Apoptosis of human macrophages by Flt-4 signaling: Implications for atherosclerotic plaque pathology

Cardiovascular Research

Volumn 71, Issue 4, 2006, Pages 774-784

  Schmeisser, A ^a   Christoph, M ^a   Augstein, A ^a   Marquetant, R ^a   Kasper, M ^a   Braun Dullaeus, R C ^a   Strasser, R H ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Apoptosis; Atherosclerosis; Flt 4; Macrophages; VEGF

Indexed keywords

DNA FRAGMENT; PROTEIN BAX; PROTEIN BCL 2; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 3;

ADULT; AGED; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CAROTID ENDARTERECTOMY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AGED; AGED, 80 AND OVER; APOPTOSIS; BLOTTING, WESTERN; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CASPASE 3; CELL LINE; CELLS, CULTURED; DNA FRAGMENTATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR D; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 33751581048     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2006.06.012     Document Type: Article

References (18)

1. Risau W. Mechanisms of angiogenesis. Nature 386 (1997) 671-674
2. Bellami J., Weidener M., Semple J.P., Welch W.R., and Folkmann J. Tumor-angiogenesis and metastasis-correlation in invasive breast cancer. NEJM 324 (1991) 1-8
3. Ausprung D.H., and Folkmann J. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during angiogenesis. Microvasc Res 14 (1997) 53-65
4. Inoue M., Itoh H., Ueda M., Naruko T., Kojima A., Komatsu R., et al. Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions. Possible pathophysiological significance of VEGF in the progression of atherosclerosis. Circulation 98 (1998) 2108-2116
5. Celletti F.L., Waugh J.M., Amabile P.G., Brendolan A., Hilfiker P.R., and Dake M.D. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med 7 (2001) 425-429
6. Luttun A., Tjwa M., Moons L., Wu Y., Angelillo-Scherrer A., Liao F., et al. Revascularization of ischemic tissues by PLGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 8 (2002) 831-840
7. Rutanen J., Leppanen P., Tuomisto T.T., Rissanen T.T., Hiltunen M.O., Vajanto I., et al. Vascular endothelial growth factor-D expression in human atherosclerotic lesions. Cardiovasc Res 59 (2003) 971-979
8. Krishnan J., Kirkin V., Steffen A., Hegen M., Weith D., Tomarev S., et al. Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. Cancer Res 63 (2003) 713-722
9. Dias S., Choy M., Alitalo K., and Rafii S. Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood 99 (2002) 2179-2184
10. Schoppmann S.F., Birner P., Stöckl J., Kalt R., Ullrich R., Caucig C., et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 161 (2002) 947-956
11. Stary H.C. The development of calcium deposits in atherosclerotic lesions and their persistence after lipid regression. Am J Cardiol 88 (2001) 16E-19E [suppl]
12. Clarijs R., Schalkwijk L., Hofmann U.B., Ruiter D.J., and de Wal R.M.W. Induction of vascular endothelial growth factor receptor-3 expression on tumor microvasculature as a new progression marker in human cutaneous melanoma. Cancer Res 62 (2002) 7059-7065
13. Hamrah P., Chen L., Zhang Q., and Dana M.R. Novel expression of vascular endothelial Growth factor receptor (VEGFR)-3 and VEGF-C on corneal dendritic cells. Am J Pathol 163 (2003) 57-68
14. Mäkinen T., Veikkola T., Mustjoki S., Karpanen T., Catimel B., Nice E.C., et al. Isolated lymphatic endothelial cells transduce growth, survival and migratori signals via the VEGF-C/D receptor VEGFR-3. EMBO J. 20 (2001) 4762-4773
15. Dias S., Shmelkov S.V., Lam G., and Rafii S. VEGF 165 promotes survival of leukemic cells by Hsp-mediated induction of Bcl-2 expression and apoptosis inhibition. Blood 99 (2002) 2532-2540
16. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat Med 9 (2003) 669-676
17. Geng Y.J., and Libby P. Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1β-converting enzyme. Am J Pathol 147 (1995) 251-266
18. Hegyi L., Skepper J.N., Cary N.R., and Mitchinson M.J. Foam cell apoptosis and the development of the lipid core of human atherosclerosis. J Pathol 180 (1996) 423-429