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Volumn 4, Issue 3, 2012, Pages 618-657

Macrophage-mediated lymphangiogenesis: The emerging role of macrophages as lymphatic endothelial progenitors

Author keywords

Lymphangiogenesis; Lymphatic endothelial cell progenitors; Lymphatic metastasis; Lymphvasculogenesis; Tumor associated macrophages

Indexed keywords

CELL MARKER; INTEGRIN ALPHA 9; LYVE 1 PROTEIN; NEUROPILIN 2; PODOPLANIN; PROSPERO RELATED HOMEOBOX 1; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 3;

EID: 84866950486     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers4030618     Document Type: Review
Times cited : (107)

References (232)
  • 1
    • 76749083490 scopus 로고    scopus 로고
    • Lymphangiogenesis: Molecular mechanisms and future promise
    • Tammela, T.; Alitalo, K. Lymphangiogenesis: Molecular mechanisms and future promise. Cell 2010, 140, 460-476.
    • (2010) Cell , vol.140 , pp. 460-476
    • Tammela, T.1    Alitalo, K.2
  • 2
    • 57749192473 scopus 로고    scopus 로고
    • Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees
    • Dejana, E.; Orsenigo, F.; Molendini, C.; Baluk, P.; McDonald, D.M. Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. Cell Tissue Res. 2009, 335, 17-25.
    • (2009) Cell Tissue Res , vol.335 , pp. 17-25
    • Dejana, E.1    Orsenigo, F.2    Molendini, C.3    Baluk, P.4    McDonald, D.M.5
  • 4
    • 0242330142 scopus 로고    scopus 로고
    • Lymphatic endothelium: Morphological, molecular and functional properties
    • Pepper, M.S.; Skobe, M. Lymphatic endothelium: Morphological, molecular and functional properties. J. Cell Biol. 2003, 163, 209-213.
    • (2003) J. Cell Biol , vol.163 , pp. 209-213
    • Pepper, M.S.1    Skobe, M.2
  • 5
    • 67650848377 scopus 로고    scopus 로고
    • Contractile physiology of lymphatics
    • Zawieja, D.C. Contractile physiology of lymphatics. Lymphat. Res. Biol. 2009, 7, 87-96.
    • (2009) Lymphat. Res. Biol , vol.7 , pp. 87-96
    • Zawieja, D.C.1
  • 6
    • 44449143412 scopus 로고    scopus 로고
    • Molecular regulation of lymphatic contractility
    • Muthuchamy, M.; Zawieja, D. Molecular regulation of lymphatic contractility. Ann. NY Acad. Sci. 2008, 1131, 89-99.
    • (2008) Ann. NY Acad. Sci , vol.1131 , pp. 89-99
    • Muthuchamy, M.1    Zawieja, D.2
  • 7
    • 44449086848 scopus 로고    scopus 로고
    • The link between lymphatic function and adipose biology
    • Harvey, N.L. The link between lymphatic function and adipose biology. Ann. NY Acad. Sci. 2008, 1131, 82-88.
    • (2008) Ann. NY Acad. Sci , vol.1131 , pp. 82-88
    • Harvey, N.L.1
  • 9
    • 33947632923 scopus 로고    scopus 로고
    • Inflammation, lymphatic function, and dendritic cell migration
    • Angeli, V.; Randolph, G.J. Inflammation, lymphatic function, and dendritic cell migration. Lymphat. Res. Biol. 2006, 4, 217-228.
    • (2006) Lymphat. Res. Biol , vol.4 , pp. 217-228
    • Angeli, V.1    Randolph, G.J.2
  • 10
    • 44449119392 scopus 로고    scopus 로고
    • Cell traffic and the lymphatic endothelium
    • Johnson, L.A.; Jackson, D.G. Cell traffic and the lymphatic endothelium. Ann. NY Acad. Sci. 2008, 1131, 119-133.
    • (2008) Ann. NY Acad. Sci , vol.1131 , pp. 119-133
    • Johnson, L.A.1    Jackson, D.G.2
  • 13
    • 0033846016 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing
    • Paavonen, K.; Puolakkainen, P.; Jussila, L.; Jahkola, T.; Alitalo, K. Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am. J. Pathol. 2000, 156, 1499-1504.
    • (2000) Am. J. Pathol , vol.156 , pp. 1499-1504
    • Paavonen, K.1    Puolakkainen, P.2    Jussila, L.3    Jahkola, T.4    Alitalo, K.5
  • 15
    • 28844505689 scopus 로고    scopus 로고
    • Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels
    • Religa, P.; Cao, R.; Bjorndahl, M.; Zhou, Z.; Zhu, Z.; Cao, Y. Presence of bone marrow-derived circulating progenitor endothelial cells in the newly formed lymphatic vessels. Blood 2005, 106, 4184-4190.
    • (2005) Blood , vol.106 , pp. 4184-4190
    • Religa, P.1    Cao, R.2    Bjorndahl, M.3    Zhou, Z.4    Zhu, Z.5    Cao, Y.6
  • 17
    • 0034842967 scopus 로고    scopus 로고
    • Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma
    • Skobe, M.; Hamberg, L.M.; Hawighorst, T.; Schirner, M.; Wolf, G.L.; Alitalo, K.; Detmar, M. Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. Am. J. Pathol. 2001, 159, 893-903.
    • (2001) Am. J. Pathol , vol.159 , pp. 893-903
    • Skobe, M.1    Hamberg, L.M.2    Hawighorst, T.3    Schirner, M.4    Wolf, G.L.5    Alitalo, K.6    Detmar, M.7
  • 19
    • 34247874642 scopus 로고    scopus 로고
    • Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing
    • Maruyama, K.; Asai, J.; Ii, M.; Thorne, T.; Losordo, D.W.; D'Amore, P.A. Decreased macrophage number and activation lead to reduced lymphatic vessel formation and contribute to impaired diabetic wound healing. Am. J. Pathol. 2007, 170, 1178-1191.
    • (2007) Am. J. Pathol , vol.170 , pp. 1178-1191
    • Maruyama, K.1    Asai, J.2    Ii, M.3    Thorne, T.4    Losordo, D.W.5    D'Amore, P.A.6
  • 21
    • 4544249442 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) on monocytic bone marrow-derived cells in the conjunctiva
    • Hamrah, P.; Chen, L.; Cursiefen, C.; Zhang, Q.; Joyce, N.C.; Dana, M.R. Expression of vascular endothelial growth factor receptor-3 (VEGFR-3) on monocytic bone marrow-derived cells in the conjunctiva. Exp. Eye Res. 2004, 79, 553-561.
    • (2004) Exp. Eye Res , vol.79 , pp. 553-561
    • Hamrah, P.1    Chen, L.2    Cursiefen, C.3    Zhang, Q.4    Joyce, N.C.5    Dana, M.R.6
  • 25
    • 0033955742 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 (VEGFR-3): A marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas
    • Folpe, A.L.; Veikkola, T.; Valtola, R.; Weiss, S.W. Vascular endothelial growth factor receptor-3 (VEGFR-3): A marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. Mod. Pathol. 2000, 13, 180-185.
    • (2000) Mod. Pathol , vol.13 , pp. 180-185
    • Folpe, A.L.1    Veikkola, T.2    Valtola, R.3    Weiss, S.W.4
  • 26
    • 0033593793 scopus 로고    scopus 로고
    • LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
    • Banerji, S.; Ni, J.; Wang, S.X.; Clasper, S.; Su, J.; Tammi, R.; Jones, M.; Jackson, D.G. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol. 1999, 144, 789-801.
    • (1999) J. Cell Biol , vol.144 , pp. 789-801
    • Banerji, S.1    Ni, J.2    Wang, S.X.3    Clasper, S.4    Su, J.5    Tammi, R.6    Jones, M.7    Jackson, D.G.8
  • 27
    • 0035890540 scopus 로고    scopus 로고
    • LYVE-1 is not restricted to the lymph vessels: Expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis
    • Mouta, C.C.; Nasser, S.M.; di Tomaso, E.; Padera, T.P.; Boucher, Y.; Tomarev, S.I.; Jain, R.K. LYVE-1 is not restricted to the lymph vessels: Expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 2001, 61, 8079-8084.
    • (2001) Cancer Res , vol.61 , pp. 8079-8084
    • Mouta, C.C.1    Nasser, S.M.2    di Tomaso, E.3    Padera, T.P.4    Boucher, Y.5    Tomarev, S.I.6    Jain, R.K.7
  • 28
    • 33646008309 scopus 로고    scopus 로고
    • Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: Implications for the assessment of lymphangiogenesis
    • Schledzewski, K.; Falkowski, M.; Moldenhauer, G.; Metharom, P.; Kzhyshkowska, J.; Ganss, R.; Demory, A.; Falkowska-Hansen, B.; Kurzen, H.; Ugurel, S.; et al. Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: Implications for the assessment of lymphangiogenesis. J. Pathol. 2006, 209, 67-77.
    • (2006) J. Pathol , vol.209 , pp. 67-77
    • Schledzewski, K.1    Falkowski, M.2    Moldenhauer, G.3    Metharom, P.4    Kzhyshkowska, J.5    Ganss, R.6    Demory, A.7    Falkowska-Hansen, B.8    Kurzen, H.9    Ugurel, S.10
  • 30
    • 84857728639 scopus 로고    scopus 로고
    • New model of macrophage acquisition of the lymphatic endothelial phenotype
    • Hall, K.L.; Volk-Draper, L.D.; Flister, M.J.; Ran, S. New model of macrophage acquisition of the lymphatic endothelial phenotype. PLoS ONE 2012, 7, e31794.
    • (2012) PLoS ONE , vol.7
    • Hall, K.L.1    Volk-Draper, L.D.2    Flister, M.J.3    Ran, S.4
  • 31
    • 79551647277 scopus 로고    scopus 로고
    • Characterization of Prox1 and VEGFR-3 expression and lymphatic phenotype in normal organs of mice lacking p50 subunit of NF-kappaB
    • Flister, M.J.; Volk, L.D.; Ran, S. Characterization of Prox1 and VEGFR-3 expression and lymphatic phenotype in normal organs of mice lacking p50 subunit of NF-kappaB. Microcirculation 2011, 18, 85-101.
