Innate immune gene polymorphisms in tuberculosis

Infection and Immunity

Volumn 80, Issue 10, 2012, Pages 3343-3359

  Azad, Abul K ^a   Sadee, Wolfgang ^b   Schlesinger, Larry S ^a  

^a Center for Microbial Interface Biology   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CD14 ANTIGEN; CD209 ANTIGEN; COMPLEMENT RECEPTOR; DECTIN 1; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; MANNOSE BINDING LECTIN; MANNOSE RECEPTOR; MONOCYTE CHEMOTACTIC PROTEIN 1; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; PURINERGIC P2X7 RECEPTOR; RANTES; SURFACTANT PROTEIN A; SURFACTANT PROTEIN D; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR; VITAMIN D RECEPTOR;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADAPTIVE IMMUNITY; ALLELE; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE PREDISPOSITION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HOST PATHOGEN INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INNATE IMMUNITY; LUNG TUBERCULOSIS; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SHORT SURVEY; SINGLE NUCLEOTIDE POLYMORPHISM; TUBERCULOSIS;

GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNITY, INNATE; POLYMORPHISM, GENETIC; RECEPTORS, PATTERN RECOGNITION; TUBERCULOSIS;

EID: 84867619205     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00443-12     Document Type: Short Survey

References (276)

1. Aguillon JC, et al. 2006. Could single-nucleotide polymorphisms (SNPs) affecting the tumour necrosis factor promoter be considered as part of rheumatoid arthritis evolution? Immunobiology 211:75- 84.
2. Alagarasu K, Selvaraj P, Swaminathan S, Narendran G, Narayanan PR. 2009. 5′ Regulatory and 3′ untranslated region polymorphisms of vitamin D receptor gene in south Indian HIV and HIV-TB patients. J. Clin. Immunol. 29:196 -204.
3. Alagarasu K, et al. 2007. Mannose binding lectin gene variants and susceptibility to tuberculosis in HIV-1 infected patients of South India. Tuberculosis (Edinb.) 87:535-543.
4. Alter A, et al. 2010. Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. Hum. Genet. 127:337- 348.
5. Amirzargar AA, et al. 2006. Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis. Eur. Cytokine Netw. 17:84-89.
6. Andraos C, Koorsen G, Knight JC, Bornman L. 2011. Vitamin D receptor gene methylation is associated with ethnicity, tuberculosis, and TaqI polymorphism. Hum. Immunol. 72:262-268.
7. Ansari A, et al. 2009. Cytokine gene polymorphisms across tuberculosis clinical spectrum in Pakistani patients. PLoS One 4:e4778. doi:10.1371/ journal.pone.0004778.
8. Ates O, et al. 2009. NRAMP1 (SLC11A1) gene polymorphisms that correlate with autoimmune versus infectious disease susceptibility in tuberculosis and rheumatoid arthritis. Int. J. Immunogenet. 36:15-19.
9. Ates O, Musellim B, Ongen G, Topal-Sarikaya A. 2008. Interleukin-10 and tumor necrosis factor-alpha gene polymorphisms in tuberculosis. J. Clin. Immunol. 28:232-236.
10. Austin CM, Ma X, Graviss EA. 2008. Common nonsynonymous polymorphisms in the NOD2 gene are associated with resistance or susceptibility to tuberculosis disease in African Americans. J. Infect. Dis. 197: 1713-1716.
11. Awomoyi AA, et al. 2005. Polymorphism in IL1B: IL1B-511 association with tuberculosis and decreased lipopolysaccharide-induced IL-1beta in IFN-gamma primed ex-vivo whole blood assay. J. Endotoxin Res. 11: 281-286.
12. Awomoyi AA, et al. 2002. Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis. J. Infect. Dis. 186:1808 -1814.
13. Azad AK, Torrelles JB, Schlesinger LS. 2008. Mutation in the DC-SIGN cytoplasmic triacidic cluster motif markedly attenuates receptor activity for phagocytosis and endocytosis of mannose-containing ligands by human myeloid cells. J. Leukoc. Biol. 84:1594 -1603.
14. Baker AR, et al. 2011. Genetic susceptibility to tuberculosis associated with cathepsin Z haplotype in a Ugandan household contact study. Hum. Immunol. 72:426-430.
15. Barnes I, Duda A, Pybus OG, Thomas MG. 2011. Ancient urbanization predicts genetic resistance to tuberculosis. Evolution 65:842- 848.
16. Barreiro LB, et al. 2009. Evolutionary dynamics of human Toll-likereceptors and their different contributions to host defense. PLoS Genet. 5:e1000562. doi:10.1371/journal.pgen.1000562.
17. Barreiro LB, et al. 2006. Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis. PLoS Med. 3:e20. doi: 10.1371/journal.pmed.0030020.
18. Bayele HK, et al. 2007. HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite. Blood 110:3039 -3048.
19. Beharka AA, et al. 2002. Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages. J. Immunol. 169:3565-3573.
20. Bekpen C, Xavier RJ, Eichler EE. 2010. Human IRGM gene "to be or not to be." Semin. Immunopathol. 32:437- 444.
21. Bellamy R, et al. 2000. Genetic susceptibility to tuberculosis in Africans: a genome-wide scan. Proc. Natl. Acad. Sci. U. S. A. 97:8005- 8009.
22. Bellamy R, et al. 1999. Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene. J. Infect. Dis. 179:721-724.
23. Bellamy R, et al. 1998. Variations in the NRAMP1 gene and susceptibility to tuberculosis in West Africans. N. Engl. J. Med. 338:640-644.
24. Ben-Ali M, Barbouche MR, Bousnina S, Chabbou A, Dellagi K. 2004. Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients. Clin. Diagn. Lab Immunol. 11:625- 626.
25. Ben-Ali M, et al. 2007. Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. Hum. Immunol. 68:908 -912.
26. Ben-Selma W, et al. 2011. Polymorphisms in the RANTES gene increase susceptibility to active tuberculosis in Tunisia. DNA Cell Biol. 30:789- 800.
