메뉴 건너뛰기




Volumn 56, Issue 12, 2004, Pages 1477-1492

Targeting β-cell cyclic 3′5′ adenosine monophosphate for the development of novel drugs for treating type 2 diabetes mellitus. A rewiew

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 2 PHENYLETHYL]PYRIDINE; 6 (5,6 DIMETHOXYBENZO[B]THIEN 2 YL) 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; ADENYLATE CYCLASE; AROFYLLINE; ATIZORAM; CILOMILAST; CILOSTAMIDE; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; DIPEPTIDYL PEPTIDASE IV; DIPYRIDAMOLE; ENOXIMONE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; MILRINONE; N CYCLOHEXYL 4 (1,2 DIHYDRO 2 OXO 6 QUINOLYLOXY) N (2 HYDROXYETHYL)BUTYRAMIDE; PEPTIDE; PHOSPHODIESTERASE INHIBITOR; PICLAMILAST; ROLIPRAM; SCH 51866; SIGUAZODAN; SILDENAFIL; UNCLASSIFIED DRUG; VINPOCETINE; ZAPRINAST; ZARDAVERINE;

EID: 10044294739     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357044805     Document Type: Review
Times cited : (32)

References (186)
  • 1
    • 0034020931 scopus 로고    scopus 로고
    • Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11
    • Ahmad, M., Abdel-Wahab, Y. H. A., Tate, R., Flatt, P. R., Pyne, N. J., Furman, B. L., (2000a) Effect of type-selective inhibitors on cyclic nucleotide phosphodiesterase activity and insulin secretion in the clonal insulin secreting cell line BRIN-BD11. Br. J. Pharmacol. 129: 1228-1234
    • (2000) Br. J. Pharmacol. , vol.129 , pp. 1228-1234
    • Ahmad, M.1    Abdel-Wahab, Y.H.A.2    Tate, R.3    Flatt, P.R.4    Pyne, N.J.5    Furman, B.L.6
  • 2
    • 0034253197 scopus 로고    scopus 로고
    • The role of cyclic GMP-inhibited cAMP-specific phosphodiesterase (PDE3) in regulating clonal BRIN-BD11 insulin secreting cell survival
    • Ahmad, M., Flatt, P. R., Furman, B. L., Pyne, N. J. (2000b) The role of cyclic GMP-inhibited cAMP-specific phosphodiesterase (PDE3) in regulating clonal BRIN-BD11 insulin secreting cell survival. Cellular Signalling 12: 541-548
    • (2000) Cellular Signalling , vol.12 , pp. 541-548
    • Ahmad, M.1    Flatt, P.R.2    Furman, B.L.3    Pyne, N.J.4
  • 3
    • 0034666562 scopus 로고    scopus 로고
    • Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice
    • Ahren, B., Holst, J. J., Martensson, H., Balkan, B. (2000) Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice. Eur. J. Pharmacol. 404: 239-245
    • (2000) Eur. J. Pharmacol. , vol.404 , pp. 239-245
    • Ahren, B.1    Holst, J.J.2    Martensson, H.3    Balkan, B.4
  • 6
    • 0029670692 scopus 로고    scopus 로고
    • Interleukin-1 beta-induced nitric oxide production from rat isolated islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine
    • Andersen, H. U., Mauricio, D., Karlsen, A. E., Mandrup-Poulsen, T., Nielsen, J. H., Nerup, J. (1996) Interleukin-1 beta-induced nitric oxide production from rat isolated islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine. Eur. J. Endocrinol. 134: 251-259
    • (1996) Eur. J. Endocrinol. , vol.134 , pp. 251-259
    • Andersen, H.U.1    Mauricio, D.2    Karlsen, A.E.3    Mandrup-Poulsen, T.4    Nielsen, J.H.5    Nerup, J.6
  • 7
    • 0000135759 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats
    • Balkan, B., Kwasnik, L., Miserendino, R., Holst, J. J., Li, X. (1999) Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats. Diabetologia 42: 1324-1331
    • (1999) Diabetologia , vol.42 , pp. 1324-1331
    • Balkan, B.1    Kwasnik, L.2    Miserendino, R.3    Holst, J.J.4    Li, X.5
  • 8
    • 0343893674 scopus 로고    scopus 로고
    • Relationship between plasma plasminogen activator inhibitor 1 and insulin resistance
    • Bastard, J. P., Pieroni, L., Hainque, B. (2000) Relationship between plasma plasminogen activator inhibitor 1 and insulin resistance. Diabetes Metab. Res. Rev. 16: 192-201
    • (2000) Diabetes Metab. Res. Rev. , vol.16 , pp. 192-201
    • Bastard, J.P.1    Pieroni, L.2    Hainque, B.3
  • 9
    • 0032547058 scopus 로고    scopus 로고
    • Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic beta cell line
    • Benes, C., Roisin, M. P., Van Tan, H., Creuzet, C., Miyazaki, J., Fagard, R. (1998) Rapid activation and nuclear translocation of mitogen-activated protein kinases in response to physiological concentration of glucose in the MIN6 pancreatic beta cell line. J. Biol. Chem. 273: 15507-15513
    • (1998) J. Biol. Chem. , vol.273 , pp. 15507-15513
    • Benes, C.1    Roisin, M.P.2    Van Tan, H.3    Creuzet, C.4    Miyazaki, J.5    Fagard, R.6
  • 10
    • 0033563110 scopus 로고    scopus 로고
    • Mode of regulation of the extracellular signal-regulated kinases in the pancreatic β-cell line MIN6 and their implication in the regulation of insulin gene transcription
    • Benes, C., Poitout, V., Marie, J.-C., Martin-Perez, J., Roisin, M. P., Fagard, R. (1999) Mode of regulation of the extracellular signal-regulated kinases in the pancreatic β-cell line MIN6 and their implication in the regulation of insulin gene transcription. Biochem. J. 340: 219-225
    • (1999) Biochem. J. , vol.340 , pp. 219-225
    • Benes, C.1    Poitout, V.2    Marie, J.-C.3    Martin-Perez, J.4    Roisin, M.P.5    Fagard, R.6
  • 11
    • 0034889541 scopus 로고    scopus 로고
    • Inhibitors of phosphodiesterase isoforms III or IV suppress islet-cell nitric oxide production
    • Besay, E., Prud'homme, G. J. (2001) Inhibitors of phosphodiesterase isoforms III or IV suppress islet-cell nitric oxide production. Lab. Invest. 81: 1109-1117
    • (2001) Lab. Invest. , vol.81 , pp. 1109-1117
    • Besay, E.1    Prud'homme, G.J.2
  • 13
    • 0347990354 scopus 로고    scopus 로고
    • Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2
    • Brubaker, P. L., Anini, Y. (2003) Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2. Can. J. Physiol. Pharmacol. 81: 1005-1012
    • (2003) Can. J. Physiol. Pharmacol. , vol.81 , pp. 1005-1012
    • Brubaker, P.L.1    Anini, Y.2
  • 14
    • 0028262136 scopus 로고
    • Feedback regulation of glucose-dependent insulinotropic polypeptide (GIP) secretion by insulin in conscious rats
    • Bryer-Ash, M., Cheung, A., Pederson, R. A. (1994) Feedback regulation of glucose-dependent insulinotropic polypeptide (GIP) secretion by insulin in conscious rats. Regul. Pept. 51: 101-109
    • (1994) Regul. Pept. , vol.51 , pp. 101-109
    • Bryer-Ash, M.1    Cheung, A.2    Pederson, R.A.3
  • 15
    • 0033005873 scopus 로고    scopus 로고
    • Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1
    • Burcelin, R., Dolci, W., Thorens, B. (1999) Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1. Metabolism 48: 252-258
    • (1999) Metabolism , vol.48 , pp. 252-258
    • Burcelin, R.1    Dolci, W.2    Thorens, B.3
  • 16
    • 0012989794 scopus 로고    scopus 로고
    • Combination treatment of a DPP-IV inhibitor NVP-LAF237 with pioglitazone completely normalized glucose tolerance in adult obese Zucker rats
    • Burkey, B. F., Li, X., Bolognese, L., Russell, M., Wang, P. R., Villhauer, E. B., Hughes, T. E. (2002) Combination treatment of a DPP-IV inhibitor NVP-LAF237 with pioglitazone completely normalized glucose tolerance in adult obese Zucker rats. Diabetes 51(Suppl. 2): A1383
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 2
    • Burkey, B.F.1    Li, X.2    Bolognese, L.3    Russell, M.4    Wang, P.R.5    Villhauer, E.B.6    Hughes, T.E.7
  • 17
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells
    • Buteau, J., Roduit, R., Susini, S., Prentki, M. (1999) Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells. Diabetologia 42: 856-864
    • (1999) Diabetologia , vol.42 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3    Prentki, M.4
  • 18
    • 0037221488 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor
    • Buteau, J., Foisy, S., Joly, E., Prentki, M. (2003) Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Diabetes 52: 124-132
    • (2003) Diabetes , vol.52 , pp. 124-132
    • Buteau, J.1    Foisy, S.2    Joly, E.3    Prentki, M.4
  • 19
    • 0031040074 scopus 로고    scopus 로고
    • The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor
    • Calleja, V., Ruiz Enriquez, P., Filloux, C., Peraldi, P., Baron, V., Van Obberghen, E. (1997) The effect of cyclic adenosine monophosphate on the mitogen-activated protein kinase pathway depends on both the cell type and the type of tyrosine kinase-receptor. Endocrinology 138: 1111-1120
    • (1997) Endocrinology , vol.138 , pp. 1111-1120
    • Calleja, V.1    Ruiz Enriquez, P.2    Filloux, C.3    Peraldi, P.4    Baron, V.5    Van Obberghen, E.6
  • 20
    • 0022505064 scopus 로고
    • Cyclic AMP phosphodiesterase activity in mouse pancreatic islets. Effects of calmodulin and phospholipids
    • Capito, K., Hedeskov, C. J., Thams, P. (1986) Cyclic AMP phosphodiesterase activity in mouse pancreatic islets. Effects of calmodulin and phospholipids. Acta Endocrinol. 111: 533-538
    • (1986) Acta Endocrinol. , vol.111 , pp. 533-538
    • Capito, K.1    Hedeskov, C.J.2    Thams, P.3
  • 21
    • 0038353630 scopus 로고    scopus 로고
    • The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose
    • Chang, A. M., Jakobsen, G., Stuns, J., Smith, M. J., Bloem, C. J., An, B., Galecki, A., Halter, J. B. (2003) The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose. Diabetes 52: 1786-1791
    • (2003) Diabetes , vol.52 , pp. 1786-1791
    • Chang, A.M.1    Jakobsen, G.2    Stuns, J.3    Smith, M.J.4    Bloem, C.J.5    An, B.6    Galecki, A.7    Halter, J.B.8
  • 22
    • 0033499058 scopus 로고    scopus 로고
    • Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer?
