The number of positive nodes and the ratio of positive to excised nodes are significant predictors of survival in women with micrometastatic node-positive breast cancer

European Journal of Cancer

Volumn 44, Issue 12, 2008, Pages 1670-1677

  Truong, Pauline T ^a   Vinh Hung, Vincent ^b   Cserni, Gabor ^c   Woodward, Wendy A ^d   Tai, Patricia ^e   Vlastos, Georges ^f  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b Department of Radiation Oncology   (Belgium)

^c BÁCS KISKUN COUNTY TEACHING HOSPITAL   (Hungary)

^d UNIVERSITY OF TEXAS   (United States)

^e UNIVERSITY OF SASKATCHEWAN   (Canada)

^f GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Breast cancer; Micrometastasis; Node positive; Prognostic factors; Survival

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST CANCER SPECIFIC SURVIVAL; CANCER GROWTH; CANCER REGISTRY; CANCER RISK; CANCER SIZE; CANCER SURVIVAL; COHORT ANALYSIS; FEMALE; HUMAN; KAPLAN MEIER METHOD; LYMPH NODE BIOPSY; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MICROMETASTASIS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; HUMANS; LYMPH NODE EXCISION; LYMPH NODES; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RISK ASSESSMENT; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 48449106054     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2008.05.011     Document Type: Article

References (41)

