-
1
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
Wood L.D., et al. The genomic landscapes of human breast and colorectal cancers. Science 318 5853 (2007) 1108-1113
-
(2007)
Science
, vol.318
, Issue.5853
, pp. 1108-1113
-
-
Wood, L.D.1
-
2
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B., and Kinzler K.W. Cancer genes and the pathways they control. Nat. Med. 10 8 (2004) 789-799
-
(2004)
Nat. Med.
, vol.10
, Issue.8
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
3
-
-
32044451325
-
Cancer: a systems biology disease
-
Hornberg J.J., et al. Cancer: a systems biology disease. Biosystems 83 2-3 (2006) 81-90
-
(2006)
Biosystems
, vol.83
, Issue.2-3
, pp. 81-90
-
-
Hornberg, J.J.1
-
4
-
-
33745588546
-
The limits of reductionism in medicine: could systems biology offer an alternative?
-
Ahn A.C., et al. The limits of reductionism in medicine: could systems biology offer an alternative?. PLoS Medicine 3 6 (2006) e208
-
(2006)
PLoS Medicine
, vol.3
, Issue.6
-
-
Ahn, A.C.1
-
5
-
-
33746462775
-
The clinical applications of a systems approach
-
Ahn A.C., et al. The clinical applications of a systems approach. PLoS Medicine 3 7 (2006) e209
-
(2006)
PLoS Medicine
, vol.3
, Issue.7
-
-
Ahn, A.C.1
-
6
-
-
0036094108
-
Essential role of AKT-1/protein kinase B{alpha} in PTEN-controlled tumorigenesis
-
Stiles B., et al. Essential role of AKT-1/protein kinase B{alpha} in PTEN-controlled tumorigenesis. Mol. Cell. Biol. 22 11 (2002) 3842-3851
-
(2002)
Mol. Cell. Biol.
, vol.22
, Issue.11
, pp. 3842-3851
-
-
Stiles, B.1
-
7
-
-
0029990003
-
Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
-
Rodriguez-Viciana P., et al. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation. EMBO J. 15 10 (1996) 2442-2451
-
(1996)
EMBO J.
, vol.15
, Issue.10
, pp. 2442-2451
-
-
Rodriguez-Viciana, P.1
-
8
-
-
28844433950
-
Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients
-
Tokunaga E., et al. Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients. International Journal of Cancer 118 2 (2006) 284-289
-
(2006)
International Journal of Cancer
, vol.118
, Issue.2
, pp. 284-289
-
-
Tokunaga, E.1
-
9
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta S.R., et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 2 (1997) 231-241
-
(1997)
Cell
, vol.91
, Issue.2
, pp. 231-241
-
-
Datta, S.R.1
-
10
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone M.H., et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 282 5392 (1998) 1318-1321
-
(1998)
Science
, vol.282
, Issue.5392
, pp. 1318-1321
-
-
Cardone, M.H.1
-
11
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor
-
Brunet A., et al. Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96 6 (1999) 857-868
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
-
12
-
-
0035949588
-
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
-
Mayo L.D., and Donner D.B. A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus. Proceedings of the National Academy of Sciences 98 20 (2001) 11598-11603
-
(2001)
Proceedings of the National Academy of Sciences
, vol.98
, Issue.20
, pp. 11598-11603
-
-
Mayo, L.D.1
Donner, D.B.2
-
13
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K., et al. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4 9 (2002) 648-657
-
(2002)
Nat. Cell Biol.
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
-
14
-
-
2542561169
-
Akt stimulates aerobic glycolysis in cancer cells
-
Elstrom R.L., et al. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res. 64 11 (2004) 3892-3899
-
(2004)
Cancer Res.
, vol.64
, Issue.11
, pp. 3892-3899
-
-
Elstrom, R.L.1
-
15
-
-
0033519453
-
Induction of NF-[kappa]B by the Akt/PKB kinase
-
Kane L.P., et al. Induction of NF-[kappa]B by the Akt/PKB kinase. Curr. Biol. 9 11 (1999) 601-605
-
(1999)
Curr. Biol.