    • (2011) Microcirculation , vol.18 , pp. 85-101
    • Flister, M.J.1    Volk, L.D.2    Ran, S.3
  • 34
    • 14244269759 scopus 로고    scopus 로고
    • The lymphangiogenic vascular endothelial growth factors VEGF-C and-D are ligands for the integrin alpha9beta1
    • Vlahakis, N.E.; Young, B.A.; Atakilit, A.; Sheppard, D. The lymphangiogenic vascular endothelial growth factors VEGF-C and-D are ligands for the integrin alpha9beta1. J. Biol. Chem. 2005, 280, 4544-4552.
    • (2005) J. Biol. Chem , vol.280 , pp. 4544-4552
    • Vlahakis, N.E.1    Young, B.A.2    Atakilit, A.3    Sheppard, D.4
  • 35
    • 0027520443 scopus 로고
    • Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle
    • Palmer, E.L.; Ruegg, C.; Ferrando, R.; Pytela, R.; Sheppard, D. Sequence and tissue distribution of the integrin alpha 9 subunit, a novel partner of beta 1 that is widely distributed in epithelia and muscle. J. Cell Biol. 1993, 123, 1289-1297.
    • (1993) J. Cell Biol , vol.123 , pp. 1289-1297
    • Palmer, E.L.1    Ruegg, C.2    Ferrando, R.3    Pytela, R.4    Sheppard, D.5
  • 36
    • 0342872023 scopus 로고    scopus 로고
    • Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III
    • Chen, H.; Chedotal, A.; He, Z.; Goodman, C.S.; Tessier-Lavigne, M. Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron 1997, 19, 547-559.
    • (1997) Neuron , vol.19 , pp. 547-559
    • Chen, H.1    Chedotal, A.2    He, Z.3    Goodman, C.S.4    Tessier-Lavigne, M.5
  • 40
    • 44449176022 scopus 로고    scopus 로고
    • Animal models for the molecular and mechanistic study of lymphatic biology and disease
    • Shin, W.S.; Rockson, S.G. Animal models for the molecular and mechanistic study of lymphatic biology and disease. Ann. NY Acad. Sci. 2008, 1131, 50-74.
    • (2008) Ann. NY Acad. Sci , vol.1131 , pp. 50-74
    • Shin, W.S.1    Rockson, S.G.2
  • 41
    • 74349115339 scopus 로고    scopus 로고
    • Endothelial cell plasticity: How to become and remain a lymphatic endothelial cell
    • Oliver, G.; Srinivasan, R.S. Endothelial cell plasticity: How to become and remain a lymphatic endothelial cell. Development 2010, 137, 363-372.
    • (2010) Development , vol.137 , pp. 363-372
    • Oliver, G.1    Srinivasan, R.S.2
  • 42
    • 84866949090 scopus 로고    scopus 로고
    • The new era of the lymphatic system: No longer secondary to the blood vascular system
    • Choi, I.; Lee, S.; Hong, Y.K. The new era of the lymphatic system: No longer secondary to the blood vascular system. Cold Spring Harb. Perspect. Med. 2012, 2, a006445.
    • (2012) Cold Spring Harb. Perspect. Med , vol.2
    • Choi, I.1    Lee, S.2    Hong, Y.K.3
  • 44
    • 77950469880 scopus 로고    scopus 로고
    • The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells
    • Srinivasan, R.S.; Geng, X.; Yang, Y.; Wang, Y.; Mukatira, S.; Studer, M.; Porto, M.P.; Lagutin, O.; Oliver, G. The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. Genes Dev. 2010, 24, 696-707.
    • (2010) Genes Dev , vol.24 , pp. 696-707
    • Srinivasan, R.S.1    Geng, X.2    Yang, Y.3    Wang, Y.4    Mukatira, S.5    Studer, M.6    Porto, M.P.7    Lagutin, O.8    Oliver, G.9
  • 46
    • 0036840138 scopus 로고    scopus 로고
    • Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate
    • Hong, Y.K.; Harvey, N.; Noh, Y.H.; Schacht, V.; Hirakawa, S.; Detmar, M.; Oliver, G. Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate. Dev. Dyn. 2002, 225, 351-357.
    • (2002) Dev. Dyn , vol.225 , pp. 351-357
    • Hong, Y.K.1    Harvey, N.2    Noh, Y.H.3    Schacht, V.4    Hirakawa, S.5    Detmar, M.6    Oliver, G.7
  • 48
    • 0034796103 scopus 로고    scopus 로고
    • Endogenous origin of the lymphatics in the avian chorioallantoic membrane
    • Papoutsi, M.; Tomarev, S.I.; Eichmann, A.; Prols, F.; Christ, B.; Wilting, J. Endogenous origin of the lymphatics in the avian chorioallantoic membrane. Dev. Dyn. 2001, 222, 238-251.
    • (2001) Dev. Dyn , vol.222 , pp. 238-251
    • Papoutsi, M.1    Tomarev, S.I.2    Eichmann, A.3    Prols, F.4    Christ, B.5    Wilting, J.6
  • 52
    • 43549094221 scopus 로고    scopus 로고
    • Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics
    • Buttler, K.; Ezaki, T.; Wilting, J. Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics. BMC Dev. Biol. 2008, 8, 43.
    • (2008) BMC Dev. Biol , vol.8 , pp. 43
    • Buttler, K.1    Ezaki, T.2    Wilting, J.3
  • 53
    • 77958482899 scopus 로고    scopus 로고
    • Podoplanin-expressing cells derived from bone marrow play a crucial role in postnatal lymphatic neovascularization
    • Lee, J.Y.; Park, C.; Cho, Y.P.; Lee, E.; Kim, H.; Kim, P.; Yun, S.H.; Yoon, Y.S. Podoplanin-expressing cells derived from bone marrow play a crucial role in postnatal lymphatic neovascularization. Circulation 2010, 122, 1413-1425.
    • (2010) Circulation , vol.122 , pp. 1413-1425
    • Lee, J.Y.1    Park, C.2    Cho, Y.P.3    Lee, E.4    Kim, H.5    Kim, P.6    Yun, S.H.7    Yoon, Y.S.8
  • 55
    • 0042344979 scopus 로고    scopus 로고
    • Lymphatic vessels in the colonic mucosa in ulcerative colitis
    • Kaiserling, E.; Krober, S.; Geleff, S. Lymphatic vessels in the colonic mucosa in ulcerative colitis. Lymphology 2003, 36, 52-61.
    • (2003) Lymphology , vol.36 , pp. 52-61
    • Kaiserling, E.1    Krober, S.2    Geleff, S.3
  • 56
    • 0344407018 scopus 로고    scopus 로고
    • Increase in podoplanin-expressing intestinal lymphatic vessels in inflammatory bowel disease
    • Geleff, S.; Schoppmann, S.F.; Oberhuber, G. Increase in podoplanin-expressing intestinal lymphatic vessels in inflammatory bowel disease. Virchows Arch. 2003, 442, 231-237.
    • (2003) Virchows Arch , vol.442 , pp. 231-237
    • Geleff, S.1    Schoppmann, S.F.2    Oberhuber, G.3
  • 60
    • 77955512358 scopus 로고    scopus 로고
    • Lymphangiogenesis and lymphatic metastasis in breast cancer
    • Ran, S.; Volk, L.; Hall, K.; Flister, M.J. Lymphangiogenesis and lymphatic metastasis in breast cancer. Pathophysiology 2009, 17, 229-251.
    • (2009) Pathophysiology , vol.17 , pp. 229-251
    • Ran, S.1    Volk, L.2    Hall, K.3    Flister, M.J.4
  • 62
    • 0037172970 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea
    • Kubo, H.; Cao, R.; Brakenhielm, E.; Makinen, T.; Cao, Y.; Alitalo, K. Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proc. Natl. Acad. Sci. USA 2002, 99, 8868-8873.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 8868-8873
    • Kubo, H.1    Cao, R.2    Brakenhielm, E.3    Makinen, T.4    Cao, Y.5    Alitalo, K.6
  • 63
    • 65049085803 scopus 로고    scopus 로고
    • Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis
    • Kajiya, K.; Sawane, M.; Huggenberger, R.; Detmar, M. Activation of the VEGFR-3 pathway by VEGF-C attenuates UVB-induced edema formation and skin inflammation by promoting lymphangiogenesis. J. Invest. Dermatol. 2009, 129, 1292-1298.
    • (2009) J. Invest. Dermatol , vol.129 , pp. 1292-1298
    • Kajiya, K.1    Sawane, M.2    Huggenberger, R.3    Detmar, M.4
  • 64
    • 73549105244 scopus 로고    scopus 로고
    • Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm
    • Kim, K.E.; Koh, Y.J.; Jeon, B.H.; Jang, C.; Han, J.; Kataru, R.P.; Schwendener, R.A.; Kim, J.M.; Koh, G.Y. Role of CD11b+ macrophages in intraperitoneal lipopolysaccharide-induced aberrant lymphangiogenesis and lymphatic function in the diaphragm. Am. J. Pathol. 2009, 175, 1733-1745.
    • (2009) Am. J. Pathol , vol.175 , pp. 1733-1745
    • Kim, K.E.1    Koh, Y.J.2    Jeon, B.H.3    Jang, C.4    Han, J.5    Kataru, R.P.6    Schwendener, R.A.7    Kim, J.M.8    Koh, G.Y.9
  • 66
    • 84861645540 scopus 로고    scopus 로고
    • Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation
    • Yao, L.C.; Baluk, P.; Srinivasan, R.S.; Oliver, G.; McDonald, D.M. Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation. Am. J. Pathol. 2012, 180, 2561-2575.
