Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma: Evidence for its role in colonic tumorigenesis

American Journal of Pathology

Volumn 157, Issue 4, 2000, Pages 1167-1175

  Friedmann, Yael ^a   Vlodavsky, Israel ^a   Aingorn, Helena ^a   Aviv, Ayelet ^a   Peretz, Tuvia ^b   Pecker, Iris ^b   Pappo, Orit ^c  

^a Departments of Oncology   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c Pathol Radiol Beth Israel D   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARANASE; MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER GROWTH; COLON CARCINOMA; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIVER METASTASIS; LUNG METASTASIS; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RNA PROBE;

EID: 0033810052     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64632-9     Document Type: Article

References (48)

1. The pathogenesis of cancer metastases
2. Tumor cell interactions with the extracellular matrix during invasion and metastasis
3. The role of proteolytic enzymes in cancer invasion and metastasis
4. Heparanase and tumor metastasis
5. Inhibition of tumor metastasis by heparanase inhibiting species of heparin
6. Substrate specificity of heparanases from human hepatoma and platelets
7. Proteoglycans: Structures and interactions
8. Integral membrane heparan sulfate proteoglycan
9. Glycosaminoglycans: Molecular properties, protein interactions and role in physiological processes
10. The role of proteoglycans in cell adhesion, migration and proliferation
11. The coordinated regulation of heparan sulfate, syndecans and cell behavior
12. Cell biology of arterial proteoglycans
13. Evidence that sulphated polysaccharides inhibit tumor metastasis by blocking tumor cell-derived heparanase
14. Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides
15. Endothelial cell-derived basic fibroblast growth factor: Synthesis and deposition into subendothelial extracellular matrix
16. Heparanase activity expressed by platelets, neutrophils and lymphoma cells releases active fibroblast growth factor from extracellular matrix
17. Extracellular sequestration and release of fibroblast growth factor: A regulatory mechanism?
18. Mammalian heparanase: Gene cloning, expression and function
19. Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis
20. Cloning and functional expression of a human heparanase gene
21. Human heparanase. Purification, characterization, cloning, and expression
22. Human HPA endoglycosidase heparanase. Map position 4q21.3
23. Regulated expression of homeobox genes Msx-1 and Msx-2 in mouse mammary gland development suggests a role in hormone action and epithelial-stromal interactions
24. Lymphoma cell mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: Relationship to tumor cell metastasis
25. Expression of heparanase by platelets and circulating cells of the immune system: Possible involvement in diapedesis and extravasation
26. Colorectal cancer staging as a prognostic feature
27. A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer
28. Identification of occult micrometastases in pericolic lymph nodes of Duke's B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49. Correlation with long-term survival
29. Augmentation of type IV collagenase, laminin receptor and Ki67 proliferation antigen associated with human colon gastric and breast carcinoma progression
30. The spread of rectal cancer and its effect on progress
31. The relationship of survival to staging and grading of colorectal carcinoma: A prospective study of 503 cases
32. The intramural extension of carcinoma at the descending colon, sigmoid, and rectosigmoid. A pathologic study
33. The Funen Adenoma Follow-Up Study. Characteristics of patients and initial adenomas in relation to severe dysplasia
34. Polyps of the large intestine in Aarhus, Denmark. An autopsy study
35. Desmoplasia and its relevance to colorectal tumor invasion
36. Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopy
37. Tumor invasion and extracellular matrix
38. From laminin to lamin: Regulation of tissue-specific gene expression by the ECM
39. Matrix metalloproteinases and their inhibitors in connective tissue remodeling
40. Expression and in situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer
41. Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization
42. Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans
43. Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence
44. A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas