Objective assessment of blood and lymphatic vessel invasion and association with macrophage infiltration in cutaneous melanoma

Modern Pathology

Volumn 25, Issue 4, 2012, Pages 493-504

  Storr, Sarah J ^a   Safuan, Sabreena ^a   Mitra, Angana ^b   Elliott, Faye ^b   Walker, Christopher ^b   Vasko, Mark J ^a   Ho, Bernard ^a   Cook, Martin ^c   Mohammed, Rabab A A ^a,d   Patel, Poulam M ^a   Ellis, Ian O ^a   Newton Bishop, Julia A ^b   Martin, Stewart G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c ROYAL SURREY COUNTY HOSPITAL   (United Kingdom)

^d Assiut University   (Egypt)

Author keywords

D2 40; melanoma; tumour associated macrophages; vascular invasion; vessel density

Indexed keywords

CD34 ANTIGEN; CD68 ANTIGEN; EOSIN; HEMATOXYLIN; MONOCLONAL ANTIBODY D2-40;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD VESSEL; CANCER INVASION; CANCER PATIENT; CANCER PROGNOSIS; CELL INFILTRATION; CONTROLLED STUDY; ENDOTHELIUM; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LABORATORY DIAGNOSIS; LYMPH VESSEL; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MELANOMA; MICROVASCULATURE; MITOSIS RATE; MULTICENTER STUDY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIMARY TUMOR; PRIORITY JOURNAL; RECURRENCE FREE SURVIVAL; SKIN CANCER; ULCER;

EID: 84859433376     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2011.182     Document Type: Article

References (39)

