메뉴 건너뛰기




Volumn 66, Issue 16, 2006, Pages 8065-8075

Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: Therapeutic implications

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN ANTIBODY; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3;

EID: 33748075460     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1392     Document Type: Article
Times cited : (299)

References (47)
  • 1
    • 0035999133 scopus 로고    scopus 로고
    • Critical determinants of metastasis
    • Fidler IJ. Critical determinants of metastasis. Semin Cancer Biol 2002;12:89-96.
    • (2002) Semin Cancer Biol , vol.12 , pp. 89-96
    • Fidler, I.J.1
  • 2
    • 2942538264 scopus 로고    scopus 로고
    • Dissecting the metastatic cascade
    • Pantel K, Brakenhoff RH. Dissecting the metastatic cascade. Nat Rev Cancer 2004;4:448-56.
    • (2004) Nat Rev Cancer , vol.4 , pp. 448-456
    • Pantel, K.1    Brakenhoff, R.H.2
  • 3
    • 0016218630 scopus 로고
    • Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
    • Liotta LA, Kleinerman J, Saidel GM. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res 1974;34:997-1004.
    • (1974) Cancer Res , vol.34 , pp. 997-1004
    • Liotta, L.A.1    Kleinerman, J.2    Saidel, G.M.3
  • 4
    • 0016607434 scopus 로고
    • Quantitation of cell shedding into efferent blood of mammary adenocarcinoma
    • Butler TP, Gullino PM. Quantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer Res 1975;35:512-6.
    • (1975) Cancer Res , vol.35 , pp. 512-516
    • Butler, T.P.1    Gullino, P.M.2
  • 5
    • 0025256084 scopus 로고
    • Metastatic inefficiency
    • Weiss L. Metastatic inefficiency. Adv Cancer Res 1990; 54:159-211.
    • (1990) Adv Cancer Res , vol.54 , pp. 159-211
    • Weiss, L.1
  • 6
    • 0032750852 scopus 로고    scopus 로고
    • Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity
    • Swartz MA, Kristensen CA, Melder RJ, et al. Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity. Br J Cancer 1999; 81:756-9.
    • (1999) Br J Cancer , vol.81 , pp. 756-759
    • Swartz, M.A.1    Kristensen, C.A.2    Melder, R.J.3
  • 7
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002;2:563-72.
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 8
    • 0345059766 scopus 로고    scopus 로고
    • Intravital imaging of cell movement in tumours
    • Condeelis J, Segall JE. Intravital imaging of cell movement in tumours. Nat Rev Cancer 2003;3:921-30.
    • (2003) Nat Rev Cancer , vol.3 , pp. 921-930
    • Condeelis, J.1    Segall, J.E.2
  • 9
    • 4344589420 scopus 로고    scopus 로고
    • Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells
    • Kim JW, Wong CW, Goldsmith JD, et al. Rapid apoptosis in the pulmonary vasculature distinguishes non-metastatic from metastatic melanoma cells. Cancer Lett 2004;213:203-12.
    • (2004) Cancer Lett , vol.213 , pp. 203-212
    • Kim, J.W.1    Wong, C.W.2    Goldsmith, J.D.3
  • 10
    • 1942506574 scopus 로고    scopus 로고
    • Differential gene expression in metastasizing cells shed from kidney tumors
    • Bockhorn M, Roberge S, Sousa C, Jain RK, Munn LL. Differential gene expression in metastasizing cells shed from kidney tumors. Cancer Res 2004;64:2469-73.
    • (2004) Cancer Res , vol.64 , pp. 2469-2473
    • Bockhorn, M.1    Roberge, S.2    Sousa, C.3    Jain, R.K.4    Munn, L.L.5
  • 11
    • 0035122537 scopus 로고    scopus 로고
    • Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis
    • Skobe M, Hawighorst T, Jackson DG, et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med 2001;7:192-8.
