Effects of short-and long-term saturated fat-enriched diet on the ceramide and neutral lipids accumulation in the insulin responsive tissues of rats

Saturated Fats: Metabolism, Disease Risks and Public Awareness

Volumn , Issue , 2011, Pages 71-98

  Babenko, Nataliya A ^a  

^a V N KARAZIN KHARKIV NATIONAL UNIVERSITY   (Ukraine)

Author keywords

Brain cortex; Ceramide; Diacylglycerol; Insulin; Liver; Muscle; Palmitic acid; Saturated fat; Sphingomyelin; Triacylglycerol

Indexed keywords

EID: 84866671177     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (70)

1. Babenko, NA; Semenova, YaA; Kharchenko, VS. Effects of fat-enriched diet on the content of sphingolipids in the brain and on cognitive functions in old rats. Neurophysiology, 2009 41, 258-263.
2. Babenko, N. A. & Semenova, Ya. A. (2010). Effects of long-term fish oilenriched diet on the sphingolipid metabolism in brain of old rats. Exp Gerontol, 45, 375-380.
3. Ballou, SP; Lozanski, FB; Hodder, S; Rzewnicki, DL; Mion, LC; Sipe, J; Ford, AB; Kushner, I. Quantitative and qualitative alterations of acute-phase proteins in healthy elderly persons. Age Ageing, 1996 25, 224-230.
4. Bartlett, GR. (1959). Phosphorus assay in column chromatography. J Biol Chem, 234, 466-468.
5. Benoit SC, Kemp CJ, Elias CF, Abplanalp W, Herman JP, Migrenne S, Lefevre AL, Cruciani-Guglielmacci C, Magnan C, Yu F, Niswender K, Irani BG, Holland WL, Clegg DJ. Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. J Clin Invest. 2009 119, 2577-2589.
6. Blair, AS; Hajduch, E; Litherland, GJ; Hundal, HS. Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress: evidence for cross-talk between the insulin and SAPK2/p38 MAP kinase signaling pathways. J Biol Chem, 1999 274, 36293-36299.
7. Bligh, E. G. & Dyer, W. J. (1959). A rapid method of total lipid extraction and purification. Can J Biochem Physiol, 37, 911-917.
8. Boini, KM; Zhang, C; Xia, M; Poklis, JL; Li, P-L. Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high fat diet. J Pharmacol Exp Ther. 2010, DOI:10.1124/jpet.110.168815.
9. Boyanovsky, B; Karakashian, A; King, K; Giltiay, N; Nikolova-Karakashian, M. Uptake and metabolism of low density lipoproteins with elevated ceramide content by human microvascular endothelial cells. J Biol Chem, 2003 278, 26992-26999.
10. Chavez, J. A. & Summers, S. A. (2003). Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys, 419, 101-109.
11. Chavez, JA; Knotts, TA; Wang, LP; Li, G; Dobrowsky, RT; Florant, GL; Summers, SA. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem, 2003 13, 10297-10303.
12. Cheng, Y; Ohlsson, L; Duan, R-D. Psyllium and fat in diets diferentially affect the activities and expressions of colonic sphingomyelinases and caspase in mice. Br J Nutr, 2004 91, 715-723.
13. Chocian, G; Chabowski, A; Zendzian-Piotrowska, M; Harasim, E; Łukaszuk, B; Górski, J. High fat diet induces ceramide and sphingomyelin formation in rat's liver nuclei. Mol Cell Biochem., 2010 340, 125-131.
14. Costantini, C; Weindruch, R; Della Valle, G; Puglielli, L. A TrkA-to-p75NTR molecular switch activates amyloid β-peptide generation during aging. Biochem J, 2005 391, 59-67.
15. Cutler, R. G. & Mattson, M. P. (2001). Sphingomyelin and ceramide as regulators of development and lifespan. Mech Ageing Dev, 122, 895-908.
