-
1
-
-
0031905861
-
Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk-1) and VEGF receptor 3 (Flt-4)
-
Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA (1998) Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk-1) and VEGF receptor 3 (Flt-4). Proc Natl Acad Sci USA 95: 548-553
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 548-553
-
-
Achen, M.G.1
Jeltsch, M.2
Kukk, E.3
Mäkinen, T.4
Vitali, A.5
Wilks, A.F.6
Alitalo, K.7
Stacker, S.A.8
-
2
-
-
13844265843
-
Focus on lymphangiogenesis in tumor metastasis
-
Achen MG, McColl BK, Stacker SA (2005) Focus on lymphangiogenesis in tumor metastasis. Cancer Cell 7: 121-127
-
(2005)
Cancer Cell
, vol.7
, pp. 121-127
-
-
Achen, M.G.1
McColl, B.K.2
Stacker, S.A.3
-
3
-
-
0034125414
-
Monoclonal antibodies to vascular endothelial growth factor-D block interactions with both VEGF receptor-2 and VEGF receptor-3
-
Achen MG, Roufail S, Domagala T, Catimel B, Nice EC, Geleick DM, Murphy R, Scott AM, Caesar C, Makinen T, Alitalo K, Stacker SA (2000) Monoclonal antibodies to vascular endothelial growth factor-D block interactions with both VEGF receptor-2 and VEGF receptor-3. Eur J Biochem 267: 2505-2515
-
(2000)
Eur J Biochem
, vol.267
, pp. 2505-2515
-
-
Achen, M.G.1
Roufail, S.2
Domagala, T.3
Catimel, B.4
Nice, E.C.5
Geleick, D.M.6
Murphy, R.7
Scott, A.M.8
Caesar, C.9
Makinen, T.10
Alitalo, K.11
Stacker, S.A.12
-
4
-
-
0036494541
-
Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer
-
Beasley NJP, Prevo R, Banerji S, Leek RD, Moore J, van Trappen P, Cox G, Harris AL, Jackson DG (2002) Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res 62: 1315-1320
-
(2002)
Cancer Res
, vol.62
, pp. 1315-1320
-
-
Beasley, N.J.P.1
Prevo, R.2
Banerji, S.3
Leek, R.D.4
Moore, J.5
Van Trappen, P.6
Cox, G.7
Harris, A.L.8
Jackson, D.G.9
-
5
-
-
5444266254
-
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis
-
Cao R, Bjorndahl MA, Religa P, Clasper S, Garvin S, Galter D, Meister B, Ikomi F, Tritsaris K, Dissing S, Ohhashi T, Jackson DG, Cao Y (2004) PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis. Cancer Cell 6: 333-345
-
(2004)
Cancer Cell
, vol.6
, pp. 333-345
-
-
Cao, R.1
Bjorndahl, M.A.2
Religa, P.3
Clasper, S.4
Garvin, S.5
Galter, D.6
Meister, B.7
Ikomi, F.8
Tritsaris, K.9
Dissing, S.10
Ohhashi, T.11
Jackson, D.G.12
Cao, Y.13
-
6
-
-
0032564411
-
Vascular endothelial growth factor C induces angiogenesis in vivo
-
Cao Y, Linden P, Farnebo J, Cao R, Eriksson A, Kumar V, Qi JH, Claesson-Welsh L, Alitalo K (1998) Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci USA 95: 14389-14394
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14389-14394
-
-
Cao, Y.1
Linden, P.2
Farnebo, J.3
Cao, R.4
Eriksson, A.5
Kumar, V.6
Qi, J.H.7
Claesson-Welsh, L.8
Alitalo, K.9
-
7
-
-
25444489567
-
Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival
-
Chen Z, Varney ML, Backora MW, Cowan K, Solheim JC, Talmadge JE, Singh RK (2005) Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival. Cancer Res 65: 9004-9011