27. Ben-Selma W, Harizi H, Boukadida J. 2011. Association of TNF-alpha and IL-10 polymorphisms with tuberculosis in Tunisian populations. Microbes Infect. 13:837- 843.
28. Ben-Selma W, Harizi H, Boukadida J. 2011. MCP-1-2518 A/G functional polymorphism is associated with increased susceptibility to active pulmonary tuberculosis in Tunisian patients. Mol. Biol. Rep. 38:5413- 5419.
29. Berrington WR, Hawn TR. 2007. Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter? Immunol. Rev. 219:167-186.
30. Blackwell JM, et al. 2001. SLC11A1 (formerly NRAMP1) and disease resistance. Cell Microbiol. 3:773-784.
31. Blackwell JM, Jamieson SE, Burgner D. 2009. HLA and infectious diseases. Clin. Microbiol. Rev. 22:370 -385.
32. Boily-Larouche G, Zijenah LS, Mbizvo M, Ward BJ, Roger M. 2007. DC-SIGN and DC-SIGNR genetic diversity among different ethnic populations: potential implications for pathogen recognition and disease susceptibility. Hum. Immunol. 68:523-530.
33. Bornman L, et al. 2004. Vitamin D receptor polymorphisms and susceptibility to tuberculosis in West Africa: a case-control and family study. J. Infect. Dis. 190:1631-1641.
34. Brooks MN, et al. 2011. NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M. bovis BCG in human macrophages. Cell. Microbiol. 13:402- 418.
35. Brown GD, Gordon S. 2001. Immune recognition. A new receptor for beta-glucans. Nature 413:36 -37.
36. Brown GD, et al. 2003. Dectin-1 mediates the biological effects of betaglucans. J. Exp. Med. 197:1119 -1124.
37. Buijtels PC, et al. 2008. Polymorphism in CC-chemokine ligand 2 associated with tuberculosis in Zambia. Int. J. Tuberc. Lung Dis. 12:1485- 1488.
38. Campbell MC, Tishkoff SA. 2008. African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping. Annu. Rev. Genomics Hum. Genet. 9:403- 433.
39. Capparelli R, et al. 2009. Role played by human mannose-binding lectin polymorphisms in pulmonary tuberculosis. J. Infect. Dis. 199:666-672.
40. Carneiro LA, Magalhaes JG, Tattoli I, Philpott DJ, Travassos LH. 2008. Nod-like proteins in inflammation and disease. J. Pathol. 214:136- 148.
41. Caws M, et al. 2008. The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLoS Pathog. 4:e1000034. doi:10.1371/journal.ppat.1000034.
42. Chan ED, Chan J, Schluger NW. 2001. What is the role of nitric oxidein murine and human host defense against tuberculosis? Current knowledge. Am. J. Respir. Cell Mol. Biol. 25:606-612.
43. Chan ED, et al. 2001. Induction of inducible nitric oxide synthase-NO by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kB signaling pathways. Infect. Immun. 69:2001-2010.
44. Chensue SW, et al. 1999. Differential expression and cross-regulatory function of RANTES during mycobacterial (type 1) and schistosomal (type 2) antigen-elicited granulomatous inflammation. J. Immunol. 163: 165-173.
45. Chu SF, et al. 2007. Association between RANTES functional polymorphisms and tuberculosis in Hong Kong Chinese. Genes Immun. 8:475- 479.
46. Comas I, et al. 2010. Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Nat. Genet. 42:498 -503.
47. Comas I, Gagneux S. 2009. The past and future of tuberculosis research. PLoS Pathog. 5:e1000600. doi:10.1371/journal.ppat.1000600.
48. Comstock GW. 1978. Tuberculosis in twins: a re-analysis of the Prophit survey. Am. Rev. Respir. Dis. 117:621- 624.
49. Cooke GS, et al. 2008. Mapping of a novel susceptibility locus suggests a role for MC3R and CTSZ in human tuberculosis. Am. J. Respir. Crit. Care Med. 178:203-207.
50. Cooke GS, et al. 2004. Interleukin-8 polymorphism is not associated with pulmonary tuberculosis in The Gambia. J. Infect. Dis. 189:1545- 1546.
51. Cooper AM, Solache A, Khader SA. 2007. Interleukin-12 and tuberculosis: an old story revisited. Curr. Opin. Immunol. 19:441- 447.
52. Cordell HJ. 2009. Detecting gene-gene interactions that underlie human diseases. Nat. Rev. Genet. 10:392- 404.
53. Correa PA, Gomez LM, Cadena J, Anaya JM. 2005. Autoimmunity and tuberculosis. Opposite association with TNF polymorphism. J. Rheumatol. 32:219 -224.
54. Coulombe F, et al. 2009. Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J. Exp. Med. 206:1709 -1716.
55. Dalgic N, et al. 2011. Arg753Gln polymorphism of the human Toll-like receptor 2 gene from infection to disease in pediatric tuberculosis. Hum. Immunol. 72:440-445.
56. Davila S, et al. 2008. Genetic association and expression studies indicate a role of Toll-like receptor 8 in pulmonary tuberculosis. PLoS Genet. 4:e1000218. doi:10.1371/journal.pgen.1000218.
57. Delgado JC, Baena A, Thim S, Goldfeld AE. 2002. Ethnic-specific genetic associations with pulmonary tuberculosis. J. Infect. Dis. 186: 1463-1468.
58. Deng G, et al. 2008. Regulatory polymorphisms in the promoter of CXCL10 gene and disease progression in male hepatitis B virus carriers. Gastroenterology 134:716 -726.
59. Denholm JT, McBryde ES, Eisen DP. 2010. Mannose-binding lectin and susceptibility to tuberculosis: a meta-analysis. Clin. Exp. Immunol. 162:84 -90.
60. Deretic V. 2011. Autophagy in immunity and cell-autonomous defense against intracellular microbes. Immunol. Rev. 240:92-104.
61. Deretic V, et al. 2009. Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. Curr. Top. Microbiol. Immunol. 335:169 -188.