, vol.9
, Issue.11
, pp. 601-605
-
-
Kane, L.P.1
-
16
-
-
41049113475
-
NF-kappa B genes have a major role in inflammatory breast cancer
-
Lerebours F., et al. NF-kappa B genes have a major role in inflammatory breast cancer. BMC Cancer 8 (2008)
-
(2008)
BMC Cancer
, vol.8
-
-
Lerebours, F.1
-
17
-
-
39849092253
-
COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells
-
Futagami S., et al. COX-2 and CCR2 induced by CD40 ligand and MCP-1 are linked to VEGF production in endothelial cells. Prostaglandins, Leukotrienes and Essential Fatty Acids 78 2 (2008) 137-146
-
(2008)
Prostaglandins, Leukotrienes and Essential Fatty Acids
, vol.78
, Issue.2
, pp. 137-146
-
-
Futagami, S.1
-
18
-
-
0038492517
-
A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells
-
Li Z., et al. A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. PNAS 100 (2003) 8164-8169
-
(2003)
PNAS
, vol.100
, pp. 8164-8169
-
-
Li, Z.1
-
19
-
-
0041344538
-
A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling
-
Hatakeyama M., et al. A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling. Biochem. J. 373 2 (2003) 451-463
-
(2003)
Biochem. J.
, vol.373
, Issue.2
, pp. 451-463
-
-
Hatakeyama, M.1
-
20
-
-
36249019789
-
Dialogue on reverse-engineering assessment and methods: the DREAM of high-throughput pathway inference
-
Stolovitzky G., Monroe D., and Califano A. Dialogue on reverse-engineering assessment and methods: the DREAM of high-throughput pathway inference. Ann. N. Y. Acad. Sci. 1115 (2007) 1-22
-
(2007)
Ann. N. Y. Acad. Sci.
, vol.1115
, pp. 1-22
-
-
Stolovitzky, G.1
Monroe, D.2
Califano, A.3
-
21
-
-
22844441552
-
Reverse engineering gene regulatory networks
-
Hartemink A.J. Reverse engineering gene regulatory networks. Nat. Biotechnol. 23 5 (2005) 554-555
-
(2005)
Nat. Biotechnol.
, vol.23
, Issue.5
, pp. 554-555
-
-
Hartemink, A.J.1
-
22
-
-
3042799574
-
A computational algebra approach to the reverse engineering of gene regulatory networks
-
Laubenbacher R., and Stigler B. A computational algebra approach to the reverse engineering of gene regulatory networks. J. Theor. Biol. (2004)
-
(2004)
J. Theor. Biol.
-
-
Laubenbacher, R.1
Stigler, B.2
-
23
-
-
0038048325
-
Inferring genetic networks and identifying compound mode of action via expression profiling
-
Gardner T.S., et al. Inferring genetic networks and identifying compound mode of action via expression profiling. Science 301 5629 (2003) 102-105
-
(2003)
Science
, vol.301
, Issue.5629
, pp. 102-105
-
-
Gardner, T.S.1
-
24
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
25
-
-
33646249607
-
A multiscale mathematical model of cancer, and its use in analyzing irratiation therapies
-
Ribba B., Colin T., and Schnell S. A multiscale mathematical model of cancer, and its use in analyzing irratiation therapies. Theor. Biol. Med. Modelling 3 (2006) 7
-
(2006)
Theor. Biol. Med. Modelling
, vol.3
, pp. 7
-
-
Ribba, B.1
Colin, T.2
Schnell, S.3
-
26
-
-
35348891430
-
Network-based classification of breast cancer metastasis
-
Chuang H.Y., et al. Network-based classification of breast cancer metastasis. Mol. Sys. Biol. 3 (2007)
-
(2007)
Mol. Sys. Biol.
, vol.3
-
-
Chuang, H.Y.1
-
27
-
-
39149143293
-
A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas
-
Mani K.M., et al. A systems biology approach to prediction of oncogenes and molecular perturbation targets in B-cell lymphomas. Mol. Syst. Biol. 4 (2008)
-
(2008)
Mol. Syst. Biol.
, vol.4
-
-
Mani, K.M.1
-
28
-
-
42949168427
-
A systems-level approach to mapping the telomere length maintenance gene circuitry
-
Shachar R., et al. A systems-level approach to mapping the telomere length maintenance gene circuitry. Mol. Syst. Biol. 4 (2008) 172
-
(2008)
Mol. Syst. Biol.
, vol.4
, pp. 172
-
-
Shachar, R.1
-
29
-
-
35648945300
-
A mathematical model of P53 gene regulatory networks under radiotherapy
-
Qi J.P., et al. A mathematical model of P53 gene regulatory networks under radiotherapy. Biosystems 90 3 (2007) 698-706
-
(2007)
Biosystems
, vol.90
, Issue.3
, pp. 698-706
-
-
Qi, J.P.1
-
30
-
-
36248988538
-
Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses
-
EMBO and Nature Publishing Group
-
Birtwistle M.R., et al. Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses. Mol. Syst. Biol. (2007) EMBO and Nature Publishing Group
-
(2007)
Mol. Syst. Biol.