-
(2005)
Cancer Res
, vol.65
, pp. 9004-9011
-
-
Chen, Z.1
Varney, M.L.2
Backora, M.W.3
Cowan, K.4
Solheim, J.C.5
Talmadge, J.E.6
Singh, R.K.7
-
8
-
-
0038243830
-
Tumor lymphangiogenesis: A novel prognostic indicator for cutaneous melanoma metastasis and survival
-
Dadras SS, Paul T, Bertoncini PT, Brown LF, Muzikansky A, Jackson DG, Ellwanger U, Garbe C, Mihm MC, Detmar M (2003) Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 162: 1951-1960
-
(2003)
Am J Pathol
, vol.162
, pp. 1951-1960
-
-
Dadras, S.S.1
Paul, T.2
Bertoncini, P.T.3
Brown, L.F.4
Muzikansky, A.5
Jackson, D.G.6
Ellwanger, U.7
Garbe, C.8
Mihm, M.C.9
Detmar, M.10
-
9
-
-
17044458971
-
Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
-
Dixelius J, Makinen T, Wirzenius M, Karkkainen MJ, Wernstedt C, Alitalo K, Claesson-Welsh L (2003) Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites. J Biol Chem 278: 40973-40979
-
(2003)
J Biol Chem
, vol.278
, pp. 40973-40979
-
-
Dixelius, J.1
Makinen, T.2
Wirzenius, M.3
Karkkainen, M.J.4
Wernstedt, C.5
Alitalo, K.6
Claesson-Welsh, L.7
-
10
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W (2004) Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 3: 391-400
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
11
-
-
4143121238
-
Tumor lymphangiogenesis in head and neck squamous cell carcinoma: A morphometric study with clinical correlations
-
Franchi A, Gallo O, Massi D, Baroni G, Santucci M (2004) Tumor lymphangiogenesis in head and neck squamous cell carcinoma: a morphometric study with clinical correlations. Cancer 101: 973-978
-
(2004)
Cancer
, vol.101
, pp. 973-978
-
-
Franchi, A.1
Gallo, O.2
Massi, D.3
Baroni, G.4
Santucci, M.5
-
12
-
-
28544433482
-
Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix
-
Gombos Z, Xu X, Chu CS, Zhang PJ, Acs G (2005) Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res 11: 8364-8371
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8364-8371
-
-
Gombos, Z.1
Xu, X.2
Chu, C.S.3
Zhang, P.J.4
Acs, G.5
-
13
-
-
0037827152
-
Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma
-
Hall FT, Freeman JL, Asa SL, Jackson DG, Beasley NJ (2003) Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg 129: 716-719
-
(2003)
Arch Otolaryngol Head Neck Surg
, vol.129
, pp. 716-719
-
-
Hall, F.T.1
Freeman, J.L.2
Asa, S.L.3
Jackson, D.G.4
Beasley, N.J.5
-
14
-
-
1242269816
-
Role of lymphangiogenic factors in tumor metastasis
-
He Y, Karpanen T, Alitalo K (2004) Role of lymphangiogenic factors in tumor metastasis. Biochim Biophys Acta 1654: 3-12
-
(2004)
Biochim Biophys Acta
, vol.1654
, pp. 3-12
-
-
He, Y.1
Karpanen, T.2
Alitalo, K.3
-
15
-
-
0037024472
-
Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
-
He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K (2002) Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. J Natl Cancer Inst 94: 819-825
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 819-825
-
-
He, Y.1
Kozaki, K.2
Karpanen, T.3
Koshikawa, K.4
Yla-Herttuala, S.5
Takahashi, T.6