    • (2001) Nat Med , vol.7 , pp. 192-198
    • Skobe, M.1    Hawighorst, T.2    Jackson, D.G.3
  • 12
    • 17744390184 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
    • Mandriota SJ, Jussila L, Jeltsch M, et al. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EMBO J 2001;20:672-82.
    • (2001) EMBO J , vol.20 , pp. 672-682
    • Mandriota, S.J.1    Jussila, L.2    Jeltsch, M.3
  • 13
    • 0035266283 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    • Karpanen T, Egeblad M, Karkkainen MJ, et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res 2001;61:1786-90.
    • (2001) Cancer Res , vol.61 , pp. 1786-1790
    • Karpanen, T.1    Egeblad, M.2    Karkkainen, M.J.3
  • 14
    • 0037036136 scopus 로고    scopus 로고
    • Lymphatic metastasis in the absence of functional intratumor lymphatics
    • Padera TP, Kadambi A, di Tomaso E, et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 2002;296:1883-6.
    • (2002) Science , vol.296 , pp. 1883-1886
    • Padera, T.P.1    Kadambi, A.2    Di Tomaso, E.3
  • 15
    • 27544483545 scopus 로고    scopus 로고
    • Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis
    • Wong SY, Haack H, Crowley D, et al. Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Res 2005;65:9789-98.
    • (2005) Cancer Res , vol.65 , pp. 9789-9798
    • Wong, S.Y.1    Haack, H.2    Crowley, D.3
  • 17
    • 33646835413 scopus 로고    scopus 로고
    • Targeting lymphangiogenesis to prevent tumour metastasis
    • Achen MG, Mann GB, Stacker SA. Targeting lymphangiogenesis to prevent tumour metastasis. British J Cancer 2006;94:1355-60.
    • (2006) British J Cancer , vol.94 , pp. 1355-1360
    • Achen, M.G.1    Mann, G.B.2    Stacker, S.A.3
  • 18
    • 2942668041 scopus 로고    scopus 로고
    • Lymphatic vasculature: Development, molecular regulation and role in tumor metastasis and inflammation
    • Saharinen P, Tammela T, Karkkainen MJ, Alitalo K. Lymphatic vasculature: development, molecular regulation and role in tumor metastasis and inflammation. Trends Immunol 2004;25:387-95.
    • (2004) Trends Immunol , vol.25 , pp. 387-395
    • Saharinen, P.1    Tammela, T.2    Karkkainen, M.J.3    Alitalo, K.4
  • 19
    • 17744396472 scopus 로고    scopus 로고
    • Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice
    • Veikkola T, Jussila L, Makinen T, et al. Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J 2001;20:1223-31.
    • (2001) EMBO J , vol.20 , pp. 1223-1231
    • Veikkola, T.1    Jussila, L.2    Makinen, T.3
  • 20
    • 2542512275 scopus 로고    scopus 로고
    • Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis
    • He Y, Rajantie I, Ilmonen M, et al. Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. Cancer Res 2004;64:3737-40.
    • (2004) Cancer Res , vol.64 , pp. 3737-3740
    • He, Y.1    Rajantie, I.2    Ilmonen, M.3
  • 21
    • 3042826827 scopus 로고    scopus 로고
    • Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function
    • Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK. Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Res 2004;64:4400-4.
    • (2004) Cancer Res , vol.64 , pp. 4400-4404
    • Isaka, N.1    Padera, T.P.2    Hagendoorn, J.3    Fukumura, D.4    Jain, R.K.5
  • 22
    • 0032564411 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C induces angiogenesis in vivo
    • Cao YH, Linden P, Farnebo J, et al. Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci U S A 1998;95:14389-94.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 14389-14394
    • Cao, Y.H.1    Linden, P.2    Farnebo, J.3
  • 23
    • 0031830312 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia
    • Witzenbichler B, Asahara T, Murohara T, et al. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. Am J Pathol 1998;153:381-94.
