Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: Correlations with prognostic parameters

Journal of Experimental and Clinical Cancer Research

Volumn 25, Issue 3, 2006, Pages 365-372

  Bolat, Filiz ^a   Kayaselcuk, F ^a   Nursal, T Z ^a   Yagmurdur, M C ^a   Bal, N ^a   Demirhan, B ^a  

^a BASKENT UNIVERSITY   (Turkey)

Author keywords

Angiogenesis; Infiltrative ductal carcinoma; Infiltrative lobular carcinoma; Microvessel density; Tumor associated macrophage; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; BREAST TUMOR; CANCER GRADING; CANCER INFILTRATION; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATIONAL STUDY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MICROVASCULATURE; MITOSIS RATE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MACROPHAGES; MICROCIRCULATION; MIDDLE AGED; MITOSIS; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33751098783     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Tavassoli F.A., Devilee P.: Tumors of the Breast. In: Tavassoli F.A., Devilee P., eds. World Health Organization Classification of Tumours. Tumours of the Breast and Female Genital Organs. IARC press, Lyon 2003 :10-12.
2. Toikkanen S., Pylkkanen L., Joensuu H.: Invaziv lobular carcinoma of the breast has better short-and long-term survival than invasive ductal carcinoma. Br. J. Cancer 76(9):1234-1240, 1997.
3. Lee A.H., Happerfield L.C., Millis R.R., Bobrow L.G.: Inflammatory infiltrate in invasive lobular and ductal carcinoma of the breast. Br. J. Cancer 74:796-801, 1996.
4. Jain S., Fisher C., Smith P., Millis R.R., Rubens R.D.: Paterns of metastatic breast cancer in relation to histological type. Eur. J. Cancer 29A(15):2155-2157, 1993.
5. Lee A.H.S., Dublin E.A., Bobrow L.G., Poulsom R.: Invaziv Lobular and Invaziv Ductal carcinoma of the breast show distinct patterns of vascular endothelial growth factor expression and angiogenesis. J. Pathol. 185(4):394-401, 1998.
6. Chhieng D.C., Tabbara S.O., Marley E.F., Talley L.I., Frost A.R.: Microvessel Density and Vascular Endothelial Growth Factor Expression in Infiltrating Lobular Mammary Carcinoma. The Breast Journal 9(3):200-207, 2003.
7. Bosari S., Lee A.K., DeLellis R.A., Wiley B.D., Heatley G.J., Silverman M.L.: Microvessel quantation and prognosis in invasive breast carcinoma. Hum. Pathol. 23(7):755-761, 1992.
8. Gasparini G., Weidner N., Bevilacqua P., Maluta S., Dalla Palma P., Caffo O., et al.: Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are revelant prognostic markers in node negative breast carcinoma. J. Clin. Oncol. 12(3):454-466, 1993.
9. Toi M., Kashitani J., Tominaga T.: Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma. Int. J. Cancer 55(3):371-374, 1993.
10. Weidner N., Semple J.P., Welch W.R., Folkman J.: Tumor angiogenesis and metastasis-correlation in invasive breast carcinoma. N. Engl. J. Med. 324(1):1-8, 1994.
11. Weidner N., Folkman J., Pozza F., Bevilacqua P., Allred E.N., Moore D.H., et al.: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst. 84(24):1875-1887, 1992.
12. Gasparini G., Toi M., Gion M., Verderio P., Dittadi R., Hanatani M., et al.: Prognostic significance of vascular endothelial growth factor protein in node-negative breast carcinoma. J. Natl. Cancer Inst. 89(2):139-147, 1997.
13. Toi M., Kondo S., Suzuki H., Yamamoto Y., Inada K., Imazawa T., et al.: Quantative analysis of vascular endothelial growth factor in primary breast cancer. Cancer 77(6):1101-1106, 1996.
14. Leek R.D., Lewis C.E., Whitehouse R., Greenall M., Clarke J., Harris A.L.: Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res. 56(20):4625-4629, 1996.
15. Leek R.D., Hunt N.C., Landers R.J., Lewis C.E., Royds J.A., Harris A.L.: Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer. J. Pathol. 190(4):430-436, 2000.
16. Valkovic T., Dobrila F., Melato M., Sasso F., Rizzardi C., Jonjic N.: Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophage in invasive ductal breast carcinoma. Virchows Arch. 440(6):583-588, 2002.
17. Nakopoulou L., Stefanaki K., Panayotopoulou E., Giannopoulou I., Athanassiadou P., Givalou H.G., Louvrou A.: Expression of the Vascular Endothelial Growth Factor Receptor-2/Flk-1 in Breast Carcinomas: Correlation With Proliferation. Hum. Pathol. 33(9):863-870, 2002.
18. Barbera-Guillem E., Nyhus J.K., Wolford C.C., Friece C.R., Sampsel J.W.: Vascular endothelial growth factor secretion by tumor-infiltrating macrophage essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process. Cancer Res. 62(23):7042-7049, 2002.