Alitalo, K.7
-
16
-
-
17144402207
-
VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
-
Hirakawa S, Kodama S, Kunstfeld R, Kajiya K, Brown LF, Detmar M (2005) VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 201: 1089-1099
-
(2005)
J Exp Med
, vol.201
, pp. 1089-1099
-
-
Hirakawa, S.1
Kodama, S.2
Kunstfeld, R.3
Kajiya, K.4
Brown, L.F.5
Detmar, M.6
-
17
-
-
0027064888
-
Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms
-
Houck KA, Leung DW, Rowland AM, Winer J, Ferrara N (1992) Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J Biol Chem 267: 26031-26037
-
(1992)
J Biol Chem
, vol.267
, pp. 26031-26037
-
-
Houck, K.A.1
Leung, D.W.2
Rowland, A.M.3
Winer, J.4
Ferrara, N.5
-
18
-
-
15944419554
-
A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3
-
Jimenez X, Lu D, Brennan L, Persaud K, Liu M, Miao H, Witte L, Zhu Z (2005) A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3. Mol Cancer Ther 4: 427-434
-
(2005)
Mol Cancer Ther
, vol.4
, pp. 427-434
-
-
Jimenez, X.1
Lu, D.2
Brennan, L.3
Persaud, K.4
Liu, M.5
Miao, H.6
Witte, L.7
Zhu, Z.8
-
19
-
-
0030026897
-
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
-
Joukov V, Pajusola K, Kaipainen A, Chilov D, Lahtinen I, Kukk E, Saksela O, Kalkkinen N, Alitalo K (1996) A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J 15: 290-298
-
(1996)
EMBO J
, vol.15
, pp. 290-298
-
-
Joukov, V.1
Pajusola, K.2
Kaipainen, A.3
Chilov, D.4
Lahtinen, I.5
Kukk, E.6
Saksela, O.7
Kalkkinen, N.8
Alitalo, K.9
-
20
-
-
0031011529
-
Proteolytic processing regulates receptor specificity and activity of VEGF-C
-
Joukov V, Sorsa T, Kumar V, Jeltsch M, Claesson-Welsh L, Cao Y, Saksela O, Kalkkinen N, Alitalo K (1997) Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J 16: 3898-3911
-
(1997)
EMBO J
, vol.16
, pp. 3898-3911
-
-
Joukov, V.1
Sorsa, T.2
Kumar, V.3
Jeltsch, M.4
Claesson-Welsh, L.5
Cao, Y.6
Saksela, O.7
Kalkkinen, N.8
Alitalo, K.9
-
21
-
-
33644825389
-
Vascular endothelial growth factor-D and its receptor VEGFR-3: Two novel independent prognostic markers in gastric adenocarcinoma
-
Juttner S, Wissmann C, Jons T, Vieth M, Hertel J, Gretschel S, Schlag PM, Kemmner W, Hocker M (2006) Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma. J Clin Oncol 24: 228-240
-
(2006)
J Clin Oncol
, vol.24
, pp. 228-240
-
-
Juttner, S.1
Wissmann, C.2
Jons, T.3
Vieth, M.4
Hertel, J.5
Gretschel, S.6
Schlag, P.M.7
Kemmner, W.8
Hocker, M.9
-
22
-
-
0035266283
-
Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
-
Karpanen T, Egeblad M, Karkkainen MJ, Kubo H, Ylä-Herttuala S, Jäättel M, Alitalo K (2001) Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res 61: 1786-1790
-
(2001)
Cancer Res
, vol.61
, pp. 1786-1790
-
-
Karpanen, T.1
Egeblad, M.2
Karkkainen, M.J.3
Kubo, H.4
Ylä-Herttuala, S.5
Jäättel, M.6
Alitalo, K.7
-
23
-
-
0037310399
-
Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats
-
Krishnan J, Kirkin V, Steffen A, Hegen M, Weih D, Tomarev S, Wilting J, Sleeman JP (2003) Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Cancer Res 63: 713-722
