Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet

Journal of Clinical Investigation

Volumn 97, Issue 9, 1996, Pages 2081-2091

  Hudgins, Lisa Cooper ^a   Hellerstein, Marc ^b,c   Seidman, Cynthia ^a   Neese, Richard ^b,c   Diakun, Jolanta ^a   Hirsch, Jules ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

fatty acids; linoleic acids; palmitic acids; triglycerides; very low density lipoproteins

Indexed keywords

CARBOHYDRATE; FAT; FATTY ACID; GLUCOSE POLYMER; LINOLEIC ACID; PALMITIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CARBOHYDRATE DIET; CARDIOVASCULAR EFFECT; FATTY ACID SYNTHESIS; FEMALE; HUMAN; HUMAN EXPERIMENT; LIPID COMPOSITION; LOW FAT DIET; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0029990980     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118645     Document Type: Article

References (50)

1. Hirsch, J., and R.B. Goldrick. 1964. Serial studies on the metabolism of human adipose tissue. I. Lipogenesis and free fatty acid uptake and release in small aspirated samples of subcutaneous fat. J. Clin. Invest. 43:1775-1792.
2. Sjostrom, L. 1973. Carbohydrate-stimulated fatty acid synthesis de novo in human adipose tissue of different cellular types. Acta Med. Scand. 194:387-404.
3. Angel, A., and G.A. Bray. 1979. Synthesis of fatty acids and cholesterol by liver, adipose tissue and intestinal mucosa from obese and control patients. Eur. J. Clin. Invest. 9:355-362.
4. Barakat, H.A., V.D. McLendon, J.W. Carpenter, R.H.L. Marks, N. Legett, K. O'Brien, and J.F. Caro. 1991. Lipogenic potential of liver from morbidly obese patients with and without non-insulin-dependent diabetes. Metab. Clin. Exp. 40:280-285.
5. Goodridge, A.G. 1987. Dietary regulation of gene expression: enzymes involved in carbohydrate and lipid metabolism. Annu. Rev. Nutr. 7:157-185.
6. Shillabeer, G., J. Hornford, J.M. Forden, N.C. Wong, and D.C. Lau. 1990. Hepatic and adipose tissue lipogenic enzyme mRNA levels are suppressed by high fat diets in the rat. J. Lipid Res. 31:623-631.
7. Acheson, K.J., Y. Schutz, T. Bessard, K. Anantharaman, J.-P. Flatt, and E. Jequier. 1988. Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. Am. J. Clin. Nutr. 48:240-247.
8. Hellerstein, M.K., M. Christiansen, S. Kaempfer, C. Kletke, K. Wu, J.S. Reid, K. Mulligan, N.S. Hellerstein, and C.H.L. Shackleton. 1991. Measurement of de novo hepatic lipogenesis in humans using stable isotopes. J. Clin. Invest. 87:1841-1852.
9. Hellerstein, M.K., and R.A. Neese. 1992. Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. Am. J. Physiol. 263:E988-E1001.
10. Leitch, C.A., and P.J.H. Jones. 1993. Measurement of human lipogenesis using deuterium incorporation. J. Lipid Res. 34:157-163.
11. Faix, D., R. Neese, C. Kletke, S. Wolden, D. Cesar, M. Coutlangus, C. Shackleton, and M. Hellerstein. 1993. Quantification of menstrual and diurnal periodicities in rates of cholesterol and fat synthesis in humans. J. Lipid Res. 34: 2063-2075.
12. Sniderman, A.D., and K. Cianflone. 1993. Substrate delivery as a determinant of hepatic apoB secretion. Arterioscler. Thromb. 13:629-636.
13. Melish, J., N. Le, H. Ginsberg, D. Steinberg, and W.V. Brown. 1980. Dissociation of apoprotein B and triglyceride production in very-low-density lipoproteins. Am. J. Physiol. 239:354-362.
