In Vivo Fate of the Inflammatory Macrophage during the Resolution of Inflammation: Inflammatory Macrophages Do Not Die Locally, but Emigrate to the Draining Lymph Nodes

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2577-2585

  Bellingan, Geoffrey J ^a,c   Caldwell, Helen ^a   Howie, Sarah E M ^b   Dransfield, Ian ^a   Haslett, Christopher ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOPTIVE TRANSFER; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C3H MOUSE; CELL CULTURE; CELL DEATH; CELL MOTION; CROSS BREEDING; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; KINETICS; LYMPH NODE; MOUSE; PATHOLOGY; PERITONEUM MACROPHAGE; PERITONITIS; PHAGOCYTOSIS; TIME;

ADOPTIVE TRANSFER; ANIMALS; CELL DEATH; CELL MOVEMENT; CELLS, CULTURED; CROSSES, GENETIC; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; KINETICS; LYMPH NODES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; PERITONITIS; PHAGOCYTOSIS; TIME FACTORS;

EID: 0030587122     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Adams, D. O., and T. A. Hamilton. 1992. Macrophages as destructive cells in host defense. In Inflammation: Basic Principles and Clinical Correlates, 2nd Ed. J. I. Gallin, I. M. Goldstein, and R. Snyderman, eds. Raven Press, New York, p. 637.
2. Baker, A. J., A. Mooney, J. Hughes, D. Lombardi, R. J. Johnson, and J. Savill. 1994. Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferate nephritis. J. Clin. Invest. 94:2105.
3. Riches, D. W. H. 1988. The multiple roles of macrophages in wound healing. In Molecular and Cellular Biology of Wound Repair. R. A. F. Clark and P. M. H. Henson. eds. Plenum Press, New York, p. 213.
4. Nathan, C. F. 1987. Secretory products of macrophages. J. Clin. Invest. 79:319.
5. Khalil, N., O. Bereznay, M. Sporn, and A. H. Greenberg. 1989. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J. Exp. Med. 170:727.
6. Eben, R. H., and H. W. Florey. 1939. The extravascular development of the monocyte observed in vivo. Br. J. Exp. Pathol. 20:342.
7. van Furth, R. 1992. Development and distribution of mononuclear phagocytes. In Inflammation: Basic Principles and Clinical Correlates. 2nd Ed. J. I. Gallin, I. M. Goldstein, and R. Snyderman, eds. Raven Press, New York, p. 325.
8. Rosen, H., and S. Gordon. 1990. Adoptive transfer of fluorescence-labeled cells shows that resident peritoneal macrophages are able to migrate into specialized lymphoid organs and inflammatory sites in the mouse. Eur. J. Immunol. 20:1251.
9. van Furth, R., M. M. C. Diesselhoff-Den Dulk, and H. Mattie. 1973. Quantitative study on the production and kinetics of mononuclear phagocytes during an acute inflammatory reaction. J. Exp. Med. 138:1314.
10. Rosser, R. 1970. The origins, kinetics and fate of macrophage populations. J. Reticuloendothel. Soc. 8:139.
11. Daems, W. T., R. E. Poelmann, P. Brederoo, and E. J. van Lohuizen. 1973. Peroxidatic activity in resident peritoneal macrophages and exudate monocytes of the guinea pig after ingestion of latex particles. J. Histochem. Cytochem. 21:93.
12. Melnicoff, M. J., P. K. Horan, E. W. Breslin, and P. S. Morahan. 1988. Maintenance of peritoneal macrophages in the steady state. J. Leukocyte Biol. 44:367.
13. van Furth, R. 1989. Origin and turnover of monocytes and macrophages. In Carrent Topics in Pathology. O. H. Iversen, ed. Springer-Verlag, Heidelberg, p. 125.
14. Haskill, S., and S. Becker. 1985. Disappearance and reappearance of resident macrophages: importance in C. parvum-induced tumoricidal activity. Cell. Immunol. 90:179.
15. Volkman, A. 1976. Disparity in origin of mononuclear phagocyte populations. J. Reticuloendothel. Soc. 19:249.
16. Ginsel, L. A. 1993. Origin of macrophages. In Blood Cell Biochemistry, Vol 5: Macrophages and Related Cells. M. A. Horton, ed. Plenum Press, New York, p. 87.
17. Bouwens, L., D. L. Knook, and E. Wisse. 1986. Local proliferation and extra-hepatic recruitment of liver macrophages (Kupffer cells) in partial-body irradiated rats. J. Leukocyte Biol. 39:687.
18. Savill, J. S., A. H. Wyllie, J. E. Henson, P. M. Henson, and C. Haslett. 1989. Macrophage phagocytosis of aging neutrophils in inflammation. J. Clin. Invest. 83:865.
19. Grigg, J. M., J. S. Savill, C. Sarraf, C. Haslett, and M. Silverman. 1991. Neutrophil apoptosis and clearance from neonatal lungs. Lancet 338:720.