-
(2003)
Cancer Res
, vol.63
, pp. 713-722
-
-
Krishnan, J.1
Kirkin, V.2
Steffen, A.3
Hegen, M.4
Weih, D.5
Tomarev, S.6
Wilting, J.7
Sleeman, J.P.8
-
24
-
-
21744452967
-
Enzyme histochemical analysis of lymphatic vessels in colon carcinoma: Occurrence of lymphangiogenesis within the tumor
-
Kuroyama S, Kobayashi N, Ohbu M, Ohtani Y, Okayasu I, Kakita A (2005) Enzyme histochemical analysis of lymphatic vessels in colon carcinoma: occurrence of lymphangiogenesis within the tumor. Hepatogastroenterol 52: 1057-1061
-
(2005)
Hepatogastroenterol
, vol.52
, pp. 1057-1061
-
-
Kuroyama, S.1
Kobayashi, N.2
Ohbu, M.3
Ohtani, Y.4
Okayasu, I.5
Kakita, A.6
-
25
-
-
23044501991
-
Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor
-
Lin J, Lalani AS, Harding TC, Gonzalez M, Wu WW, Luan B, Tu GH, Koprivnikar K, VanRoey MJ, He Y, Alitalo K, Jooss K (2005) Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor. Cancer Res 65: 6901-6909
-
(2005)
Cancer Res
, vol.65
, pp. 6901-6909
-
-
Lin, J.1
Lalani, A.S.2
Harding, T.C.3
Gonzalez, M.4
Wu, W.W.5
Luan, B.6
Tu, G.H.7
Koprivnikar, K.8
Vanroey, M.J.9
He, Y.10
Alitalo, K.11
Jooss, K.12
-
26
-
-
0034048349
-
Anti-cytokine therapy for rheumatoid arthritis
-
Maini RN, Taylor PC (2000) Anti-cytokine therapy for rheumatoid arthritis. Annu Rev Med 51: 207-229
-
(2000)
Annu Rev Med
, vol.51
, pp. 207-229
-
-
Maini, R.N.1
Taylor, P.C.2
-
27
-
-
0242624291
-
Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
-
Makinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, Wise L, Mercer A, Kowalski H, Kerjaschki D, Stacker SA, Achen MG, Alitalo K (2001) Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J 20: 4762-4773
-
(2001)
EMBO J
, vol.20
, pp. 4762-4773
-
-
Makinen, T.1
Veikkola, T.2
Mustjoki, S.3
Karpanen, T.4
Catimel, B.5
Nice, E.C.6
Wise, L.7
Mercer, A.8
Kowalski, H.9
Kerjaschki, D.10
Stacker, S.A.11
Achen, M.G.12
Alitalo, K.13
-
28
-
-
0035220429
-
Preoperative chemotherapy for resectable thoracic esophageal cancer
-
Malthaner R, Fenlon D (2003) Preoperative chemotherapy for resectable thoracic esophageal cancer. Cochrane Database Syst Rev CD001556
-
(2003)
Cochrane Database Syst Rev
-
-
Malthaner, R.1
Fenlon, D.2
-
29
-
-
17744390184
-
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
-
Mandriota SJ, Jussila L, Jeltsch M, Compagni A, Baetens D, Prevo R, Banerji S, Huarte J, Montesano R, Jackson DG, Orci L, Alitalo K, Christofori G, Pepper MS (2001) Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J 20: 672-682
-
(2001)
EMBO J
, vol.20
, pp. 672-682
-
-
Mandriota, S.J.1
Jussila, L.2
Jeltsch, M.3
Compagni, A.4
Baetens, D.5
Prevo, R.6
Banerji, S.7
Huarte, J.8
Montesano, R.9
Jackson, D.G.10
Orci, L.11
Alitalo, K.12
Christofori, G.13
Pepper, M.S.14
-
30
-
-
0037140120
-
VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumours
-
Mattila MM, Ruohola JK, Karpanen T, Jackson DG, Härkönen PL (2002) VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumours. Int J Cancer 98: 946-951