16. Cutler, RG; Kelly, J; Storie, K; Pedersen, WA; Tammara, A; Hatanpaa, K; Troncoso, JC; Mattson, MP. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc Natl Aca. Sci USA, 2004 101, 2070-2075.
17. de la Monte, SM. Insulin resistance and Alzheimer's disease. BMB reports, 2009 42, 475-481.
18. de Wilde, J; Mohren, R; van den Berg, S; Boekschoten, M; Dijk, KW; de Groot, P; Müller, M; Mariman, E; Smit, E. Short-term high-fat-feeding results in morphologival and metabolic adaptations in skeletal muscle of C57BL/6J mice. Physiol Genomics, 2008 32, 360-369.
19. Deevska, GM; Rozenova, KA; Giltiay, NV; Chambers, MA; White, J; Boyanovsky, BB; Wei, J; Daugherty, A; Smart, EJ; Reid, MB; Merrill, AH JR; Nikolova-Karakashian, M. Acid sphingomyelinase deficiency prevents diet-induced hepatic triacylglycerol accumulation and hyperglycemia in mice. J Biol Chem, 2009 284, 8359-8368.
20. Delgado, TC; Pinheiro, D; Caldeira, M; Castro, MM; Geraldes, CF; López-Larrubia P; Cerdán S; Jones JG. Sources of hepatic triglyceride accumulation during high-fat feeding in the healthy rats. NMR Biomed, 2009 22, 310-317.
21. Fox, TE; Houck, KL; O'Neill, SM; Nagarajan, M; Stover, TC; Pomianowski, PT; Unal, O; Yun, JK; Naides, SJ; Kester, M. Ceramide recruits and activates protein kinase C ζ (PKC ζ) within structured membrane microdomains. J Biol Chem, 2007 282, 12450-12457.
22. Granholm, AC; Bimonte-Nelson, HA; Moore, AB; Nelson, ME; Freeman, LR; Sambamurti, K. Effects of a saturated fat and high cholesterol diet on memory and hippocampal morphology in the middle-aged rat. J Alzheimers Dis, 2008 14, 133-145.
23. Guenther, GG; Peralta, ER; Rosales, KR; Wong, SY; Siskind, LJ; Edinger, AL. Ceramide starves cells to death by downregulating nutrient transporter proteins. Proc Natl Acad Sci USA, 2008 105, 17402-17407.
24. Gustavsson, L; Moehern, G; Torres-Morquez, ME; Benistant, C; Rubin, R; Hock, JB. The role of cytosolic Ca2+, protein kinase C and protein kinase D in rat hepatocytes. J Biol Chem, 1994 269, 849-859.
25. Hajduch, E; Alessi, DR; Hemmings, BA; Hundal, HS. Constitutive activation of protein kinase Bα (PKBα) by membrane targeting promotes glucose and system A amino acid transport, protein synthesis and GSK3 inactivation in L6 muscle cells. Diabetes, 1998 47, 1006-1013.
26. Hajduch, E; Turban, S; Le Liepvre, X; Le Lay, S; Lipina, C; Dimopoulos, N; Dugail, I; Hundal, HS. Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKBdirected signaling by ceramide. Biochem J, 2008 410, 369-379.
27. He, X; Huang, Y; Li, B; Gong, CX; Schuchman, EH. Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging, 2008 31, 398-408.
28. Holland, W. L. & Summers, S. A. (2008). Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism. Endocrine Reviews, 29, 381-402.
29. Holland, WL; Brozinick JT; Wang, L-P; Hawkins, ED; Sargent, KM; Liu, Y; Narra, K; Hoehn, KL; Knotts, TA; Siesky, A; Nelson, DH; Karathanasis, SK; Fontenot, GK; Birnbaum, MJ; Summers, SA. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated fat-, and obesity-induced insulin resistance. Cell Metab, 2007 5, 167-179.
30. Hudgins, LC; Hellerstein, MK; Seidman, C; Neese, R; Diakun, J; Hirsch, J. Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. J Clin Invest, 1996 97, 2081-2091.
31. JeBailey, L; Wanono, O; Niu, W; Roessler, J; Rudich, A; Klip, A. Ceramide-and oxidant-induced insulin resistance involve loss of insulin-dependent Racactivation and actin remodeling in muscle cells. Diabetes, 2007 56, 394-403.
