, M.2    Yada, T.3
  • 16
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000;49:1751-1760
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.C.1
  • 17
    • 0023525741 scopus 로고
    • 2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion
    • Prentki M, Matschinsky FM. Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion. Physiol Rev 1987;67: 1185-1248 (Pubitemid 18003171)
    • (1987) Physiological Reviews , vol.67 , Issue.4 , pp. 1185-1248
    • Prentki, M.1    Matschinsky, F.M.2
  • 19
    • 31144458770 scopus 로고    scopus 로고
    • Oscillations of cyclic AMP in hormone-stimulated insulin-secreting b-cells
    • DOI 10.1038/nature04410, PII NATURE04410
    • Dyachok O, Isakov Y, Sågetorp J, Tengholm A. Oscillations of cyclic AMP in hormone-stimulated insulin-secreting b-cells. Nature 2006;439:349-352 (Pubitemid 43128861)
    • (2006) Nature , vol.439 , Issue.7074 , pp. 349-352
    • Dyachok, O.1    Isakov, Y.2    Sagetorp, J.3    Tengholm, A.4
  • 20
    • 0035197958 scopus 로고    scopus 로고
    • 2+ signaling in rat islet β-cells: Strict regulation by glucose, link to insulin release, and cooperation with glucagon-like peptide-1(7-36)amide and pituitary adenylate cyclase-activating polypeptide
    • 2+ signaling in rat islet β-cells: strict regulation by glucose, link to insulin release, and cooperation with glucagon-like peptide-1(7-36)amide and pituitary adenylate cyclase-activating polypeptide. J Pharmacol Exp Ther 2001;296:22-30
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 22-30
    • Hashiguchi, S.1    Yada, T.2    Arima, T.3
  • 21
    • 0030828409 scopus 로고    scopus 로고
    • Imaging of cAMP-dependent protein kinase activity in living neural cells using a novel fluorescent substrate
    • DOI 10.1016/S0014-5793(97)00970-8, PII S0014579397009708
    • Higashi H, Sato K, Ohtake A, Omori A, Yoshida S, Kudo Y. Imaging of cAMP-dependent protein kinase activity in living neural cells using a novel fluorescent substrate. FEBS Lett 1997;414:55-60 (Pubitemid 27380354)
    • (1997) FEBS Letters , vol.414 , Issue.1 , pp. 55-60
    • Higashi, H.1    Sato, K.2    Ohtake, A.3    Omori, A.4    Yoshida, S.5    Kudo, Y.6
  • 22
    • 0042879894 scopus 로고    scopus 로고
    • + channels in pancreatic beta cells: Role, regulation and potential as therapeutic targets
    • DOI 10.1007/s00125-003-1159-8
    • MacDonald PE, Wheeler MB. Voltage-dependent K+ channels in pancreatic β cells: role, regulation and potential as therapeutic targets. Diabetologia 2003;46:1046-1062 (Pubitemid 37041235)
    • (2003) Diabetologia , vol.46 , Issue.8 , pp. 1046-1062
    • MacDonald, P.E.1    Wheeler, M.B.2
  • 25
    • 0023718389 scopus 로고
    • A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase
    • Bubis J, Neitzel JJ, Saraswat LD, Taylor SS. A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase. J Biol Chem 1988;263:9668-9673
    • (1988) J Biol Chem , vol.263 , pp. 9668-9673
    • Bubis, J.1    Neitzel, J.J.2    Saraswat, L.D.3    Taylor, S.S.4
  • 26
    • 0025252387 scopus 로고
    • Effects of cAMP-binding site mutations on intradomain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I
    • Ringheim GE, Taylor SS. Effects of cAMP-binding site mutations on intra-domain cross-communication in the regulatory subunit of cAMP-dependent protein kinase I. J Biol Chem 1990;265:19472-19478 (Pubitemid 120013888)
    • (1990) Journal of Biological Chemistry , vol.265 , Issue.32 , pp. 19472-19478
    • Ringheim, G.E.1    Taylor, S.S.2
  • 28
    • 77349096383 scopus 로고    scopus 로고
    • PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me-cAMP-AM in human islets of Langerhans
    • Chepurny OG, Kelley GG, Dzhura I, et al. PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2′-O-Me- cAMP-AM in human islets of Langerhans. Am J Physiol Endocrinol Metab 2010;298:E622-E633
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Chepurny, O.G.1    Kelley, G.G.2    Dzhura, I.3
  • 29
    • 0031936954 scopus 로고    scopus 로고
    • Glucagon-like peptides
    • Drucker DJ. Glucagon-like peptides. Diabetes 1998;47:159-169 (Pubitemid 28079969)
    • (1998) Diabetes , vol.47 , Issue.2 , pp. 159-169
    • Drucker, D.J.1
  • 30
    • 0029077296 scopus 로고
    • Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor
    • Gremlich S, Porret A, Hani EH, et al. Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor. Diabetes 1995;44:1202-1208
    • (1995) Diabetes , vol.44 , pp. 1202-1208
    • Gremlich, S.1    Porret, A.2    Hani, E.H.3
  • 31
    • 0344908216 scopus 로고    scopus 로고
    • Signaling mechanisms underlying the insulinotropic effect of pituitary adenylate cyclase-activating polypeptide in HIT-T15 cells