62. de Wit E, van der Merwe L, Van Helden PD, Hoal EG. 2011. Genegene interaction between tuberculosis candidate genes in a South African population. Mamm. Genome 22:100 -110.
63. Dinarello CA. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27:519 -550.
64. Dinarello CA, et al. 1998. Overview of interleukin-18: more than an interferon-gamma inducing factor. J. Leukoc. Biol. 63:658-664.
65. Dommett RM, Klein N, Turner MW. 2006. Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens 68:193-209.
66. Dubos R, Dubos J. 1952. The white plague: tuberculosis, man and society. Little, Brown & Co., Boston, MA.
67. El Baghdadi J, et al. 2003. Variants of the human NRAMP1 gene and susceptibility to tuberculosis in Morocco. Int. J. Tuberc. Lung Dis. 7:599-602.
68. El Sahly HM, Reich RA, Dou SJ, Musser JM, Graviss EA. 2004. The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups. Scand. J. Infect. Dis. 36:106- 108.
69. Fairbairn IP, Stober CB, Kumararatne DS, Lammas DA. 2001. ATPMinireviewmediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosomelysosome fusion. J. Immunol. 167:3300 -3307.
70. Fenton MJ, Riley LW, Schlesinger LS. 2005. Receptor-mediated recognition of Mycobacterium tuberculosis by host cells, p 405-426. In Cole ST, Eisenach KD, McMurray DN, Jacobs WR, Jr. (ed), Tuberculosis and the tubercle bacillus. ASM Press, Washington, DC.
71. Ferguson JS, et al. 2006. Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages. Infect. Immun. 74:7005-7009.
72. Ferguson JS, Voelker DR, McCormack FX, Schlesinger LS. 1999. Surfactant protein D binds to Mycobacterium tuberculosis bacilli and lipoarabinomannan via carbohydrate-lectin interactions resulting in reduced phagocytosis of the bacteria by macrophages. J. Immunol. 163: 312-321.
73. Fernando SL, et al. 2007. A polymorphism in the P2X7 gene increases susceptibility to extrapulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 175:360 -366.
74. Ferwerda B, Kibiki GS, Netea MG, Dolmans WM, van der Ven, AJ. 2007. The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania. AIDS 21:1375-1377.
75. Figdor CG, Van Kooyk Y, Adema GJ. 2002. C-type lectin receptors on dendritic cells and Langerhans cells. Nat. Rev. Immunol. 2:77- 84.
76. Fitness J, et al. 2004. Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi. Am. J. Trop. Med. Hyg. 71:330-340.
77. Flesch IE, Hess JH, Kaufmann SH. 1994. NADPH diaphorase staining suggests a transient and localized contribution of nitric oxide to host defence against an intracellular pathogen in situ. Int. Immunol. 6:1751- 1757.
78. Flores-Villanueva PO, et al. 2005. A functional promoter polymorphism in monocyte chemoattractant protein-1 is associated with increased susceptibility to pulmonary tuberculosis. J. Exp. Med. 202:1649- 1658.
79. Floros J, et al. 2000. Surfactant protein genetic marker alleles identify a subgroup of tuberculosis in a Mexican population. J. Infect. Dis. 182: 1473-1478.
80. Flynn JL, Chan J. 2001. Immunology of tuberculosis. Annu. Rev. Immunol. 19:93-129.
81. Flynn JL, et al. 1995. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2:561-572.
82. Franchi L, Warner N, Viani K, Nunez G. 2009. Function of Nod-like receptors in microbial recognition and host defense. Immunol. Rev. 227: 106-128.
83. Freidin MB, Rudko AA, Kolokolova OV, Strelis AK, Puzyrev VP. 2006. Association between the 1188 A/C polymorphism in the human IL12B gene and Th1-mediated infectious diseases. Int. J. Immunogenet. 33: 231-232.
84. Fulton SA, Johnsen JM, Wolf SF, Sieburth DS, Boom WH. 1996. Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis. Infect. Immun. 64:2523-2531.
85. Gao L, Tao Y, Zhang L, Jin Q. 2010. Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and metaanalysis. Int. J. Tuberc. Lung Dis. 14:15-23.
86. Geijtenbeek TB, et al. 2003. Mycobacteria target DC-SIGN to suppress dendritic cell function. J. Exp. Med. 197:7-17.
87. Glaziou P, Floyd K, Raviglione M. 2009. Global burden and epidemiology of tuberculosis. Clin. Chest Med. 30:621- 636.
88. Gomez LM, et al. 2006. Analysis of DC-SIGN (CD209) functional variants in patients with tuberculosis. Hum. Immunol. 67:808-811.
89. Gomez LM, et al. 2007. A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis. Tuberculosis (Edinb.) 87: 288-294.
90. Gomez LM, et al. 2006. Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis. Tissue Antigens 67:290- 296.
91. Gruenheid S, Pinner E, Desjardins M, Gros P. 1997. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185:717-730.
92. Haataja R, Hallman M. 2002. Surfactant proteins as genetic determinants of multifactorial pulmonary diseases. Ann. Med. 34:324 -333.
93. Han M, et al. 2011. Relationship between single nucleotide polymorphism of interleukin-18 and susceptibility to pulmonary tuberculosis in the Chinese Han population. Microbiol. Immunol. 55:388 -393.
94. Harishankar M, Selvaraj P, Rajeswari DN, Anand SP, Narayanan PR. 2007. Promoter polymorphism of IL-18 gene in pulmonary tuberculosis in South Indian population. Int. J. Immunogenet. 34:317-320.
95. Hawn TR, et al. 2006. A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis. J. Infect. Dis. 194:1127-1134.
96. Heldwein KA, Fenton MJ. 2002. The role of Toll-like receptors in immunity against mycobacterial infection. Microbes Infect. 4:937-944.
97. Henao MI, Montes C, Paris SC, Garcia LF. 2006. Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis. Tuberculosis (Edinb.) 86:11-19.
98. Henning LN, et al. 2008. Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J. Immunol. 180:7847- 7858.
99. Hoal EG, et al. 2004. SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are associated with susceptibility to tuberculosis in a highincidence community in South Africa. Int. J. Tuberc. Lung Dis. 8:1464- 1471.