-
(2002)
Int J Cancer
, vol.98
, pp. 946-951
-
-
Mattila, M.M.1
Ruohola, J.K.2
Karpanen, T.3
Jackson, D.G.4
Härkönen, P.L.5
-
31
-
-
0141672945
-
Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D
-
McColl BK, Baldwin ME, Roufail S, Freeman C, Moritz RL, Simpson RJ, Alitalo K, Stacker SA, Achen MG (2003) Plasmin activates the lymphangiogenic growth factors VEGF-C and VEGF-D. J Exp Med 198: 863-868
-
(2003)
J Exp Med
, vol.198
, pp. 863-868
-
-
McColl, B.K.1
Baldwin, M.E.2
Roufail, S.3
Freeman, C.4
Moritz, R.L.5
Simpson, R.J.6
Alitalo, K.7
Stacker, S.A.8
Achen, M.G.9
-
32
-
-
30444444987
-
Importance of lymph vessels in gastric cancer: A prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer
-
Nakamura Y, Yasuoka H, Tsujimoto M, Kurozumi K, Nakahara M, Nakao K, Kakudo K (2006) Importance of lymph vessels in gastric cancer: a prognostic indicator in general and a predictor for lymph node metastasis in early stage cancer. J Clin Pathol 59: 77-82
-
(2006)
J Clin Pathol
, vol.59
, pp. 77-82
-
-
Nakamura, Y.1
Yasuoka, H.2
Tsujimoto, M.3
Kurozumi, K.4
Nakahara, M.5
Nakao, K.6
Kakudo, K.7
-
33
-
-
4444378842
-
Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma
-
Nishida N, Yano H, Komai K, Nishida T, Kamura T, Kojiro M (2004) Vascular endothelial growth factor C and vascular endothelial growth factor receptor 2 are related closely to the prognosis of patients with ovarian carcinoma. Cancer 101: 1364-1374
-
(2004)
Cancer
, vol.101
, pp. 1364-1374
-
-
Nishida, N.1
Yano, H.2
Komai, K.3
Nishida, T.4
Kamura, T.5
Kojiro, M.6
-
34
-
-
0037036136
-
Lymphatic metastasis in the absence of functional intratumor lymphatics
-
Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK (2002) Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 296: 1883-1886
-
(2002)
Science
, vol.296
, pp. 1883-1886
-
-
Padera, T.P.1
Kadambi, A.2
Di Tomaso, E.3
Carreira, C.M.4
Brown, E.B.5
Boucher, Y.6
Choi, N.C.7
Mathisen, D.8
Wain, J.9
Mark, E.J.10
Munn, L.L.11
Jain, R.K.12
-
35
-
-
12444343144
-
Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody
-
Pytowski B, Goldman J, Persaud K, Wu Y, Witte L, Hicklin DJ, Skobe M, Boardman KC, Swartz MA (2005) Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J Natl Cancer Inst 97: 14-21
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 14-21
-
-
Pytowski, B.1
Goldman, J.2
Persaud, K.3
Wu, Y.4
Witte, L.5
Hicklin, D.J.6
Skobe, M.7
Boardman, K.C.8
Swartz, M.A.9
-
36
-
-
27144543581
-
Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer
-
Renyi-Vamos F, Tovari J, Fillinger J, Timar J, Paku S, Kenessey I, Ostoros G, Agocs L, Soltesz I, Dome B (2005) Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer. Clin Cancer Res 11: 7344-7353
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7344-7353
-
-
Renyi-Vamos, F.1
Tovari, J.2
Fillinger, J.3
Timar, J.4
Paku, S.5
Kenessey, I.6
Ostoros, G.7
Agocs, L.8
Soltesz, I.9
Dome, B.10
-
37
-
-
0037714018
-
VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses
-