    • Cheng, H. C., Abdel-Ghany, M., Zhang, S., Pauli, B. U. (1999) Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer? Clin. Exp. Metastasis 17: 609-615
    • (1999) Clin. Exp. Metastasis , vol.17 , pp. 609-615
    • Cheng, H.C.1    Abdel-Ghany, M.2    Zhang, S.3    Pauli, B.U.4
  • 23
    • 0030790289 scopus 로고    scopus 로고
    • A radioimmunoassay for LY315902, an analog of glucagon-like insulinotropic peptide, and its application in the study of canine pharmacokinetics
    • Chou, J. Z., Place, G. D., Waters, D. G., Kirkwood, J. A., Bowsher, R. R. (1997) A radioimmunoassay for LY315902, an analog of glucagon-like insulinotropic peptide, and its application in the study of canine pharmacokinetics. J. Pharm. Sci. 86: 768-773
    • (1997) J. Pharm. Sci. , vol.86 , pp. 768-773
    • Chou, J.Z.1    Place, G.D.2    Waters, D.G.3    Kirkwood, J.A.4    Bowsher, R.R.5
  • 24
    • 0035795589 scopus 로고    scopus 로고
    • Cloning of dog heart PDE1A - A first detailed characterization at the molecular level
    • Clapham, J. C., Widerspin, A. F. (2001) Cloning of dog heart PDE1A-a first detailed characterization at the molecular level. Gene 268: 165-171
    • (2001) Gene , vol.268 , pp. 165-171
    • Clapham, J.C.1    Widerspin, A.F.2
  • 25
    • 0033553509 scopus 로고    scopus 로고
    • Cyclic GMP phosphodiesterase-5: Target of sildenafil
    • Corbin, J. D., Francis, S. H. (1999) Cyclic GMP phosphodiesterase-5: target of sildenafil. J. Biol. Chem. 274: 13729-13732
    • (1999) J. Biol. Chem. , vol.274 , pp. 13729-13732
    • Corbin, J.D.1    Francis, S.H.2
  • 26
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients
    • Creutzfeldt, W. O., Kleine, N., Willms, B., Ørskov, C., Holst, J. J., Nauck, M. A. (1996) Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients. Diabetes Care 19: 580-586
    • (1996) Diabetes Care , vol.19 , pp. 580-586
    • Creutzfeldt, W.O.1    Kleine, N.2    Willms, B.3    Ørskov, C.4    Holst, J.J.5    Nauck, M.A.6
  • 28
    • 0031782440 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity
    • Deacon, C. F., Knudsen, L. B., Madsen, K., Wiberg, F. C., Jacobsen, O., Holst, J. J. (1998) Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity. Diabetologia 41: 271-278
    • (1998) Diabetologia , vol.41 , pp. 271-278
    • Deacon, C.F.1    Knudsen, L.B.2    Madsen, K.3    Wiberg, F.C.4    Jacobsen, O.5    Holst, J.J.6
  • 29
    • 0035403058 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
    • Deacon, C. F., Danielsen, P., Klarskov, L., Olesen, M., Holst, J. J. (2001) Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs. Diabetes 50: 1588-1597
    • (2001) Diabetes , vol.50 , pp. 1588-1597
    • Deacon, C.F.1    Danielsen, P.2    Klarskov, L.3    Olesen, M.4    Holst, J.J.5
  • 30
    • 0036188070 scopus 로고    scopus 로고
    • Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs
    • Deacon, C. F., Wamberg, S., Bie, P., Hughes, T. E., Holst, J. J. (2002) Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs. J. Endocrinol. 172: 355-362
    • (2002) J. Endocrinol. , vol.172 , pp. 355-362
    • Deacon, C.F.1    Wamberg, S.2    Bie, P.3    Hughes, T.E.4    Holst, J.J.5
  • 31
    • 0142125207 scopus 로고    scopus 로고
    • Type VIII adenylyl cyclase in rat beta cells: Coincidence signal detector/generator for glucose and GLP-1
    • Delmeire, D., Flamez, D., Hinke, S. A., Cali, J. J., Pipeleers, D., Schuit, F. (2003) Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1. Diabetologia 46: 1383-1393
    • (2003) Diabetologia , vol.46 , pp. 1383-1393
    • Delmeire, D.1    Flamez, D.2    Hinke, S.A.3    Cali, J.J.4    Pipeleers, D.5    Schuit, F.6
  • 32
    • 0037209639 scopus 로고    scopus 로고
    • Forskolin suppresses insulin gene transcription in islet beta-cells through a protein kinase A-independent pathway
    • Ding, W. Q., Dong, M., Ninova, D., Holicky, E. L., Stegall, M. D., Miller, L. J. (2003) Forskolin suppresses insulin gene transcription in islet beta-cells through a protein kinase A-independent pathway. Cell Signal 15: 27-35
    • (2003) Cell Signal. , vol.15 , pp. 27-35
    • Ding, W.Q.1    Dong, M.2    Ninova, D.3    Holicky, E.L.4    Stegall, M.D.5    Miller, L.J.6
  • 33
    • 0034806376 scopus 로고    scopus 로고
    • Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent
    • Doyle, M. E., Greig, N. H., Holloway, H. W., Betkey, J. A., Bernier, M., Egan, J. M. (2001) Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent. Endocrinology 142: 4462-4468
    • (2001) Endocrinology , vol.142 , pp. 4462-4468
    • Doyle, M.E.1    Greig, N.H.2    Holloway, H.W.3    Betkey, J.A.4    Bernier, M.5    Egan, J.M.6
  • 34
    • 0028018378 scopus 로고
    • Significance of membrane repolarization and cAMP changes in mouse pancreatic B-cells for the inhibition of insulin release by galanin
    • Drews, G., Debuyser, A., Henquin, J. C. (1994) Significance of membrane repolarization and cAMP changes in mouse pancreatic B-cells for the inhibition of insulin release by galanin. Mol. Cell Endocrinol. 105: 97-102
    • (1994) Mol. Cell Endocrinol. , vol.105 , pp. 97-102
    • Drews, G.1    Debuyser, A.2    Henquin, J.C.3
  • 35
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker, D. J. (2003) Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 26: 2929-2940
    • (2003) Diabetes Care , vol.26 , pp. 2929-2940
    • Drucker, D.J.1
  • 36
    • 0344357096 scopus 로고
    • Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line
    • Drucker, D. J., Philippe, J., Mojsov, S., Chick, W. L., Habener, J. F. (1987) Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc. Natl. Acad. Sci. USA 84: 3434-3438
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3434-3438
    • Drucker, D.J.1    Philippe, J.2    Mojsov, S.3    Chick, W.L.4    Habener, J.F.5
  • 37
    • 0018672563 scopus 로고
    • Gastric inhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes
    • Eckel, R. H., Fujimoto, W. Y., Brunzell, J. D. (1979) Gastric inhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes. Diabetes 28: 1141-1142
    • (1979) Diabetes , vol.28 , pp. 1141-1142
    • Eckel, R.H.1    Fujimoto, W.Y.2    Brunzell, J.D.3
  • 39
    • 0032908809 scopus 로고    scopus 로고
    • Initiation of increased pancreatic islet growth in young normoglycemic mice (Umea +/?)
