Death by caspase dimerization

Advances in Experimental Medicine and Biology

Volumn 747, Issue , 2012, Pages 55-73

  MacKenzie, Sarah H ^a   Clark, A Clay ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 2; CASPASE 8; CASPASE 9; INTERLEUKIN 1BETA CONVERTING ENZYME; PROCASPASE; PROTEIN PRECURSOR; UNCLASSIFIED DRUG; ENZYME PRECURSOR; ISOENZYME;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL DEATH; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; HYDROPHILICITY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN FUNCTION; RESIDUE ANALYSIS; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; ENZYME ACTIVATION; HUMAN; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN STABILITY; REVIEW; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; APOPTOSIS; CASPASES; CATALYTIC DOMAIN; DIMERIZATION; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STABILITY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84866790349     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-3229-6_4     Document Type: Article

References (53)

1. Jacobson MD, Weill M, Raff MC. Programmed cell death in animal development. Cell 1997; 88:347-354.
2. Fadeel B, Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Internal Med 2005; 258:479-517.
3. Kabore AF, Johnston JB, Gibson SB. Changes in the apoptotic and survival signaling in cancer cells and their potential therapeutic implications. Current Cancer Drug Targets 2004; 4:147-163.
4. Fulda S, Debatin K-M. Targeting apoptosis pathways in cancer therapy. Current Cancer Drug Targets 2004; 4:569-576.
5. Meng XW, Lee S-H, Kaufmann SH. Apoptosis in the treatment of cancer: a promise kept? Curr Op Cell Biol 2006; 18:668-676.
6. Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates and functions during apoptosis. Ann Rev Biochem 1999; 68:383-424.
7. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Intern Rev Cytol 1980; 68:251-306.
8. Kaufmann SH. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 1989; 49:5870-5878.
9. Canman CE, Tange H-Y, Normolle DP et al. Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity. Proc Natl Acad Sci 1992; 89:10474-10478.
10. Jin Z, El-Deiry W. Overview of cell death signaling pathways. Cancer Biology and Therapy 2005; 4:139-163.
11. Enari M, Sakahira H, Yokoyama H et al. A caspase-activated DNase that degrades DNA during apoptosis and its inhibitor ICAD. Nature. 1998; 391:43-50.
12. Fuentes-Prior P, Salvesen GS. The protein structures that shape caspase activity, specificity activation and inhibition. Biochem J 2004; 384:201-232.
13. Thornberry NA, Bull HG, Calaycay JR et al. A novel heterodimeric cysteine protease is required for interleukin-1- processing in monocytes. Nature 1992; 356:768-774.
14. Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-574.
15. Ahn E-Y, Pan G, Vickers SM et al. IFN- upregulates apoptosis-related molecules and enhances FAS-mediated apoptosis in human cholangiocarcinoma. Intern J Cancer 2002; 100:445-451.
16. Boatright KM, Salvesen GS. Mechanisms of caspase activation. Curr Op Cell Biol 2003; 15:725-731.
17. Boatright KM, Renatus M, Scott FL et al. A unified model for apical caspase activation. Mol Cell 2003; 11:529-541.
18. Leung BP, Culshaw S, Gracie JA et al. A role for IL-18 in neutrophil activation. J Immunol 2001; 167:2879-2886.
19. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-. Mol Cell 2002; 10:417-426.
20. Thornberry NA, Rano TA, Peterson EP et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B. J Biol Chem 1997; 272:17907-17911.
21. Schweizer A, Briand C, Grutter MG. Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway. J Biol Chem 2003; 278:42441-42447.
22. Hofmann K, Bucher P, Tschopp J. The CARD domain: a new apoptotic signalling motif. Trends Biochem Sci 1997; 22:155-156.
23. Thome M, Hofmann K, Burns K et al. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Curr Biol 1998; 8:885-888.