14. Jayakumar, A., M. Tai, W. Huang, W. Al-Feel, M. Hsu, L. Abu-Elheiga, S.S. Chirala, and S.J. Wakil. 1995. Human fatty acid synthase: properties and molecular cloning. Proc. Natl. Acad. Sci. USA. 92:8695-8699.
15. NIH. 1993. National Institutes of Health Consensus Conference: Triglyceride, high-density lipoprotein, and coronary heart disease. J. Am. Med. Assoc. 269:505-510.
16. DHHS. 1988. Department of Health and Human Services: Nutrition and Health. Surgeon General's Report.
17. Goodnight, S., W. Harris, W. Connor, and D.R. Illingworth. 1982. Polyunsaturated fatty acids, hyperlipidemia and thrombosis. Arteriosclerosis. 2:87-113.
18. Lindgren, F., L. Jensen, and F. Hatch. 1972. The isolation and quantitative analysis of serum lipoproteins. In Blood Lipids and Lipoproteins: Quantitation, Composition, and Metabolism. G. Nelson, editor. John Wiley and Sons, Inc., New York. 221-244.
19. Folch, J., M. Lees, and G. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissue. J. Biol. Chem. 226:497-509.
20. Hirsch, J., J.W. Farquhar, E.H. Ahrens, M.L. Peterson, and W. Stoffel. 1960. Studies of adipose tissue in man. Am. J. Clin. Nutr. 8:499-511.
21. Ito, Y., L.C. Hudgins, J. Hirsch, and M. Shike, 1991. Adipose tissue fatty acid composition in recipients of long-term total parenteral nutrition (TPN). Am. J. Clin. Nutr. 53:1487-1492.
22. 2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin. Chem. 28:1379-1388.
23. Herbert, V., K. Lau, C.W. Gottlieb, and S.J. Bleicher. 1965. Coated charcoal immunoassay of insulin. J. Clin. Endocrinol. & Metab. 25:1375-1384.
24. Hudgins, L.C., and J. Hirsch. 1991. Changes in abdominal and gluteal adipose tissue fatty acid compositions in obese subjects after weight gain and weight loss. Am. J. Clin. Nutr. 53:1372-1377.
25. Phinney, S.D., J.S. Stern, K.E. Burke, A.B. Tang, G. Miller, and R.T. Holman. 1994. Human subcutaneous adipose tissue shows site-specific differences in fatty acid composition. Am. J. Clin. Nutr. 60:725-729.
26. Ahrens, E.H., and N. Spritz. 1963. Further studies on fat and carbohydrate-induced lipemia in man. Reduction of lipemia by feeding fat. In Biochemical Problems of Lipids. A.C. Frazer, editor. Elsevier Publishing Company, Amsterdam. 304-312.
27. Bierman, E.L., D. Porte, D.D. O'Hara, M. Schwartz, and F.C. Wood. 1965. Characterization of fat particles in plasma of hyperlipemic subjects maintained on fat-free high-carbohydrate diets. J. Clin. Invest. 44:261-270.
28. Wene, J.D., W.E. Connor, and L. DenBesten. 1975. The development of essential fatty acid deficiency in healthy men fed fat free diets intravenously and orally. J. Clin. Invest. 56:127-134.
29. Sweeney, M.J., J.N. Etteldorf, L.J. Throop, D.L. Timma, and E.L. Wrenn. 1963. Diet and fatty acid distribution in subcutaneous fat and in the cholesterol-triglycerides fraction of serum of young infants. J. Clin. Invest. 42:1-9.
30. Spritz, N., and M.A. Mishkel. 1969. Effects of dietary fats on plasma lipids and lipoproteins: an hypothesis for the lipid-lowering effect of unsaturated fatty acids. J. Clin. Invest. 48:78-86.
31. Baudet, M.F., O. Esteva, B. Delplanque, N. Winchene, and B. Jacotot. 1980. Effects of three dietary fats on plasma lipids and lipoproteins in fasting and post-prandial humans after a short-term diet. Lipids. 15:216-223.