    • Edvell, A., Lindstrom, P. (1999) Initiation of increased pancreatic islet growth in young normoglycemic mice (Umea +/?). Endocrinology 140: 778-783
    • (1999) Endocrinology , vol.140 , pp. 778-783
    • Edvell, A.1    Lindstrom, P.2
  • 40
    • 0036965113 scopus 로고    scopus 로고
    • The insulinotropic effect of acute exendin-4 administered to humans: Comparison of nondiabetic state to type 2 diabetes
    • Egan, J. M., Clocquet, A. R., Elahi, D. (2002) The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes. J. Clin. Endocrinol. Metab. 87: 1282-1290
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 1282-1290
    • Egan, J.M.1    Clocquet, A.R.2    Elahi, D.3
  • 41
    • 0038178058 scopus 로고    scopus 로고
    • Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes
    • Egan, J. M., Meneilly, G. S., Elahi, D. (2003) Effects of 1-mo bolus subcutaneous administration of exendin-4 in type 2 diabetes. Am. J. Physiol. Endocrinol. Metab. 4: E1072-E1079
    • (2003) Am. J. Physiol. Endocrinol. Metab. , vol.4
    • Egan, J.M.1    Meneilly, G.S.2    Elahi, D.3
  • 42
    • 0037020242 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway
    • Ehses, J. A., Pelech, S. L., Pederson, R. A., Mclntosh, C. H. (2002) Glucose-dependent insulinotropic polypeptide activates the Raf-Mek1/2-ERK1/2 module via a cyclic AMP/cAMP-dependent protein kinase/Rap1-mediated pathway. J. Biol. Chem. 277: 37088-37097
    • (2002) J. Biol. Chem. , vol.277 , pp. 37088-37097
    • Ehses, J.A.1    Pelech, S.L.2    Pederson, R.A.3    Mclntosh, C.H.4
  • 43
    • 0025345694 scopus 로고
    • Effect of glucagon-like peptide-1 on gastric somatostatin and gastrin secretion in the rat
    • Eissele, R., Koop, H., Arnold, R. (1990) Effect of glucagon-like peptide-1 on gastric somatostatin and gastrin secretion in the rat. Scand. J. Gastroenterol. 25: 449-454
    • (1990) Scand. J. Gastroenterol. , vol.25 , pp. 449-454
    • Eissele, R.1    Koop, H.2    Arnold, R.3
  • 45
    • 0030951666 scopus 로고    scopus 로고
    • The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat
    • El-Metwally, M., Shafiee-Nick, R., Pyne, N. J., Furman, B. L. (1997) The effect of selective phosphodiesterase inhibitors on plasma insulin concentrations and insulin secretion in vitro in the rat. Eur. J. Pharmacol. 324: 227-232
    • (1997) Eur. J. Pharmacol. , vol.324 , pp. 227-232
    • El-Metwally, M.1    Shafiee-Nick, R.2    Pyne, N.J.3    Furman, B.L.4
  • 46
    • 0035489991 scopus 로고    scopus 로고
    • Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1
    • Elrick, L. J., Docherty, K. (2001) Phosphorylation-dependent nucleocytoplasmic shuttling of pancreatic duodenal homeobox-1. Diabetes 500: 2244-2252
    • (2001) Diabetes , vol.500 , pp. 2244-2252
    • Elrick, L.J.1    Docherty, K.2
  • 47
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells
    • Fehmann, H. C., Habener, J. F. (1992) Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 130: 159-166
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H.C.1    Habener, J.F.2
  • 48
    • 0029127019 scopus 로고
    • Characterization of GIP(1-30) and GIP(1-42) as stimulators of proinsulin gene transcription
    • Fehmann, H. C., Göke, R. (1995) Characterization of GIP(1-30) and GIP(1-42) as stimulators of proinsulin gene transcription. Peptides 16: 1149-1152
    • (1995) Peptides , vol.16 , pp. 1149-1152
    • Fehmann, H.C.1    Göke, R.2
  • 49
    • 0036701253 scopus 로고    scopus 로고
    • Plasma glucagon-like peptide-1 (GLP-I) responses to duodenal fat and glucose infusions in lean and obese men
    • Feinle, C., Chapman, I. M., Wishart, J., Horowitz, M. (2002) Plasma glucagon-like peptide-1 (GLP-I) responses to duodenal fat and glucose infusions in lean and obese men. Peptides 23: 1491-1495
    • (2002) Peptides , vol.23 , pp. 1491-1495
    • Feinle, C.1    Chapman, I.M.2    Wishart, J.3    Horowitz, M.4
  • 51
    • 0035461315 scopus 로고    scopus 로고
    • The neuropeptide pituitary adenylate cyclase-activating polypeptide and islet function
    • Filipsson, K., Kvist-Reimer, M., Ahren, B. (2001) The neuropeptide pituitary adenylate cyclase-activating polypeptide and islet function. Diabetes 50: 1959-1969
    • (2001) Diabetes , vol.50 , pp. 1959-1969
    • Filipsson, K.1    Kvist-Reimer, M.2    Ahren, B.3
  • 52
    • 0032546779 scopus 로고    scopus 로고
    • Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase
    • Fisher, D. A., Smith, J. F., Pillar, J. S., St Denis, S. H., Cheng, J. B. (1998) Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J. Biol. Chem. 273: 15559-15564
    • (1998) J. Biol. Chem. , vol.273 , pp. 15559-15564
    • Fisher, D.A.1    Smith, J.F.2    Pillar, J.S.3    St. Denis, S.H.4    Cheng, J.B.5
  • 53
    • 0013661901 scopus 로고
    • Islet phosphodiesterase isoenzymes and insulin secretion
    • Furman, B. L., Pyne, N. J. (1990) Islet phosphodiesterase isoenzymes and insulin secretion. Diabetic Med. 7: 19A
    • (1990) Diabetic Med. , vol.7
    • Furman, B.L.1    Pyne, N.J.2
  • 54
    • 1442321740 scopus 로고    scopus 로고
    • Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo
    • Gault, V. A., Parker, J. C., Harriott, P., Flatt, P. R., O'Harte, F. P. M. (2002a) Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J. Endocrinol. 175: 525-533
    • (2002) J. Endocrinol. , vol.175 , pp. 525-533
    • Gault, V.A.1    Parker, J.C.2    Harriott, P.3    Flatt, P.R.4    O'Harte, F.P.M.5
  • 56
    • 0036289106 scopus 로고    scopus 로고
    • Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide
    • Gault, V. A., O'Harte, F. P. M., Harriott, P., Flatt, P. R. (2002c) Characterization of the cellular and metabolic effects of a novel enzyme-resistant antagonist of glucose-dependent insulinotropic polypeptide. Biochem. Biophys. Res. Commun. 290: 1420-1426
    • (2002) Biochem. Biophys. Res. Commun. , vol.290 , pp. 1420-1426
    • Gault, V.A.1    O'Harte, F.P.M.2    Harriott, P.3    Flatt, P.R.4
  • 57
    • 0242432370 scopus 로고    scopus 로고
    • Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide
    • Gault, V. A., Harriott, P., Flatt, P. R., O'Harte, F. P. M. (2002d) Cyclic AMP production and insulin releasing activity of synthetic fragment peptides of glucose-dependent insulinotropic polypeptide. Biosci. Rep. 22: 523-528
    • (2002) Biosci. Rep. , vol.22 , pp. 523-528
    • Gault, V.A.1    Harriott, P.2    Flatt, P.R.3    O'Harte, F.P.M.4
  • 58
    • 0041592594 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes
    • Gault, V. A., Flatt, P. R., O'Harte, F. P. M. (2003a) Glucose-dependent insulinotropic polypeptide analogues and their therapeutic potential for the treatment of obesity-diabetes. Biochem. Biophys. Res. Commun. 308: 207-213
    • (2003) Biochem. Biophys. Res. Commun. , vol.308 , pp. 207-213
    • Gault, V.A.1    Flatt, P.R.2    O'Harte, F.P.M.3
  • 60
    • 0037299115 scopus 로고    scopus 로고
    • 3)GIP antagonist and exendin(9-39) amide on GIP and GLP-1 induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: Evidence that GIP is the major physiological incretin
    • 3)GIP antagonist and exendin(9-39) amide on GIP and GLP-1 induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: Evidence that GIP is the major physiological incretin. Diabetologia 46: 222-230
    • (2003) Diabetologia , vol.46 , pp. 222-230
    • Gault, V.A.1    Flatt, P.R.2    Harriott, P.3    Green, B.D.4    O'Harte, F.P.M.5
  • 61
    • 0034786750 scopus 로고    scopus 로고
    • Mechanism and physiological significance of the cholinergic control of pancreatic beta cell function
    • Gilon, P., Henquin, J. C. (2001) Mechanism and physiological significance of the cholinergic control of pancreatic beta cell function. Endocr. Rev. 22: 565-604
    • (2001) Endocr. Rev. , vol.22 , pp. 565-604
    • Gilon, P.1    Henquin, J.C.2
  • 62
    • 0034864659 scopus 로고    scopus 로고
    • Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test
    • Graham, T. E., Sathasivam, P., Rowland, M., Marko, N., Greer, F., Battram, D. (2001) Caffeine ingestion elevates plasma insulin response in humans during an oral glucose tolerance test. Can. J. Physiol. Pharmacol. 79: 559-566
    • (2001) Can. J. Physiol. Pharmacol. , vol.79 , pp. 559-566
    • Graham, T.E.1    Sathasivam, P.2    Rowland, M.3    Marko, N.4    Greer, F.5    Battram, D.6
  • 63