1. Balch CM, Gershenwald JE, Soong SJ, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009;27:6199-6206.
2. Mohammed RA, Martin SG, Gill MS, et al. Improved methods of detection of lymphovascular invasion demonstrate that it is the predominant method of vascular invasion in breast cancer and has important clinical consequences. Am J Surg Pathol 2007;31: 1825-1833. (Pubitemid 350175809)
3. Straume O, Jackson DG, Akslen LA. Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma. Clin Cancer Res 2003;9:250-256. (Pubitemid 36109741)
4. Valencak J, Heere-Ress E, Kopp T, et al. Selective immunohistochemical staining shows significant prognostic influence of lymphatic and blood vessels in patients with malignant melanoma. Eur J Cancer 2004; 40:358-364. (Pubitemid 38121272)
5. Massi D, Puig S, Franchi A, et al. Tumour lymphangiogenesis is a possible predictor of sentinel lymph node status in cutaneous melanoma: a case-control study. J Clin Pathol 2006;59:166-173. (Pubitemid 43235582)
6. Shields JD, Borsetti M, Rigby H, et al. Lymphatic density and metastatic spread in human malignant melanoma. Br J Cancer 2004;90:693-700. (Pubitemid 38297212)
7. Emmett MS, Symonds KE, Rigby H, et al. Prediction of melanoma metastasis by the Shields index based on lymphatic vessel density. BMC Cancer 2010;10:208.
8. Dadras SS, Paul T, Bertoncini J, et al. Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 2003;162:1951-1960. (Pubitemid 36613052)
9. Petersson F, Diwan AH, Ivan D, et al. Immunohistochemical detection of lymphovascular invasion with D2-40 in melanoma correlates with sentinel lymph node status, metastasis and survival. J Cutan Pathol 2009;36:1157-1163.
10. Niakosari F, Kahn HJ, McCready D, et al. Lymphatic invasion identified by monoclonal antibody D2-40, younger age, and ulceration: predictors of sentinel lymph node involvement in primary cutaneous melanoma. Arch Dermatol 2008;144:462-467. (Pubitemid 351581102)
11. Xu X, Gimotty PA, Guerry D, et al. Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis. Hum Pathol 2008;39:901-909.
12. Doeden K, Ma Z, Narasimhan B, et al. Lymphatic invasion in cutaneous melanoma is associated with sentinel lymph node metastasis. J Cutan Pathol 2009;36:772-780.
13. Fohn LE, Rodriguez A, Kelley MC, et al. D2-40 lymphatic marker for detecting lymphatic invasion in thin to intermediate thickness melanomas: association with sentinel lymph node status and prognostic valuea retrospective case study. J Am Acad Dermatol 2011;64:336-345.
14. Petitt M, Allison A, Shimoni T, et al. Lymphatic invasion detected by D2-40/S-100 dual immunohistochemistry does not predict sentinel lymph node status in melanoma. J Am Acad Dermatol 2009;61:819-828.
15. Sahni D, Robson A, Orchard G, et al. The use of LYVE-antibody for detecting lymphatic involvement in patients with malignant melanoma of known sentinel node status. J Clin Pathol 2005;58:715-721 (Pubitemid 40956825)
16. Kashani-Sabet M, Sagebiel RW, Ferreira CM, et al. Vascular involvement in the prognosis of primary cutaneous melanoma. Arch Dermatol 2001;137: 1169-1173. (Pubitemid 32847838)
17. Vuylsteke RJ, van Leeuwen PA, Statius Muller MG, et al. Clinical outcome of stage I/II melanoma patients after selective sentinel lymph node dissection: long-term follow-up results. J Clin Oncol 2003;21: 1057-1065. (Pubitemid 46594135)
18. Nagore E, Oliver V, Botella-Estrada R, et al. Prognostic factors in localized invasive cutaneous melanoma: high value of mitotic rate, vascular invasion and microscopic satellitosis. Melanoma Res 2005;15: 169-177. (Pubitemid 40839464)
19. Paek SC, Griffith KA, Johnson TM, et al. The impact of factors beyond Breslow depth on predicting sentinel lymph node positivity in melanoma. Cancer 2007;109: 100-108. (Pubitemid 46120199)
20. Jensen TO, Schmidt H, Moller HJ, et al. Macrophage markers in serum and tumor have prognostic impact in American Joint Committee on Cancer stage I/II melanoma. J Clin Oncol 2009;27:3330-3337.
21. Shi L, Lei D, Ma C, et al. Clinicopathological implications of tumour-associated macrophages and vascularization in sinonasal melanoma. J Int Med Res 2010; 38:1276-1286.
22. Rofstad EK, Mathiesen B. Metastasis in melanoma xenografts is associated with tumor microvascular density rather than extent of hypoxia. Neoplasia 2010; 12:889-898.
23. Mitra A, Conway C, Walker C, et al. Melanoma sentinel node biopsy and prediction models for relapse and overall survival. Br J Cancer 2010;103:1229-1236.
24. Mohammed RA, Martin SG, Mahmmod AM, et al. Objective assessment of lymphatic and blood vascular invasion in lymph node-negative breast carcinoma: findings from a large case series with long-term followup. J Pathol 2011;223:358-365.
25. Ammar A, Mohammed RA, Salmi M, et al. Lymphatic expression of CLEVER-1 in breast cancer and its relationship with lymph node metastasis. Anal Cell Pathol (Amst) 2011;34:67-78.
26. Fox SB, Harris AL. Histological quantitation of tumour angiogenesis. APMIS 2004;112:413-430. (Pubitemid 39626050)
27. Mohammed RA, Ellis IO, Elsheikh S, et al. Lymphatic and angiogenic characteristics in breast cancer: morphometric analysis and prognostic implications. Breast Cancer Res Treat 2009;113:261-273.
28. Pulford KA, Rigney EM, Micklem KJ, et al. KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol 1989;42:414-421. (Pubitemid 19121590)
29. Niakosari F, Kahn HJ, Marks A, et al. Detection of lymphatic invasion in primary melanoma with monoclonal antibody D2-40: a new selective immunohistochemical marker of lymphatic endothelium. Arch Dermatol 2005;141:440-444. (Pubitemid 40547402)
30. Mohammed RA, Ellis IO, Lee AH, Martin SG. Vascular invasion in breast cancer; an overview of recent prognostic developments and molecular pathophysiological mechanisms. Histopathology 2009;55:1-9.
31. Kriehuber E, Breiteneder-Geleff S, Groeger M, et al. Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J Exp Med 2001;194:797-808. (Pubitemid 32983015)
32. Padera TP, Kadambi A, di Tomaso E, et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 2002;296:1883-1886. (Pubitemid 34596277)
33. Dadras SS, Lange-Asschenfeldt B, Velasco P, et al. Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol 2005;18:1232-1242. (Pubitemid 43079923)
34. Boone B, Blokx W, De Bacquer D, et al. The role of VEGF-C staining in predicting regional metastasis in melanoma. Virchows Arch 2008;453:257-265.
35. Skobe M, Hamberg LM, Hawighorst T, et al. Concurrent induction of lymphangiogenesis, angiogenesis, and macrophage recruitment by vascular endothelial growth factor-C in melanoma. Am J Pathol 2001;159: 893-903. (Pubitemid 32847180)
36. Massi D, De Nisi MC, Franchi A, et al. Inducible nitric oxide synthase expression in melanoma: implications in lymphangiogenesis. Mod Pathol 2009;22:21-30.
37. Massi D, Marconi C, Franchi A, et al. Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors. Hum Pathol 2007;38:1516-1525. (Pubitemid 47418963)
38. Torisu-Itakura H, Lee JH, Scheri RP, et al. Molecular characterization of inflammatory genes in sentinel and nonsentinel nodes in melanoma. Clin Cancer Res 2007;13:3125-3132. (Pubitemid 46944893)
39. Woodward JK, Elshaw SR, Murray AK, et al. Stimulation and inhibition of uveal melanoma invasion by HGF, GRO, IL-1alpha and TGF-beta. Invest Ophthalmol Vis Sci 2002;43:3144-3152.