19. Pepper M.S., Ferrara N., Orci L., Montesano R.: Vascular endothelial growth factor (VEGF) induces plasminogen activators and plasminogen activator inhibitor-1 in microvascular endothelial cells. Biochem. Biophisy Res. Commun. 181(2):902-906, 1991.
20. Unemori E.N., Ferrara N., Bauer E.A., Arnento E.P.: Vascular endothelial growth factor induces interstitial collogenase expression in human endothelial cells. J. Cell. Physiol. 153(3):557-562, 1992.
21. Samoto K., Ikezaki K., Ono M., Shono T., Kohno K., Kuwano M., et al.: Expression of vascular endothelial growth factor and its possible relation with neovascularisation in human brain tumors. Cancer Res. 55(5):1189-1193, 1995.
22. Brown L.F., Berse B., Jackman R.W., Tognazzi K., Manseau E.J., Senger D.R., et al.: Expression of vascular permeability factor (vascular endothelial growth factor) and its receptor in adenocarcinomas of the gastrointestinal tract. Cancer Res. 53(19):4727-4735, 1993.
23. Brown L.F., Berse B., Jackman R.W., Tognazzi K., Manseau E.J., Dvorak H.F., et al.: Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas. Am. J. Pathol. 143(5):1255-1262, 1993.
24. Boocock C.A., Charnock-Jones D.S., Sharkey A.M., McLaren J., Barker P.J., Wright K.A., et al.: Expression of vascular endothelial growth factor and its receptors fit and KDR in ovarian carcinoma. J Natl. Cancer Inst. 87(7):506-516, 1995.
25. Guidi A.J., Abu-Jawdeh G., Berse B., Jackman R.W., Tognazzi K., Dvorak H.F., et al.: Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in cervical neoplasia. J Natl. Cancer Inst. 87(16):1237-1245, 1995.
26. Mattern J., Koomagi R., Volm M.: Vascular endothelial growth factor expression and angiogenesis in non-small cell lung carcinomas. Int. J. Oncol. 6:1059-1062, 1995.
27. Dvorak H.F., Sioussatt T.M., Brown L.F., Berse B., Nagy J.A., Sotrel A., et al.: Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: concentration in tumor blood vessels. J. Exp. Med. 174(5):1275-1278, 1991.
28. Inoue K., Ozeki Y., Suganuma T., Sugiura Y., Tanaka S.: Vascular endothelial growth factor expression in primary esophageal squamous cell carcinoma. Association with angiogenesis and tumor progression. Cancer 79(2):206-213, 1997.
29. Potgens A.J., Lubsen N.H., van Altena M.C., Schoenmakers J.G., Ruiter D.J., de Waal R.M.: Vascular permeability factor expression influences tumor angiogenesis in human melanoma lines xenografted to nude mice. Am. J. Pathol. 146(1):197-209, 1995.
30. Toi M., Inada K., Suzuki H., Tominaga T.: Tumor angiogenesis in breast cancer: Its importance as a prognostic indicator and association with vascular endothelial growth factor expression. Breast Cancer Res. Treat. 36(2):193-204, 1995.
31. Rilke F., Colnaghi M.I., Cascinelli N., Andreola S., Baldini M.T., Bufalino R., et al.: Prognostic significance of HER-2/neu expression in breast cancer and its relationship to other prognostic factors. Int. J. Cancer 49(1):44-49, 1991.
32. Pari F.F., Dupont W.D.: A retrospective cohort study of Histologic risk factors in breast cancer patients. Cancer 50(11):2410-2416, 1982.
33. Alderson M.R., Hamlin I., Staunton M.D.: The relative significance of prognostic factors in breast carcinoma. Br. J. Cancer 25(4):646-656, 1971.
34. Tsutsui S., Yasuda K., Suzuki K., Tahara K., Higashi H., Era S.: Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol. Rep. 14(2):425-431, 2005.
35. Le Doussal V, Tubiana- Hulin M., Friedman S., Hacene K., Spyratos F., Brunet M.: Prognostic value of histologic grade nuclear components of Scarff-Bloom- Richardson (SBR). An improved score modification based on a multivariate analysis of 1262 invasive ductal breast carcinomas. Cancer 64:1914-1921, 1989.
36. Hellman S., Harris J., Canellos G., Fisher B.: Cancer of the breast. In: Devita V., Hellman S., Rosenberg S., eds. Cancer: Principles and Practice of Oncology. Philedelphia: JB Lipinncott, 1982:922-924.
37. Harris J., Morrow M., Bonadonna G.: Cancer Principles and Practice of Oncology. Philedelphia: JB Lipinncott, 1993:1278-1280.
38. Weidner N., Folkman J., Pozza F., Bevilacqua P., Allred E.N., Moore D.H., et al.: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst. 84(24):1875-1887, 1992.
39. Hall N.R., Fish D.E., Hunt N., Goldin R.D., Guillou P.J., Monson J.R.: Is the relationship between angiogenesis and metastasis in breast cancer real? Surg. Oncol. 1(3):223-229, 1992.
40. Harris A.L., Horak E., Leek R.: Quantative angiogenesis in human breast cancer- correlation with lymph node metastasis and assesment of vascular growth factors. Proc. AACR 33:75, 1992.
41. Morphopoulos G., Pearson M., Ryder W.D., Howell A., Harris M.: Tumour angiogenesis as a prognostic marker in infiltrating lobular carcinoma of the breast. J. Pathol. 180(1):44-49, 1996.