-
-
Birtwistle, M.R.1
-
31
-
-
31744445943
-
The effects of EGF-receptor density on multiscale tumor growth patterns
-
Athale C.A., and Deisboeck T.S. The effects of EGF-receptor density on multiscale tumor growth patterns. J. Theor. Biol. 238 4 (2006) 771-779
-
(2006)
J. Theor. Biol.
, vol.238
, Issue.4
, pp. 771-779
-
-
Athale, C.A.1
Deisboeck, T.S.2
-
32
-
-
34547881522
-
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
-
Huang P.H., et al. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc. Nat. Acad. Sci. 104 31 (2007) 12867-12872
-
(2007)
Proc. Nat. Acad. Sci.
, vol.104
, Issue.31
, pp. 12867-12872
-
-
Huang, P.H.1
-
33
-
-
45949089741
-
Transcription profiling of lung adenocarinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network
-
Reymann S., and Borlak J. Transcription profiling of lung adenocarinomas of c-myc-transgenic mice: identification of the c-myc regulatory gene network. B.M.C. Sys. Biol. 2 (2008) 46
-
(2008)
B.M.C. Sys. Biol.
, vol.2
, pp. 46
-
-
Reymann, S.1
Borlak, J.2
-
34
-
-
0036072924
-
Ras/Raf signalling and emerging pharmacotherapeutic targets
-
Kolch W. Ras/Raf signalling and emerging pharmacotherapeutic targets. Exp. Opin. Pharmacother. 3 (2002) 709-718
-
(2002)
Exp. Opin. Pharmacother.
, vol.3
, pp. 709-718
-
-
Kolch, W.1
-
36
-
-
0141530936
-
HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms
-
Hendriks B.S., Wiley H.S., and Lauffenburger D. HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms. Biophys. J. 85 4 (2003) 2732-2745
-
(2003)
Biophys. J.
, vol.85
, Issue.4
, pp. 2732-2745
-
-
Hendriks, B.S.1
Wiley, H.S.2
Lauffenburger, D.3
-
37
-
-
33846554088
-
Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data.
-
Kumar N., et al. Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data. PLoS Computational Biology 3 1 (2007) e4
-
(2007)
PLoS Computational Biology
, vol.3
, Issue.1
-
-
Kumar, N.1
-
38
-
-
38449095766
-
Integrating signals between cAMP and MAPK pathways in breast cancer
-
Castoria G., et al. Integrating signals between cAMP and MAPK pathways in breast cancer. Front. Biosci. 13 (2008) 1318-1327
-
(2008)
Front. Biosci.
, vol.13
, pp. 1318-1327
-
-
Castoria, G.1
-
39
-
-
33746021158
-
Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops
-
Kiyatkin A., et al. Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops. J. Biol. Chem. 281 29 (2006) 19925-19938
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.29
, pp. 19925-19938
-
-
Kiyatkin, A.1
-
40
-
-
35348988164
-
Network analysis of oncogenic Ras activation in cancer
-
Stites E.C., et al. Network analysis of oncogenic Ras activation in cancer. Science 318 5849 (2007) 463-467
-
(2007)
Science
, vol.318
, Issue.5849
, pp. 463-467
-
-
Stites, E.C.1
-
42
-
-
33847066734
-
A systems biology dynamical model of mammalian G1 cell cycle progression
-
Haberichter T., et al. A systems biology dynamical model of mammalian G1 cell cycle progression. Mol. Syst. Biol. 3 (2007) 84
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 84
-
-
Haberichter, T.1
-
43
-
-
39749124274
-
MYC in mammalian epidermis: how can an oncogene stimulate differentiation?
-
Watt F., Frye M., and Benitah S. MYC in mammalian epidermis: how can an oncogene stimulate differentiation?. Nat. Rev., Cancer 8 3 (2008) 234-242
-
(2008)
Nat. Rev., Cancer
, vol.8
, Issue.3
, pp. 234-242
-
-
Watt, F.1
Frye, M.2
Benitah, S.3
-
44
-
-
35448939671
-
Analysis of a minimal model for p53 oscillations
-
Bottani S., and Grammaticos B. Analysis of a minimal model for p53 oscillations. J. Theor. Biol. 249 2 (2007) 235-245
-
(2007)
J. Theor. Biol.
, vol.249
, Issue.2
, pp. 235-245
-
-
Bottani, S.1
Grammaticos, B.2
-
45
-
-
33745451921
-
Oscillations and variability in the p53 systems
-
Geva-Zatorsky N., et al. Oscillations and variability in the p53 systems. Mol. Syst. Biol. 2006 2 (2006) 0033
-
(2006)
Mol. Syst. Biol.