    • (1998) Am J Pathol , vol.153 , pp. 381-394
    • Witzenbichler, B.1    Asahara, T.2    Murohara, T.3
  • 24
    • 0035866775 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: Role of VEGF-receptor 2 and host VEGF-A
    • Kadambi A, Carreira CM, Yun CO, et al. Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Res 2001; 61:2404-8.
    • (2001) Cancer Res , vol.61 , pp. 2404-2408
    • Kadambi, A.1    Carreira, C.M.2    Yun, C.O.3
  • 25
    • 0037036097 scopus 로고    scopus 로고
    • Cancer. Targeting lymphatic metastasis
    • Gershenwald JE, Fidler IJ. Cancer. Targeting lymphatic metastasis. Science 2002;296:1811-2.
    • (2002) Science , vol.296 , pp. 1811-1812
    • Gershenwald, J.E.1    Fidler, I.J.2
  • 26
    • 10844242206 scopus 로고    scopus 로고
    • Lymphangiogenesis and cancer: Meeting report
    • Alitalo K, Mohla S, Ruoslahti E. Lymphangiogenesis and cancer: meeting report. Cancer Res 2004;64:9225-9.
    • (2004) Cancer Res , vol.64 , pp. 9225-9229
    • Alitalo, K.1    Mohla, S.2    Ruoslahti, E.3
  • 27
    • 0037024472 scopus 로고    scopus 로고
    • Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor-3 signalling
    • He Y, Kozaki K, Karpanen T, et al. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor-3 signalling. J Natl Cancer Inst 2002;94:819-25.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 819-825
    • He, Y.1    Kozaki, K.2    Karpanen, T.3
  • 28
    • 12444343144 scopus 로고    scopus 로고
    • Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody
    • Pytowski B, Goldman J, Persaud K, et al. Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J Natl Cancer Inst 2005;97:14-21.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 14-21
    • Pytowski, B.1    Goldman, J.2    Persaud, K.3
  • 30
    • 0037011070 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis
    • Nagy JA, Vasile E, Feng D, et al. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J Exp Med 2002; 196:1497-506.
    • (2002) J Exp Med , vol.196 , pp. 1497-1506
    • Nagy, J.A.1    Vasile, E.2    Feng, D.3
  • 31
    • 0030040196 scopus 로고    scopus 로고
    • Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching
    • Berk DA, Swartz MA, Leu AJ, Jain RK. Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching. Am J Physiol 1996;270:H330-7.
    • (1996) Am J Physiol , vol.270
    • Berk, D.A.1    Swartz, M.A.2    Leu, A.J.3    Jain, R.K.4
  • 32
    • 0034918106 scopus 로고    scopus 로고
    • In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy
    • Brown EB, Campbell RB, Tsuzuki Y, et al. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med 2001;7:864-8.
    • (2001) Nat Med , vol.7 , pp. 864-868
    • Brown, E.B.1    Campbell, R.B.2    Tsuzuki, Y.3
  • 33
    • 0003138605 scopus 로고    scopus 로고
    • Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions
    • Padera TP, Stoll BR, So PT, Jain RK. Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions. Mol Imaging 2002;1:9-15.
    • (2002) Mol Imaging , vol.1 , pp. 9-15
    • Padera, T.P.1    Stoll, B.R.2    So, P.T.3    Jain, R.K.4
  • 34
    • 0038578294 scopus 로고    scopus 로고
    • Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation
    • Brown E, McKee T, diTomaso E, et al. Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation. Nat Med 2003;9:796-800.
    • (2003) Nat Med , vol.9 , pp. 796-800
    • Brown, E.1    McKee, T.2    Ditomaso, E.3
  • 35
    • 17144402207 scopus 로고    scopus 로고
    • VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis
    • Hirakawa S, Kodama S, Kunstfeld R, et al. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J Exp Med 2005;201:1089-99.