    • (2012) Am. J. Pathol , vol.180 , pp. 2561-2575
    • Yao, L.C.1    Baluk, P.2    Srinivasan, R.S.3    Oliver, G.4    McDonald, D.M.5
  • 67
    • 53949101092 scopus 로고    scopus 로고
    • Lymphangiogenesis induced by VEGF-C and VEGF-D promotes metastasis and a poor outcome in breast carcinoma: A retrospective study of 61 cases
    • Gu, Y.; Qi, X.; Guo, S. Lymphangiogenesis induced by VEGF-C and VEGF-D promotes metastasis and a poor outcome in breast carcinoma: A retrospective study of 61 cases. Clin. Exp. Metastasis 2008, 25, 717-725.
    • (2008) Clin. Exp. Metastasis , vol.25 , pp. 717-725
    • Gu, Y.1    Qi, X.2    Guo, S.3
  • 69
    • 33745298519 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in cancer development and progression
    • Karin, M. Nuclear factor-kappaB in cancer development and progression. Nature 2006, 441, 431-436.
    • (2006) Nature , vol.441 , pp. 431-436
    • Karin, M.1
  • 70
    • 4544228457 scopus 로고    scopus 로고
    • Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology
    • Beinke, S.; Ley, S.C. Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology. Biochem. J. 2004, 382, 393-409.
    • (2004) Biochem. J , vol.382 , pp. 393-409
    • Beinke, S.1    Ley, S.C.2
  • 71
    • 0037442674 scopus 로고    scopus 로고
    • VEGF expression in human macrophages is NF-kappaB-dependent: Studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2
    • Kiriakidis, S.; Andreakos, E.; Monaco, C.; Foxwell, B.; Feldmann, M.; Paleolog, E. VEGF expression in human macrophages is NF-kappaB-dependent: Studies using adenoviruses expressing the endogenous NF-kappaB inhibitor IkappaBalpha and a kinase-defective form of the IkappaB kinase 2. J. Cell Sci. 2003, 116, 665-674.
    • (2003) J. Cell Sci , vol.116 , pp. 665-674
    • Kiriakidis, S.1    Andreakos, E.2    Monaco, C.3    Foxwell, B.4    Feldmann, M.5    Paleolog, E.6
  • 72
    • 0037458645 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway
    • Tsai, P.W.; Shiah, S.G.; Lin, M.T.; Wu, C.W.; Kuo, M.L. Up-regulation of vascular endothelial growth factor C in breast cancer cells by heregulin-beta 1. A critical role of p38/nuclear factor-kappa B signaling pathway. J. Biol. Chem. 2003, 278, 5750-5759.
    • (2003) J. Biol. Chem , vol.278 , pp. 5750-5759
    • Tsai, P.W.1    Shiah, S.G.2    Lin, M.T.3    Wu, C.W.4    Kuo, M.L.5
  • 73
    • 2642641324 scopus 로고    scopus 로고
    • Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C
    • Ristimaki, A.; Narko, K.; Enholm, B.; Joukov, V.; Alitalo, K. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. J. Biol. Chem. 1998, 273, 8413-8418.
    • (1998) J. Biol. Chem , vol.273 , pp. 8413-8418
    • Ristimaki, A.1    Narko, K.2    Enholm, B.3    Joukov, V.4    Alitalo, K.5
  • 75
    • 33645046619 scopus 로고    scopus 로고
    • Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2
    • Roberts, N.; Kloos, B.; Cassella, M.; Podgrabinska, S.; Persaud, K.; Wu, Y.; Pytowski, B.; Skobe, M. Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. Cancer Res. 2006, 66, 2650-2657.
    • (2006) Cancer Res , vol.66 , pp. 2650-2657
    • Roberts, N.1    Kloos, B.2    Cassella, M.3    Podgrabinska, S.4    Persaud, K.5    Wu, Y.6    Pytowski, B.7    Skobe, M.8
  • 77
    • 1342284184 scopus 로고    scopus 로고
    • Comparative expression of vascular endothelial growth factor family members, VEGF-B,-C and-D, by normal human keratinocytes and fibroblasts
    • Trompezinski, S.; Berthier-Vergnes, O.; Denis, A.; Schmitt, D.; Viac, J. Comparative expression of vascular endothelial growth factor family members, VEGF-B,-C and-D, by normal human keratinocytes and fibroblasts. Exp. Dermatol. 2004, 13, 98-105.
    • (2004) Exp. Dermatol , vol.13 , pp. 98-105
    • Trompezinski, S.1    Berthier-Vergnes, O.2    Denis, A.3    Schmitt, D.4    Viac, J.5
  • 78
    • 0002606253 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system in cancer: Implications for tumor angiogenesis and metastasis
    • Mazar, A.P.; Henkin, J.; Goldfarb, R.H. The urokinase plasminogen activator system in cancer: Implications for tumor angiogenesis and metastasis. Angiogenesis 1999, 3, 15-32.
    • (1999) Angiogenesis , vol.3 , pp. 15-32
    • Mazar, A.P.1    Henkin, J.2    Goldfarb, R.H.3
  • 80
    • 77955510391 scopus 로고    scopus 로고
    • VEGF-mediated signal transduction in lymphatic endothelial cells
    • Bahram, F.; Claesson-Welsh, L. VEGF-mediated signal transduction in lymphatic endothelial cells. Pathophysiology. 2010, 17, 253-261.
    • (2010) Pathophysiology , vol.17 , pp. 253-261
    • Bahram, F.1    Claesson-Welsh, L.2
  • 83
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak, H.F. Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J. Clin. Oncol. 2002, 20, 4368-4380.
    • (2002) J. Clin. Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 84
    • 2942590261 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a target for anticancer therapy
    • Ferrara, N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 2004, 9, 2-10.
    • (2004) Oncologist , vol.9 , pp. 2-10
    • Ferrara, N.1
  • 85
    • 0027980960 scopus 로고
    • Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis
    • Detmar, M.; Brown, L.F.; Claffey, K.P.; Yeo, K.T.; Kocher, O.; Jackman, R.W.; Berse, B.; Dvorak, H.F. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J. Exp. Med. 1994, 180, 1141-1146.
    • (1994) J. Exp. Med , vol.180 , pp. 1141-1146
    • Detmar, M.1    Brown, L.F.2    Claffey, K.P.3    Yeo, K.T.4    Kocher, O.5    Jackman, R.W.6    Berse, B.7    Dvorak, H.F.8
  • 86
    • 0028216495 scopus 로고
    • Vascular permeability factor/endothelial growth factor (VPF/VEGF): Accumulation and expression in human synovial fluids and rheumatoid synovial tissue
    • Fava, R.A.; Olsen, N.J.; Spencer-Green, G.; Yeo, K.T.; Yeo, T.K.; Berse, B.; Jackman, R.W.; Senger, D.R.; Dvorak, H.F.; Brown, L.F. Vascular permeability factor/endothelial growth factor (VPF/VEGF): Accumulation and expression in human synovial fluids and rheumatoid synovial tissue. J. Exp. Med. 1994, 180, 341-346.
    • (1994) J. Exp. Med , vol.180 , pp. 341-346
    • Fava, R.A.1    Olsen, N.J.2    Spencer-Green, G.3    Yeo, K.T.4    Yeo, T.K.5    Berse, B.6    Jackman, R.W.7    Senger, D.R.8    Dvorak, H.F.9    Brown, L.F.10
  • 87
    • 0035072493 scopus 로고    scopus 로고
    • VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: A novel mechanism of chronic intestinal inflammation
    • Kanazawa, S.; Tsunoda, T.; Onuma, E.; Majima, T.; Kagiyama, M.; Kikuchi, K. VEGF, basic-FGF, and TGF-beta in Crohn's disease and ulcerative colitis: A novel mechanism of chronic intestinal inflammation. Am. J. Gastroenterol. 2001, 96, 822-828.
    • (2001) Am. J. Gastroenterol , vol.96 , pp. 822-828
    • Kanazawa, S.1    Tsunoda, T.2    Onuma, E.3    Majima, T.4    Kagiyama, M.5    Kikuchi, K.6
  • 88
    • 7044260315 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    • Lee, C.G.; Link, H.; Baluk, P.; Homer, R.J.; Chapoval, S.; Bhandari, V.; Kang, M.J.; Cohn, L.; Kim, Y.K.; McDonald, D.M.; et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat. Med. 2004, 10, 1095-1103.
    • (2004) Nat. Med , vol.10 , pp. 1095-1103
    • Lee, C.G.1    Link, H.2    Baluk, P.3    Homer, R.J.4    Chapoval, S.5    Bhandari, V.6    Kang, M.J.7    Cohn, L.8    Kim, Y.K.9    McDonald, D.M.10
  • 93
    • 17144402207 scopus 로고    scopus 로고
    • VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    • Hirakawa, S.; Kodama, S.; Kunstfeld, R.; Kajiya, K.; Brown, L.F.; Detmar, M. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J. Exp. Med. 2005, 201, 1089-1099.
    • (2005) J. Exp. Med , vol.201 , pp. 1089-1099
    • Hirakawa, S.1    Kodama, S.2    Kunstfeld, R.3    Kajiya, K.4    Brown, L.F.5    Detmar, M.6
  • 94
    • 27144524895 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis
    • Bjorndahl, M.A.; Cao, R.; Burton, J.B.; Brakenhielm, E.; Religa, P.; Galter, D.; Wu, L.; Cao, Y. Vascular endothelial growth factor-a promotes peritumoral lymphangiogenesis and lymphatic metastasis. Cancer Res. 2005, 65, 9261-9268.
    • (2005) Cancer Res , vol.65 , pp. 9261-9268
    • Bjorndahl, M.A.1    Cao, R.2    Burton, J.B.3    Brakenhielm, E.4    Religa, P.5    Galter, D.6    Wu, L.7    Cao, Y.8
  • 97
    • 0035254646 scopus 로고    scopus 로고
    • Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans
    • Sawano, A.; Iwai, S.; Sakurai, Y.; Ito, M.; Shitara, K.; Nakahata, T.; Shibuya, M. Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood 2001, 97, 785-791.
