Pachymic acid impairs breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression

Breast Cancer Research and Treatment

Volumn 126, Issue 3, 2011, Pages 609-620

  Ling, Hui ^a   Zhang, Yaochun ^a   Ng, Ka Yun ^a   Chew, Eng Hui ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Breast cancer; Invasion; MMP 9; NF B; Pachymic acid

Indexed keywords

GELATINASE B; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PACHYMIC ACID; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR AP 1; TRITERPENOID; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMA CELL; CELL INVASION; CELL STRAIN MCF 7; CELL STRAIN MDA MB 231; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; ENZYME RELEASE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL SURVIVAL; DENSITOMETRY; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION; TRITERPENES;

EID: 79958723466     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0929-5     Document Type: Article

References (39)

1. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57-70 (Pubitemid 30046295)
2. Bogenrieder T, Herlyn M (2003) Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 22:6524-6536 (Pubitemid 37372332)
3. Overall CM, Lopez-Otin C (2002) Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2:657-672 (Pubitemid 37328917)
4. Brinckerhoff CE, Matrisian LM (2002) Matrix metalloproteinases: a tail of a frog that became a prince. Nat Rev Mol Cell Biol 3:207-214
5. Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T (2003) Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem 253:269-285
6. Bernardo MM, Fridman R (2003) TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP. Biochem J 374:739-745 (Pubitemid 37163919)
7. Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161-174 (Pubitemid 37328786)
8. Sato H, Seiki M (1993) Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 8:395-405 (Pubitemid 23073756)
9. Akihisa T, Nakamura Y, Tokuda H, Uchiyama E, Suzuki T, Kimura Y, Uchikura K, Nishino H (2007) Triterpene acids from Poria cocos and their anti-tumor-promoting effects. J Nat Prod 70:948-953 (Pubitemid 47056108)
10. Tai T, Akita Y, Kinoshita K, Koyama K, Takahashi K, Watanabe K (1995) Anti-emetic principles of Poria cocos. Planta Med 61:527-530
11. Giner EM, Manez S, Recio MC, Giner RM, Cerda-Nicolas M, Rios JL (2000) In vivo studies on the anti-inflammatory activity of pachymic and dehydrotumulosic acids. Planta Med 66:221-227 (Pubitemid 30235581)
12. Kaminaga T, Yasukawa K, Kanno H, Tai T, Nunoura Y, Takido M (1996) Inhibitory effects of lanostane-type triterpene acids, the components of Poria cocos, on tumor promotion by 12-O-tetra-decanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 53:382-385 (Pubitemid 26283780)
13. Gapter L, Wang Z, Glinski J, Ng KY (2005) Induction of apoptosis in prostate cancer cells by pachymic acid from Poria cocos. Biochem Biophys Res Commun 332:1153-1161 (Pubitemid 40798205)
14. Li G, Xu ML, Lee CS, Woo MH, Chang HW, Son JK (2004) Cytotoxicity and DNA topoisomerases inhibitory activity of constituents from the sclerotium of Poria cocos. Arch Pharm Res 27:829-833 (Pubitemid 43073702)
15. Cuella MJ, Giner RM, Recio MC, Just MJ, Manez S, Rios JL (1996) Two fungal lanostane derivatives as phospholipase A2 inhibitors. J Nat Prod 59:977-979 (Pubitemid 26365494)
16. Cuellar MJ, Giner RM, Recio MC, Just MJ, Manez S, Rios JL (1997) Effect of the basidiomycete Poria cocos on experimental dermatitis and other inflammatory conditions. Chem Pharm Bull (Tokyo) 45:492-494 (Pubitemid 27150211)
17. Zhou L, Zhang Y, Gapter LA, Ling H, Agarwal R, Ng KY (2008) Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. Chem Pharm Bull (Tokyo) 56:1459-1462