1. Cronin-Fenton D.P., Ries L.A., Clegg L.X., and Edwards B.K. Rising incidence rates of breast carcinoma with micrometastatic lymph node involvement. J Natl Cancer Inst 99 (2007) 1044-1049
2. American Joint Committee on Cancer. Breast. In: AJCC Cancer Staging Manual, 5th ed. Philadelphia: Lippincott-Raven; 1997.
3. Huvos A.G., Hutter R.V., and Berg J.W. Significance of axillary macrometastases and micrometastases in mammary cancer. Ann Surg 173 (1971) 44-46
4. Attiyeh F.F., Jensen M., Huvos A.G., and Fracchia A. Axillary micrometastasis and macrometastasis in carcinoma of the breast. Surg Gynecol Obstet 144 (1977) 839-842
5. Fisher E.R., Palekar A., Rockette H., Redmond C., and Fisher B. Pathologic findings from the National Surgical Adjuvant Breast Project (Protocol No. 4). V. Significance of axillary nodal micro- and macrometastases. Cancer 42 (1978) 2032-2038
6. Rosen P.P., Saigo P.E., Braun D.W., Weathers E., Fracchia A.A., and Kinne D.W. Axillary micro- and macrometastases in breast cancer: prognostic significance of tumor size. Ann Surg 194 (1981) 585-591
7. International (Ludwig) Breast Cancer Study Group. Prognostic importance of occult axillary lymph node micrometastases from breast cancers. Lancet 1990;335:1565-68.
8. Clayton F., and Hopkins C.L. Pathologic correlates of prognosis in lymph node-positive breast carcinomas. Cancer 71 (1993) 1780-1790
9. Greene F.L., Page D.L., Fleming I.D., et al. AJCC cancer staging handbook. 6th ed. TNM classification of malignant tumors (2002), Springer, New York
10. Woodward W.A., Vinh-Hung V., Ueno N.T., et al. Prognostic value of nodal ratios in node-positive breast cancer. J Clin Oncol 24 (2006) 2910-2916
11. Vinh-Hung V., Verschraegen C., Promish D.I., et al. Ratios of involved nodes in early breast cancer. Breast Cancer Res 6 (2004) 680-688
12. van der Wal B.C., Butzelaar R.M., van der Meij S., and Boermeester M.A. Axillary lymph node ratio and total number of removed lymph nodes: predictors of survival in stage I and II breast cancer. Eur J Surg Oncol 28 (2002) 481-489
13. Voordeckers M., Vinh-Hung V., Van de Steene J., Lamote J., and Storme G. The lymph node ratio as prognostic factor in node-positive breast cancer. Radiother Oncol 70 (2004) 225-230
14. Truong P.T., Berthelet E., Lee J., Kader H., and Olivotto I.A. The prognostic significance of the percentage of positive/dissected axillary lymph nodes in breast cancer recurrence and survival in patients with one to three positive axillary lymph nodes. Cancer 103 (2005) 2006-2014
15. Maggard M.A., Lane K.E., O'Connell J.B., Nanyakkara D.D., and Ko C.Y. Beyond the clinical trials: how often is sentinel lymph node dissection performed for breast cancer?. Ann Surg Oncol 12 (2005) 41-47
16. Edge S.B., Niland S.C., Bookman M.A., et al. Emergence of sentinel node biopsy in breast cancer as standard of care in academic comprehensive cancer centres. J Natl Cancer Inst 95 (2003) 1514-1521
17. Wallgren A., Bonetti M., Gelber R.D., et al. Risk factors for locoregional recurrence among breast cancer patients: results from international breast cancer study group trials I through VII. J Clin Oncol 21 (2003) 1205-1213
18. Woodward W.A., Strom E.A., Tucker S.L., et al. Changes in the 2003 American Joint Committee on Cancer staging for breast cancer dramatically affect stage-specific survival. J Clin Oncol 21 (2003) 3244-3248
19. Vinh-Hung V., and Storme G. No nodal cutoff in node-positive breast cancer women treated with mastectomy. Breast Cancer Res Treat 98 (2006) 173-178
20. Chen S.L., Hoehne F.M., and Giuliano A.E. The prognostic significance of micrometastases in breast cancer: a SEER population-based analysis. Ann Surg Oncol 14 (2007) 3378-3384
21. Colleoni M., Rotmensz N., Peruzzotti G., et al. Size of breast cancer metastases in axillary lymph nodes: clinical relevance of minimal lymph node involvement. J Clin Oncol 23 (2005) 1379-1389
22. Goldhirsch A., Glick J.H., Gelber R.D., et al. Meeting highlights: International consensus panel on the treatment of primary breast cancer. J Natl Cancer Inst 90 (1998) 1601-1608
23. Veronesi U., Paganelli G., Viale G., et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. New Engl J Med 349 (2003) 546-553
24. Lyman G.H., Giuliano A.E., Somerfield M.R., et al. American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol 23 (2005) 7703-7720
25. Viale G., Maiorano E., Mazzarol G., et al. Histologic detection and clinical implications of micrometastases in axillary sentinel lymph nodes for patients with breast carcinoma. Cancer 92 (2001) 1378-1384
26. Fournier K., Schiller A., Perry R.R., and Laronga C. Micrometastasis in the sentinel lymph node of breast cancer does not mandate completion axillary dissection. Ann Surg 239 (2004) 859-863
27. Dabbs D.J., Fung M., Landsittel D., McManus K., and Johnson R. Sentinel lymph node micrometastasis as a predictor of axillary tumor burden. Breast J 10 (2004) 101-105
28. Cserni G., Gregori D., Merletti F., et al. Non-sentinel node metastases associated with micrometastatic sentinel nodes in breast cancer: metaanalysis of 25 studies. Br J Surg 91 (2004) 1245-1252
29. Cserni G., Burzykowski T., Vinh-Hung V., et al. Axillary sentinel node and tumour-related factors associated with non-sentinel node involvement in breast cancer. Jpn J Clin Oncol 34 (2004) 519-524
30. Tan Y.Y., Fan Y.G., Lu Y., et al. Ratio of positive to total number of sentinel nodes predicts nonsentinel node status in breast cancer patients. Breast J 11 (2005) 248-253
31. Cserni G., Bianchi S., Vezzosi V., et al. Sentinel lymph node biopsy and non-sentinel node involvement in special type breast carcinomas with a good prognosis. Eur J Cancer 43 (2007) 1407-1414
32. Van Zee K.J., Manasseh D., Bevilacqua J., et al. A nomogram for predicting the likelihood of additional nodal metastasis in breast cancer patients with a positive sentinel node biopsy. Ann Surg Oncol 10 (2003) 1140-1145
33. Hwang R.F., Krishnamurthy S., Hunt K.K., et al. Clinicopathologic factors predicting involvement of nonsentinel axillary nodes in women with breast cancer. Ann Surg Oncol 10 (2003) 248-254
34. Barranger E., Coutant C., Flahault A., et al. An axilla scoring system to predict non-sentinel lymph node status in breast cancer patients with sentinel lymph node involvement. Breast Cancer Res Treat 91 (2005) 113-119
35. Wong S.L., Edwards M.J., Chao C., et al. Predicting the status of the nonsentinel axillary nodes: a multicenter study. Arch Surg 136 (2001) 563-568
36. Degnim A.C., Reynolds C., Pantvaidya G., et al. Nonsentinel node metastasis in breast cancer patients: assessment of an existing and a new predictive nomogram. Am J Surg 190 (2005) 543-550
37. Ponzone R., Maggiorotto F., Mariani L., et al. Comparison of two models for the prediction of nonsentinel node metastases in breast cancer. Am J Surg 193 (2007) 686-692
38. Alran S., De Rycke Y., Fourchotte V., et al. Validation and limitations of use of a breast cancer nomogram predicting the likelihood of non-sentinel node involvement after positive sentinel node biopsy. Ann Surg Oncol 14 (2007) 2195-2201
39. Gillanders W.E., Mikhitarian K., Hebert R., et al. Molecular detection of micrometastatic breast cancer in histopathology-negative axillary lymph nodes correlates with traditional predictors of prognosis: an interim analysis of a prospective multi-institutional cohort study. Ann Surg 239 (2004) 828-837
40. Cserni G., Bianchi S., Boecker W., et al. Improving the reproducibility of diagnosing micrometastases and isolated tumor cells. Cancer 103 (2005) 358-367
41. Turner R.R., Weaver D.L., Cserni G., et al. Nodal stage classification for breast carcinoma: improving interobserver reproducibility through standardized histologic criteria and image-based training. J Clin Oncol 26 (2008) 258-263