32. Clandinin, M.T., S. Cheema. C.J. Field, M.L. Garg, J. Venkatraman, and T.R. Clandinin. 1991. Dietary fat: exogenous determination of membrane structure and cell function. FASEB (Fed. Am. Soc. Exp. Biol.) J. 5:2761-2769.
33. Clarke, S.D., and D.B. Jump. 1994. Dietary polyunsaturated fatty acid regulation of gene transcription. Annu. Rev. Nutr. 14:83-98.
34. Siguel, E.N. 1994. Altered fatty acid metabolism in patients with angiographically documented coronary artery disease. Metab. Clin. Exp. 43:982-993.
35. Riemersma, R.A., D.A. Wood, S. Butler, R.A. Elton, M. Oliver, M. Salo, T. Nikkari, E. Vartiainen, P. Puska, F. Gey, et al. 1986. Linoleic acid content in adipose tissue and coronary heart disease. Br. Med. J. 292:1423-1427.
36. Wood, D.A., R.A. Riemersma, S. Butler, M. Thomson, C. Macintyre, R.A. Elton, and M.F. Oliver. 1987. Linoleic and eicosapentaenoic acids in adipose tissue and platelets and risk of coronary heart disease. Lancet. (Jan. 24): 177-183.
37. Flatt, J.P. 1978. The biochemistry of energy expenditure. Recent Adv. Obes. Res. 2:211-227.
38. Hellerstein, M.K., R. Neese, and J.-M. Schwartz. 1993. Model for measuring absolute rates of hepatic de novo lipogenesis and reesterification of free fatty acids. Am. J. Physiol. 265:E814-E820.
39. Ntambi, J.M. 1992. Dietary regulation of stearoyl-coA desaturase 1 gene expression in mouse liver. J. Biol. Chem. 267:10925-10930.
40. Elovson, J. 1965. Conversions of palmitic and stearic acid in the intact rat. Biochem. Biophys. Acta. 106:291-303.
41. Emken, E.A., R.O. Adlof, W.K. Rohwedder, and R.M. Gulley. 1993. Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. Biochim. Biophys. Acta. 1170:173-181.
42. Toorop, A.I., D.R. Romsos, and G.A. Leveille. 1979. The metabolic fate of dietary 1-[14C]palmitate in meal-fed rats. Proc. Soc. Exp. Biol. Med. 160: 312-316.
43. Nestel, P.J., and P. Barter. 1971. Metabolism of palmitic and linoleic acids in man: differences in turnover and conversion to glycerides. Clin. Sci. 40: 345-350.
44. Jones, P.J.H., and D.A. Schoeller. 1988. Polyunsaturated:saturated ratio of diet influences energy substrate utilization in the human. Metab. Clin. Exp. 37:145-151.
45. Moustaid, N., R.S. Beyer, and H.S. Sul. 1994. Identification of an insulin response element in the fatty acid synthase promoter. J. Biol. Chem. 269:5629-5634.
46. Coulston, A.M., G.C. Liu, and G.M. Reaven. 1983. Plasma glucose, insulin and lipid responses to high-carbohydrate low-fat diets in normal humans. Metab. Clin. Exp. 32:52-56.
47. Hudgins, L.C., M.K. Hellerstein, C. Seidman, J. Diakun, and J. Hirsch. 1993. Carbohydrate induced lipogenesis: a potential adverse effect of low fat diets. Circulation. 88(Suppl. 2):1-317.
48. Hudgins, L.C. 1995. Decreased fatty acid synthesis after substitution of dietary starch for sugar. Circulation. 92(Suppl.):1-157.
49. Frayn, K., and S. Kingman. 1995. Dietary sugars and lipid metabolism in humans. Am. J. Clin. Nutr. 62(Suppl.):250S-263S.
50. Schwartz, J., R. Neese, C. Shackelton, and M. Hellerstein. 1993. De novo lipogenesis during fasting and oral fructose in lean and obese hyperinsulinemic subjects. Diabetes. 42(Suppl. 1):39A.