, vol.2006
, Issue.2
, pp. 0033
-
-
Geva-Zatorsky, N.1
-
46
-
-
33751217466
-
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment
-
Anderson A.R., et al. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127 (2006) 905-915
-
(2006)
Cell
, vol.127
, pp. 905-915
-
-
Anderson, A.R.1
-
47
-
-
28444483647
-
A multiscale model for avascular tumor growth
-
Jiang Y., et al. A multiscale model for avascular tumor growth. Biophys. J. 89 6 (2005) 3884-3894
-
(2005)
Biophys. J.
, vol.89
, Issue.6
, pp. 3884-3894
-
-
Jiang, Y.1
-
48
-
-
33750974791
-
Development of a three-dimensional agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes, and multicellular patterns in brain cancer
-
Zhang L., Athale C.A., and Deisboeck T.S. Development of a three-dimensional agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes, and multicellular patterns in brain cancer. J. Theor. Biol. 244 (2007) 96-107
-
(2007)
J. Theor. Biol.
, vol.244
, pp. 96-107
-
-
Zhang, L.1
Athale, C.A.2
Deisboeck, T.S.3
-
50
-
-
8144228952
-
Friends or foes-bipolar effects of the tumor stroma in cancer
-
Mueller M.M., and Fusenig N.E. Friends or foes-bipolar effects of the tumor stroma in cancer. Nat. Rev., Cancer 4 (2004) 839-849
-
(2004)
Nat. Rev., Cancer
, vol.4
, pp. 839-849
-
-
Mueller, M.M.1
Fusenig, N.E.2
-
52
-
-
0037137519
-
A gene-expression signature as a predictor of survival in breast cancer
-
van de Vijver M.J., et al. A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 347 25 (2002) 1999-2009
-
(2002)
N. Engl. J. Med.
, vol.347
, Issue.25
, pp. 1999-2009
-
-
van de Vijver, M.J.1
-
53
-
-
13844310310
-
Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer
-
Wang Y., et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365 9460 (2005) 671-679
-
(2005)
Lancet
, vol.365
, Issue.9460
, pp. 671-679
-
-
Wang, Y.1
-
54
-
-
25144516911
-
Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome
-
Ramani A.K., et al. Consolidating the set of known human protein-protein interactions in preparation for large-scale mapping of the human interactome. Genome Biol. 6 5 (2005) R40
-
(2005)
Genome Biol.
, vol.6
, Issue.5
-
-
Ramani, A.K.1
-
55
-
-
27144530248
-
Towards a proteome-scale map of the human protein-protein interaction network
-
Rual J.F., et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 7062 (2005) 1173-1178
-
(2005)
Nature
, vol.437
, Issue.7062
, pp. 1173-1178
-
-
Rual, J.F.1
-
56
-
-
18244409687
-
Gene expression profiling predicts clinical outcome of breast cancer
-
van 't Veer L.J., et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415 6871 (2002) 530-536
-
(2002)
Nature
, vol.415
, Issue.6871
, pp. 530-536
-
-
van 't Veer, L.J.1
-
57
-
-
38049129809
-
A context-specific network of protein-DNA and protein-protein interactions reveals new regulatory motifs in human B-cells
-
Lefebvre C., et al. A context-specific network of protein-DNA and protein-protein interactions reveals new regulatory motifs in human B-cells. Lecture Notes in Bioinf 4532 (2007) 42-56
-
(2007)
Lecture Notes in Bioinf
, vol.4532
, pp. 42-56
-
-
Lefebvre, C.1
-
58
-
-
13444256478
-
Inparanoid: a comprehensive database of eukaryotic orthologs
-
O'Brian K., Remm M., and Sonnhammer E. Inparanoid: a comprehensive database of eukaryotic orthologs. Nucleic Acids Res. 33 Database issue (2005) D476-D480
-
(2005)
Nucleic Acids Res.
, vol.33
, Issue.Database issue
-
-
O'Brian, K.1
Remm, M.2
Sonnhammer, E.3
-
59
-
-
33947305781
-
ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context
-
Margolin A., et al. ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. B.M.C. Bioinformatics 7 Suppl. 1 (2006) S1-S7
-
(2006)
B.M.C. Bioinformatics
, vol.7
, Issue.SUPPL. 1
-
-
Margolin, A.1
-
60
-
-
34547110511
-
Early blood profiles of virus infection in a monkey model for Lassa Fever
-
Djavani M., et al. Early blood profiles of virus infection in a monkey model for Lassa Fever. J. Virology 81 15 (2007) 7960-7973
-
(2007)
J. Virology
, vol.81
, Issue.15
, pp. 7960-7973
-
-
Djavani, M.1
-
61
-
-
70349172273
-
Gene expression in primate liver during viral hemorrhagic fever
-
under review
-
Djavani M., et al. Gene expression in primate liver during viral hemorrhagic fever. J. Virology (2008) under review
-
(2008)
J. Virology
-
-
Djavani, M.1
|