100. Inohara N, Nunez G. 2003. NODs: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3:371-382.
101. Jabado N, et al. 2000. Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J. Exp. Med. 192:1237-1248.
102. Jamieson SE, et al. 2004. Evidence for a cluster of genes on chromosome 17q11-q21 controlling susceptibility to tuberculosis and leprosy in Brazilians. Genes Immun. 5:46 -57.
103. Jin J, et al. 2009. SLC11A1 (formerly NRAMP1) gene polymorphisms associated with pediatric tuberculosis in China. Clin. Infect. Dis. 48:733- 738.
104. Jo EK. 2008. Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs. Curr. Opin. Infect. Dis. 21:279 -286.
105. Jo EK, Yang CS, Choi CH, Harding CV. 2007. Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors. Cell Microbiol. 9:1087-1098.
106. Kang BK, et al. 2005. The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J. Exp. Med. 202:987-999.
107. Kang BK, Schlesinger LS. 1998. Characterization of mannose receptordependent phagocytosis mediated by Mycobacterium tuberculosis lipoarabinomannan. Infect. Immun. 66:2769 -2777.
108. Kang YA, et al. 2009. Association between the -159C/T CD14 gene polymorphism and tuberculosis in a Korean population. FEMS Immunol. Med. Microbiol. 57:229 -235.
109. Kawai T, Akira S. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11:373- 384.
110. Khor CC, et al. 2007. A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. Nat. Genet. 39:523-528.
111. Kobayashi KS, et al. 2005. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 307:731-734.
112. Kusner DJ, Adams J. 2000. ATP-induced killing of virulent Mycobacterium tuberculosis within human macrophages requires phospholipase D. J. Immunol. 164:379 -388.
113. Kusuhara K, Yamamoto K, Okada K, Mizuno Y, Hara T. 2007. Association of IL12RB1 polymorphisms with susceptibility to and severity of tuberculosis in Japanese: a gene-based association analysis of 21 candidate genes. Int. J. Immunogenet. 34:35- 44.
114. Ladel CH, et al. 1997. Lethal tuberculosis in interleukin-6-deficient mutant mice. Infect. Immun. 65:4843- 4849.
115. Larcombe LA, et al. 2008. Functional gene polymorphisms in Canadian aboriginal populations with high rates of tuberculosis. J. Infect. Dis. 198: 1175-1179.
116. Lee HW, et al. 2005. Lack of an association between interleukin-12 receptor beta1 polymorphisms and tuberculosis in Koreans. Respiration 72:365-368.
117. Lee SH, et al. 2011. Association between the interleukin-18 promoter polymorphism and pulmonary tuberculosis in a Korean population. Int. J. Tuberc. Lung Dis. 15:1246 -1251.
118. Leung KH, et al. 2007. Sex- and age-dependent association of SLC11A1polymorphisms with tuberculosis in Chinese: a case control study. BMC Infect. Dis. 7:19. doi:10.1186/1471-2334-7-19.
119. Li CM, et al. 2002. Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J. Infect. Dis. 186:1458 -1462.
120. Li D, et al. 2011. Genetic study of two single nucleotide polymorphisms within corresponding microRNAs and susceptibility to tuberculosis in a Chinese Tibetan and Han population. Hum. Immunol. 72:598-602.
121. Li HT, Zhang TT, Zhou YQ, Huang QH, Huang J. 2006. SLC11A1 (formerly NRAMP1) gene polymorphisms and tuberculosis susceptibility: a meta-analysis. Int. J. Tuberc. Lung Dis. 10:3-12.
122. Li X, et al. 2011. SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: updated systematic review and meta-analysis. PLoS One 6:e15831. doi:10.1371/journal.pone.0015831.
123. Lin Y, Gong J, Zhang M, Xue W, Barnes PF. 1998. Production of monocyte chemoattractant protein 1 in tuberculosis patients. Infect. Immun. 66:2319 -2322.
124. Liu PT, et al. 2006. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311:1770 -1773.
125. Liu W, et al. 2004. VDR and NRAMP1 gene polymorphisms in susceptibility to pulmonary tuberculosis among the Chinese Han population: a case-control study. Int. J. Tuberc. Lung Dis. 8:428-434.
126. Liu W, et al. 2006. Sequence variations in the MBL gene and their relationship to pulmonary tuberculosis in the Chinese Han population. Int. J. Tuberc. Lung Dis. 10:1098 -1103.
127. Lombard Z, Dalton DL, Venter PA, Williams RC, Bornman L. 2006. Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa. Hum. Immunol. 67:643- 654.
128. Lopez-Maderuelo D, et al. 2003. Interferon-gamma and interleukin-10 gene polymorphisms in pulmonary tuberculosis. Am. J. Respir. Crit. Care Med. 167:970 -975.
129. Lu B, et al. 1998. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J. Exp. Med. 187:601- 608.
130. Ma X, et al. 2002. 5′ dinucleotide repeat polymorphism of NRAMP1 and susceptibility to tuberculosis among Caucasian patients in Houston, Texas. Int. J. Tuberc. Lung Dis. 6:818-823.
131. Ma X, et al. 2007. Full-exon resequencing reveals Toll-like receptor variants contribute to human susceptibility to tuberculosis disease. PLoS One 2:e1318. doi:10.1371/journal.pone.0001318.
132. Ma X, et al. 2003. Association between interleukin-8 gene alleles and human susceptibility to tuberculosis disease. J. Infect. Dis. 188:349 -355.
133. MacMicking JD, et al. 1997. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 94: 5243-5248.
134. Madan T, Saxena S, Murthy KJ, Muralidhar K, Sarma PU. 2002. Association of polymorphisms in the collagen region of human SP-A1 and SP-A2 genes with pulmonary tuberculosis in Indian population. Clin. Chem. Lab. Med. 40:1002-1008.
135. Mahasirimongkol S, et al. 2012. Genome-wide association studies of tuberculosis in Asians identify distinct at-risk locus for young tuberculosis. J. Hum. Genet. 57:363-367.