    • (2001) Blood , vol.97 , pp. 785-791
    • Sawano, A.1    Iwai, S.2    Sakurai, Y.3    Ito, M.4    Shitara, K.5    Nakahata, T.6    Shibuya, M.7
  • 99
    • 77951227230 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by the local environment
    • Hall, K.; Ran, S. Regulation of tumor angiogenesis by the local environment. Front. Biosci. 2010, 15, 195-212.
    • (2010) Front. Biosci , vol.15 , pp. 195-212
    • Hall, K.1    Ran, S.2
  • 103
    • 18644382318 scopus 로고    scopus 로고
    • Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1
    • Gale, N.W.; Thurston, G.; Hackett, S.F.; Renard, R.; Wang, Q.; McClain, J.; Martin, C.; Witte, C.; Witte, M.H.; Jackson, D.; et al. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev. Cell 2002, 3, 411-423.
    • (2002) Dev. Cell , vol.3 , pp. 411-423
    • Gale, N.W.1    Thurston, G.2    Hackett, S.F.3    Renard, R.4    Wang, Q.5    McClain, J.6    Martin, C.7    Witte, C.8    Witte, M.H.9    Jackson, D.10
  • 104
    • 46049111407 scopus 로고    scopus 로고
    • Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice
    • Dellinger, M.; Hunter, R.; Bernas, M.; Gale, N.; Yancopoulos, G.; Erickson, R.; Witte, M. Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice. Dev. Biol. 2008, 319, 309-320.
    • (2008) Dev. Biol , vol.319 , pp. 309-320
    • Dellinger, M.1    Hunter, R.2    Bernas, M.3    Gale, N.4    Yancopoulos, G.5    Erickson, R.6    Witte, M.7
  • 106
    • 77954369555 scopus 로고    scopus 로고
    • Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions
    • Coffelt, S.B.; Tal, A.O.; Scholz, A.; de Palma, M.; Patel, S.; Urbich, C.; Biswas, S.K.; Murdoch, C.; Plate, K.H.; Reiss, Y.; et al. Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions. Cancer Res. 2010, 70, 5270-5280.
    • (2010) Cancer Res , vol.70 , pp. 5270-5280
    • Coffelt, S.B.1    Tal, A.O.2    Scholz, A.3    de Palma, M.4    Patel, S.5    Urbich, C.6    Biswas, S.K.7    Murdoch, C.8    Plate, K.H.9    Reiss, Y.10
  • 107
    • 24344451690 scopus 로고    scopus 로고
    • The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells
    • Al Rawi, M.A.; Watkins, G.; Mansel, R.E.; Jiang, W.G. The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells. Int. J. Oncol. 2005, 27, 721-730.
    • (2005) Int. J. Oncol , vol.27 , pp. 721-730
    • Al Rawi, M.A.1    Watkins, G.2    Mansel, R.E.3    Jiang, W.G.4
  • 108
    • 15944366221 scopus 로고    scopus 로고
    • Interleukin 7 upregulates vascular endothelial growth factor D in breast cancer cells and induces lymphangiogenesis in vivo
    • Al-Rawi, M.A.; Watkins, G.; Mansel, R.E.; Jiang, W.G. Interleukin 7 upregulates vascular endothelial growth factor D in breast cancer cells and induces lymphangiogenesis in vivo. Br. J. Surg. 2005, 92, 305-310.
    • (2005) Br. J. Surg , vol.92 , pp. 305-310
    • Al-Rawi, M.A.1    Watkins, G.2    Mansel, R.E.3    Jiang, W.G.4
  • 109
    • 0037789421 scopus 로고    scopus 로고
    • Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours
    • Al-Rawi, M.A.; Mansel, R.E.; Jiang, W.G. Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours. Histol. Histopathol. 2003, 18, 911-923.
    • (2003) Histol. Histopathol , vol.18 , pp. 911-923
    • Al-Rawi, M.A.1    Mansel, R.E.2    Jiang, W.G.3
  • 112
    • 33646407806 scopus 로고    scopus 로고
    • Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action
    • Cao, R.; Bjorndahl, M.A.; Gallego, M.I.; Chen, S.; Religa, P.; Hansen, A.J.; Cao, Y. Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Blood 2006, 107, 3531-3536.
    • (2006) Blood , vol.107 , pp. 3531-3536
    • Cao, R.1    Bjorndahl, M.A.2    Gallego, M.I.3    Chen, S.4    Religa, P.5    Hansen, A.J.6    Cao, Y.7
  • 114
    • 33846333812 scopus 로고    scopus 로고
    • Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor
    • Backhed, F.; Crawford, P.A.; O'Donnell, D.; Gordon, J.I. Postnatal lymphatic partitioning from the blood vasculature in the small intestine requires fasting-induced adipose factor. Proc. Natl. Acad. Sci. USA 2007, 104, 606-611.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 606-611
    • Backhed, F.1    Crawford, P.A.2    O'Donnell, D.3    Gordon, J.I.4
  • 115
    • 51649099579 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways
    • Yoon, C.M.; Hong, B.S.; Moon, H.G.; Lim, S.; Suh, P.G.; Kim, Y.K.; Chae, C.B.; Gho, Y.S. Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. Blood 2008, 112, 1129-1138.
    • (2008) Blood , vol.112 , pp. 1129-1138
    • Yoon, C.M.1    Hong, B.S.2    Moon, H.G.3    Lim, S.4    Suh, P.G.5    Kim, Y.K.6    Chae, C.B.7    Gho, Y.S.8
  • 116
    • 33646163924 scopus 로고    scopus 로고
    • COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer
    • Timoshenko, A.V.; Chakraborty, C.; Wagner, G.F.; Lala, P.K. COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer. Br. J. Cancer 2006, 94, 1154-1163.
    • (2006) Br. J. Cancer , vol.94 , pp. 1154-1163
    • Timoshenko, A.V.1    Chakraborty, C.2    Wagner, G.F.3    Lala, P.K.4
  • 117
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill, F.; Charles, K.A.; Mantovani, A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005, 7, 211-217.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 118
    • 77950346282 scopus 로고    scopus 로고
    • Immunity, inflammation, and cancer
    • Grivennikov, S.I.; Greten, F.R.; Karin, M. Immunity, inflammation, and cancer. Cell 2010, 140, 883-899.
    • (2010) Cell , vol.140 , pp. 883-899
    • Grivennikov, S.I.1    Greten, F.R.2    Karin, M.3
  • 120
    • 34347231274 scopus 로고    scopus 로고
    • Macrophages and the hypoxic tumour microenvironment
    • Knowles, H.J.; Harris, A.L. Macrophages and the hypoxic tumour microenvironment. Front. Biosci. 2007, 12, 4298-4314.
    • (2007) Front. Biosci , vol.12 , pp. 4298-4314
    • Knowles, H.J.1    Harris, A.L.2
  • 121
    • 0033067163 scopus 로고    scopus 로고
    • Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast
    • Leek, R.D.; Landers, R.J.; Harris, A.L.; Lewis, C.E. Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br. J. Cancer 1999, 79, 991-995.
    • (1999) Br. J. Cancer , vol.79 , pp. 991-995
    • Leek, R.D.1    Landers, R.J.2    Harris, A.L.3    Lewis, C.E.4
  • 122
    • 0024421675 scopus 로고
    • Leaky vessels, fibrin deposition, and fibrosis: A sequence of events common to solid tumors and to many other types of disease
    • Brown, L.F.; Dvorak, A.M.; Dvorak, H.F. Leaky vessels, fibrin deposition, and fibrosis: A sequence of events common to solid tumors and to many other types of disease. Am. Rev. Respir. Dis. 1989, 140, 1104-1107.
    • (1989) Am. Rev. Respir. Dis , vol.140 , pp. 1104-1107
    • Brown, L.F.1    Dvorak, A.M.2    Dvorak, H.F.3
  • 123
    • 25844459154 scopus 로고    scopus 로고
    • NF-kappaB: Linking inflammation and immunity to cancer development and progression
    • Karin, M.; Greten, F.R. NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005, 5, 749-759.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 125
    • 40049088602 scopus 로고    scopus 로고
    • The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages
    • Allavena, P.; Sica, A.; Solinas, G.; Porta, C.; Mantovani, A. The inflammatory micro-environment in tumor progression: The role of tumor-associated macrophages. Crit Rev. Oncol. Hematol. 2008, 66, 1-9.
    • (2008) Crit Rev. Oncol. Hematol , vol.66 , pp. 1-9
    • Allavena, P.1    Sica, A.2    Solinas, G.3    Porta, C.4    Mantovani, A.5
  • 126
    • 36148960830 scopus 로고    scopus 로고
    • Inflammatory cell infiltration of tumors: Jekyll or Hyde
    • Talmadge, J.E.; Donkor, M.; Scholar, E. Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Rev. 2007, 26, 373-400.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 373-400
    • Talmadge, J.E.1    Donkor, M.2    Scholar, E.3
  • 127
    • 46049109335 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis and melanoma metastasis
    • Rinderknecht, M.; Detmar, M. Tumor lymphangiogenesis and melanoma metastasis. J. Cell Physiol. 2008, 216, 347-354.
    • (2008) J. Cell Physiol , vol.216 , pp. 347-354
    • Rinderknecht, M.1    Detmar, M.2
  • 128
    • 34447099001 scopus 로고    scopus 로고
    • Axillary lymph node micrometastases in invasive breast cancer: National figures on incidence and overall survival
    • Grabau, D.; Jensen, M.B.; Rank, F.; Blichert-Toft, M. Axillary lymph node micrometastases in invasive breast cancer: National figures on incidence and overall survival. APMIS 2007, 115, 828-837.
    • (2007) APMIS , vol.115 , pp. 828-837
    • Grabau, D.1    Jensen, M.B.2    Rank, F.3    Blichert-Toft, M.4
  • 129
    • 33744548905 scopus 로고    scopus 로고
    • Node-related factors and survival in node-positive breast carcinomas
    • Sivridis, E.; Giatromanolaki, A.; Galazios, G.; Koukourakis, M.I. Node-related factors and survival in node-positive breast carcinomas. Breast 2006, 15, 382-389.