Rissanen TT, Markkanen JE, Gruchala M, Heikura T, Puranen A, Kettunen MI, Kholov I, Kauppinen RA, Achen MG, Stacker SA, Alitalo K, Ylä-Herttuala S (2003) VEGF-D is the strongest angiogenic and lymphangiogenic effector among VEGFs delivered into skeletal muscle via adenoviruses. Circ Res 92: 1098-1106
-
(2003)
Circ Res
, vol.92
, pp. 1098-1106
-
-
Rissanen, T.T.1
Markkanen, J.E.2
Gruchala, M.3
Heikura, T.4
Puranen, A.5
Kettunen, M.I.6
Kholov, I.7
Kauppinen, R.A.8
Achen, M.G.9
Stacker, S.A.10
Alitalo, K.11
Ylä-Herttuala, S.12
-
38
-
-
2942668041
-
Lymphatic vasculature: Development, molecular regulation and role in tumor metastasis and inflammation
-
Saharinen P, Tammela T, Karkkainen MJ, Alitalo K (2004) Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 25: 387-395
-
(2004)
Trends Immunol
, vol.25
, pp. 387-395
-
-
Saharinen, P.1
Tammela, T.2
Karkkainen, M.J.3
Alitalo, K.4
-
39
-
-
3242705881
-
Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer
-
Schoppmann SF, Bayer G, Aumayr K, Taucher S, Geleff S, Rudas M, Kubista E, Hausmaninger H, Samonigg H, Gnant M, Jakesz R, Horvat R (2004) Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Ann Surg 240: 306-312
-
(2004)
Ann Surg
, vol.240
, pp. 306-312
-
-
Schoppmann, S.F.1
Bayer, G.2
Aumayr, K.3
Taucher, S.4
Geleff, S.5
Rudas, M.6
Kubista, E.7
Hausmaninger, H.8
Samonigg, H.9
Gnant, M.10
Jakesz, R.11
Horvat, R.12
-
40
-
-
0036733564
-
Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis
-
Schoppmann SF, Birner P, Stockl J, Kalt R, Ullrich R, Caucig C, Kriehuber E, Nagy K, Alitalo K, Kerjaschki D (2002) Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 161: 947-956
-
(2002)
Am J Pathol
, vol.161
, pp. 947-956
-
-
Schoppmann, S.F.1
Birner, P.2
Stockl, J.3
Kalt, R.4
Ullrich, R.5
Caucig, C.6
Kriehuber, E.7
Nagy, K.8
Alitalo, K.9
Kerjaschki, D.10
-
41
-
-
0038481179
-
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis
-
Siegfried G, Basak A, Cromlish JA, Benjannet S, Marcinkiewicz J, Chrétien M, Seidah NG, Khatib A-M (2003) The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. J Clin Invest 111: 1723-1732
-
(2003)
J Clin Invest
, vol.111
, pp. 1723-1732
-
-
Siegfried, G.1
Basak, A.2
Cromlish, J.A.3
Benjannet, S.4
Marcinkiewicz, J.5
Chrétien, M.6
Seidah, N.G.7
Khatib, A.-M.8
-
42
-
-
27144488288
-
Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases
-
Siegfried G, Basak A, Prichett-Pejic W, Scamuffa N, Ma L, Benjannet S, Veinot JP, Calvo F, Seidah N, Khatib AM (2005) Regulation of the stepwise proteolytic cleavage and secretion of PDGF-B by the proprotein convertases. Oncogene 24: 6925-6935
-
(2005)
Oncogene
, vol.24
, pp. 6925-6935
-
-
Siegfried, G.1
Basak, A.2
Prichett-Pejic, W.3
Scamuffa, N.4
Ma, L.5
Benjannet, S.6
Veinot, J.P.7
Calvo, F.8
Seidah, N.9
Khatib, A.M.10
-
43
-
-
0034842967
-
Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma
-
Skobe M, Hamberg LM, Hawighorst T, Schirner M, Wolf GL, Alitalo K, Detmar M (2001a) Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. Am J Pathol 159: 893-903