136. Mahasirimongkol S, et al. 2009. Genome-wide SNP-based linkage analysis of tuberculosis in Thais. Genes Immun. 10:77- 83.
137. Malik S, et al. 2005. Alleles of the NRAMP1 gene are risk factors for pediatric tuberculosis disease. Proc. Natl. Acad. Sci. U. S. A. 102:12183- 12188.
138. Malik S, et al. 2006. Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia. Hum. Genet. 118:752-759.
139. McGreal EP, Martinez-Pomares L, Gordon S. 2004. Divergent roles for C-type lectins expressed by cells of the innate immune system. Mol. Immunol. 41:1109 -1121.
140. Means TK, et al. 1999. Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis. J. Immunol. 163:3920 -3927.
141. Merza M, et al. 2009. The NRAMPI, VDR and TNF-alpha gene polymorphisms in Iranian tuberculosis patients: the study on host susceptibility. Braz. J. Infect. Dis. 13:252-256.
142. Miao R, Li J, Sun Z, Xu F, Shen H. 2011. Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility. Tuberculosis (Edinb.) 91:268-272.
143. Miller CL. 2009. The evolution of schizophrenia: a model for selection by infection, with a focus on NAD. Curr. Pharm. Des. 15:100 -109.
144. Miller EN, et al. 2004. Genome-wide scans for leprosy and tuberculosis susceptibility genes in Brazilians. Genes Immun. 5:63- 67.
145. Mokrousov I, Sapozhnikova N, Narvskaya O. 2008. Mycobacterium tuberculosis co-existence with humans: making an imprint on the macrophage P2X(7) receptor gene? J. Med. Microbiol. 57:581-584.
146. Moller M, de Wit E, Hoal EG. 2010. Past, present and future directions in human genetic susceptibility to tuberculosis. FEMS Immunol. Med. Microbiol. 58:3-26.
147. Moller M, et al. 2010. A functional haplotype in the 3′untranslated region of TNFRSF1B is associated with tuberculosis in two African populations. Am. J. Respir. Crit. Care Med. 181:388 -393.
148. Moller M, Hoal EG. 2010. Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis. Tuberculosis (Edinb.) 90:71- 83.
149. Moller M, et al. 2007. Host susceptibility to tuberculosis: CARD15 polymorphisms in a South African population. Mol. Cell Probes 21:148- 151.
150. Moller M, et al. 2009. Investigation of chromosome 17 candidate genes in susceptibility to TB in a South African population. Tuberculosis (Edinb.) 89:189 -194.
151. Morahan G, et al. 2007. Association of variants in the IL12B gene with leprosy and tuberculosis. Tissue Antigens 69(Suppl 1):234 -236.
152. Morris GA, et al. 2011. Interleukin 12B (IL12B) genetic variation and pulmonary tuberculosis: a study of cohorts from The Gambia, Guinea-Bissau, United States and Argentina. PLoS One 6:e16656. doi:10.1371/ journal.pone.0016656.
153. Mortellaro A, Robinson L, Ricciardi-Castagnoli P. 2009. Spotlight on mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge? EMBO Mol. Med. 1:19 -29.
154. Mosaad YM, Soliman OE, Tawhid ZE, Sherif DM. 2010. Interferongamma +874 T/A and interleukin-10-1082 A/G single nucleotide polymorphism in Egyptian children with tuberculosis. Scand. J. Immunol. 72:358 -364.
155. Motsinger-Reif AA, et al. 2010. Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. BMC Med. Genet. 11:37. doi:10.1186/ 1471-2350-11-37.
156. Nejentsev S, et al. 2008. Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations. Nat. Genet. 40:261- 262.
157. Newport MJ, et al. 2004. The Toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The Gambia. Tuberculosis (Edinb.) 84:347-352.
158. Newport MJ, Finan C. 2011. Genome-wide association studies and susceptibility to infectious diseases. Brief. Funct. Genomics 10:98 -107.
159. Neyrolles O, Gicquel B, Quintana-Murci L. 2006. Towards a crucial role for DC-SIGN in tuberculosis and beyond. Trends Microbiol. 14: 383-387.
160. Nicholson S, et al. 1996. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J. Exp. Med. 183: 2293-2302.
161. Nino-Moreno P, et al. 2007. P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis. Clin. Exp. Immunol. 148:469-477.
162. Ogus AC, et al. 2004. The Arg753GLn polymorphism of the human toll-like receptor 2 gene in tuberculosis disease. Eur. Respir. J. 23:219- 223.
163. Oh JH, et al. 2007. Polymorphisms of interleukin-10 and tumour necrosis factor-alpha genes are associated with newly diagnosed and recurrent pulmonary tuberculosis. Respirology 12:594 -598.
164. Okamura H, Kashiwamura S, Tsutsui H, Yoshimoto T, Nakanishi K. 1998. Regulation of interferon-gamma production by IL-12 and IL-18. Curr. Opin. Immunol. 10:259 -264.
165. O'Leary S, O'Sullivan MP, Keane J. 2011. IL-10 blocks phagosome maturation in Mycobacterium tuberculosis-infected human macrophages. Am. J. Respir. Cell Mol. Biol. 45:172-180.
166. Olesen R, et al. 2007. DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans. Genes Immun. 8:456-467.
167. Reference deleted
168. Oral HB, et al. 2006. Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis. Cytokine 35:143-147.
169. Pacheco AG, Cardoso CC, Moraes MO. 2008. IFNG +874T/A, IL10-1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: a meta-analysis study. Hum. Genet. 123:477- 484.
170. Parwati I, van Crevel R, van Soolingen D. 2010. Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains. Lancet Infect. Dis. 10:103-111.
171. Perkins TT, et al. 2009. A strand-specific RNA-Seq analysis of the transcriptome of the typhoid bacillus Salmonella typhi. PLoS Genet. 5:e1000569. doi:10.1371/journal.pgen.1000569.
172. Png E, et al. 2012. A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians. BMC Med. Genet. 13:5. doi: 10.1186/1471-2350-13-5.