    • 0346728540 scopus 로고    scopus 로고
    • Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1
    • Green, B. D., Gault, V. A., Mooney, M. H., Irwin, N., Bailey, C. J., Harriott, P., Greer, B., Flatt, P. R., O'Harte, F. P. M. (2003a) Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1 . Biol. Chem. 384: 1543-1551
    • (2003) Biol. Chem. , vol.384 , pp. 1543-1551
    • Green, B.D.1    Gault, V.A.2    Mooney, M.H.3    Irwin, N.4    Bailey, C.J.5    Harriott, P.6    Greer, B.7    Flatt, P.R.8    O'Harte, F.P.M.9
  • 64
    • 0346098008 scopus 로고    scopus 로고
    • Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo
    • Green, B. D., Gault, V. A., Mooney, M. H., Irwin, N., Bailey, C. J., Harriott, P., Greer, B., Flatt, P. R., O'Harte, F. P. M. (2003b) Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo. J. Mol. Endocrinol. 31: 529-540
    • (2003) J. Mol. Endocrinol. , vol.31 , pp. 529-540
    • Green, B.D.1    Gault, V.A.2    Mooney, M.H.3    Irwin, N.4    Bailey, C.J.5    Harriott, P.6    Greer, B.7    Flatt, P.R.8    O'Harte, F.P.M.9
  • 67
    • 0842284596 scopus 로고    scopus 로고
    • 9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39)
    • 9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39). Metabolism 53: 252-259
    • (2004) Metabolism , vol.53 , pp. 252-259
    • Green, B.D.1    Mooney, M.H.2    Gault, V.A.3    Irwin, N.4    Bailey, C.J.5    Harriott, P.6    Greer, B.7    Flatt, P.R.8    O'Harte, F.P.M.9
  • 68
    • 0036547562 scopus 로고    scopus 로고
    • Pharmacological modulation of K(ATP) channels
    • Gribble, F. M., Reimann, F. (2002) Pharmacological modulation of K(ATP) channels. Biochem. Soc. Trans. 30: 333-339
    • (2002) Biochem. Soc. Trans. , vol.30 , pp. 333-339
    • Gribble, F.M.1    Reimann, F.2
  • 69
    • 0015800525 scopus 로고
    • Activation by glucose of adenyl cyclase in pancreatic islets of the rat
    • Grill, V., Cerasi, E. (1973) Activation by glucose of adenyl cyclase in pancreatic islets of the rat. FEBS Lett. 33: 311-314
    • (1973) FEBS Lett. , vol.33 , pp. 311-314
    • Grill, V.1    Cerasi, E.2
  • 70
    • 0034105467 scopus 로고    scopus 로고
    • Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat islets
    • Guenifi, A., Portela-Gomes, G. M., Grimelius, L., Efendic, S., Abdel-Halim, S. M. (2000) Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat islets. Histochem. Cell Biol. 113: 81-89
    • (2000) Histochem. Cell Biol. , vol.113 , pp. 81-89
    • Guenifi, A.1    Portela-Gomes, G.M.2    Grimelius, L.3    Efendic, S.4    Abdel-Halim, S.M.5
  • 71
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus
    • Gutniak, M., Orskov, C., Holst, J. J., Ahren, B., Efendic, S. (1992) Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus. N. Engl. J. Med. 326: 1316-1322
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Orskov, C.2    Holst, J.J.3    Ahren, B.4    Efendic, S.5
  • 72
    • 0033529693 scopus 로고    scopus 로고
    • The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion
    • Han, P., Werber, J., Surana, M., Fleischer, N., Michaeli, T. (1999) The calcium/calmodulin-dependent phosphodiesterase PDE1C down-regulates glucose-induced insulin secretion. J. Biol. Chem. 274: 22337-22344
    • (1999) J. Biol. Chem. , vol.274 , pp. 22337-22344
    • Han, P.1    Werber, J.2    Surana, M.3    Fleischer, N.4    Michaeli, T.5
  • 74
    • 0037020258 scopus 로고    scopus 로고
    • Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin
    • Harndähl, L., Jing, X. J., Ivarsson, R., Degerman, E., Ahren, B., Manganiello, V. C., Renstrom, E., Holst, L. S. (2002) Important role of phosphodiesterase 3B for the stimulatory action of cAMP on pancreatic beta-cell exocytosis and release of insulin. J. Biol. Chem. 277: 37446-37455
    • (2002) J. Biol. Chem. , vol.277 , pp. 37446-37455
    • Harndähl, L.1    Jing, X.J.2    Ivarsson, R.3    Degerman, E.4    Ahren, B.5    Manganiello, V.C.6    Renstrom, E.7    Holst, L.S.8
  • 75
    • 2442423329 scopus 로고    scopus 로고
    • Beta-cell-targeted over-expression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology
    • Harndähl, L., Wierup, N., Enerback, S., Mulder, H., Manganiello, V. C., Sundler, F., Degerman, E., Ahren, B., Holst, L. S. (2004) Beta-cell-targeted over-expression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology. J. Biol. Chem. 279: 15214-15222
    • (2004) J. Biol. Chem. , vol.279 , pp. 15214-15222
    • Harndähl, L.1    Wierup, N.2    Enerback, S.3    Mulder, H.4    Manganiello, V.C.5    Sundler, F.6    Degerman, E.7    Ahren, B.8    Holst, L.S.9
  • 76
    • 0022454622 scopus 로고
    • Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: A receptor for new cardiotonic drugs
    • Harrison, S. A., Reifsnyder, D. H., Gallis, B., Cadd, G. G., Beavo, J. A. (1986) Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. Mol. Pharmacol. 29: 506-514
    • (1986) Mol. Pharmacol. , vol.29 , pp. 506-514
    • Harrison, S.A.1    Reifsnyder, D.H.2    Gallis, B.3    Cadd, G.G.4    Beavo, J.A.5
  • 78
    • 0035810678 scopus 로고    scopus 로고
    • Identification of a bioactive domain in the amino-termmus of glucose-dependent insulinotropic polypeptide (GIP)
    • Hinke, S. A., Manhart, S., Pamir, N., Demuth, H., Gelling, R. W., Pederson, R. A., McIntosh, C. H. (2001) Identification of a bioactive domain in the amino-termmus of glucose-dependent insulinotropic polypeptide (GIP). Biochim. Biophys. Ada. 1547: 143-155
    • (2001) Biochim. Biophys. Ada , vol.1547 , pp. 143-155
    • Hinke, S.A.1    Manhart, S.2    Pamir, N.3    Demuth, H.4    Gelling, R.W.5    Pederson, R.A.6    McIntosh, C.H.7
  • 80
    • 1042301414 scopus 로고    scopus 로고
    • [Ser2]- and [SerP2] incretin analogs: Comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo
    • Hinke, S. A., Manhart, S., Kühn-Wache, K., Nian, C., Demuth, H. U., Pederson, R. A., McIntosh, C. H. (2004) [Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo. J. Biol. Chem. 279: 3998-4006
    • (2004) J. Biol. Chem. , vol.279 , pp. 3998-4006
    • Hinke, S.A.1    Manhart, S.2    Kühn-Wache, K.3    Nian, C.4    Demuth, H.U.5    Pederson, R.A.6    McIntosh, C.H.7
  • 81
    • 0032701468 scopus 로고    scopus 로고
    • Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential
    • Holst, J. J. (1999) Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential. Curr. Med. Chem. 6: 1005-1017
    • (1999) Curr. Med. Chem. , vol.6 , pp. 1005-1017
    • Holst, J.J.1
  • 82
    • 0038363769 scopus 로고    scopus 로고
    • Implementation of GLP-1 based therapy of type 2 diabetes mellitus using DPP-IV inhibitors
    • Holst, J. J. (2003) Implementation of GLP-1 based therapy of type 2 diabetes mellitus using DPP-IV inhibitors. Adv. Exp. Med. Biol. 524: 263-279
    • (2003) Adv. Exp. Med. Biol. , vol.524 , pp. 263-279
    • Holst, J.J.1
  • 83
    • 2642519637 scopus 로고    scopus 로고
    • Treatment of Type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors
    • Holst, J. J. (2004) Treatment of Type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors. Expert Opin. Emerg. Drugs 9: 155-166
    • (2004) Expert Opin. Emerg. Drugs , vol.9 , pp. 155-166
    • Holst, J.J.1
  • 84
    • 0023104829 scopus 로고
    • Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
    • Holst, J. J., Orskov, C., Nielsen, O. V., Schwartz, T. W. (1987) Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. FEBS Lett. 211: 169-174
    • (1987) FEBS Lett. , vol.211 , pp. 169-174
    • Holst, J.J.1    Orskov, C.2    Nielsen, O.V.3    Schwartz, T.W.4
  • 85
    • 0347990624 scopus 로고    scopus 로고
    • Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell
    • Holz, G. G. (2004) Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 53: 5-13
    • (2004) Diabetes , vol.53 , pp. 5-13
    • Holz, G.G.1
  • 86
    • 0026645809 scopus 로고
    • Signal transduction crosstalk in the endocrine system: Pancreatic beta-cells and the glucose competence concept
    • Holz, G. G., Habener, J. F. (1992) Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem. Sci. 17: 388-393
    • (1992) Trends Biochem. Sci. , vol.17 , pp. 388-393
    • Holz, G.G.1    Habener, J.F.2
  • 87
    • 0141953908 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 synthetic analogs: New therapeutic agents for use in the treatment of diabetes mellitus