32. Lauter, C. J. & Trams, E. G. (1962). A spectrophometric determination of sphingosine. J Lipid Res, 3, 136-138.
33. Le Stunff, H; Giussani, P; Maceyka, M; Lépine, S; Milstien, S; Spiegel, S. Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. J Biol Chem, 2007 282, 34372-34380.
34. Lin, J; Yang, R; Tarr, PT; Wu, PH; Handschin, C; Li, S; Yang, W; Pei, L; Uldry, M; Tontonoz, P; Newgard, CB; Spiegelman, BM. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1 beta coactivation of SREBP. Cell, 2005 120, 261-273.
35. Long, S. D. & Pekala, P. H. (1996). Lipid mediators of insulin resistance: ceramide signaling down regulates GLUT4 gene transcription in 3T3-L1 adipocytes. Biochem J, 319, 179-184.
36. Lyn-Cook, LE, Jr; Lawton, M; Tong, M; Silbermann, E; Longato, L; Jiao, P; Mark, P; Wands, JR; Xu, H; de la Monte, S. Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and nonalcoholic steatohepatitis. J Alzheimer Dis, 2009 16, 715-729.
37. Marsh, J. B. & Weinstein, D. B. (1966). Simple charring method for determination of lipids. J Lipid Res, 7, 574-576.
38. Mattson, MP. Diet-brain connection: impact on memory, mood, aging and disease. Ed. Kluwer Academic Publishers; USA: Mattson, MP; 2002.
39. Merrill, AH, Jr; Lingrell, S; Wang, E; Nikolova-Karakashian, M; Vales, TR; Vance, DE. Sphingolipid biosynthesis de novo by rat hepatocytes in culture. J Biol Chem, 1995 270, 13834-13841
40. Michalopoulos, G., & Pitot, H. C. (1975). Primary cultures of parenchymal liver cells on collagen membranes. Exp Cell Res, 33, 545-552.
41. Morino, K; Petersen, KF; Shulman, GI. Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes, 2006 55, S9-S15.
42. Muskiet, FA; van Doormaal, IJ; Martini, IA; Wolthers, BG; van der Slick, W. Capillary gas chromatographic profiling of total long-chain fatty acids and cholesterol in biological materials. J Chromatogr, 1983 278, 231-244.
43. Nagle, CA; An, J; Shiota, M; Torres, TP; Cline, GW; Liu, Z-X; Wang, S; Catlin, RL; Shulman, GI; Newgard, CB; Coleman, RA. Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J Biol Chem, 2007 282, 14807-14815.
44. Nagle, CA; Klett, EL; Coleman, RA. Hepatic triacylglycerol accumulation and insulin resistance. J Lipid Res, 2009 50, S74-S79.
45. Neschen, SK; Morino, LE; Hammond, D; Zhang, ZX; Liu, AJ; Romanelli, GW; Cline, RL; Pongratz, XM; Zhang, CS; Choi, CS; Coleman, RA; Shulman, GI. Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knock out mice. Cell Metab, 2005 2, 55-65.
46. Neumann, KF; Rojo, L; Navarrete, LP; Farías, G; Reyes, P; Maccioni, RB. Insulin resistance and Alzheimer's disease: molecular links & climical implications. Curr Alzheimer Res, 2008 5, 438-447.
47. Ogretmen, B; Pettus, BJ; Rossi, MJ; Wood, R; Usta, J; Szulc, Z; Bielawska, A; Obeid, LM; Hannun, YA. Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous shirt chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide. J Biol Chem, 2002 277, 12960-12969.
48. Parrott, M. D. & Greenwood, C. E. (2007). Dietary influences on cognitive function with aging: from high-fat diets to healthful eating. Ann N Y Acad Sci, 1114, 389-397.
49. Patil, S. & Chan, C. (2005). Palmitic and stearic acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons. Neurosci Lett, 384, 288-293.
