Lymphatic Neoangiogenesis in Human Kidney Transplants Is Associated with Immunologically Active Lymphocytic Infiltrates

Journal of the American Society of Nephrology

Volumn 15, Issue 3, 2004, Pages 603-612

  Kerjaschki, Dontscho ^a,c   Regele, Heinrich M ^a   Moosberger, Isabella ^a   Nagy Bojarski, Katalyn ^a   Watschinger, Bruno ^a   Soleiman, Afschin ^a   Birner, Peter ^a   Krieger, Sigurd ^a   Hovorka, Anny ^a   Silberhumer, Georg ^a   Laakkonen, Pirjo ^b   Petrova, Tatiana ^b   Langer, Brigitte ^a   Raab, Ingrid ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOANTIGEN; CD20 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR7; KI 67 ANTIGEN; PODOPLANIN; PROTEIN S 100;

ADULT; AGED; ANGIOGENESIS; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENDOTHELIUM CELL; FEMALE; GRAFT REJECTION; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY CORTEX; KIDNEY TRANSPLANTATION; KIDNEY TUBULE; LYMPH VESSEL; LYMPHOCYTIC INFILTRATION; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 10744229023     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000113316.52371.2E     Document Type: Article

References (28)

1. Karlberg I, Nyberg G: Cost-effectiveness studies of renal transplantation. Int J Technol Assess Health Care 11: 611-622, 1995
2. Massy ZA, Guijarro C, Kasike BL: Clinical predictors of chronic renal allograft rejection. Kidney Int Suppl 52: S85-S88, 1995
3. Pirsch JD, Ploeg RJ, Gange S, D'Alessandro AM, Knechtle SJ, Sollinger HW, Kalayoglu M, Belzer FO: Determinants of graft survival after renal transplantation. Transplantation 61: 1581-1586, 1996
4. Slakey DP, Thomas JM: Mechanisms of cell-mediated rejection. In: Kidney Transplant Rejection: Diagnosis and Treatment, edited by Racusen LC, Solez K, Burdick JF, New York, Marcel Dekker, 1998, pp 423-468
5. Meehan SM, McCluskey RT, Pascual M, Preffer FI, Anderson P, Schlossman SF, Colvin RB: Cytotoxicity and apoptosis in human renal allografts: Identification, distribution, and quantitation of cells with a cytotoxic granule protein GMP-17 (TIA-1) and cells with fragmented nuclear DNA. Lab Invest 76: 639-649, 1997
6. Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K: Vascular endothelial growth factor receptor-3 in lymphangiogenesis in wound healing. Am J Pathol 56: 1499-1504, 2000
7. Pedersen NC, Morris BJ: The role of the lymphatic system in the rejection of homografts: A study of lymph from renal transplants. J Exp Med 131: 936-969, 1970
8. Sleeman JP, Krishnan J, Kirkin V, Baumann P: Markers for the lymphatic endothelium: In search of the holy grail? Microsc Res Tech 55: 61-69, 2001
9. Kain R, Matsui K, Exner M, Binder S, Schaffner G, Sommer EM, Kerjaschki D: A novel class of autoantigens of anti-neutrophil cytoplasmic antibodies in necrotizing and crescentic glomerulonephritis: The lysosomal membrane glycoprotein h-lamp-2 in neutrophil granulocytes and a related membrane protein in glomerular endothelial cells. J Exp Med 181: 585-597, 1995
10. Schoppmann SF, Birner P, Stockl J, Kalt R, Ullrich R, Caucig C, Kriehuber E, Nagy K, Alitalo K, Kerjaschki D: Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 161: 947-956, 2002
11. Yang N, Isbel NM, Nikolic-Paterson DJ, Li Y, Ye R, Atkins RC, Lan HY: Local macrophage proliferation in human glomerulonephritis. Kidney Int 54: 143-151, 1998
12. Breiteneder-Geleff S, Soleiman A, Kowalski H, Horvat R, Amann G, Kriehuber E, Diem K, Weninger W, Tschachler E, Alitalo K, Kerjaschki D: Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 154: 385-394, 1999
13. Jain RK, Padera TP: Lymphatics make the break. Science 299: 209-210, 2003
14. Kriehuber E, Breiteneder-Geleff S, Groeger M, Soleiman A, Schoppmann SF, Stingl G, Kerjaschki D, Maurer D: Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages. J Exp Med 194: 797-808, 2001
15. Makinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, Wise L, Mercer A, Kowalski H, Kerjaschki D, Stacker SA, Achen MG, Alitalo K: Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J 20: 4762-4773, 2001
16. Alitalo K, Carmeliet P: Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 1: 219-227, 2002
17. Banerji S, Ni J, Wang SX, Clasper S, Su J, Tammi R, Jones M, Jackson DG: LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol 144: 789-801, 1999
18. Wigle JT, Oliver G: Prox1 function is required for the development of the murine lymphatic system. Cell 98: 769-778, 1999
19. McIntosh GH, Morris B: The lymphatics of the kidney and the formation of renal lymph. J Physiol 214: 365-376, 1971
20. Matsui K, Nagy-Bojarsky K, Laakonen P, Krieger S, Mechtler K, Geleff S, Kang DH, Johnson RJ, Kerjaschki D: Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase P and Podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels. J Am Soc Nephrol 14: 1981-1989, 2003
21. Armengol MP, Juan M, Lucas-Martin A, Femandez-Figueras MT, Jaraquemada D, Gallart T, Pujol-Borrell R: Thyroid autoimmune disease: Demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers. Am J Pathol 159: 861-873, 2001
22. Fan L, Reilly CR, Luo Y, Dorf ME, Lo D: Cutting edge: Ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis. J Immunol 164: 3955-3959, 2000
23. Weninger W, Carlsen HS, Goodarzi M, Moazed F, Crowley MA, Baekkevold ES, Cavanagh LL, von Andrian UH: Naive Tcell recruitment to nonlymphoid tissues: A role for endothelium-expressed CC chemokine ligand 21 in autoimmune disease and lymphoid neogenesis. J Immunol 170: 4638-4648, 2003
24. Gunn MD, Kyuwa S, Tam C, Kakiuchi T, Matsuzawa A, Williams LT, Nakano H: Mice lacking expression of secondary lymphoid organ chemokine have defects in lymphocyte homing and dendritic cell localization. J Exp Med 189: 451-460, 1999
25. Hirose J, Kawashima H, Yoshie O, Tashiro K, Miyasaka M: Versican interacts with chemokines and modulates cellular responses. J Biol Chem 276: 5228-5234, 2001
26. Christopherson KW 2nd, Campbell JJ, Travers JB, Hromas RA: Low-molecular-weight heparins inhibit CCL21-induced T cell adhesion and migration. J Pharmacol Exp Ther 302: 290-295, 2002
27. Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M: T1α/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J 22: 3546-3556, 2003
28. Regele H, Bohmig GA, Habicht A, Gollowitzer D, Schillinger M, Rockenschaub S, Watschinger B, Kerjaschki D, Exner M: Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: A contribution of humoral immunity to chronic allograft rejection. J Am Soc Nephrol 13: 2371-2380, 2002