Tumor-associated macrophages infiltration is associated with peritumoral lymphangiogenesis and poor prognosis in lung adenocarcinoma

Medical Oncology

Volumn 28, Issue 4, 2011, Pages 1447-1452

  Zhang, Bi Cheng ^a   Gao, Juan ^a   Wang, Jun ^b   Rao, Zhi Guo ^a   Wang, Bao Cheng ^b   Gao, Jian Fei ^a  

^a WUHAN GENERAL HOSPITAL OF GUANGZHOU COMMAND   (China)

^b JINAN MILITARY GENERAL HOSPITAL   (China)

Author keywords

Lung adenocarcinoma; Lymphangiogenesis; Lymphatic microvessel density; Prognosis; Tumor associated macrophages

Indexed keywords

ADULT; AGED; ARTICLE; CANCER STAGING; CELL COUNT; CELL DENSITY; CELL INFILTRATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG LOBECTOMY; LUNG RESECTION; LYMPH NODE METASTASIS; LYMPHANGIOGENESIS; LYMPHATIC MICROVESSEL DENSITY; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; TUMOR ASSOCIATED LEUKOCYTE; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; ADULT; AGED; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; LYMPHANGIOGENESIS; LYMPHATIC METASTASIS; MACROPHAGES; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS;

EID: 84655175066     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-010-9638-5     Document Type: Article

References (25)

1. M Tiseo M Bartolotti F Gelsomino A Ardizzoni 2009 First-line treatment in advanced non-small-cell lung cancer: the emerging role of the histologic subtype Expert Rev Anticancer Ther 9 425 435
2. KE de Visser LM Coussens 2006 The inflammatory tumor microenvironment and its impact on cancer development Contrib Microbiol 13 118 137
3. G Solinas G Germano A Mantovani P Allavena 2009 Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation J Leukoc Biol 86 1065 1073
4. CE Lewis JW Pollard 2006 Distinct role of macrophages in different tumor microenvironments Cancer Res 66 605 612
5. C Porta B Subhra Kumar P Larghi L Rubino A Mancino 2007 Tumor promotion by tumor-associated macrophages Adv Exp Med Biol 604 67 86
6. P Allavena A Sica G Solinas C Porta A Mantovani 2008 The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages Crit Rev Oncol Hematol 66 1 9
7. A Mantovani 2010 La mala educación of tumor-associated macrophages: diverse pathways and new players Cancer Cell 17 111 112
8. I Takanami K Takeuchi S Kodaira 1999 Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: association with angiogenesis and poor prognosis Oncology 57 138 142
9. YS Shieh YJ Hung CB Hsieh JS Chen KC Chou 2009 Tumor-associated macrophage correlated with angiogenesis and progression of mucoepidermoid carcinoma of salivary glands Ann Surg Oncol 16 751 760
10. M Ryder RA Ghossein JC Ricarte-Filho JA Knauf JA Fagin 2008 Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer Endocr Relat Cancer 15 1069 1074
11. CH Lee I Espinosa S Vrijaldenhoven S Subramanian KD Montgomery 2008 Prognostic significance of macrophage infiltration in leiomyosarcomas Clin Cancer Res 14 1423 1430
12. SA Stacker RH Farnsworth T Karnezis R Shayan DP Smith 2007 Molecular pathways for lymphangiogenesis and their role in human disease Novartis Found Symp 281 38 43
13. HS Kim W Sung S Lee SG Chang YK Park 2009 Lymphatic vessel densities of lymph node-negative prostate adenocarcinoma in Korea Pathol Res Pract 205 249 254
14. SF Schoppmann P Birner J Stöckl R Kalt R Ullrich 2002 Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis Am J Pathol 161 947 956
15. SF Schoppmann A Fenzl K Nagy S Unger G Bayer 2006 VEGF-C expressing tumor-associated macrophages in lymph node positive breast cancer: impact on lymphangiogenesis and survival Surgery 139 839 846
16. B Zhang J Wang J Gao Y Guo X Chen 2009 Alternatively activated RAW264.7 macrophages enhance tumor lymphangiogenesis in mouse lung adenocarcinoma J Cell Biochem 107 134 143
17. H Deniz Y Kibar ME Güldür K Bakir 2009 Is D2-40 a useful marker for distinguishing malignant mesothelioma from pulmonary adenocarcinoma and benign mesothelial proliferations? Pathol Res Pract 205 749 752
18. MS Pepper 2001 Lymphangiogenesis and tumor metastasis: myth or reality? Clin Cancer Res 7 462 468
19. SJ Mandriota L Jussila M Jeltsch A Compagni D Baetens 2001 Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis EMBO J 20 672 682
20. SA Stacker C Caesar ME Baldwin GE Thornton RA Williams 2001 Vascular endothelial growth factor-D promotes the metastatic spread of cancer via the lymphatics Nature Med 7 186 191
21. JP Edwards X Zhang KA Frauwirth DM Mosser 2006 Biochemical and functional characterization of three activated macrophage populations J Leukoc Biol 80 1298 1307
22. FO Martinez A Sica A Mantovani M Locati 2008 Macrophage activation and polarization Front Biosci 13 453 461
23. H Kojima N Shijubo G Yamada S Ichimiya S Abe 2005 Clinical significance of vascular endothelial growth factor-C and vascular endothelial growth factor receptor 3 in patients with T1 lung adenocarcinoma Cancer 104 1668 1677
24. F Renyi-Vamos J Tovari J Fillinger J Timar S Paku 2005 Lymphangiogenesis correlates with lymph node metastasis, prognosis, and angiogenic phenotype in human non-small cell lung cancer Clin Cancer Res 11 7344 7353
25. K Kadota CL Huang D Liu M Ueno Y Kushida 2008 The clinical significance of lymphangiogenesis and angiogenesis in non-small cell lung cancer patients Eur J Cancer 44 1057 1067