-
(2001)
Am J Pathol
, vol.159
, pp. 893-903
-
-
Skobe, M.1
Hamberg, L.M.2
Hawighorst, T.3
Schirner, M.4
Wolf, G.L.5
Alitalo, K.6
Detmar, M.7
-
44
-
-
0035122537
-
Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
-
Skobe M, Hawighorst T, Jackson DG, Prevo R, Janes L, Velasco P, Riccardi L, Alitalo K, Claffey K, Detmar M (2001b) Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 7: 192-198
-
(2001)
Nat Med
, vol.7
, pp. 192-198
-
-
Skobe, M.1
Hawighorst, T.2
Jackson, D.G.3
Prevo, R.4
Janes, L.5
Velasco, P.6
Riccardi, L.7
Alitalo, K.8
Claffey, K.9
Detmar, M.10
-
45
-
-
0036673666
-
Lymphangiogenesis and cancer metastasis
-
Stacker SA, Achen MG, Jussila L, Baldwin ME, Alitalo K (2002a) Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2: 573-583
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 573-583
-
-
Stacker, S.A.1
Achen, M.G.2
Jussila, L.3
Baldwin, M.E.4
Alitalo, K.5
-
46
-
-
0036310316
-
The role of tumor lymphangiogenesis in metastatic spread
-
Stacker SA, Baldwin ME, Achen MG (2002b) The role of tumor lymphangiogenesis in metastatic spread. FASEB J 16: 922-934
-
(2002)
FASEB J
, vol.16
, pp. 922-934
-
-
Stacker, S.A.1
Baldwin, M.E.2
Achen, M.G.3
-
47
-
-
0035126049
-
VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
-
Stacker SA, Caesar C, Baldwin ME, Thornton GE, Williams RA, Prevo R, Jackson DG, Nishikawa S-I, Kubo H, Achen MG (2001) VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 7: 186-191
-
(2001)
Nat Med
, vol.7
, pp. 186-191
-
-
Stacker, S.A.1
Caesar, C.2
Baldwin, M.E.3
Thornton, G.E.4
Williams, R.A.5
Prevo, R.6
Jackson, D.G.7
Nishikawa, S.-I.8
Kubo, H.9
Achen, M.G.10
-
48
-
-
0033527634
-
Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers
-
Stacker SA, Stenvers K, Caesar C, Vitali A, Domagala T, Nice E, Roufail S, Simpson RJ, Moritz R, Karpanen T, Alitalo K, Achen MG (1999) Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. J Biol Chem 274: 32127-32136
-
(1999)
J Biol Chem
, vol.274
, pp. 32127-32136
-
-
Stacker, S.A.1
Stenvers, K.2
Caesar, C.3
Vitali, A.4
Domagala, T.5
Nice, E.6
Roufail, S.7
Simpson, R.J.8
Moritz, R.9
Karpanen, T.10
Alitalo, K.11
Achen, M.G.12
-
49
-
-
10344237560
-
Lymphangiogenic growth factors as markers of tumor metastasis
-
Stacker SA, Williams RA, Achen MG (2004) Lymphangiogenic growth factors as markers of tumor metastasis. APMIS 112: 539-549
-
(2004)
APMIS
, vol.112
, pp. 539-549
-
-
Stacker, S.A.1
Williams, R.A.2
Achen, M.G.3
-
50
-
-
13844275193
-
Adjuvant therapy of colon cancer
-
Sun W, Haller DG (2005) Adjuvant therapy of colon cancer. Semin Oncol 32: 95-102
-
(2005)
Semin Oncol
, vol.32
, pp. 95-102
-
-
Sun, W.1
Haller, D.G.2
-
51
-
-
0037139421
-
Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas
-
Ueda M, Terai Y, Yamashita Y, Kumagai K, Ueki K, Yamaguchi H, Akise D, Hung Y-C, Ueki M (2002) Correlation between vascular endothelial growth factor-C expression and invasion phenotype in cervical carcinomas. Int J Cancer 98: 335-343
-
(2002)
Int J Cancer
