Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 42, 2011, Pages 17408-17413

  Rajaram, Murugesan V S ^a   Ni, Bin ^a   Morris, Jessica D ^a   Brooks, Michelle N ^a   Carlson, Tracy K ^a   Bakthavachalu, Baskar ^a   Schoenberg, Daniel R ^a   Torrelles, Jordi B ^a   Schlesinger, Larry S ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Cell signaling; Innate immunity; Intracellular pathogen; Lipoglycans

Indexed keywords

ENVELOPE PROTEIN; LIPOMANNAN; MESSENGER RNA; MICRORNA; MICRORNA 125B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME REGULATION; HALF LIFE TIME; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MACROPHAGE; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA BINDING; RNA STABILITY;

HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE KINASE 2; MAP KINASE SIGNALING SYSTEM; MICRORNAS; MYCOBACTERIUM TUBERCULOSIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RNA STABILITY; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA; VIRULENCE;

MYCOBACTERIUM TUBERCULOSIS;

EID: 80054810826     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1112660108     Document Type: Article

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