    • DOI 10.1210/en.137.7.2791
    • Klinteberg KA, Karlsson S, Ahrén B. Signaling mechanisms underlying the insulinotropic effect of pituitary adenylate cyclase-activating polypeptide in HIT-T15 cells. Endocrinology 1996;137:2791-2798 (Pubitemid 26192172)
    • (1996) Endocrinology , vol.137 , Issue.7 , pp. 2791-2798
    • Af, K.K.1    Karlsson, S.2    Ahren, B.3
  • 32
    • 0346732301 scopus 로고    scopus 로고
    • + currents by exendin 4 requires dual activation of the cAMP/ protein kinase A and phosphatidylinositol 3-kinase signaling pathways
    • + currents by exendin 4 requires dual activation of the cAMP/ protein kinase A and phosphatidylinositol 3-kinase signaling pathways. J Biol Chem 2003;278:52446-52453
    • (2003) J Biol Chem , vol.278 , pp. 52446-52453
    • MacDonald, P.E.1    Wang, X.2    Xia, F.3
  • 34
    • 0030474003 scopus 로고    scopus 로고
    • Mechanisms of inhibition of insulin release
    • Sharp GW. Mechanisms of inhibition of insulin release. Am J Physiol 1996;271:C1781-C1799
    • (1996) Am J Physiol , vol.271
    • Sharp, G.W.1
  • 35
    • 79952126080 scopus 로고    scopus 로고
    • Augmented glucose-induced insulin release in mice lacking Go2, but not Go1 or Gi proteins
    • Wang Y, Park S, Bajpayee NS, et al. Augmented glucose-induced insulin release in mice lacking Go2, but not Go1 or Gi proteins. Proc Natl Acad Sci USA 2011;108:1693-1698
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 1693-1698
    • Wang, Y.1    Park, S.2    Bajpayee, N.S.3
  • 37
    • 0023676354 scopus 로고
    • The muscarinic receptor subtype in mouse pancreatic B-cells
    • Henquin JC, Nenquin M. The muscarinic receptor subtype in mouse pancreatic B-cells. FEBS Lett 1988;236:89-92
    • (1988) FEBS Lett , vol.236 , pp. 89-92
    • Henquin, J.C.1    Nenquin, M.2
  • 39
    • 0024595383 scopus 로고
    • 2+for acetylcholine stimulation of insulin release in mouse islets
    • 2+ for acetylcholine stimulation of insulin release in mouse islets. Diabetes 1989;38:198-204
    • (1989) Diabetes , vol.38 , pp. 198-204
    • Hermans, M.P.1    Henquin, J.C.2
  • 43
    • 53549108041 scopus 로고    scopus 로고
    • Ghrelin signalling in guinea-pig femoral artery smooth muscle cells
    • Oxf
    • Mladenov MI, Hristov KL, Dimitrova DZ, et al. Ghrelin signalling in guinea-pig femoral artery smooth muscle cells. Acta Physiol (Oxf) 2008;194:195-206
    • (2008) Acta Physiol , vol.194 , pp. 195-206
    • Mladenov, M.I.1    Hristov, K.L.2    Dimitrova, D.Z.3
  • 44
    • 0038540318 scopus 로고    scopus 로고
    • Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
    • DOI 10.1016/S0163-7258(03)00051-2
    • Hermans E. Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors. Pharmacol Ther 2003;99:25-44 (Pubitemid 36694748)
    • (2003) Pharmacology and Therapeutics , vol.99 , Issue.1 , pp. 25-44
    • Hermans, E.1
  • 46
    • 34347391255 scopus 로고    scopus 로고
    • Identification of a mouse ghrelin gene transcipt that contains intron 2 and is regulated in the pituitary andd hypothalamus in responce to metabolic stress
    • DOI 10.1677/JME-06-0026
    • Kineman RD, Gahete MD, Luque RM. Identification of a mouse ghrelin gene transcript that contains intron 2 and is regulated in the pituitary and hypothalamus in response to metabolic stress. J Mol Endocrinol 2007;38:511-521 (Pubitemid 47019056)
    • (2007) Journal of Molecular Endocrinology , vol.38 , Issue.5-6 , pp. 511-521
    • Kineman, R.D.1    Gahete, M.D.2    Luque, R.M.3
  • 47
    • 33746583963 scopus 로고    scopus 로고
    • Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers
    • DOI 10.1210/me.2005-0084
    • Jiang H, Betancourt L, Smith RG. Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol 2006;20:1772-1785 (Pubitemid 44148083)
    • (2006) Molecular Endocrinology , vol.20 , Issue.8 , pp. 1772-1785
    • Jiang, H.1    Betancourt, L.2    Smith, R.G.3
  • 48
    • 33646141847 scopus 로고    scopus 로고
    • Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    • Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab 2006;3:379-386
    • (2006) Cell Metab , vol.3 , pp. 379-386
    • Sun, Y.1    Asnicar, M.2    Saha, P.K.3    Chan, L.4    Smith, R.G.5
  • 50
    • 78650304822 scopus 로고    scopus 로고
    • Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor
    • Barnett BP, Hwang Y, Taylor MS, et al. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science 2010;330:1689-1692
    • (2010) Science , vol.330 , pp. 1689-1692
    • Barnett, B.P.1    Hwang, Y.2    Taylor, M.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.