Crystal structures of a ligand-free and malonate-bound human caspase-1: Implications for the mechanism of substrate binding

Structure

Volumn 12, Issue 8, 2004, Pages 1361-1371

  Romanowski, Michael J ^a   Scheer, Justin M ^a   O'Brien, Tom ^a   McDowell, Robert S ^a  

^a Sunesis Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN; INTERLEUKIN 1BETA CONVERTING ENZYME; LIGAND; MALONIC ACID;

ARTICLE; CONFORMATION; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; HYDROGEN BOND; MOLECULAR RECOGNITION; PRIORITY JOURNAL; REACTION ANALYSIS; REPRODUCIBILITY;

ASPARTIC ACID; CASPASE 1; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; HUMANS; HYDROGEN BONDING; LIGANDS; MALONATES; MODELS, MOLECULAR; MUTATION; RECOMBINANT PROTEINS;

EID: 4143096903     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2004.05.010     Document Type: Article

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