    • (2006) Breast , vol.15 , pp. 382-389
    • Sivridis, E.1    Giatromanolaki, A.2    Galazios, G.3    Koukourakis, M.I.4
  • 131
    • 12744274533 scopus 로고    scopus 로고
    • Predicting the status of axillary sentinel lymph nodes in 4351 patients with invasive breast carcinoma treated in a single institution
    • Viale, G.; Zurrida, S.; Maiorano, E.; Mazzarol, G.; Pruneri, G.; Paganelli, G.; Maisonneuve, P.; Veronesi, U. Predicting the status of axillary sentinel lymph nodes in 4351 patients with invasive breast carcinoma treated in a single institution. Cancer 2005, 103, 492-500.
    • (2005) Cancer , vol.103 , pp. 492-500
    • Viale, G.1    Zurrida, S.2    Maiorano, E.3    Mazzarol, G.4    Pruneri, G.5    Paganelli, G.6    Maisonneuve, P.7    Veronesi, U.8
  • 132
    • 48449106054 scopus 로고    scopus 로고
    • The number of positive nodes and the ratio of positive to excised nodes are significant predictors of survival in women with micrometastatic node-positive breast cancer
    • Truong, P.T.; Vinh-Hung, V.; Cserni, G.; Woodward, W.A.; Tai, P.; Vlastos, G. The number of positive nodes and the ratio of positive to excised nodes are significant predictors of survival in women with micrometastatic node-positive breast cancer. Eur. J. Cancer 2008, 44, 1670-1677.
    • (2008) Eur. J. Cancer , vol.44 , pp. 1670-1677
    • Truong, P.T.1    Vinh-Hung, V.2    Cserni, G.3    Woodward, W.A.4    Tai, P.5    Vlastos, G.6
  • 133
    • 0036803355 scopus 로고    scopus 로고
    • Lymph node status combined with lymphovascular invasion creates a more powerful tool for predicting outcome in patients with invasive breast cancer
    • Woo, C.S.; Silberman, H.; Nakamura, S.K.; Ye, W.; Sposto, R.; Colburn, W.; Waisman, J.R.; Silverstein, M.J. Lymph node status combined with lymphovascular invasion creates a more powerful tool for predicting outcome in patients with invasive breast cancer. Am. J. Surg. 2002, 184, 337-340.
    • (2002) Am. J. Surg , vol.184 , pp. 337-340
    • Woo, C.S.1    Silberman, H.2    Nakamura, S.K.3    Ye, W.4    Sposto, R.5    Colburn, W.6    Waisman, J.R.7    Silverstein, M.J.8
  • 135
    • 0037140120 scopus 로고    scopus 로고
    • VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors
    • Mattila, M.M.; Ruohola, J.K.; Karpanen, T.; Jackson, D.G.; Alitalo, K.; Harkonen, P.L. VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors. Int. J. Cancer 2002, 98, 946-951.
    • (2002) Int. J. Cancer , vol.98 , pp. 946-951
    • Mattila, M.M.1    Ruohola, J.K.2    Karpanen, T.3    Jackson, D.G.4    Alitalo, K.5    Harkonen, P.L.6
  • 136
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
    • He, Y.; Kozaki, K.; Karpanen, T.; Koshikawa, K.; Yla-Herttuala, S.; Takahashi, T.; Alitalo, K. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J. Natl. Cancer Inst. 2002, 94, 819-825.
    • (2002) J. Natl. Cancer Inst , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3    Koshikawa, K.4    Yla-Herttuala, S.5    Takahashi, T.6    Alitalo, K.7
  • 137
    • 54249140119 scopus 로고    scopus 로고
    • Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis
    • Burton, J.B.; Priceman, S.J.; Sung, J.L.; Brakenhielm, E.; An, D.S.; Pytowski, B.; Alitalo, K.; Wu, L. Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. Cancer Res. 2008, 68, 7828-7837.
    • (2008) Cancer Res , vol.68 , pp. 7828-7837
    • Burton, J.B.1    Priceman, S.J.2    Sung, J.L.3    Brakenhielm, E.4    An, D.S.5    Pytowski, B.6    Alitalo, K.7    Wu, L.8
  • 138
    • 33748075460 scopus 로고    scopus 로고
    • Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: Therapeutic implications
    • Hoshida, T.; Isaka, N.; Hagendoorn, J.; di Tomaso, E.; Chen, Y.L.; Pytowski, B.; Fukumura, D.; Padera, T.P.; Jain, R.K. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: Therapeutic implications. Cancer Res. 2006, 66, 8065-8075.
    • (2006) Cancer Res , vol.66 , pp. 8065-8075
    • Hoshida, T.1    Isaka, N.2    Hagendoorn, J.3    di Tomaso, E.4    Chen, Y.L.5    Pytowski, B.6    Fukumura, D.7    Padera, T.P.8    Jain, R.K.9
  • 140
    • 13444259521 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C promotes lymph node metastasis in a rectal cancer orthotopic model
    • Kawakami, M.; Yanai, Y.; Hata, F.; Hirata, K. Vascular endothelial growth factor C promotes lymph node metastasis in a rectal cancer orthotopic model. Surg. Today 2005, 35, 131-138.
    • (2005) Surg. Today , vol.35 , pp. 131-138
    • Kawakami, M.1    Yanai, Y.2    Hata, F.3    Hirata, K.4
  • 142
    • 25444489567 scopus 로고    scopus 로고
    • Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival
    • Chen, Z.; Varney, M.L.; Backora, M.W.; Cowan, K.; Solheim, J.C.; Talmadge, J.E.; Singh, R.K. Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival. Cancer Res. 2005, 65, 9004-9011.
    • (2005) Cancer Res , vol.65 , pp. 9004-9011
    • Chen, Z.1    Varney, M.L.2    Backora, M.W.3    Cowan, K.4    Solheim, J.C.5    Talmadge, J.E.6    Singh, R.K.7
  • 143
    • 27544483545 scopus 로고    scopus 로고
    • Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis
    • Wong, S.Y.; Haack, H.; Crowley, D.; Barry, M.; Bronson, R.T.; Hynes, R.O. Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Res. 2005, 65, 9789-9798.
    • (2005) Cancer Res , vol.65 , pp. 9789-9798
    • Wong, S.Y.1    Haack, H.2    Crowley, D.3    Barry, M.4    Bronson, R.T.5    Hynes, R.O.6
  • 144
    • 56049097901 scopus 로고    scopus 로고
    • Combination therapy with short interfering RNA vectors against VEGF-C and VEGF-A suppresses lymph node and lung metastasis in a mouse immunocompetent mammary cancer model
    • Shibata, M.A.; Morimoto, J.; Shibata, E.; Otsuki, Y. Combination therapy with short interfering RNA vectors against VEGF-C and VEGF-A suppresses lymph node and lung metastasis in a mouse immunocompetent mammary cancer model. Cancer Gene Ther. 2008, 15, 776-786.
    • (2008) Cancer Gene Ther , vol.15 , pp. 776-786
    • Shibata, M.A.1    Morimoto, J.2    Shibata, E.3    Otsuki, Y.4
  • 148
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis
    • Condeelis, J.; Pollard, J.W. Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006, 124, 263-266.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 150
    • 0032820711 scopus 로고    scopus 로고
    • Proteolysis and cell migration: Creating a path?
    • Murphy, G.; Gavrilovic, J. Proteolysis and cell migration: Creating a path? Curr. Opin. Cell Biol. 1999, 11, 614-621.
    • (1999) Curr. Opin. Cell Biol , vol.11 , pp. 614-621
    • Murphy, G.1    Gavrilovic, J.2
  • 151
    • 0042424548 scopus 로고    scopus 로고
    • Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells
    • Rolli, M.; Fransvea, E.; Pilch, J.; Saven, A.; Felding-Habermann, B. Activated integrin alphavbeta3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells. Proc. Natl. Acad. Sci. USA 2003, 100, 9482-9487.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9482-9487
    • Rolli, M.1    Fransvea, E.2    Pilch, J.3    Saven, A.4    Felding-Habermann, B.5
  • 152
    • 16644369738 scopus 로고    scopus 로고
    • Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells
    • Jadhav, U.; Chigurupati, S.; Lakka, S.S.; Mohanam, S. Inhibition of matrix metalloproteinase-9 reduces in vitro invasion and angiogenesis in human microvascular endothelial cells. Int. J. Oncol. 2004, 25, 1407-1414.
    • (2004) Int. J. Oncol , vol.25 , pp. 1407-1414
    • Jadhav, U.1    Chigurupati, S.2    Lakka, S.S.3    Mohanam, S.4
  • 153
    • 77952099582 scopus 로고    scopus 로고
    • Involvement of endothelial progenitor cells in tumor vascularization
    • Patenaude, A.; Parker, J.; Karsan, A. Involvement of endothelial progenitor cells in tumor vascularization. Microvasc. Res. 2010, 79, 217-223.
    • (2010) Microvasc. Res , vol.79 , pp. 217-223
    • Patenaude, A.1    Parker, J.2    Karsan, A.3
  • 154
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon, S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3, 23-35.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 155
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas, G.; Germano, G.; Mantovani, A.; Allavena, P. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol. 2009, 86, 1065-1073.
    • (2009) J. Leukoc. Biol , vol.86 , pp. 1065-1073
    • Solinas, G.1    Germano, G.2    Mantovani, A.3    Allavena, P.4
  • 156
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani, A.; Sica, A.; Sozzani, S.; Allavena, P.; Vecchi, A.; Locati, M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25, 677-686.