    • Holz, G. G., Chepurny, O. G. (2003) Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus. Curr. Med. Chem. 10: 2471-2483
    • (2003) Curr. Med. Chem. , vol.10 , pp. 2471-2483
    • Holz, G.G.1    Chepurny, O.G.2
  • 89
    • 0032044238 scopus 로고    scopus 로고
    • Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases
    • Houslay, M. D. (1998) Adaptation in cyclic AMP signalling processes: a central role for cyclic AMP phosphodiesterases. Semin. Cell Dev. Biol. 9: 161-167
    • (1998) Semin. Cell Dev. Biol. , vol.9 , pp. 161-167
    • Houslay, M.D.1
  • 90
    • 0027933317 scopus 로고
    • Regulation of insulin secretion: The role of second messengers
    • Howell, S. L., Jones, P. M., Persaud, S. J. (1994) Regulation of insulin secretion: the role of second messengers. Diabetologia 37(Suppl. 2): S30-S35
    • (1994) Diabetologia , vol.37 , Issue.SUPPL. 2
    • Howell, S.L.1    Jones, P.M.2    Persaud, S.J.3
  • 91
    • 0035084164 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells
    • Hui, H., Wright, C., Perfetti, R. (2001) Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells. Diabetes 50: 785-796
    • (2001) Diabetes , vol.50 , pp. 785-796
    • Hui, H.1    Wright, C.2    Perfetti, R.3
  • 92
    • 0033847126 scopus 로고    scopus 로고
    • Glucagon receptors on human islet cells contribute to glucose competence of insulin release
    • Huypens, P., Ling, Z., Pipeleers, D., Schuit, F. (2000) Glucagon receptors on human islet cells contribute to glucose competence of insulin release. Diabetologia. 43: 1012-1019
    • (2000) Diabetologia , vol.43 , pp. 1012-1019
    • Huypens, P.1    Ling, Z.2    Pipeleers, D.3    Schuit, F.4
  • 95
    • 0030764551 scopus 로고    scopus 로고
    • PAI-1, obesity, insulin resistance and risk of cardiovascular events
    • Juhan-Vague, I., Alessi, M. C. (1997) PAI-1, obesity, insulin resistance and risk of cardiovascular events. Thromb. Haemost. 78: 656-660
    • (1997) Thromb. Haemost. , vol.78 , pp. 656-660
    • Juhan-Vague, I.1    Alessi, M.C.2
  • 96
    • 0037283601 scopus 로고    scopus 로고
    • The relative contribution of insulin resistance and beta cell dysfunction to the pathophysiology of Type 2 diabetes
    • Kahn, S. E. (2003) The relative contribution of insulin resistance and beta cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia 46: 3-19
    • (2003) Diabetologia , vol.46 , pp. 3-19
    • Kahn, S.E.1
  • 97
    • 85069301304 scopus 로고    scopus 로고
    • Expression of protein kinase G and cGMP-phosphodiesterase isoforms in pancreatic β-cells and investigation of the roles of these enzymes in control of cell viability
    • Kaminski, A., Morgan, N. G. (2004) Expression of protein kinase G and cGMP-phosphodiesterase isoforms in pancreatic β-cells and investigation of the roles of these enzymes in control of cell viability. Diabetologia 47(Suppl. 1): A180
    • (2004) Diabetologia , vol.47 , Issue.SUPPL. 1
    • Kaminski, A.1    Morgan, N.G.2
  • 101
    • 0035824548 scopus 로고    scopus 로고
    • Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion
    • Kashima, Y., Miki, T., Shibasaki, T., Ozaki, N., Miyazaki, M., Yano, H., Seino, S. (2001) Critical role of cAMP-GEFII-Rim2 complex in incretin-potentiated insulin secretion. J. Biol. Chem. 276: 46046-46053
    • (2001) J. Biol. Chem. , vol.276 , pp. 46046-46053
    • Kashima, Y.1    Miki, T.2    Shibasaki, T.3    Ozaki, N.4    Miyazaki, M.5    Yano, H.6    Seino, S.7
  • 102
    • 0037339649 scopus 로고    scopus 로고
    • Development and characterization of a glucagon-like peptide 1-albumin conjugate: The ability to activate the glucagon-like peptide 1 receptor in vivo
    • Kim, J. G., Baggio, L. L., Bridon, D. P., Castaigne, J. P., Robitaille, M. F., Jette, L., Benquet, C., Drucker, D. J. (2003) Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo. Diabetes 52: 751-759
    • (2003) Diabetes , vol.52 , pp. 751-759
    • Kim, J.G.1    Baggio, L.L.2    Bridon, D.P.3    Castaigne, J.P.4    Robitaille, M.F.5    Jette, L.6    Benquet, C.7    Drucker, D.J.8
  • 103
    • 0028855353 scopus 로고
    • Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36) amide on lipoprotein lipase activity in explants of rat adipose tissue
    • Knapper, J. M., Puddicombe, S. M., Morgan, L. M., Fletcher, J. M. (1995) Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36) amide on lipoprotein lipase activity in explants of rat adipose tissue. J. Nutr. 125:183-188
    • (1995) J. Nutr. , vol.125 , pp. 183-188
    • Knapper, J.M.1    Puddicombe, S.M.2    Morgan, L.M.3    Fletcher, J.M.4
  • 105
    • 0024836493 scopus 로고
    • Glucagonostatic and insulinotropic action of glucagon like peptide I-(7-36)-amide
    • Komatsu, R., Matsuyama, T, Namba, M., Watanabe, N., Itoh, H., Kono, N., Tarui, S. (1989) Glucagonostatic and insulinotropic action of glucagon like peptide I-(7-36)-amide. Diabetes 38: 902-905
    • (1989) Diabetes , vol.38 , pp. 902-905
    • Komatsu, R.1    Matsuyama, T.2    Namba, M.3    Watanabe, N.4    Itoh, H.5    Kono, N.6    Tarui, S.7
  • 106
    • 0038199731 scopus 로고    scopus 로고
    • cAMP effector mechanisms. Novel twists for an 'old' signaling system
    • Kopperud, R., Krakstad, C., Selheim, F., Doskeland, S. O. (2003) cAMP effector mechanisms. Novel twists for an 'old' signaling system. FEBS Lett. 546: 121-126
    • (2003) FEBS Lett. , vol.546 , pp. 121-126
    • Kopperud, R.1    Krakstad, C.2    Selheim, F.3    Doskeland, S.O.4
  • 107
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann, B., Williams, G., Ghatei, M. A., Bloom, S. R. (1987) Glucagon-like peptide-1 7-36: a physiological incretin in man. Lancet 2: 1300-1304
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 110
    • 0031434473 scopus 로고    scopus 로고
    • Anchoring of protein kinase A facilitates hormone-mediated insulin secretion
    • Lester, L. B., Langenberg, L. K., Scott, J. D. (1997) Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proc. Natl. Acad. Sci. USA 94: 14942-14947
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14942-14947
    • Lester, L.B.1    Langenberg, L.K.2    Scott, J.D.3
  • 111
    • 0031921308 scopus 로고    scopus 로고
    • The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice
    • Liang, L., Beshay, E., Prud'homme, G. J. (1998) The phosphodiesterase inhibitors pentoxifylline and rolipram prevent diabetes in NOD mice. Diabetes 47: 570-575
    • (1998) Diabetes , vol.47 , pp. 570-575
    • Liang, L.1    Beshay, E.2    Prud'homme, G.J.3
  • 112
    • 0020681907 scopus 로고
    • The role of calmodulin in insulin secretion: The presence of a calmodulin-stimulatable phosphodiesterase in pancreatic islets of normal and pregnant rats
    • Lipson, L. G., Oldham, S. B. (1983) The role of calmodulin in insulin secretion: the presence of a calmodulin-stimulatable phosphodiesterase in pancreatic islets of normal and pregnant rats. Life Sci. 32: 775-780
    • (1983) Life Sci. , vol.32 , pp. 775-780
    • Lipson, L.G.1    Oldham, S.B.2
  • 113
    • 0031737058 scopus 로고    scopus 로고
    • Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: Differential subcellular localization and regulated expression by cyclic AMP
    • Liu, H., Maurice, D. H. (1998) Expression of cyclic GMP-inhibited phosphodiesterases 3A and 3B (PDE3A and PDE3B) in rat tissues: differential subcellular localization and regulated expression by cyclic AMP. Br. J. Pharmacol. 125: 1501-1510
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 1501-1510
    • Liu, H.1    Maurice, D.H.2
  • 114
    • 0030601939 scopus 로고    scopus 로고
    • Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic beta-cells
    • Loweth, A. C., Williams, G. T., Scarpello, J. H., Morgan, N. G. (1996) Heterotrimeric G-proteins are implicated in the regulation of apoptosis in pancreatic beta-cells. Exp. Cell. Res. 229: 69-76
    • (1996) Exp. Cell. Res. , vol.229 , pp. 69-76
    • Loweth, A.C.1    Williams, G.T.2    Scarpello, J.H.3    Morgan, N.G.4
  • 115
    • 0020026919 scopus 로고
    • Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem
    • Lund, P. K., Goodman, R. H., Dee, P. C., Habener, J. F. (1982) Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem. Proc. Natl. Acad. Sci. USA 79: 345-349
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 345-349
    • Lund, P.K.1    Goodman, R.H.2    Dee, P.C.3    Habener, J.F.4