173. Prabhu Anand S, Selvaraj P, Jawahar MS, Adhilakshmi AR, Narayanan PR. 2007. Interleukin-12B & interleukin-10 gene polymorphisms in pulmonary tuberculosis. Indian J. Med. Res. 126:135-138.
174. Prigozy TI, et al. 1997. The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules. Immunity 6:187-197.
175. Puig-Kroger A, et al. 2004. Regulated expression of the pathogen receptor dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin in THP-1 human leukemic cells, monocytes, and macrophages. J. Biol. Chem. 279:25680 -25688.
176. Pulido I, et al. 2010. The TLR4 ASP299GLY polymorphism is a risk factor for active tuberculosis in Caucasian HIV-infected patients. Curr. HIV Res. 8:253-258.
177. Quesniaux V, et al. 2004. Toll-like receptor pathways in the immune responses to mycobacteria. Microbes Infect. 6:946 -959.
178. Quesniaux VJ, et al. 2004. Toll-like receptor 2 (TLR2)-dependentpositive and TLR2-independent-negative regulation of proinflammatory cytokines by mycobacterial lipomannans. J. Immunol. 172:4425- 4434.
179. Rajaram MV, et al. 2010. Mycobacterium tuberculosis activates human macrophage peroxisome proliferator-activated receptor gamma linking mannose receptor recognition to regulation of immune responses. J. Immunol. 185:929 -942.
180. Rajaram MV, et al. 2011. Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc. Natl. Acad. Sci. U. S. A. 108:17408 -17413.
181. Remus N, et al. 2004. Association of IL12RB1 polymorphisms with pulmonary tuberculosis in adults in Morocco. J. Infect. Dis. 190:580- 587.
182. Riedel DD, Kaufmann SH. 1997. Chemokine secretion by human polymorphonuclear granulocytes after stimulation with Mycobacterium tuberculosis and lipoarabinomannan. Infect. Immun. 65:4620-4623.
183. Roach DR, et al. 2001. Secreted lymphotoxin-alpha is essential for the control of an intracellular bacterial infection. J. Exp. Med. 193:239 -246.
184. Rosas-Taraco AG, et al. 2007. CD14 C(-159)T polymorphism is a risk factor for development of pulmonary tuberculosis. J. Infect. Dis. 196: 1698-1706.
185. Rosenberg PS, Che A, Chen BE. 2006. Multiple hypothesis testing strategies for genetic case-control association studies. Stat. Med. 25: 3134-3149.
186. Rothfuchs AG, et al. 2007. Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. J. Immunol. 179:3463-3471.
187. Ryu S, et al. 2000. 3′UTR polymorphisms in the NRAMP1 gene are associated with susceptibility to tuberculosis in Koreans. Int. J. Tuberc. Lung Dis. 4:577-580.
188. Sabat R, et al. 2010. Biology of interleukin-10. Cytokine Growth Factor Rev. 21:331-344.
189. Sadek MI, Sada E, Toossi Z, Schwander SK, Rich EA. 1998. Chemokines induced by infection of mononuclear phagocytes with mycobacteria and present in lung alveoli during active pulmonary tuberculosis. Am. J. Respir. Cell Mol. Biol. 19:513-521.
190. Saiga, H., Y. Shimada, and K. Takeda. 2011. Innate immune effectors in mycobacterial infection. Clin. Dev. Immunol. 2011:347594. doi:10.1155/ 2011/347594.
191. Salam N, et al. 2008. Protective immunity to Mycobacterium tuberculosis infection by chemokine and cytokine conditioned CFP-10 differentiated dendritic cells. PLoS One 3:e2869. doi:10.1371/journal-pone.0002869.
192. Sanchez-Castanon M, et al. 2009. Polymorphisms in CCL5 promoter are associated with pulmonary tuberculosis in northern Spain. Int. J. Tuberc. Lung Dis. 13:480-485.
193. Sasindran J, Torrelles JB. 2011. Mycobacterium tuberculosis infection and inflammation: what is beneficial for the host and for the bacterium? Front. Microbiol. 2:2. doi:10.3389/fmicb.2011.00002.
194. Saukkonen JJ, et al. 2002. Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth. Infect. Immun. 70:1684 -1693.
195. Schindler R, et al. 1990. Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF. Blood 75:40 - 47.
196. Schlesinger LS, et al. 2008. Determinants of phagocytosis, phagosome biogenesis and autophagy for Mycobacterium tuberculosis, p 1-22. In Kaufmann SHE, Britton WJ (ed), Handbook of tuberculosis: immunology and cell biology. Wiley-VCH, Weinheim, Germany.
197. Schlesinger LS, Hull SR, Kaufman TM. 1994. Binding of the terminal mannosyl units of lipoarabinomannan from a virulent strain of Mycobacterium tuberculosis to human macrophages. J. Immunol. 152:4070- 4079.
198. Schneemann M, Schoeden G. 2007. Macrophage biology and immunology: man is not a mouse. J. Leukoc. Biol. 81:579.
199. Searle S, Blackwell JM. 1999. Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility. J. Med. Genet. 36: 295-299.
200. Selvaraj P. 2004. Host genetics and tuberculosis susceptibility. Curr. Science 86:115-121.
201. Selvaraj P, et al. 2008. Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis. Cytokine 43:26 -33.
202. Selvaraj P, Alagarasu K, Swaminathan S, Harishankar M, Narendran G. 2009. CD209 gene polymorphisms in South Indian HIV and HIV-TB patients. Infect. Genet. Evol. 9:256 -262.
203. Selvaraj P, Narayannan PR, Reetha AM. 1999. Association of functional mutant homozygotes of the mannose binding protein gene with susceptibility to pulmonary tuberculosis in India. Tuber. Lung Dis. 79:221-227.
204. Serrano-Gomez D, et al. 2004. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages. J. Immunol. 173:5635-5643.
205. Sharma S, et al. 2010. Association of P2X7 receptor +1513 (A->C) polymorphism with tuberculosis in a Punjabi population. Int. J. Tuberc. Lung Dis. 14:1159 -1163.