    • (2004) Trends Immunol , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 157
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce, J.A.; Pollard, J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 2009, 9, 239-252.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 158
    • 39449096958 scopus 로고    scopus 로고
    • Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer
    • Jeon, B.H.; Jang, C.; Han, J.; Kataru, R.P.; Piao, L.; Jung, K.; Cha, H.J.; Schwendener, R.A.; Jang, K.Y.; Kim, K.S.; et al. Profound but dysfunctional lymphangiogenesis via vascular endothelial growth factor ligands from CD11b+ macrophages in advanced ovarian cancer. Cancer Res. 2008, 68, 1100-1109.
    • (2008) Cancer Res , vol.68 , pp. 1100-1109
    • Jeon, B.H.1    Jang, C.2    Han, J.3    Kataru, R.P.4    Piao, L.5    Jung, K.6    Cha, H.J.7    Schwendener, R.A.8    Jang, K.Y.9    Kim, K.S.10
  • 159
    • 36148936760 scopus 로고    scopus 로고
    • VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes
    • Halin, C.; Tobler, N.E.; Vigl, B.; Brown, L.F.; Detmar, M. VEGF-A produced by chronically inflamed tissue induces lymphangiogenesis in draining lymph nodes. Blood 2007, 110, 3158-3167.
    • (2007) Blood , vol.110 , pp. 3158-3167
    • Halin, C.1    Tobler, N.E.2    Vigl, B.3    Brown, L.F.4    Detmar, M.5
  • 161
    • 0031905861 scopus 로고    scopus 로고
    • Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
    • Achen, M.G.; Jeltsch, M.; Kukk, E.; Makinen, T.; Vitali, A.; Wilks, A.F.; Alitalo, K.; Stacker, S.A. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). Proc. Natl. Acad. Sci. USA 1998, 95, 548-553.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 548-553
    • Achen, M.G.1    Jeltsch, M.2    Kukk, E.3    Makinen, T.4    Vitali, A.5    Wilks, A.F.6    Alitalo, K.7    Stacker, S.A.8
  • 162
    • 33744992723 scopus 로고    scopus 로고
    • Possible predictive markers related to micro-metastasis in breast cancer patients
    • Zhu, L.; Loo, W.T.; Cheng, C.W.; Chow, L.W. Possible predictive markers related to micro-metastasis in breast cancer patients. Oncol. Rep. 2006, 15, 1217-1223.
    • (2006) Oncol. Rep , vol.15 , pp. 1217-1223
    • Zhu, L.1    Loo, W.T.2    Cheng, C.W.3    Chow, L.W.4
  • 163
    • 82555205503 scopus 로고    scopus 로고
    • Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner
    • Chen, P.; Huang, Y.; Bong, R.; Ding, Y.; Song, N.; Wang, X.; Song, X.; Luo, Y. Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner. Clin. Cancer Res. 2011, 17, 7230-7239.
    • (2011) Clin. Cancer Res , vol.17 , pp. 7230-7239
    • Chen, P.1    Huang, Y.2    Bong, R.3    Ding, Y.4    Song, N.5    Wang, X.6    Song, X.7    Luo, Y.8
  • 164
    • 38149064606 scopus 로고    scopus 로고
    • Adrenomedullin signaling is necessary for murine lymphatic vascular development
    • Fritz-Six, K.L.; Dunworth, W.P.; Li, M.; Caron, K.M. Adrenomedullin signaling is necessary for murine lymphatic vascular development. J. Clin. Invest. 2008, 118, 40-50.
    • (2008) J. Clin. Invest , vol.118 , pp. 40-50
    • Fritz-Six, K.L.1    Dunworth, W.P.2    Li, M.3    Caron, K.M.4
  • 166
    • 30544452034 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes lymphatic vessel formation and function
    • Kajiya, K.; Hirakawa, S.; Ma, B.; Drinnenberg, I.; Detmar, M. Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J. 2005, 24, 2885-2895.
    • (2005) EMBO J , vol.24 , pp. 2885-2895
    • Kajiya, K.1    Hirakawa, S.2    Ma, B.3    Drinnenberg, I.4    Detmar, M.5
  • 168
    • 0038010530 scopus 로고    scopus 로고
    • Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma
    • Denkert, C.; Winzer, K.J.; Muller, B.M.; Weichert, W.; Pest, S.; Kobel, M.; Kristiansen, G.; Reles, A.; Siegert, A.; Guski, H.; et al. Elevated expression of cyclooxygenase-2 is a negative prognostic factor for disease free survival and overall survival in patients with breast carcinoma. Cancer 2003, 97, 2978-2987.
    • (2003) Cancer , vol.97 , pp. 2978-2987
    • Denkert, C.1    Winzer, K.J.2    Muller, B.M.3    Weichert, W.4    Pest, S.5    Kobel, M.6    Kristiansen, G.7    Reles, A.8    Siegert, A.9    Guski, H.10
  • 169
    • 0028080215 scopus 로고
    • Cytokine networks in solid human tumors: Regulation of angiogenesis
    • Leek, R.D.; Harris, A.L.; Lewis, C.E. Cytokine networks in solid human tumors: Regulation of angiogenesis. J. Leukoc. Biol. 1994, 56, 423-435.
    • (1994) J. Leukoc. Biol , vol.56 , pp. 423-435
    • Leek, R.D.1    Harris, A.L.2    Lewis, C.E.3
  • 171
    • 33646011249 scopus 로고    scopus 로고
    • The intratumoral microvessel density and expression of bFGF and nm23-H1 in colorectal cancer
    • Elagoz, S.; Egilmez, R.; Koyuncu, A.; Muslehiddinoglu, A.; Arici, S. The intratumoral microvessel density and expression of bFGF and nm23-H1 in colorectal cancer. Pathol. Oncol. Res. 2006, 12, 21-27.
    • (2006) Pathol. Oncol. Res , vol.12 , pp. 21-27
    • Elagoz, S.1    Egilmez, R.2    Koyuncu, A.3    Muslehiddinoglu, A.4    Arici, S.5
  • 172
    • 0029001004 scopus 로고
    • Cytokine regulation of angiogenesis in breast cancer: The role of tumor-associated macrophages
    • Lewis, C.E.; Leek, R.; Harris, A.; McGee, J.O. Cytokine regulation of angiogenesis in breast cancer: The role of tumor-associated macrophages. J. Leukoc. Biol. 1995, 57, 747-751.
    • (1995) J. Leukoc. Biol , vol.57 , pp. 747-751
    • Lewis, C.E.1    Leek, R.2    Harris, A.3    McGee, J.O.4
  • 173
    • 0031800372 scopus 로고    scopus 로고
    • Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
    • Leek, R.D.; Landers, R.; Fox, S.B.; Ng, F.; Harris, A.L.; Lewis, C.E. Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma. Br. J. Cancer 1998, 77, 2246-2251.
    • (1998) Br. J. Cancer , vol.77 , pp. 2246-2251
    • Leek, R.D.1    Landers, R.2    Fox, S.B.3    Ng, F.4    Harris, A.L.5    Lewis, C.E.6
  • 175
    • 1142275237 scopus 로고    scopus 로고
    • Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270
    • Nakamura, E.S.; Koizumi, K.; Kobayashi, M.; Saiki, I. Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270. Cancer Sci. 2004, 95, 25-31.
    • (2004) Cancer Sci , vol.95 , pp. 25-31
    • Nakamura, E.S.1    Koizumi, K.2    Kobayashi, M.3    Saiki, I.4
  • 177
    • 0033810052 scopus 로고    scopus 로고
    • Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis
    • Friedmann, Y.; Vlodavsky, I.; Aingorn, H.; Aviv, A.; Peretz, T.; Pecker, I.; Pappo, O. Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis. Am. J. Pathol. 2000, 157, 1167-1175.
    • (2000) Am. J. Pathol , vol.157 , pp. 1167-1175
    • Friedmann, Y.1    Vlodavsky, I.2    Aingorn, H.3    Aviv, A.4    Peretz, T.5    Pecker, I.6    Pappo, O.7
  • 180
    • 0032990269 scopus 로고    scopus 로고
    • Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue
    • Hildenbrand, R.; Wolf, G.; Bohme, B.; Bleyl, U.; Steinborn, A. Urokinase plasminogen activator receptor (CD87) expression of tumor-associated macrophages in ductal carcinoma in situ, breast cancer, and resident macrophages of normal breast tissue. J. Leukoc. Biol. 1999, 66, 40-49.
    • (1999) J. Leukoc. Biol , vol.66 , pp. 40-49
    • Hildenbrand, R.1    Wolf, G.2    Bohme, B.3    Bleyl, U.4    Steinborn, A.5
  • 183
    • 23944505764 scopus 로고    scopus 로고
    • Expression and regulation of murine macrophage angiopoietin-2
    • Hubbard, N.E.; Lim, D.; Mukutmoni, M.; Cai, A.; Erickson, K.L. Expression and regulation of murine macrophage angiopoietin-2. Cell Immunol. 2005, 234, 102-109.
    • (2005) Cell Immunol , vol.234 , pp. 102-109
    • Hubbard, N.E.1    Lim, D.2    Mukutmoni, M.3    Cai, A.4    Erickson, K.L.5
  • 184
    • 33947285048 scopus 로고    scopus 로고
    • Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2
    • Nguyen, V.P.; Chen, S.H.; Trinh, J.; Kim, H.; Coomber, B.L.; Dumont, D.J. Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2. BMC Cell Biol. 2007, 8, 10.
    • (2007) BMC Cell Biol , vol.8 , pp. 10
    • Nguyen, V.P.1    Chen, S.H.2    Trinh, J.3    Kim, H.4    Coomber, B.L.5    Dumont, D.J.6
  • 185
    • 80052211625 scopus 로고    scopus 로고
    • Angiopoietin-1 and-2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis
    • Fagiani, E.; Lorentz, P.; Kopfstein, L.; Christofori, G. Angiopoietin-1 and-2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis. Cancer Res. 2011, 71, 5717-5727.