  • 116
    • 0035051335 scopus 로고    scopus 로고
    • Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men
    • MacIntosh, C. G., Horowitz, M., Verhagen, M. A., Smout, A. J., Wishart, J., Morris, H., Goble, E., Morley, J. E., Chapman, I. M. (2001) Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men. Am. J. Gastroenterol. 96: 997-1007
    • (2001) Am. J. Gastroenterol. , vol.96 , pp. 997-1007
    • MacIntosh, C.G.1    Horowitz, M.2    Verhagen, M.A.3    Smout, A.J.4    Wishart, J.5    Morris, H.6    Goble, E.7    Morley, J.E.8    Chapman, I.M.9
  • 117
    • 0242500960 scopus 로고    scopus 로고
    • Structure-function analysis of a series of novel GIP analogues containing different helical length linkers
    • Manhart, S., Hinke, S. A., McIntosh, C. H., Pederson, R. A., Demuth, H. U. (2003) Structure-function analysis of a series of novel GIP analogues containing different helical length linkers. Biochemistry 42: 3081-3088
    • (2003) Biochemistry , vol.42 , pp. 3081-3088
    • Manhart, S.1    Hinke, S.A.2    McIntosh, C.H.3    Pederson, R.A.4    Demuth, H.U.5
  • 118
    • 0036134416 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling
    • Mehats, C., Andersen, C. B., Filopanti, M. (2002) Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling. Trends Endocrinol. Metab. 13: 29-35
    • (2002) Trends Endocrinol. Metab. , vol.13 , pp. 29-35
    • Mehats, C.1    Andersen, C.B.2    Filopanti, M.3
  • 119
    • 0037667613 scopus 로고    scopus 로고
    • Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    • Meier, J. J., Gallwitz, B., Salmen, S., Goetze, O., Holst, J. J., Schmidt, W. E., Nauck, M. A. (2003) Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. J. Clin. Endocrinol. Metab. 88: 2719-2725
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 2719-2725
    • Meier, J.J.1    Gallwitz, B.2    Salmen, S.3    Goetze, O.4    Holst, J.J.5    Schmidt, W.E.6    Nauck, M.A.7
  • 120
    • 0141669196 scopus 로고    scopus 로고
    • Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes
    • Meneilly, G. S., Greig, N., Tildesley, H., Habener, J. F., Egan, J. M., Elahi, D. (2003) Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes. Diabetes Care 26: 2835-2841
    • (2003) Diabetes Care , vol.26 , pp. 2835-2841
    • Meneilly, G.S.1    Greig, N.2    Tildesley, H.3    Habener, J.F.4    Egan, J.M.5    Elahi, D.6
  • 121
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
    • Mentlein, R. (1999) Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul. Pept. 85: 9-24
    • (1999) Regul. Pept. , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 123
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mojsov, S., Weir, G. C., Habener, J. F. (1987) Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J. Clin. Invest. 79: 616-619
    • (1987) J. Clin. Invest. , vol.79 , pp. 616-619
    • Mojsov, S.1    Weir, G.C.2    Habener, J.F.3
  • 124
    • 0347360186 scopus 로고    scopus 로고
    • Pharmacology of exenatide (synthetic exendin-4): A potential therapeutic for improved glycemic control of type 2 diabetes
    • Nielsen, L. L., Young, A. A., Parkes, D. G. (2004) Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regul. Pept. 117: 77-88
    • (2004) Regul. Pept. , vol.117 , pp. 77-88
    • Nielsen, L.L.1    Young, A.A.2    Parkes, D.G.3
  • 125
    • 0025808278 scopus 로고
    • Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue
    • Oben, J., Morgan, L. M., Fletcher, J., Marks, V. (1991) Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue. J. Endocrinol. 130: 267-272
    • (1991) J. Endocrinol. , vol.130 , pp. 267-272
    • Oben, J.1    Morgan, L.M.2    Fletcher, J.3    Marks, V.4
  • 126
    • 0030691128 scopus 로고    scopus 로고
    • Effects of non-glycated and glycated glucagon-like peptide-1(7-36) amide on glucose metabolism in isolated mouse abdominal muscle
    • O'Harte, F. P. M., Gray, A. M., Abdel-Wahab, Y. H., Flatt, P. R. (1997) Effects of non-glycated and glycated glucagon-like peptide-1(7-36) amide on glucose metabolism in isolated mouse abdominal muscle. Peptides 18: 1327-1333
    • (1997) Peptides , vol.18 , pp. 1327-1333
    • O'Harte, F.P.M.1    Gray, A.M.2    Abdel-Wahab, Y.H.3    Flatt, P.R.4
  • 127
    • 0031757194 scopus 로고    scopus 로고
    • Amino terminal glycation of gastric inhibitory polypeptide enhances its insulinotropic action on clonal pancreatic B-cells
    • O'Harte, F. P. M., Abdel-Wahab, Y. H. A., Conlon, J. M., Flatt, P. R. (1998) Amino terminal glycation of gastric inhibitory polypeptide enhances its insulinotropic action on clonal pancreatic B-cells. Biochim. Biophys. Acta 1425: 319-327
    • (1998) Biochim. Biophys. Acta , vol.1425 , pp. 319-327
    • O'Harte, F.P.M.1    Abdel-Wahab, Y.H.A.2    Conlon, J.M.3    Flatt, P.R.4
  • 128
    • 0032587206 scopus 로고    scopus 로고
    • N-terminally modified gastric inhibitory polypeptide exhibits aminopeptidase resistance and enhanced antihyperglycaemic activity
    • O'Harte, F. P. M., Mooney, M. H., Flatt, P. R. (1999) N-terminally modified gastric inhibitory polypeptide exhibits aminopeptidase resistance and enhanced antihyperglycaemic activity. Diabetes 48: 758-765
    • (1999) Diabetes , vol.48 , pp. 758-765
    • O'Harte, F.P.M.1    Mooney, M.H.2    Flatt, P.R.3
  • 129
    • 0034131227 scopus 로고    scopus 로고
    • Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide
    • O'Harte, F. P. M., Mooney, M. H., Kelly, C. M. N., Flatt, P. R. (2000a) Improved glycaemic control in obese diabetic ob/ob mice using N-terminally modified gastric inhibitory polypeptide. J. Endocrinol. 165: 639-648
    • (2000) J. Endocrinol. , vol.165 , pp. 639-648
    • O'Harte, F.P.M.1    Mooney, M.H.2    Kelly, C.M.N.3    Flatt, P.R.4
  • 130
    • 0033974696 scopus 로고    scopus 로고
    • N-terminally modified glucagon-like peptide-1(7-36) amide exhibits resistance to enzymatic degradation while maintaining its antihyperglycaemic activity in vivo
    • O'Harte, F. P. M., Mooney, M. H., Lawlor, A., Flatt, P. R. (2000b) N-terminally modified glucagon-like peptide-1(7-36) amide exhibits resistance to enzymatic degradation while maintaining its antihyperglycaemic activity in vivo. Biochim. Biophys. Acta 1474: 13-22
    • (2000) Biochim. Biophys. Acta , vol.1474 , pp. 13-22
    • O'Harte, F.P.M.1    Mooney, M.H.2    Lawlor, A.3    Flatt, P.R.4
  • 131
    • 0035847301 scopus 로고    scopus 로고
    • Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice
    • O'Harte, F. P. M., Mooney, M. H., Kelly, C. M., McKillop, A. M., Flatt, P. R. (2001) Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice. Regul. Pept. 96: 95-104
    • (2001) Regul. Pept. , vol.96 , pp. 95-104
    • O'Harte, F.P.M.1    Mooney, M.H.2    Kelly, C.M.3    McKillop, A.M.4    Flatt, P.R.5
  • 132
    • 0036383414 scopus 로고    scopus 로고
    • Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of glucose-dependent insulinotropic polypeptide: N-acetyl-GIP and pGlu-GIP
    • O'Harte, F. P. M., Gault, V. A., Parker, J. C., Harriott, P., Mooney, M. H., Bailey, C. J., Flatt, P. R. (2002) Improved stability, insulin-releasing activity and antidiabetic potential of two novel N-terminal analogues of glucose-dependent insulinotropic polypeptide: N-acetyl-GIP and pGlu-GIP. Diabetologia 45: 1281-1291
    • (2002) Diabetologia , vol.45 , pp. 1281-1291
    • O'Harte, F.P.M.1    Gault, V.A.2    Parker, J.C.3    Harriott, P.4    Mooney, M.H.5    Bailey, C.J.6    Flatt, P.R.7
  • 134
    • 0029562996 scopus 로고
    • Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: Contributions of types III and IV to the modulation of insulin secretion
    • Parker, J. C., Van Volkenberg, M. A., Ketchum, R. J., Brayman, K. L., Andrews, K. M. (1995) Cyclic AMP phosphodiesterases of human and rat islets of Langerhans: contributions of types III and IV to the modulation of insulin secretion. Biochem. Biophys. Res. Commun. 217: 916-923
    • (1995) Biochem. Biophys. Res. Commun. , vol.217 , pp. 916-923
    • Parker, J.C.1    Van Volkenberg, M.A.2    Ketchum, R.J.3    Brayman, K.L.4    Andrews, K.M.5
  • 135
    • 0031591662 scopus 로고    scopus 로고
    • Modulation of insulin secretion and glycemia by selective inhibition of cyclic AMP phosphodiesterase III
    • Parker, J. C., VanVolkenburg, M. A., Nardone, N. A. (1997) Modulation of insulin secretion and glycemia by selective inhibition of cyclic AMP phosphodiesterase III. Biochem. Biophys. Res. Commun. 236: 665-669