206. Shaw TC, Thomas LH, Friedland JS. 2000. Regulation of IL-10 secretion after phagocytosis of Mycobacterium tuberculosis by human monocytic cells. Cytokine 12:483- 486.
207. Shin HD, et al. 2005. Common interleukin 10 polymorphism associated with decreased risk of tuberculosis. Exp. Mol. Med. 37:128 -132.
208. Shiratsuchi H, Johnson JL, Ellner JJ. 1991. Bidirectional effects of cytokines on the growth of Mycobacterium avium within human monocytes. J. Immunol. 146:3165-3170.
209. Singla N, Gupta D, Joshi A, Batra N, Singh J. 2012. Genetic polymorphisms in the P2X7 gene and its association with susceptibility to tuberculosis. Int. J. Tuberc. Lung Dis. 16:224 -229.
210. Singla N, et al. 2012. Association of mannose-binding lectin gene polymorphism with tuberculosis susceptibility and sputum conversion time. Int. J. Immunogenet. 39:10 -14.
211. Soborg C, et al. 2007. Influence of candidate susceptibility genes on tuberculosis in a high endemic region. Mol. Immunol. 44:2213-2220.
212. Soborg C, et al. 2003. Mannose-binding lectin polymorphisms in clinical tuberculosis. J. Infect. Dis. 188:777-782.
213. Stahl PD, Ezekowitz RA. 1998. The mannose receptor is a pattern recognition receptor involved in host defense. Curr. Opin. Immunol. 10: 50-55.
214. Stead WW, Senner JW, Reddick WT, Lofgren JP. 1990. Racial differences in susceptibility to infection by Mycobacterium tuberculosis. N. Engl. J. Med. 322:422- 427.
215. Stein CM. 2011. Genetic epidemiology of tuberculosis susceptibility: impact of study design. PLoS Pathog. 7:e1001189. doi:10.1371/ journal.ppat.1001189.
216. Stein CM, et al. 2007. Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes. Hum. Genet. 121:663- 673.
217. Stein CM, et al. 2008. Genome scan of M. tuberculosis infection anddisease in Ugandans. PLoS One 3:e4094. doi:10.1371/journal. pone.0004094.
218. Stockton JC, et al. 2004. Polymorphism in NOD2, Crohn's disease, and susceptibility to pulmonary tuberculosis. FEMS Immunol. Med. Microbiol. 41:157-160.
219. Sugawara I, et al. 1999. Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice. Infect. Immun. 67:2585-2589.
220. Tailleux L, et al. 2005. DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis. PLoS Med. 2:e381. doi:10.1371/journal.pmed.0020381.
221. Tailleux L, et al. 2003. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J. Exp. Med. 197:121-127.
222. Takahashi K, Ezekowitz RA. 2005. The role of the mannose-binding lectin in innate immunity. Clin. Infect. Dis. 41(Suppl 7):S440 -S444.
223. Takahashi K, et al. 2008. SLC11A1 (formerly NRAMP1) polymorphisms associated with multidrug-resistant tuberculosis. Tuberculosis (Edinb.) 88:52-57.
224. Takeuchi O, et al. 2002. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 169: 10-14.
225. Tang NL, et al. 2009. Genetic association between a chemokine gene CXCL-10 (IP-10, interferon gamma inducible protein 10) and susceptibility to tuberculosis. Clin. Chim. Acta 406:98 -102.
226. Thuong NT, et al. 2007. A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis. Genes Immun. 8:422- 428.
227. Thye T, et al. 2009. MCP-1 promoter variant -362C associated with protection from pulmonary tuberculosis in Ghana, West Africa. Hum. Mol. Genet. 18:381-388.
228. Thye T, et al. 2011. Variant G57E of mannose binding lectin associated with protection against tuberculosis caused by Mycobacterium africanum but not by M. tuberculosis. PLoS One 6:e20908. doi:10.1371/ journal.pone.0020908.
229. Thye T, et al. 2010. Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nat. Genet. 42:739 -741.
230. Torrelles JB, Azad AK, Schlesinger LS. 2006. Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors. J. Immunol. 177:1805-1816.
231. Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS. 2008. Role of C-type lectins in mycobacterial infections. Curr. Drug Targets 9:102-112.
232. Trajkov D, et al. 2009. Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians. Indian J. Tuberc. 56:117-131.
233. Trinchieri G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigenspecific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
234. Trinchieri G, Pflanz S, Kastelein RA. 2003. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity. 19:641- 644.
235. Trowsdale J. 2011. The MHC, disease and selection. Immunol. Lett. 137:1- 8.
236. Tso HW, Lau YL, Tam CM, Wong HS, Chiang AK. 2004. Associations between IL12B polymorphisms and tuberculosis in the Hong Kong Chinese population. J. Infect. Dis. 190:913-919.
237. Turner DM, et al. 1997. An investigation of polymorphism in the interleukin-10 gene promoter. Eur. J. Immunogenet. 24:1- 8.
238. Turner J, et al. 2002. In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL/6 mice. J. Immunol. 169:6343- 6351.
239. Uciechowski P, et al. 2011. Susceptibility to tuberculosis is associated with TLR1 polymorphisms resulting in a lack of TLR1 cell surface expression. J. Leukoc. Biol. 90:377-388.
240. Underhill DM. 2007. Collaboration between the innate immune receptors dectin-1, TLRs, and Nods. Immunol. Rev. 219:75- 87.
241. van Crevel R, et al. 2009. Infection with Mycobacterium tuberculosis Beijing genotype strains is associated with polymorphisms in SLC11A1/ NRAMP1 in Indonesian patients with tuberculosis. J. Infect. Dis. 200: 1671-1674.
242. van der Eijk EA, Van DV, Vandenbroucke JP, Van Dissel JT. 2007. Heredity versus environment in tuberculosis in twins: the 1950s United Kingdom Prophit survey: Simonds and Comstock revisited. Am. J. Respir. Crit. Care Med. 176:1281-1288.
243. van de Veerdonk FL, et al. 2010. Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1. J. Leukoc. Biol. 88:227-232.
