Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

Journal of Clinical Investigation

Volumn 119, Issue 9, 2009, Pages 2577-2589

  Benoit, Stephen C ^a   Kemp, Christopher J ^a   Elias, Carol F ^b   Abplanalp, William ^a   Herman, James P ^a   Migrenne, Stephanie ^c   Lefevre, Anne Laure ^c   Cruciani Guglielmacci, Céline ^c   Magnan, Christophe ^c   Yu, Fang ^d,e   Niswender, Kevin ^d,e   Irani, Boman G ^b   Holland, William L ^b   Clegg, Deborah J ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c CNRS   (France)

^d DEPARTMENT OF VETERANS AFFAIRS   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; INSULIN; ISOPROTEIN; MONOUNSATURATED FATTY ACID; NEUROPEPTIDE Y; OLEIC ACID; PALMITIC ACID; PROTEIN KINASE C THETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENERGY BALANCE; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INSULIN RESISTANCE; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BASE SEQUENCE; DIETARY FATS; GLUCONEOGENESIS; HYPOTHALAMUS; INSULIN RESISTANCE; ISOENZYMES; LEPTIN; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PALMITIC ACID; PROTEIN KINASE C; RATS; RATS, LONG-EVANS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

EID: 70349200763     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI36714     Document Type: Article

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