    • (2011) Cancer Res , vol.71 , pp. 5717-5727
    • Fagiani, E.1    Lorentz, P.2    Kopfstein, L.3    Christofori, G.4
  • 187
    • 0038066574 scopus 로고    scopus 로고
    • Host microenvironment in breast cancer development: Inflammatory cells, cytokines and chemokines in breast cancer progression: Reciprocal tumor-microenvironment interactions
    • Ben Baruch, A. Host microenvironment in breast cancer development: Inflammatory cells, cytokines and chemokines in breast cancer progression: Reciprocal tumor-microenvironment interactions. Breast Cancer Res. 2003, 5, 31-36.
    • (2003) Breast Cancer Res , vol.5 , pp. 31-36
    • Ben Baruch, A.1
  • 188
    • 0037686184 scopus 로고    scopus 로고
    • Host microenvironment in breast cancer development: Inflammatory and immune cells in tumour angiogenesis and arteriogenesis
    • Yu, J.L.; Rak, J.W. Host microenvironment in breast cancer development: Inflammatory and immune cells in tumour angiogenesis and arteriogenesis. Breast Cancer Res. 2003, 5, 83-88.
    • (2003) Breast Cancer Res , vol.5 , pp. 83-88
    • Yu, J.L.1    Rak, J.W.2
  • 189
    • 23244457362 scopus 로고    scopus 로고
    • Inflammation and cancer: When NF-kappaB amalgamates the perilous partnership
    • Dobrovolskaia, M.A.; Kozlov, S.V. Inflammation and cancer: When NF-kappaB amalgamates the perilous partnership. Curr. Cancer Drug Targets 2005, 5, 325-344.
    • (2005) Curr. Cancer Drug Targets , vol.5 , pp. 325-344
    • Dobrovolskaia, M.A.1    Kozlov, S.V.2
  • 190
    • 22344436554 scopus 로고    scopus 로고
    • NF-kappaB: Key mediator of inflammation-associated cancer
    • Ditsworth, D.; Zong, W.X. NF-kappaB: Key mediator of inflammation-associated cancer. Cancer Biol. Ther. 2004, 3, 1214-1216.
    • (2004) Cancer Biol. Ther , vol.3 , pp. 1214-1216
    • Ditsworth, D.1    Zong, W.X.2
  • 191
    • 28244456279 scopus 로고    scopus 로고
    • Tumor inflammatory angiogenesis and its chemoprevention
    • Albini, A.; Tosetti, F.; Benelli, R.; Noonan, D.M. Tumor inflammatory angiogenesis and its chemoprevention. Cancer Res. 2005, 65, 10637-10641.
    • (2005) Cancer Res , vol.65 , pp. 10637-10641
    • Albini, A.1    Tosetti, F.2    Benelli, R.3    Noonan, D.M.4
  • 192
    • 12944273470 scopus 로고    scopus 로고
    • Targeting of nuclear factor kappaB pathways by dehydroxymethylepoxyquinomicin, a novel inhibitor of breast carcinomas: Antitumor and antiangiogenic potential in vivo
    • Matsumoto, G.; Namekawa, J.; Muta, M.; Nakamura, T.; Bando, H.; Tohyama, K.; Toi, M.; Umezawa, K. Targeting of nuclear factor kappaB pathways by dehydroxymethylepoxyquinomicin, a novel inhibitor of breast carcinomas: Antitumor and antiangiogenic potential in vivo. Clin. Cancer Res. 2005, 11, 1287-1293.
    • (2005) Clin. Cancer Res , vol.11 , pp. 1287-1293
    • Matsumoto, G.1    Namekawa, J.2    Muta, M.3    Nakamura, T.4    Bando, H.5    Tohyama, K.6    Toi, M.7    Umezawa, K.8
  • 193
    • 16644393679 scopus 로고    scopus 로고
    • Inflammatory triggers of lymphangiogenesis
    • Mouta, C.; Heroult, M. Inflammatory triggers of lymphangiogenesis. Lymphat. Res. Biol. 2003, 1, 201-218.
    • (2003) Lymphat. Res. Biol , vol.1 , pp. 201-218
    • Mouta, C.1    Heroult, M.2
  • 194
    • 0036964816 scopus 로고    scopus 로고
    • Chemopreventive agents induce suppression of nuclear factorkappaB leading to chemosensitization
    • Bharti, A.C.; Aggarwal, B.B. Chemopreventive agents induce suppression of nuclear factorkappaB leading to chemosensitization. Ann. NY Acad. Sci. 2002, 973, 392-395.
    • (2002) Ann. NY Acad. Sci , vol.973 , pp. 392-395
    • Bharti, A.C.1    Aggarwal, B.B.2
  • 195
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis
    • Huang, S.; Pettaway, C.A.; Uehara, H.; Bucana, C.D.; Fidler, I.J. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene 2001, 20, 4188-4197.
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1    Pettaway, C.A.2    Uehara, H.3    Bucana, C.D.4    Fidler, I.J.5
  • 198
    • 81555202006 scopus 로고    scopus 로고
    • M2-polarized tumorassociated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma
    • Zhang, B.; Yao, G.; Zhang, Y.; Gao, J.; Yang, B.; Rao, Z.; Gao, J. M2-polarized tumorassociated macrophages are associated with poor prognoses resulting from accelerated lymphangiogenesis in lung adenocarcinoma. Clinics (Sao Paulo) 2011, 66, 1879-1886.
    • (2011) Clinics (Sao Paulo) , vol.66 , pp. 1879-1886
    • Zhang, B.1    Yao, G.2    Zhang, Y.3    Gao, J.4    Yang, B.5    Rao, Z.6    Gao, J.7
  • 199
    • 84655175066 scopus 로고    scopus 로고
    • Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma
    • Zhang, B.C.; Gao, J.; Wang, J.; Rao, Z.G.; Wang, B.C.; Gao, J.F. Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma. Med. Oncol. 2011, 28, 1447-1452.
    • (2011) Med. Oncol , vol.28 , pp. 1447-1452
    • Zhang, B.C.1    Gao, J.2    Wang, J.3    Rao, Z.G.4    Wang, B.C.5    Gao, J.F.6
  • 200
    • 33751098783 scopus 로고    scopus 로고
    • Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: Correlations with prognostic parameters
    • Bolat, F.; Kayaselcuk, F.; Nursal, T.Z.; Yagmurdur, M.C.; Bal, N.; Demirhan, B. Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: Correlations with prognostic parameters. J. Exp. Clin. Cancer Res. 2006, 25, 365-372.
    • (2006) J. Exp. Clin. Cancer Res , vol.25 , pp. 365-372
    • Bolat, F.1    Kayaselcuk, F.2    Nursal, T.Z.3    Yagmurdur, M.C.4    Bal, N.5    Demirhan, B.6
  • 201
    • 0037145727 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas
    • Ohta, M.; Kitadai, Y.; Tanaka, S.; Yoshihara, M.; Yasui, W.; Mukaida, N.; Haruma, K.; Chayama, K. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas. Int. J. Cancer 2002, 102, 220-224.
    • (2002) Int. J. Cancer , vol.102 , pp. 220-224
    • Ohta, M.1    Kitadai, Y.2    Tanaka, S.3    Yoshihara, M.4    Yasui, W.5    Mukaida, N.6    Haruma, K.7    Chayama, K.8
  • 202
    • 84859433376 scopus 로고    scopus 로고
    • Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma
    • Storr, S.J.; Safuan, S.; Mitra, A.; Elliott, F.; Walker, C.; Vasko, M.J.; Ho, B.; Cook, M.; Mohammed, R.A.; Patel, P.M.; et al. Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma. Mod. Pathol. 2011, 25, 493-504.
    • (2011) Mod. Pathol , vol.25 , pp. 493-504
    • Storr, S.J.1    Safuan, S.2    Mitra, A.3    Elliott, F.4    Walker, C.5    Vasko, M.J.6    Ho, B.7    Cook, M.8    Mohammed, R.A.9    Patel, P.M.10
  • 203
    • 0036329210 scopus 로고    scopus 로고
    • Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma
    • Valkovic, T.; Dobrila, F.; Melato, M.; Sasso, F.; Rizzardi, C.; Jonjic, N. Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma. Virchows Arch. 2002, 440, 583-588.
    • (2002) Virchows Arch , vol.440 , pp. 583-588
    • Valkovic, T.1    Dobrila, F.2    Melato, M.3    Sasso, F.4    Rizzardi, C.5    Jonjic, N.6
  • 205
    • 33745165865 scopus 로고    scopus 로고
    • VEGF-C expressing tumor-associated macrophages in lymph node positive breast cancer: Impact on lymphangiogenesis and survival
    • Schoppmann, S.F.; Fenzl, A.; Nagy, K.; Unger, S.; Bayer, G.; Geleff, S.; Gnant, M.; Horvat, R.; Jakesz, R.; Birner, P. VEGF-C expressing tumor-associated macrophages in lymph node positive breast cancer: Impact on lymphangiogenesis and survival. Surgery 2006, 139, 839-846.
    • (2006) Surgery , vol.139 , pp. 839-846
    • Schoppmann, S.F.1    Fenzl, A.2    Nagy, K.3    Unger, S.4    Bayer, G.5    Geleff, S.6    Gnant, M.7    Horvat, R.8    Jakesz, R.9    Birner, P.10
  • 206
    • 77957731938 scopus 로고    scopus 로고
    • Clinicopathological implications of tumour-associated macrophages and vascularization in sinonasal melanoma
    • Shi, L.; Lei, D.; Ma, C.; Xu, F.; Li, Y.; Wang, Y.; Cong, N.; Liu, D.; Pan, X.L. Clinicopathological implications of tumour-associated macrophages and vascularization in sinonasal melanoma. J. Int. Med. Res. 2010, 38, 1276-1286.
    • (2010) J. Int. Med. Res , vol.38 , pp. 1276-1286
    • Shi, L.1    Lei, D.2    Ma, C.3    Xu, F.4    Li, Y.5    Wang, Y.6    Cong, N.7    Liu, D.8    Pan, X.L.9
  • 207
    • 41149131620 scopus 로고    scopus 로고
    • Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels
    • Kawai, Y.; Hosaka, K.; Kaidoh, M.; Minami, T.; Kodama, T.; Ohhashi, T. Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels. Lymphat. Res. Biol. 2008, 6, 15-27.