    • (2005) J Exp Med , vol.201 , pp. 1089-1099
    • Hirakawa, S.1    Kodama, S.2    Kunstfeld, R.3
  • 36
    • 0030187427 scopus 로고    scopus 로고
    • Rates of flow of technetium 99m-labeled human serum albumin from peripheral injection sites to sentinel lymph nodes
    • Nathanson SD, Nelson L, Karvelis KC. Rates of flow of technetium 99m-labeled human serum albumin from peripheral injection sites to sentinel lymph nodes. Ann Surg Oncol 1996;3:329-35.
    • (1996) Ann Surg Oncol , vol.3 , pp. 329-335
    • Nathanson, S.D.1    Nelson, L.2    Karvelis, K.C.3
  • 37
    • 0037442695 scopus 로고    scopus 로고
    • Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts
    • Izumi Y, di Tomaso E, Hooper A, et al. Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts. Cancer Res 2003;63: 747-51.
    • (2003) Cancer Res , vol.63 , pp. 747-751
    • Izumi, Y.1    Di Tomaso, E.2    Hooper, A.3
  • 38
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Muller A, Homey B, Soto H, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001;410:50-6.
    • (2001) Nature , vol.410 , pp. 50-56
    • Muller, A.1    Homey, B.2    Soto, H.3
  • 39
    • 0242330142 scopus 로고    scopus 로고
    • Lymphatic endothelium: Morphological, molecular and functional properties
    • Pepper MS, Skobe M. Lymphatic endothelium: morphological, molecular and functional properties. J Cell Biol 2003;163:209-13.
    • (2003) J Cell Biol , vol.163 , pp. 209-213
    • Pepper, M.S.1    Skobe, M.2
  • 40
    • 14744286895 scopus 로고    scopus 로고
    • Tumor cells caught in the act of invading: Their strategy for enhanced cell motility
    • Wang W, Goswami S, Sahai E, et al. Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol 2005;15:138-45.
    • (2005) Trends Cell Biol , vol.15 , pp. 138-145
    • Wang, W.1    Goswami, S.2    Sahai, E.3
  • 41
    • 21144437844 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
    • He Y, Rajantie I, Pajusola K, et al. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 2005;65:4739-46.
    • (2005) Cancer Res , vol.65 , pp. 4739-4746
    • He, Y.1    Rajantie, I.2    Pajusola, K.3
  • 42
    • 0035126049 scopus 로고    scopus 로고
    • VEGF-D promotes the metastatic spread of tumor cells via the lymphatics
    • Stacker SA, Caesar C, Baldwin ME, et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Nat Med 2001;7:186-91.
    • (2001) Nat Med , vol.7 , pp. 186-191
    • Stacker, S.A.1    Caesar, C.2    Baldwin, M.E.3
  • 43
    • 23044501991 scopus 로고    scopus 로고
    • Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor
    • Lin J, Lalani AS, Hording TC, et al. Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor. Cancer Res 2005;65:6901-9.
    • (2005) Cancer Res , vol.65 , pp. 6901-6909
    • Lin, J.1    Lalani, A.S.2    Hording, T.C.3
  • 44
    • 25444489567 scopus 로고    scopus 로고
    • Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival
    • Chen Z, Varney ML, Backora MW, et al. Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival. Cancer Res 2005;65:9004-11.
    • (2005) Cancer Res , vol.65 , pp. 9004-9011
    • Chen, Z.1    Varney, M.L.2    Backora, M.W.3
  • 45
    • 0033451902 scopus 로고    scopus 로고
    • Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors
    • Partanen TA, Alitalo K, Miettinen M. Lack of lymphatic vascular specificity of vascular endothelial growth factor receptor 3 in 185 vascular tumors. Cancer 1999;86:2406-12.
    • (1999) Cancer , vol.86 , pp. 2406-2412
    • Partanen, T.A.1    Alitalo, K.2    Miettinen, M.3
  • 46
    • 0032933883 scopus 로고    scopus 로고
    • VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer
    • Valtola R, Salven P, Heikkila P, et al. VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer. Am J Pathol 1999;154:1381-90.
    • (1999) Am J Pathol , vol.154 , pp. 1381-1390
    • Valtola, R.1    Salven, P.2    Heikkila, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.