A bifunctional allosteric site in the dimer interface of procaspase-3

Biophysical Chemistry

Volumn 159, Issue 1, 2011, Pages 100-109

  Schipper, Joshua L ^a   MacKenzie, Sarah H ^a   Sharma, Anil ^a,b   Clark, A Clay ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b Envigen Pharmaceuticals   (United States)

Author keywords

Allosteric activator; Apoptosis; Cancer therapy; Caspase; Drug design

Indexed keywords

ENZYME PRECURSOR; PROCASPASE 3;

ARTICLE; BINDING SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN INTERACTION;

ALLOSTERIC SITE; CASPASE 3; ENZYME ACTIVATION; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; SMALL MOLECULE LIBRARIES;

EID: 80052307868     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2011.05.013     Document Type: Article

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