Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor

EMBO Journal

Volumn 21, Issue 17, 2002, Pages 4593-4599

  Petrova, Tatiana V ^a   Mäkinen, Taija ^a   Mäkelä, Tomi P ^a   Saarela, Janna ^a   Virtanen, Ismo ^a   Ferrell, Robert E ^a   Finegold, David N ^a   Kerjaschki, Dontscho ^a   Ylä Herttuala, Seppo ^a   Alitalo, Kari ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Gene profiling; Lymphatic endothelium; Transcription factor Prox 1

Indexed keywords

CYCLIN E; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PROX 1; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENE OVEREXPRESSION; GENE REPRESSION; HOMEOBOX; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOSURVEILLANCE; IN VITRO STUDY; IN VIVO STUDY; LIPID ABSORPTION; LYMPH VESSEL ENDOTHELIUM; METASTASIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; VASCULAR ENDOTHELIUM;

CELL ADHESION MOLECULES; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CYCLINS; CYTOKINES; CYTOSKELETAL PROTEINS; DERMIS; ENDOTHELIUM, LYMPHATIC; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; MUTAGENESIS, SITE-DIRECTED; ORGAN SPECIFICITY; PHENOTYPE; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOKINE; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 18544386859     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf470     Document Type: Article

References (32)

1. Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter
2. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium
3. Desmoplakin as a specific marker of lymphatic vessels
4. Integrin signaling
5. Interleukin-13 selectively induces monocyte chemoattractant protein-1 synthesis and secretion by human endothelial cells. Involvement of IL-4Rα and Stat6 phosphorylation
6. Fatal bilateral chylothorax in mice lacking the integrin α9β1
7. The Stat family in cytokine signaling
8. Mannose receptor is a novel ligand for L-selectin and mediates lymphocyte binding to lymphatic endothelium
9. Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase
10. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice
11. Expression of the fms-like tyrosine kinase FLT4 gene becomes restricted to lymphatic endothelium during development
12. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis
13. Missense mutations interfere with VEGFR-3 signaling in primary lymphoedema
14. A model for gene therapy of human hereditary lymphedema
15. Lymphatic vessels as targets of tumor therapy?
16. Stat6 activation is essential for interleukin-4 induction of P-selectin transcription in human umbilical vein endothelial cells
17. Consequences of Stat6 deletion on Sis/PDGF- and IL-4-induced proliferation and transcriptional activation in murine fibroblasts
18. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
19. Adenovirus-mediated gene transfer to lower limb artery of patients with chronic critical leg ischemia
20. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3
21. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
22. Regulation of the cyclin E gene by transcription factor E2F1
23. Sequence and tissue distribution of the integrin α9 subunit, a novel partner of β1 that is widely distributed in epithelia and muscle
24. Controversies at the cytoplasmic face of the cadherin-based adhesion complex
25. Identification of plakoglobin domains required for association with N-cadherin and α-catenin
26. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
27. Prox1 function is required for the development of the murine lymphatic system
28. Prox1 function is crucial for mouse lens-fibre elongation
29. An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
30. Lymphangiogenesis and lymphangiodysplasia: From molecular to clinical lymphology
31. Kip2 results in increased apoptosis and delayed differentiation during mouse development
32. KIP2 indicates a role in Beckwith-Wiedemann syndrome