18. Liotta LA, Stetler-Stevenson WG (1990) Metalloproteinases and cancer invasion. Semin Cancer Biol 1:99-106
19. Liang JA, Wu SL, Lo HY, Hsiang CY, Ho TY (2009) Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatocellular carcinoma cells. Mol Pharmacol 75:151-157
20. Shaulian E, Karin M (2002) AP-1 as a regulator of cell life and death. Nat Cell Biol 4:E131-E136 (Pubitemid 34521026)
21. Ghosh S, Hayden MS (2008) New regulators of NF-kappaB in inflammation. Nat Rev Immunol 8:837-848
22. Ghosh S, Baltimore D (1990) Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature 344:678-682
23. Duffy MJ, Maguire TM, Hill A, McDermott E, O'Higgins N (2000) Metalloproteinases: role in breast carcinogenesis, invasion and metastasis. Breast Cancer Res 2:252-257 (Pubitemid 32223594)
24. Zucker S, Hymowitz M, Conner C, Zarrabi HM, Hurewitz AN, Matrisian L, Boyd D, Nicolson G, Montana S (1999) Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applications. Ann N Y Acad Sci 878:212-227 (Pubitemid 29353573)
25. Park JM, Kim A, Oh JH, Chung AS (2007) Methylseleninic acid inhibits PMA-stimulated pro-MMP-2 activation mediated by MT1-MMP expression and further tumor invasion through suppression of NF-kappaB activation. Carcinogenesis 28:837-847 (Pubitemid 46530375)
26. Lin CW, Hou WC, Shen SC, Juan SH, Ko CH, Wang LM, Chen YC (2008) Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1- dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 29:1807-1815
27. Zhang S, Li Z, Wu X, Huang Q, Shen HM, Ong CN (2006) Methyl-3- indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway. Mol Cancer Ther 5:3285-3293 (Pubitemid 46092072)
28. Huang Q, Shen HM, Ong CN (2004) Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB. Biochem Pharmacol 68:361-371 (Pubitemid 38757705)
29. Woo JH, Lim JH, Kim YH, Suh SI, Min DS, Chang JS, Lee YH, Park JW, Kwon TK (2004) Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction. Oncogene 23:1845-1853 (Pubitemid 38445410)
30. Takada Y, Ichikawa H, Badmaev V, Aggarwal BB (2006) Acetyl-11-keto-beta- boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression. J Immunol 176:3127-3140
31. Park SK, Hwang YS, Park KK, Park HJ, Seo JY, Chung WY (2009) Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. Carcinogenesis 30:1225-1233
32. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS (2001) Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 480-481:243-268 (Pubitemid 32744832)
33. Chun KS, Keum YS, Han SS, Song YS, Kim SH, Surh YJ (2003) Curcumin inhibits phorbol ester-induced expression of cycloox-ygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation. Carcinogenesis 24:1515-1524 (Pubitemid 37160842)
34. Nomura M, Ma W, Chen N, Bode AM, Dong Z (2000) Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins. Carcinogenesis 21:1885-1890
35. Shin Y, Yoon SH, Choe EY, Cho SH, Woo CH, Rho JY, Kim JH (2007) PMA-induced up-regulation of MMP-9 is regulated by a PKCalpha-NF-kappaB cascade in human lung epithelial cells. Exp Mol Med 39:97-105 (Pubitemid 46356010)
36. Hussaini IM, Trotter C, Zhao Y, Abdel-Fattah R, Amos S, Xiao A, Agi CU, Redpath GT, Fang Z, Leung GK, Lopes MB, Laws ER Jr (2007) Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line. Am J Pathol 170:356-365 (Pubitemid 47339213)
37. Lallena MJ, Diaz-Meco MT, Bren G, Paya CV, Moscat J (1999) Activation of IkappaB kinase beta by protein kinase C isoforms. Mol Cell Biol 19:2180-2188 (Pubitemid 29098275)
38. Hughes K, Edin S, Antonsson A, Grundstrom T (2001) Calmodulin-dependent kinase II mediates T cell receptor/CD3- and phorbol ester-induced activation of IkappaB kinase. J Biol Chem 276:36008-36013
39. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85