20. Savill, J. S., I. Dransfield, N. Hogg, and C. Haslett. 1990. Macrophage recognition of 'senescent self;' the vitronectin receptor mediates phagocytosis of cells undergoing apoptosis. Nature 342:170.
21. Savill, J. S., N. Hogg, and C. Haslett. 1992. Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of aged neutrophils. J. Clin. Invest. 90:1513.
22. 2. J. Leukocyte Biol. 52:269.
23. Haslett, C., J. S. Savill, M. K. B. Whyte, M. Stern, I. Dransfield, and L. C. Meagher. 1994. Granulocyte apoptosis and the control of inflammation. Philos. Trans. R. Soc. Lond B Biol. Sci. 345:327.
24. Mangan, D. F., and S. M. Wahl. 1991. Differential regulation of human monocyte programmed cell death (apoptosis) by chemotactic factors and pro-inflammatory cytokines. J. Immunol. 147:3408.
25. Papadimitriou, J. M., and I. van Bruggen. 1993. Quantitative investigations of apoptosis of murine mononuclear phagocytes during mild hyperthermia. Exp. Mol. Pathol. 59:1.
26. Khelef, N., A. Zychlinsky, and N. Guiso. 1993. Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin. Infect. Immun. 61:4064.
27. Albina, J. E., S. Cui, R. B. Mateo, and J. S. Reichner. 1993. Nitric oxide-mediated apoptosis in murine peritoneal macrophages. J. Immunol. 150:5080.
28. Sarih, M., V. Souvannavong, and A. Adam. 1993. Nitric oxide synthase induces macrophage death by apoptosis. Biochem. Biophys. Res. Commun. 191:503.
29. Zychlinsky, A., M. C. Pravost, and P. J. Sansonetti. 1992. Shigella flexneri induces apoptosis in infected macrophages. Nature 358:167.
30. Melnicoff, M. J., P. S. Morahan, B. D. Jensen, E. W. Breslin, and P. K. Horan. 1988. In vivo labelling of resident peritoneal macrophages. J. Leukocyte Biol. 43:387.
31. Soesatyo, M., T. Thepen, M. Ghufron, J. Biewenga, and T. Sminia. 1993. Peritoneal cell labelling: a study on the migration of macrophages and dendritic cells towards the gut. In Dendritic Cells in Fundamental and Clinical Immunology. E. W. A. Kamperdijk, P. Nieuwenhuis, and E. C. M. Hoefsmit, eds. Plenum Press, New York, p. 321.
32. Beelen, R. H. J., D. M. Fluitsma, and E. C. M. Hoefsmit. 1980. The cellular composition of omentum milky spots and the ultrastructure of milky spot macrophages and reticulum cells. J. Reticuloendothel. Soc. 28:585.
33. Lan, H. Y., D. J. Nikolic, and R. C. Atkins. 1993. Trafficking of inflammatory macrophages from the kidney to draining lymph nodes during experimental glomerulonephritis. Clin. Exp. Immunol. 92:336.
34. Harmensen, A. G., B. A. Muggenberg, M. Burton Snipes, and D. E. Bice. 1985. The role of macrophages in particle translocation from lungs to lymph nodes. Science 230:1277.
35. Thepen, T., E. Claasen, K. Hoeben, J. Breve, and G. Kraal. 1993. Migration patterns of alveolar macrophages from alveolar space to paracortical area of the draining lymph node. In Dendritic Cells in Fundamental and Clinical Immunology. E. W. A. Kamperdijk, P. Nieuwenhuis, and E. C. M. Hoefsmit, eds. Plenum Press, New York, p. 305.
36. Ryan, G. B., and W. G. Spector. 1970. Macrophage turnover in inflamed connective tissue. Proc. R. Soc. Lond. B Biol. Sci. 175:269.
37. Hopper, K. E. 1986. Kinetics of macrophage recruitment and turnover in peritoneal inflammatory exudates induced by salmonella or thioglycollate broth. J. Leukocyte Biol. 39:435.
38. Bitterman, P. B., L. E. Saltzman, S. Adelberg, V. J. Ferrans, and R. G. Crystal. 1984. Alveolar macrophage replication. One mechanism for the expansion of the mononuclear phagocyte population in the chronically inflamed lung. J Clin. Invest. 74:460.
39. Coggle, J. E., and J. D. Tarling. 1982. Cell kinetics of pulmonary alveolar macrophages in the mouse. Cell Tissue Kinet. 15:139.
40. Bell, E. B. 1984. Antigen transport. II. The significance of the localisation of antigen-laden cells in the spleen. Cell. Immunol. 88:273.
41. Melnicoff, M. J., P. K. Horan, and P. S. Morahan. 1989. Kinetics of changes in peritoneal cell populations following acute inflammation. Cell. Immunol. 118: 178.
42. Stern, M., L. C. Meagher, J. S. Savill, and C. Haslett. 1992. Apoptosis in human eosinophils: programmed cell death in the eosmophil leads to phagocytosis by macrophages and is modulated by IL-5. J. Immunol. 148:3543.
43. Yoffey, J. M., and F. C. Courtice. 1970. Lymphatics, Lymph and the Lymphomyeloid Complex. Academic Press, London, p. 295.
44. Leak, L. V. 1983. Interaction of mesothelium to intraperitoneal stimulation: aggregation of peritoneal cells. Lab. Invest. 48:479.