Heterogeneity in immunohistochemical, genomic, and biological properties of human lymphatic endothelial cells between initial and collecting lymph vessels

Lymphatic Research and Biology

Volumn 6, Issue 1, 2008, Pages 15-27

  Kawai, Yoshiko ^a   Hosaka, Kayoko ^a   Kaidoh, Maki ^a   Minami, Takashi ^b   Kodama, Tatsuhiko ^b   Ohhashi, Toshio ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BIOLOGICAL MARKER; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRIC OXIDE SYNTHASE; OXYGEN; PROTEIN LYVE 1; PROTEIN PROX 1; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN C;

ARTICLE; CELL HETEROGENEITY; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; ENDOTHELIUM CELL; GENE EXPRESSION; GENOMICS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LYMPH VESSEL; LYMPH VESSEL ENDOTHELIUM; LYMPHATIC DRAINAGE; LYMPHATIC SYSTEM; MICROARRAY ANALYSIS; OXYGEN CONCENTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE;

CELL PROLIFERATION; ENDOTHELIAL CELLS; FIBROBLAST GROWTH FACTOR 2; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC VESSELS; NITRIC OXIDE SYNTHASE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VESICULAR TRANSPORT PROTEINS;

EID: 41149131620     PISSN: 15396851     EISSN: None     Source Type: Journal    
DOI: 10.1089/lrb.2007.1019     Document Type: Article

References (20)

1. Ohhashi T, Mizuno R, Ikomi F, Kawai Y. Current topics of physiology and pharmacology in the lymphatic system. Pharmacol Ther 2005;105:165-188.
2. Leak LV, Burke JF. Electron microscopic study of lymphatic capillaries in the removal of connective tissue fluids and particulate substances. Lymphology 1968;1:39-52.
3. Leak LV, Burke JF. Ultrastructural studies on the lymphatic anchoring filaments. J Cell Biol 1968;36:129-149.
4. Ohhashi T, Fukushima S, Azuma T. Vasa vasorum within the media of bovine mesenteric lymphatics. Proc Soc Exp Biol Med 1977;154:582-586.
5. Kinmonth JB, Taylor GW. Spontaneous rhythmic contractility in human lymphatics. J Physiol (Lond) 1956; 133:3.
6. Hall JG, Morris B, Woolley G. Intrinsic rhythmic propulsion of lymph in the unanaesthetized sheep. J Physiol (Lond) 1965;180:336-349.
7. Mawhinney HJ, Roddie IC. Spontaneous activity in isolated bovine mesenteric lymphatics. J Physiol (Lond) 1973;229:339-348.
8. Ohhashi T, Azuma T, Sakaguchi M. Active and passive mechanical characteristics of bovine mesenteric lymphatics. Am J Physiol 1980;239:H88-H95.
9. Nojiri H, Ohhashi T. Immunolocalization of nitric oxide synthase and VEGF receptors in cultured lymphatic endothelial cells. Microcirculation 1999;6:75-78.
10. Kawai Y, Minami T, Fujimori M, Hosaka K, Mizuno R, Ikomi F, Kodama T, Ohhashi T. Characterization and microarray analysis of genes in human lymphatic endothelial cells from patients with breast cancer. Lymphat Res Biol 2007;5:115-126.
11. Ohhashi T, Takahashi N. Acetylcholine-induced release of endothelium-derived relaxing factor from lymphatic endothelial cells. Am J Physiol 1991;260: H1172-H1178.
12. Ohhashi T, Yokoyama S. Nitric oxide and the lymphatic system (Minireview). Jpn J Physiol 1994;44: 327-342.
13. Shirasawa Y, Ikomi F, Ohhashi T. Physiological roles of endogenous nitric oxide in lymphatic pump activity of rat mesentery in vivo. Am J Physiol 2000;278: G551-G556.
14. Gebb S, Stevens T. On lung endothelial cell heterogeneity. Microvasc Res 2004;68:1-12.
15. Garcia JG, Pavalko FM, Patterson CE. Vascular endothelial cell activation and permeability responses to thrombin. Blood Coagulation Fibrinolysis 1995;6:609-626.
16. Moore TM, Chetham PM, Kelly JJ, Stevens T. Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP. Am J Physiol 1998;275:L203-L222.
17. Ohhashi T, Azuma T. Variegated effects of prostaglandins on spontaneous activity in bovine mesenteric lymphatics. Microvasc Res 1984;27:71-80.
18. Ohhashi T. Mechanisms for regulating tone in lymphatic vessels. Biochem Pharmacol 1993;45:1941-1946.
19. Yokoyama S, Ohhashi T. Effects of acetylcholine on spontaneous contractions in isolated bovine mesenteric lymphatics. Am J Physiol 1993;264:H1460-1464.
20. Jain RK. Delivery of molecular and cellular medicine to solid tumors. Microcirculation 1997;4:1-23.