    • (2008) Lymphat. Res. Biol , vol.6 , pp. 15-27
    • Kawai, Y.1    Hosaka, K.2    Kaidoh, M.3    Minami, T.4    Kodama, T.5    Ohhashi, T.6
  • 208
    • 84862556278 scopus 로고    scopus 로고
    • Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients
    • Algars, A.; Irjala, H.; Vaittinen, S.; Huhtinen, H.; Sundstrom, J.; Salmi, M.; Ristamaki, R.; Jalkanen, S. Type and location of tumor-infiltrating macrophages and lymphatic vessels predict survival of colorectal cancer patients. Int. J. Cancer 2012, 131, 864-873.
    • (2012) Int. J. Cancer , vol.131 , pp. 864-873
    • Algars, A.1    Irjala, H.2    Vaittinen, S.3    Huhtinen, H.4    Sundstrom, J.5    Salmi, M.6    Ristamaki, R.7    Jalkanen, S.8
  • 209
    • 83455203338 scopus 로고    scopus 로고
    • Identification and manipulation of tumor associated macrophages in human cancers
    • Heusinkveld, M.; van der Burg, S.H. Identification and manipulation of tumor associated macrophages in human cancers. J. Transl. Med. 2011, 9, 216.
    • (2011) J. Transl. Med , vol.9 , pp. 216
    • Heusinkveld, M.1    van der Burg, S.H.2
  • 211
    • 66049154097 scopus 로고    scopus 로고
    • M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis
    • Kubota, Y.; Takubo, K.; Shimizu, T.; Ohno, H.; Kishi, K.; Shibuya, M.; Saya, H.; Suda, T. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J. Exp. Med. 2009, 206, 1089-1102.
    • (2009) J. Exp. Med , vol.206 , pp. 1089-1102
    • Kubota, Y.1    Takubo, K.2    Shimizu, T.3    Ohno, H.4    Kishi, K.5    Shibuya, M.6    Saya, H.7    Suda, T.8
  • 212
    • 79953790937 scopus 로고    scopus 로고
    • Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer
    • Yang, H.; Kim, C.; Kim, M.J.; Schwendener, R.A.; Alitalo, K.; Heston, W.; Kim, I.; Kim, W.J.; Koh, G.Y. Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Mol. Cancer 2011, 10, 36.
    • (2011) Mol. Cancer , vol.10 , pp. 36
    • Yang, H.1    Kim, C.2    Kim, M.J.3    Schwendener, R.A.4    Alitalo, K.5    Heston, W.6    Kim, I.7    Kim, W.J.8    Koh, G.Y.9
  • 213
    • 0345831221 scopus 로고    scopus 로고
    • Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic nd osteolytic lesions in bone
    • Lee, Y.; Schwarz, E.; Davies, M.; Jo, M.; Gates, J.; Wu, J.; Zhang, X.; Lieberman, J.R. Differences in the cytokine profiles associated with prostate cancer cell induced osteoblastic nd osteolytic lesions in bone. J. Orthop. Res. 2003, 21, 62-72.
    • (2003) J. Orthop. Res , vol.21 , pp. 62-72
    • Lee, Y.1    Schwarz, E.2    Davies, M.3    Jo, M.4    Gates, J.5    Wu, J.6    Zhang, X.7    Lieberman, J.R.8
  • 214
    • 33646835413 scopus 로고    scopus 로고
    • Targeting lymphangiogenesis to prevent tumour metastasis
    • Achen, M.G.; Mann, G.B.; Stacker, S.A. Targeting lymphangiogenesis to prevent tumour metastasis. Br. J. Cancer 2006, 94, 1355-1360.
    • (2006) Br. J. Cancer , vol.94 , pp. 1355-1360
    • Achen, M.G.1    Mann, G.B.2    Stacker, S.A.3
  • 215
    • 0037222688 scopus 로고    scopus 로고
    • VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells
    • Salven, P.; Mustjoki, S.; Alitalo, R.; Alitalo, K.; Rafii, S. VEGFR-3 and CD133 identify a population of CD34+ lymphatic/vascular endothelial precursor cells. Blood 2003, 101, 168-172.
    • (2003) Blood , vol.101 , pp. 168-172
    • Salven, P.1    Mustjoki, S.2    Alitalo, R.3    Alitalo, K.4    Rafii, S.5
  • 216
    • 63449135769 scopus 로고    scopus 로고
    • High VEGFR-3-positive circulating lymphatic/vascular endothelial progenitor cell level is associated with poor prognosis in human small cell lung cancer
    • Bogos, K.; Renyi-Vamos, F.; Dobos, J.; Kenessey, I.; Tovari, J.; Timar, J.; Strausz, J.; Ostoros, G.; Klepetko, W.; Ankersmit, H.J.; et al. High VEGFR-3-positive circulating lymphatic/vascular endothelial progenitor cell level is associated with poor prognosis in human small cell lung cancer. Clin. Cancer Res. 2009, 15, 1741-1746.
    • (2009) Clin. Cancer Res , vol.15 , pp. 1741-1746
    • Bogos, K.1    Renyi-Vamos, F.2    Dobos, J.3    Kenessey, I.4    Tovari, J.5    Timar, J.6    Strausz, J.7    Ostoros, G.8    Klepetko, W.9    Ankersmit, H.J.10
  • 219
    • 78149246290 scopus 로고    scopus 로고
    • Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation
    • Gordon, E.J.; Rao, S.; Pollard, J.W.; Nutt, S.L.; Lang, R.A.; Harvey, N.L. Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development 2010, 137, 3899-3910.
    • (2010) Development , vol.137 , pp. 3899-3910
    • Gordon, E.J.1    Rao, S.2    Pollard, J.W.3    Nutt, S.L.4    Lang, R.A.5    Harvey, N.L.6
  • 220
    • 34548798765 scopus 로고    scopus 로고
    • Tie2-expressing monocytes and tumor angiogenesis: Regulation by hypoxia and angiopoietin-2
    • Lewis, C.E.; de Palma, M.; Naldini, L. Tie2-expressing monocytes and tumor angiogenesis: Regulation by hypoxia and angiopoietin-2. Cancer Res. 2007, 67, 8429-8432.
    • (2007) Cancer Res , vol.67 , pp. 8429-8432
    • Lewis, C.E.1    de Palma, M.2    Naldini, L.3
  • 222
    • 73949156419 scopus 로고    scopus 로고
    • Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
    • Pflicke, H.; Sixt, M. Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J. Exp. Med. 2009, 206, 2925-2935.
    • (2009) J. Exp. Med , vol.206 , pp. 2925-2935
    • Pflicke, H.1    Sixt, M.2
  • 223
    • 23444451916 scopus 로고    scopus 로고
    • Dendritic-cell trafficking to lymph nodes through lymphatic vessels
    • Randolph, G.J.; Angeli, V.; Swartz, M.A. Dendritic-cell trafficking to lymph nodes through lymphatic vessels. Nat. Rev. Immunol. 2005, 5, 617-628.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 617-628
    • Randolph, G.J.1    Angeli, V.2    Swartz, M.A.3
  • 224
    • 0030587122 scopus 로고    scopus 로고
    • In vivo fate of the inflammatory macrophage during the resolution of inflammation: Inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes
    • Bellingan, G.J.; Caldwell, H.; Howie, S.E.; Dransfield, I.; Haslett, C. In vivo fate of the inflammatory macrophage during the resolution of inflammation: Inflammatory macrophages do not die locally, but emigrate to the draining lymph nodes. J. Immunol. 1996, 157, 2577-2585.
    • (1996) J. Immunol , vol.157 , pp. 2577-2585
    • Bellingan, G.J.1    Caldwell, H.2    Howie, S.E.3    Dransfield, I.4    Haslett, C.5
  • 225
    • 0035182533 scopus 로고    scopus 로고
    • Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations
    • Weissman, I.L.; Anderson, D.J.; Gage, F. Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 2001, 17, 387-403.
    • (2001) Annu. Rev. Cell Dev. Biol , vol.17 , pp. 387-403
    • Weissman, I.L.1    Anderson, D.J.2    Gage, F.3
  • 227
    • 2442422177 scopus 로고    scopus 로고
    • C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: Further evidence of a mechanistic link between C-reactive protein and cardiovascular disease
    • Verma, S.; Kuliszewski, M.A.; Li, S.H.; Szmitko, P.E.; Zucco, L.; Wang, C.H.; Badiwala, M.V.; Mickle, D.A.; Weisel, R.D.; Fedak, P.W.; et al. C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: Further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation 2004, 109, 2058-2067.
    • (2004) Circulation , vol.109 , pp. 2058-2067
    • Verma, S.1    Kuliszewski, M.A.2    Li, S.H.3    Szmitko, P.E.4    Zucco, L.5    Wang, C.H.6    Badiwala, M.V.7    Mickle, D.A.8    Weisel, R.D.9    Fedak, P.W.10
  • 228
    • 17044416487 scopus 로고    scopus 로고
    • The involvement of endothelial progenitor cells in tumor angiogenesis
    • Ribatti, D. The involvement of endothelial progenitor cells in tumor angiogenesis. J. Cell Mol. Med. 2004, 8, 294-300.
    • (2004) J. Cell Mol. Med , vol.8 , pp. 294-300
    • Ribatti, D.1
  • 231
  • 232
    • 82455168038 scopus 로고    scopus 로고
    • Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-beta1 inhibition
    • Yan, A.; Avraham, T.; Zampell, J.C.; Haviv, Y.S.; Weitman, E.; Mehrara, B.J. Adipose-derived stem cells promote lymphangiogenesis in response to VEGF-C stimulation or TGF-beta1 inhibition. Future Oncol. 2011, 7, 1457-1473
    • (2011) Future Oncol , vol.7 , pp. 1457-1473
    • Yan, A.1    Avraham, T.2    Zampell, J.C.3    Haviv, Y.S.4    Weitman, E.5    Mehrara, B.J.6


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