    • (1997) Biochem. Biophys. Res. Commun. , vol.236 , pp. 665-669
    • Parker, J.C.1    VanVolkenburg, M.A.2    Nardone, N.A.3
  • 136
    • 0032969356 scopus 로고    scopus 로고
    • Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide
    • Pauly, R. P., Demuth, H. U., Rosche, F., Schmidt, J., White, H. A., Lynn, F., McIntosh, C. H., Pederson, R. A. (1999) Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide. Metabolism 48: 385-389
    • (1999) Metabolism , vol.48 , pp. 385-389
    • Pauly, R.P.1    Demuth, H.U.2    Rosche, F.3    Schmidt, J.4    White, H.A.5    Lynn, F.6    McIntosh, C.H.7    Pederson, R.A.8
  • 137
    • 0031870418 scopus 로고    scopus 로고
    • Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide
    • Pederson, R. A., White, H. A., Schlenzig, D., Pauly, R. P., McIntosh, C. H., Demuth, H. U. (1998a) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47: 1253-1258
    • (1998) Diabetes , vol.47 , pp. 1253-1258
    • Pederson, R.A.1    White, H.A.2    Schlenzig, D.3    Pauly, R.P.4    McIntosh, C.H.5    Demuth, H.U.6
  • 138
    • 0031747107 scopus 로고    scopus 로고
    • Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice
    • Pederson, R. A., Satkunarajah, M., McIntosh, C. H., Scrocchi, L. A., Flamez, D., Schuit, F., Drucker, D. J., Wheeler, M. B. (1998b) Enhanced glucose-dependent insulinotropic polypeptide secretion and insulinotropic action in glucagon-like peptide 1 receptor -/- mice. Diabetes 47: 1046-1052
    • (1998) Diabetes , vol.47 , pp. 1046-1052
    • Pederson, R.A.1    Satkunarajah, M.2    McIntosh, C.H.3    Scrocchi, L.A.4    Flamez, D.5    Schuit, F.6    Drucker, D.J.7    Wheeler, M.B.8
  • 139
    • 0034522773 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats
    • Perfetti, R., Zhou, J., Doyle, M. E., Egan, J. M. (2000) Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 141: 4600-4605
    • (2000) Endocrinology , vol.141 , pp. 4600-4605
    • Perfetti, R.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 140
    • 0032134209 scopus 로고    scopus 로고
    • Chemotherapeutic potential of phosphodiesterase inhibitors
    • Perry, M. J., Higgs, G. A. (1998) Chemotherapeutic potential of phosphodiesterase inhibitors. Curr. Opin. Chem. Biol. 2: 472-481
    • (1998) Curr. Opin. Chem. Biol. , vol.2 , pp. 472-481
    • Perry, M.J.1    Higgs, G.A.2
  • 141
    • 0025562585 scopus 로고
    • Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A
    • Persaud, S. J., Jones, P. M., Howell, S. L. (1990) Glucose-stimulated insulin secretion is not dependent on activation of protein kinase A. Biochem. Biophys. Res. Commun. 173: 833-839
    • (1990) Biochem. Biophys. Res. Commun. , vol.173 , pp. 833-839
    • Persaud, S.J.1    Jones, P.M.2    Howell, S.L.3
  • 142
    • 0142247456 scopus 로고    scopus 로고
    • Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice
    • Peterhoff, M., Sieg, A., Brede, M., Chao, C.M., Hein, L., Ullrich, S. (2003) Inhibition of insulin secretion via distinct signaling pathways in alpha2-adrenoceptor knockout mice. Eur J Endocrinol. 149: 343-350
    • (2003) Eur J Endocrinol. , vol.149 , pp. 343-350
    • Peterhoff, M.1    Sieg, A.2    Brede, M.3    Chao, C.M.4    Hein, L.5    Ullrich, S.6
  • 143
    • 0025268781 scopus 로고
    • Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene
    • Pittler, S. J., Baehr, W., Wasmuth, J. J., McConnell, D. G., Champagne, M. S., vanTuinen, P., Ledbetter, D., Davis, R. L. (1990) Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene. Genomics 6: 272-283
    • (1990) Genomics , vol.6 , pp. 272-283
    • Pittler, S.J.1    Baehr, W.2    Wasmuth, J.J.3    McConnell, D.G.4    Champagne, M.S.5
  • 144
    • 0035125001 scopus 로고    scopus 로고
    • Beta-cell dysfunction and failure in type 2 diabetes: Potential mechanisms
    • Porte, D., Kahn, S. E. (2001) Beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms. Diabetes 50(Suppl. 1): S160-S163
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Porte, D.1    Kahn, S.E.2
  • 145
    • 0036228243 scopus 로고    scopus 로고
    • Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats
    • Pospisilik, J. A., Stafford, S. G., Demuth, H. U., Brownsey, R., Parkhouse, W., Finegood, D. T., McIntosh, C. H., Pederson, R. A. (2002a) Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats. Diabetes 51: 943-950
    • (2002) Diabetes , vol.51 , pp. 943-950
    • Pospisilik, J.A.1    Stafford, S.G.2    Demuth, H.U.3    Brownsey, R.4    Parkhouse, W.5    Finegood, D.T.6    McIntosh, C.H.7    Pederson, R.A.8
  • 146
    • 0036724721 scopus 로고    scopus 로고
    • Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: A euglycemic-hyperinsulinemic clamp study
    • Pospisilik, J. A., Stafford, S. G., Demuth, H. U., McIntosh, C. H., Pederson, R. A. (2002b) Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study. Diabetes 51: 2677-2683
    • (2002) Diabetes , vol.51 , pp. 2677-2683
    • Pospisilik, J.A.1    Stafford, S.G.2    Demuth, H.U.3    McIntosh, C.H.4    Pederson, R.A.5
  • 147
    • 0037342614 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
    • Pospisilik, J. A., Martin, J., Doty, T., Ehses, J. A., Pamir, N., Lynn, F. C., Piteau, S., Demuth, H. U., McIntosh, C. H., Pederson, R. A. (2003) Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes 52: 741-750
    • (2003) Diabetes , vol.52 , pp. 741-750
    • Pospisilik, J.A.1    Martin, J.2    Doty, T.3    Ehses, J.A.4    Pamir, N.5    Lynn, F.C.6    Piteau, S.7    Demuth, H.U.8    McIntosh, C.H.9    Pederson, R.A.10
  • 149
    • 0034037083 scopus 로고    scopus 로고
    • Metabolic factors that affect beta-cell function and survival
    • Purrello, F., Rabuazzo, A. M. (2000) Metabolic factors that affect beta-cell function and survival. Diabetes Nutr. Metab. 13: 84-91
    • (2000) Diabetes Nutr. Metab. , vol.13 , pp. 84-91
    • Purrello, F.1    Rabuazzo, A.M.2
  • 150
    • 0023095416 scopus 로고
    • The insulin-and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity
    • Pyne, N. J., Cooper, M. E., Houslay, M. D. (1987) The insulin-and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity. Biochem. J. 242: 33-42
    • (1987) Biochem. J. , vol.242 , pp. 33-42
    • Pyne, N.J.1    Cooper, M.E.2    Houslay, M.D.3
  • 151
    • 0028949423 scopus 로고
    • Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases
    • Reinhardt, R. R., Chin, E., Zhou, J., Taira, M., Murata, T., Manganiello, V. C., Bondy, C. A. (1995) Distinctive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phosphodiesterases. J. Clin. Invest. 95: 1528-1538
    • (1995) J. Clin. Invest. , vol.95 , pp. 1528-1538
    • Reinhardt, R.R.1    Chin, E.2    Zhou, J.3    Taira, M.4    Murata, T.5    Manganiello, V.C.6    Bondy, C.A.7
  • 152
    • 0030792753 scopus 로고    scopus 로고
    • Protein kinase A-dependent and independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells
    • Renstrom, E., Eliasson, L., Rorsman, P. (1997) Protein kinase A-dependent and independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J. Physiol. 502: 105-118
    • (1997) J. Physiol. , vol.502 , pp. 105-118
    • Renstrom, E.1    Eliasson, L.2    Rorsman, P.3
  • 156
    • 0029781231 scopus 로고    scopus 로고
    • Factors determining the glucose sensitivity and glucose responsiveness of pancreatic beta cells
    • Schuit, F. C. (1996) Factors determining the glucose sensitivity and glucose responsiveness of pancreatic beta cells. Horm. Res. 46: 99-106
    • (1996) Horm. Res. , vol.46 , pp. 99-106
    • Schuit, F.C.1
  • 157
    • 0031922709 scopus 로고    scopus 로고
    • Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling
    • Scrocchi, L. A., Marshall, B. A., Cook, S. M., Brubaker, P. L., Drucker, D. J. (1998) Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling. Diabetes 47: 632-639
    • (1998) Diabetes , vol.47 , pp. 632-639
    • Scrocchi, L.A.1    Marshall, B.A.2    Cook, S.M.3    Brubaker, P.L.4    Drucker, D.J.5
  • 159
    • 0029122198 scopus 로고
    • Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity
    • Shafiee-Nick, R., Pyne, N. J., Furman, B. L. (1995) Effects of type-selective phosphodiesterase inhibitors on glucose-induced insulin secretion and islet phosphodiesterase activity. Br. J. Pharmacol. 115: 1486-1492