244. Vankayalapati R, et al. 2001. T cells enhance production of IL-18 by monocytes in response to an intracellular pathogen. J. Immunol. 166: 6749-6753.
245. van Kooyk Y. 2008. C-type lectins on dendritic cells: key modulators for the induction of immune responses. Biochem. Soc. Trans. 36:1478- 1481.
246. Vannberg FO, Chapman SJ, Hill AV. 2011. Human genetic susceptibility to intracellular pathogens. Immunol. Rev. 240:105-116.
247. Vannberg FO, et al. 2008. CD209 genetic polymorphism and tuberculosis disease. PLoS One 3:e1388. doi:10.1371/journal.pone.0001388.
248. Vejbaesya S, Chierakul N, Luangtrakool P, Sermduangprateep C. 2007. NRAMP1 and TNF-alpha polymorphisms and susceptibility to tuberculosis in Thais. Respirology 12:202-206.
249. Velez DR, et al. 2009. Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. Int. J. Tuberc. Lung Dis. 13:1068 -1076.
250. Velez DR, et al. 2009. NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. Hum. Genet. 126:643- 653.
251. Velez DR, et al. 2010. Variants in toll-like receptors 2 and 9 influence susceptibility to pulmonary tuberculosis in Caucasians, African-Americans, and West Africans. Hum. Genet. 127:65-73.
252. Vesosky B, Rottinghaus EK, Stromberg P, Turner J, Beamer G. 2010. CCL5 participates in early protection against Mycobacterium tuberculosis. J. Leukoc. Biol. 87:1153-1165.
253. Vidal SM, Malo D, Vogan K, Skamene E, Gros P. 1993. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73:469-485.
254. Vishnoi A, Srivastava A, Roy R, Bhattacharya A. 2008. MGDD: Mycobacterium tuberculosis genome divergence database. BMC Genomics 9:373. doi:10.1186/1471-2164-9-373.
255. Wang D, Johnson AD, Papp AC, Kroetz DL, Sadee W. 2005. Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet. Genomics 15:693-704.
256. Wang Q, Zhan P, Qiu LX, Qian Q, Yu LK. 2012. TNF-308 gene polymorphism and tuberculosis susceptibility: a meta-analysis involving 18 studies. Mol. Biol. Rep. 39:3393-3400.
257. Wang X, Xiao H, Lan H, Mao C, Chen Q. 2011. Lack of association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis: a meta-analysis. Respirology 16:790 -795.
258. WHO. 2010. Multidrug and extensively drug-resistant TB (M/XDRTB): 2010 global report on surveillance and response. WHO/HTM/TB/ 2010.3. WHO Press, Geneva, Switzerland.
259. Wiens GD, Glenney GW. 2011. Origin and evolution of TNF and TNF receptor superfamilies. Dev. Comp. Immunol. 35:1324 -1335.
260. Wilbur AK, Kubatko LS, Hurtado AM, Hill KR, Stone AC. 2007. Vitamin D receptor gene polymorphisms and susceptibility to M. tuberculosis in native Paraguayans. Tuberculosis (Edinb.) 87:329 -337.
261. Wright JR. 2005. Immunoregulatory functions of surfactant proteins. Nat. Rev. Immunol. 5:58-68.
262. Xiao J, et al. 2009. Lack of association between polymorphisms in the P2X7 gene and tuberculosis in a Chinese Han population. FEMS Immunol. Med. Microbiol. 55:107-111.
263. Xiao J, et al. 2010. Metaanalysis of P2X7 gene polymorphisms and tuberculosis susceptibility. FEMS Immunol. Med. Microbiol. 60:165- 170.
264. Yadav M, Schorey JS. 2006. The {beta}-glucan receptor Dectin-1 functions together with TLR2 to mediate macrophage activation by mycobacteria. Blood 108:3168 -3175.
265. Yim JJ, Adams AA, Kim JH, Holland SM. 2006. Evolution of an intronic microsatellite polymorphism in Toll-like receptor 2 among primates. Immunogenetics 58:740 -745.
266. Yim JJ, Selvaraj P. 2010. Genetic susceptibility in tuberculosis. Respirology 15:241-256.
267. Yoshikai Y. 2006. Immunological protection against mycobacterium tuberculosis infection. Crit. Rev. Immunol. 26:515-526.
268. Zakham F, et al. 2011. Mycobacterial species as case-study of comparative genome analysis. Cell Mol. Biol. (Noisy-le-Grand) 57(Suppl): OL1462-OL1469.
269. Zenaro E, Donini M, Dusi S. 2009. Induction of Th1/Th17 immuneresponse by Mycobacterium tuberculosis: role of dectin-1, mannose receptor, and DC-SIGN. J. Leukoc. Biol. 86:1393-1401.
270. Zhang J, et al. 2011. Interleukin-10 polymorphisms and tuberculosis susceptibility: a meta-analysis. Int. J. Tuberc. Lung Dis. 15:594-601.
271. Zhang W, et al. 2005. Variants of the natural resistance-associated macrophage protein 1 gene (NRAMP1) are associated with severe forms of pulmonary tuberculosis. Clin. Infect. Dis. 40:1232-1236.
272. Zhang X, et al. 2012. Polymorphic allele of human MRC1 confers protection against tuberculosis in a Chinese population. Int. J. Biol. Sci. 8:375-382.
273. Zhang Y, et al. 1995. Enhanced interleukin-8 release and gene expression in macrophages after exposure to Mycobacterium tuberculosis and its components. J. Clin. Invest. 95:586 -592.
274. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W. 2005. Allelic expression imbalance of humanmuopioid receptor (OPRM1) caused by variant A118G. J. Biol. Chem. 280:32618 -32624.
275. Zheng R, et al. 2011. Relationship between polymorphism of DC-SIGN (CD209) gene and the susceptibility to pulmonary tuberculosis in an eastern Chinese population. Hum. Immunol. 72:183-186.
276. Zhu XW, Friedland JS. 2006. Multinucleate giant cells and the control of chemokine secretion in response to Mycobacterium tuberculosis. Clin. Immunol. 120:10 -20.