24. Weber CH, Vincenz C. The death domain superfamily: a tale of two interfaces? Trends Biochem Sci 2001; 26:475-481.
25. Feeney B, Clark AC. Reassembly of active caspase-3 is facilitated by the propeptide. J Biol Chem 2005; 280:39772-39785.
26. Denault J-B, Salvesen GS. Human caspase-7 activity and regulation by its N-terminal peptide. J Biol Chem 2003; 278:34042-34050.
27. Meergans T, Hildebrandt A-K, Horak D et al. The short prodomain influences caspase-3 activation in HeLa cells. Biochem J 2000; 349:135-140.
28. Cowling V, Downward J. Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain. Cell Death and Differentiation 2002; 9:1046-1056.
29. Muzio M, Stockwell BR, Stennicke H et al. An induced proximity model for capase-8 activation. J Biol Chem 1998; 273:2926-2930.
30. Pop C, Timmer J, Sperandio S et al. The apoptosome activates caspase-9 by dimerization. Mol Cell 2006; 22:269-275.
31. Boatright KM, Renatus M, Scott FL et al. A unified model for apical caspase activation. Mol Cell 2003; 11:529-541.
32. Renatus M, Stennicke HR, Scott FL et al. Dimer formation drives the activation of the cell death protease caspase 9. Proc Natl Acad Sci 2001; 98:14250-14255.
33. Li H, Bergeron L, Cryns V et al. Activation of caspase-2 in apoptosis. J Biol Chem 1997; 272:21010-21017.
34. Baliga BC, Read SH, Kumar S. The biochemical mechanism of caspase-2 activation. Cell Death and Differentiation. 2004; 11:1234-1241.
35. Launay S, Hermine O, Fontenay M et al. Vital functions for lethal caspases. Oncogene 2005; 24:5137-5148.
36. Bose K, Clark AC. Dimeric procaspase-3 unfolds via a four-state equilibrium process. Biochemistry 2001; 40:14236-14242.
37. Bose K, Clark AC. pH effects on the stability and dimerization of procaspase-3. Protein Sci 2005; 14:24-36.
38. Matsuyama S, Llopis J, Deveraux QL et al. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2000; 2:318-325.
39. Bose K, Pop C, Feeney B et al. An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3. Biochemistry 2003; 42:12298-12310.
40. Mittl PRE, DiMarco S, Krebs JF et al. Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-asp-val-ala-asp fluoromethyl ketone. J Biol Chem 1997; 272:6539-6547.
41. Ganesan R, Mittl PRE, Jelakovic S et al. Extended substrate recognition in caspase-3 revealed by high resolution X-ray structure analysis. J Mol Biol 2006; 359:1378-1388.
42. Richardson JS, Richardson DC. Natural - - sheet proteins use negative design to avoid edge-to-edge aggregation. Proc Natl Acad Sci 2002; 99:2754-2759.
43. Scheer JM, Romanowski MJ, Wells JA. A common allosteric site and mechanism in caspases. Proc Natl Acad Sci 2006; 103:7595-7600.
44. Blanchard H, Kodandapani L, Mittl PRE et al. The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis. Structure 1999; 7:1125-1133.
45. Chai J, Wu Q, Shiozaki E et al. Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding. Cell 2001; 107:399-407.
46. Riedl SJ, Fuentes-Prior P, Renatus M et al. Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci 2001; 98:14790-14795.
47. Wilson KP, Black J-AF, Thomson JA et al. Structure and mechanism of interleukin-1- converting enzyme. Nature 1994; 370:270-275.
48. Romanowski MJ, Scheer JM, O'Brien T et al. Crystal structures of ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding. Structure 2004; 12:1361-1371.
49. Hardy JA, Lam J, Nguyen JT et al. Discovery of an allosteric site in the caspases. Proc Natl Acad Sci 2004; 101:12461-12466.
50. Walters J, Pop C, Scott FL et al. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biophys J 2009; 424:335-345.
51. Schipper JL, MacKenzie SH, Sharma A, Clark AC. A bifunctional allosteric site in the dimer interface of procaspase-3. Biophys Chem 2011; 159:100-109.
52. Wolan DW, Zorn JA, Gray DC, Wells JA. Small molecule activators of a proenzyme. Science 2009; 326:853-858
53. Peterson QP, Goode DR, West DC, Ramsey KN, Lee JJ, Hergenrother PJ. PAC-1 activates procaspase-3 in vitro through relief of zinc-mediated inhibition. J Mol Biol 2009; 388:144-158.