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1486-1492
    • Shafiee-Nick, R.1    Pyne, N.J.2    Furman, B.L.3
  • 160
    • 0018411266 scopus 로고
    • The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release
    • Sharp, G. W. (1979) The adenylate cyclase-cyclic AMP system in islets of Langerhans and its role in the control of insulin release. Diabetologia 16: 287-296
    • (1979) Diabetologia , vol.16 , pp. 287-296
    • Sharp, G.W.1
  • 162
    • 0033034275 scopus 로고    scopus 로고
    • Comparison of the effect of native glucagon-like peptide 1 and dipeptidyl peptidase IV-resistant analogues on insulin release from rat pancreatic islets
    • Siegel, E. G., Scharf, G., Gallwitz, B., Mentlein, R., Morys-Wortmann, C., Folsch, U. R., Schmidt, W. E. (1999b) Comparison of the effect of native glucagon-like peptide 1 and dipeptidyl peptidase IV-resistant analogues on insulin release from rat pancreatic islets. Eur. J. Clin. Invest. 29: 610-614
    • (1999) Eur. J. Clin. Invest. , vol.29 , pp. 610-614
    • Siegel, E.G.1    Scharf, G.2    Gallwitz, B.3    Mentlein, R.4    Morys-Wortmann, C.5    Folsch, U.R.6    Schmidt, W.E.7
  • 163
    • 0033947157 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element
    • Skoglund, G., Hussain, M. A., Holz, G. G. (2000) Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element. Diabetes 49: 1156-1164
    • (2000) Diabetes , vol.49 , pp. 1156-1164
    • Skoglund, G.1    Hussain, M.A.2    Holz, G.G.3
  • 164
    • 0034009080 scopus 로고    scopus 로고
    • Regulation of cAMP and cGMP signaling: New phosphodiesterases and new functions
    • Soderling, S. H., Beavo, J. A. (2000) Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr. Opin. Cell Biol. 12: 174-179
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 174-179
    • Soderling, S.H.1    Beavo, J.A.2
  • 165
    • 0036312876 scopus 로고    scopus 로고
    • Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats
    • Sudre, B., Broqua, P., White, R. B., Ashworth, D., Evans, D. M., Haigh, R., Junien, J. L., Aubert, M. L. (2002) Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats. Diabetes 51: 1461-1469
    • (2002) Diabetes , vol.51 , pp. 1461-1469
    • Sudre, B.1    Broqua, P.2    White, R.B.3    Ashworth, D.4    Evans, D.M.5    Haigh, R.6    Junien, J.L.7    Aubert, M.L.8
  • 167
    • 0031656888 scopus 로고    scopus 로고
    • Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells
    • Susini, S., Roche, E., Prentki, M., Schlegel, W. (1998) Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells. FASEB J. 12: 1173-1182
    • (1998) FASEB J. , vol.12 , pp. 1173-1182
    • Susini, S.1    Roche, E.2    Prentki, M.3    Schlegel, W.4
  • 168
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group (1993) The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329: 977-986
    • (1993) N. Engl. J. Med. , vol.329 , pp. 977-986
  • 169
    • 0026775150 scopus 로고
    • Expression cloning of the pancreatic beta-cell receptor for the gluco-incretin hormone glucagon-like peptide 1
    • Thorens, B. (1992) Expression cloning of the pancreatic beta-cell receptor for the gluco-incretin hormone glucagon-like peptide 1. Proc. Natl. Acad. Sci. USA 89: 8641-8645
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8641-8645
    • Thorens, B.1
  • 170
    • 0031914520 scopus 로고    scopus 로고
    • Phosphodiesterase isozymes. Molecular targets for novel antiasthma agents
    • Torphy, T. J. (1998) Phosphodiesterase isozymes. Molecular targets for novel antiasthma agents. Am. J. Respir. Crit. Care Med. 157:351-370
    • (1998) Am. J. Respir. Crit. Care Med. , vol.157 , pp. 351-370
    • Torphy, T.J.1
  • 171
    • 0034838323 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling
    • Trumper, A., Trumper, K., Trusheim, H., Arnold, R., Göke, B., Horsch, D. (2001) Glucose-dependent insulinotropic polypeptide is a growth factor for beta (INS-1) cells by pleiotropic signaling. Mol. Endocrinol. 15: 1559-1570
    • (2001) Mol. Endocrinol. , vol.15 , pp. 1559-1570
    • Trumper, A.1    Trumper, K.2    Trusheim, H.3    Arnold, R.4    Göke, B.5    Horsch, D.6
  • 172
    • 0028342792 scopus 로고
    • Regulation of glucose-dependent insulinotropic peptide gene expression by a glucose meal
    • Tseng, C. C., Jarboe, L. A., Wolfe, M. M. (1994) Regulation of glucose-dependent insulinotropic peptide gene expression by a glucose meal. Am. J. Physiol. 266: G887-G891
    • (1994) Am. J. Physiol. , vol.266
    • Tseng, C.C.1    Jarboe, L.A.2    Wolfe, M.M.3
  • 173
    • 0031729818 scopus 로고    scopus 로고
    • The U.K. Prospective Diabetes Study. A review
    • Turner, R. C. (1998) The U.K. Prospective Diabetes Study. A review. Diabetes Care 21 (Suppl 3): C35-C38
    • (1998) Diabetes Care , vol.21 , Issue.SUPPL. 3
    • Turner, R.C.1
  • 174
    • 0027136670 scopus 로고
    • Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain
    • Usdin, T. B., Mezey, E., Button, D. C., Brownstein, M. J., Bonner, T. I. (1993) Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 133: 2861-2870
    • (1993) Endocrinology , vol.133 , pp. 2861-2870
    • Usdin, T.B.1    Mezey, E.2    Button, D.C.3    Brownstein, M.J.4    Bonner, T.I.5
  • 177
    • 1842855423 scopus 로고    scopus 로고
    • Incretins, insulin secretion and Type 2 diabetes mellitus
    • Vilsboll, T., Holst, J. J. (2004) Incretins, insulin secretion and Type 2 diabetes mellitus. Diabetologia 47: 357-366
    • (2004) Diabetologia , vol.47 , pp. 357-366
    • Vilsboll, T.1    Holst, J.J.2
  • 178
    • 0035046251 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism
    • Wang, X., Zhou, J., Doyle, M. E., Egan, J. M. (2001) Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism. Endocrinology 142: 1820-1827
    • (2001) Endocrinology , vol.142 , pp. 1820-1827
    • Wang, X.1    Zhou, J.2    Doyle, M.E.3    Egan, J.M.4
  • 179
    • 0030052774 scopus 로고    scopus 로고
    • GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells
    • Wang, Y., Montrose-Rafizadeh, C., Adams, L., Raygada, M., Nadiv, O., Egan, J. M. (1996) GIP regulates glucose transporters, hexokinases, and glucose-induced insulin secretion in RIN 1046-38 cells. Mol. Cell Endocrinol. 116: 81-87
    • (1996) Mol. Cell Endocrinol. , vol.116 , pp. 81-87
    • Wang, Y.1    Montrose-Rafizadeh, C.2    Adams, L.3    Raygada, M.4    Nadiv, O.5    Egan, J.M.6
  • 180
    • 0024515406 scopus 로고
    • Glucagon like peptide I (7-37) actions on endocrine pancreas
    • Weir, G. C., Mojsov, S., Hendrick, G. K., Habener, J. F. (1989) Glucagon like peptide I (7-37) actions on endocrine pancreas. Diabetes 38: 338-342
    • (1989) Diabetes , vol.38 , pp. 338-342
    • Weir, G.C.1    Mojsov, S.2    Hendrick, G.K.3    Habener, J.F.4
  • 182
    • 0028786933 scopus 로고
    • Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons
    • Yan, C., Zhao, A. Z., Bentley, J. K., Loughney, K., Ferguson, K., Beavo, J. A. (1995) Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc. Nat. Acad. Sci. USA 92: 9677-9681
    • (1995) Proc. Nat. Acad. Sci. USA , vol.92 , pp. 9677-9681
    • Yan, C.1    Zhao, A.Z.2    Bentley, J.K.3    Loughney, K.4    Ferguson, K.5    Beavo, J.A.6
  • 184
    • 0031730586 scopus 로고    scopus 로고
    • Functional GIP receptors are present on adipocytes
    • Yip, R. G., Boylan, M. O., Kieffer, T. J., Wolfe, M. M. (1998) Functional GIP receptors are present on adipocytes. Endocrinology 139: 4004-4007
    • (1998) Endocrinology , vol.139 , pp. 4004-4007
    • Yip, R.G.1    Boylan, M.O.2    Kieffer, T.J.3    Wolfe, M.M.4
  • 185
    • 0031006544 scopus 로고    scopus 로고
    • Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B
    • Zhao, A. Z., Zhao, H., Teague, J., Fujimoto, W., Beavo, J. A. (1997) Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B. Proc. Natl. Acad. Sci. USA 94: 3223-3228
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3223-3228
    • Zhao, A.Z.1    Zhao, H.2    Teague, J.3    Fujimoto, W.4    Beavo, J.A.5
  • 186
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou, J., Wang, X., Pineyro, M. Á., Egan, J. M. (1999) Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 48: 2358-2366
    • (1999) Diabetes , vol.48 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.Á.3    Egan, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.