50. Patil, S; Balu, D; Melrose, J; Chan, C. Brain region-specificity of palmitic acidinduced abnormalities associated with Alzheimer's disease. BMC Research Notes, 2008 1, 20.
51. Patil, S; Melrose, J; Chan, C. Involvement of astroglial ceramide in palmitic acidinduced Alzheimer-like changes in primary neurons. Eur J Neurosci, 2007 26, 2131-2141.
52. Patil, S; Sheng,, L; Masserang, A; Chan, C. Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons. Neurosci Lett, 2006 406, 55-59.
53. Puglielli, L; Tanzi, RE; Kovacs, DM. Alzheimer's disease: the cholesterol connection. Nat Neurosci, 2003 6, 345-351.
54. Rutkute, K; Asmis, RH; Nikolova-Karakashian, MN. Regulation of neutral aphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation. J Lipid Res, 2007 48, 2443-2452.
55. Salinas, M; Lopez-Valdaliso, R; Martin, D; Alvarez, A; Cuadrado, A. Inhibition of PKB/Akt by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Mol Cell Neurosci, 2000 15, 156-169.
56. Sampath, H; Miyazaki, M; Dobrzyn, A; Ntambi, JM. Srearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem, 2007 282, 2483-2493.
57. Samuel, VT; Liu, Z-X; Qu, X; Elder, BD; Bilz, S; Befroy, D; Romanelli, AJ; Shulman, GI. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem, 2004 279, 32345-32353.
58. Sathishkumar, S; Boyanovsky, B; Karakashian, AA; Rozenova, K; Giltiay, NV; Kudrimoti, M; Mohiuddin, M; Ahmed, MM; Nikolova-Karakashian, M. Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosis. Cancer Biol Ther, 2005 4, 979-986.
59. Schmitz-Peiffer, C. & Biden, T.J. (2008). Protein kinase C function in muscle, liver, and ß-cells and its therapeutic implications for type 2 diabetes. Diabetes, 57, 1774-1783.
60. Schmitz-Peiffer, C; Craig, DL; Bidn, TJ. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem, 1999 274, 24202-24210.
61. Schwarz, JM; Neese, RA; Turner, S; Dare, D; Hellerstein, MK. Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J Clin Invest, 1995 96, 2735-2743.
62. Shah, C; Yang, G; Lee, I; Bielawski, J; Hannun, YA; Samad, F. Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem, 2008 283, 13538-13548.
63. Solfrizzi, V; D'Introno, A; Colacicco, AM; Capurso, C; Del Parigi, A; Capurso, S; Gadaleta, A; Capurso, A; Panza, F. Dietary fatty acids intake: possible role in cognitive decline and dementia. Exp Gerontol, 2005 40, 257-270.
64. Stratford, S; DeWald, DB; Sammers, SA. Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation. Biochem J, 2001 354, 359-368.
65. Teruel, T; Hernandez, R; Lorenzo, M. Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes, 2001 50, 2563-2571.
66. Uauy, R. & Dangour, A. (2006). Dietary lipids and the brain during development and ageing. Scand J Food Nutr, 50, 27-32.
67. Ugi, S; Imamura, T; Maegawa, H; Egawa, K; Yoshizaki, T; Shi, K; Obata, T; Ebina, Y; Kashiwagi, A; Olefsky, JM. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol Cell Biol, 2004 24, 8778-8789.
68. Vranckx, R; Savu, L; Lambert, N; de Conchard GV; Grosse, R; Mourey, MS; Corman, B. Plasma proteins as biomarkers of the aging process. Am J Physiol, 1995 268, R536-548.
69. Winocur, G. & Greenwood, C. E. (2005). Studies of the effects of high fat diets on cognitive function in a rat model. Neurobiol Aging, 26 Sappl 1, 46-49.
70. Zinda, MJ; Vlahos, CJ; Lai, MT. Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells. Biochem Biophys Res Commun, 2001 280, 1107-1115.