, vol.98
, pp. 335-343
-
-
Ueda, M.1
Terai, Y.2
Yamashita, Y.3
Kumagai, K.4
Ueki, K.5
Yamaguchi, H.6
Akise, D.7
Hung, Y.-C.8
Ueki, M.9
-
52
-
-
17744396472
-
Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
-
Veikkola T, Jussila L, Makinen T, Karpanen T, Jeltsch M, Petrova TV, Kubo H, Thurston G, McDonald DM, Achen MG, Stacker SA, Alitalo K (2001) Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J 20: 1223-1231
-
(2001)
EMBO J
, vol.20
, pp. 1223-1231
-
-
Veikkola, T.1
Jussila, L.2
Makinen, T.3
Karpanen, T.4
Jeltsch, M.5
Petrova, T.V.6
Kubo, H.7
Thurston, G.8
McDonald, D.M.9
Achen, M.G.10
Stacker, S.A.11
Alitalo, K.12
-
53
-
-
24344509918
-
Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer
-
Von Marschall Z, Scholz A, Stacker SA, Achen MG, Jackson DG, Alves F, Schirner M, Haberey M, Thierauch KH, Wiedenmann B, Rosewicz S (2005) Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. Int J Oncol 27: 669-679
-
(2005)
Int J Oncol
, vol.27
, pp. 669-679
-
-
Von Marschall, Z.1
Scholz, A.2
Stacker, S.A.3
Achen, M.G.4
Jackson, D.G.5
Alves, F.6
Schirner, M.7
Haberey, M.8
Thierauch, K.H.9
Wiedenmann, B.10
Rosewicz, S.11
-
54
-
-
0037086278
-
Vascular endothelial growth factor-D expression is an independent prognostic marker for survival in colorectal carcinoma
-
White JD, Hewett PW, Kosuge D, McCulloch T, Enholm BC, Carmichael J, Murray JC (2002) Vascular endothelial growth factor-D expression is an independent prognostic marker for survival in colorectal carcinoma. Cancer Res 62: 1669-1675
-
(2002)
Cancer Res
, vol.62
, pp. 1669-1675
-
-
White, J.D.1
Hewett, P.W.2
Kosuge, D.3
McCulloch, T.4
Enholm, B.C.5
Carmichael, J.6
Murray, J.C.7
-
55
-
-
0035751675
-
Preoperative chemotherapy in patients with operable breast cancer: Nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18
-
Wolmark N, Wang J, Mamounas E, Bryant J, Fisher B (2001) Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18. J Natl Cancer Inst Monogr No. 30, 96-102
-
(2001)
J Natl Cancer Inst Monogr No. 30
, pp. 96-102
-
-
Wolmark, N.1
Wang, J.2
Mamounas, E.3
Bryant, J.4
Fisher, B.5
-
56
-
-
27544483545
-
Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis
-
Wong SY, Haack H, Crowley D, Barry M, Bronson RT, Hynes RO (2005) Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Res 65: 9789-9798
-
(2005)
Cancer Res
, vol.65
, pp. 9789-9798
-
-
Wong, S.Y.1
Haack, H.2
Crowley, D.3
Barry, M.4
Bronson, R.T.5
Hynes, R.O.6
-
57
-
-
0037468102
-
Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma
-
Yokoyama Y, Charnock-Jones DS, Licence D, Yanaihara A, Hastings JM, Holland CM, Emoto M, Umemoto M, Sakamoto T, Sato S, Mizunuma H, Smith SK (2003) Vascular endothelial growth factor-D is an independent prognostic factor in epithelial ovarian carcinoma. Br J Cancer 88: 237-244
-
(2003)
Br J Cancer
, vol.88
, pp. 237-244
-
-
Yokoyama, Y.1
Charnock-Jones, D.S.2
Licence, D.3
Yanaihara, A.4
Hastings, J.M.5
Holland, C.M.6
Emoto, M.7
Umemoto, M.8
Sakamoto, T.9
Sato, S.10
Mizunuma, H.11
Smith, S.K.12
|