A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

Biochemical Journal

Volumn 424, Issue 3, 2009, Pages 335-345

  Walters, Jad ^a   Pop, Cristina ^b   Scott, Fiona L ^b   Drag, Marcin ^b,c   Swartz, Paul ^a   Mattos, Carla ^a   Salvesen, Guy S ^b   Clark, A Clark ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b BURNHAM INSTITUTE   (United States)

^c WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

Apoptosis; Cancer therapy; Co operative dimer interface; Conformational switch; Procaspase activation

Indexed keywords

APOPTOSIS; CANCER THERAPY; CONFORMATIONAL SWITCHES; DIMER INTERFACE; PROCASPASE;

BINDING SITES; MAMMALS;

CELL DEATH;

CASPASE 3; ENZYME PRECURSOR; PROCASPASE 3; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE MUTATION; GENE SWITCHING; GENETIC VARIABILITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN TARGETING; STRUCTURE ANALYSIS;

AMINO ACID SUBSTITUTION; APOPTOSIS; BINDING SITES; BLOTTING, WESTERN; CASPASE 3; CELL LINE; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ENZYME PRECURSORS; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

MAMMALIA;

EID: 73149085726     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090825     Document Type: Article

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