메뉴 건너뛰기




Volumn 18, Issue 10, 2012, Pages 1982-1996

Epigenetics: Concepts and relevance to IBD pathogenesis

Author keywords

Chromatin; Epigenetics; Gene transcription; Inflammation; Inflammatory bowel disease

Indexed keywords

DNA METHYLTRANSFERASE INHIBITOR; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE INHIBITOR; HISTONE METHYLTRANSFERASE; UNTRANSLATED RNA;

EID: 84866367184     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.22934     Document Type: Review
Times cited : (48)

References (139)
  • 2
    • 80455140368 scopus 로고    scopus 로고
    • Ulcerative colitis
    • Danese S, Fiocchi C,. Ulcerative colitis. N Engl J Med. 2011; 365: 1713-1725.
    • (2011) N Engl J Med. , vol.365 , pp. 1713-1725
    • Danese, S.1    Fiocchi, C.2
  • 3
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • DOI 10.1172/JCI30587
    • Strober W, Fuss I, Mannon P,. The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007; 117: 514-521. (Pubitemid 46348505)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.3 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 4
  • 5
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor B, Gardet A, Xavier RJ,. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011; 474: 307-317.
    • (2011) Nature. , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 7
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela A, Esteller M,. Epigenetic modifications and human disease. Nat Biotechnol. 2010; 28: 1057-1068.
    • (2010) Nat Biotechnol. , vol.28 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 8
    • 78049402859 scopus 로고    scopus 로고
    • Molecular signals of epigenetic states
    • Bonasio R, Tu S, Reinberg D,. Molecular signals of epigenetic states. Science. 2010; 330: 612-616.
    • (2010) Science. , vol.330 , pp. 612-616
    • Bonasio, R.1    Tu, S.2    Reinberg, D.3
  • 9
    • 77953469917 scopus 로고    scopus 로고
    • Epigenetics as a unifying principle in the aetiology of complex traits and diseases
    • Petronis A,. Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature. 2010; 465: 721-727.
    • (2010) Nature. , vol.465 , pp. 721-727
    • Petronis, A.1
  • 10
    • 77949678340 scopus 로고    scopus 로고
    • Chromatin structure and the inheritance of epigenetic information
    • Margueron R, Reinberg D,. Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet. 2010; 11: 285-296.
    • (2010) Nat Rev Genet. , vol.11 , pp. 285-296
    • Margueron, R.1    Reinberg, D.2
  • 11
    • 79955473684 scopus 로고    scopus 로고
    • Operating on chromatin, a colorful language where context matters
    • Gardner KE, Allis CD, Strahl BD,. Operating on chromatin, a colorful language where context matters. J Mol Biol. 2011; 409: 36-46.
    • (2011) J Mol Biol. , vol.409 , pp. 36-46
    • Gardner, K.E.1    Allis, C.D.2    Strahl, B.D.3
  • 12
    • 80052805267 scopus 로고    scopus 로고
    • Histone modification: Cause or cog?
    • Henikoff S, Shilatifard A,. Histone modification: cause or cog? Trends Genet. 2011; 27: 389-396.
    • (2011) Trends Genet. , vol.27 , pp. 389-396
    • Henikoff, S.1    Shilatifard, A.2
  • 13
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • DOI 10.1016/j.cell.2007.02.005, PII S0092867407001845
    • Kouzarides T,. Chromatin modifications and their function. Cell. 2007; 128: 693-705. (Pubitemid 46273577)
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 14
    • 77949874234 scopus 로고    scopus 로고
    • Histone variants-ancient wrap artists of the epigenome
    • Talbert PB, Henikoff S,. Histone variants-ancient wrap artists of the epigenome. Nat Rev Mol Cell Biol. 2010; 11: 264-275.
    • (2010) Nat Rev Mol Cell Biol. , vol.11 , pp. 264-275
    • Talbert, P.B.1    Henikoff, S.2
  • 15
    • 36448949026 scopus 로고    scopus 로고
    • Multivalent engagement of chromatin modifications by linked binding modules
    • DOI 10.1038/nrm2298, PII NRM2298
    • Ruthenburg AJ, Li H, Patel DJ, et al. Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol. 2007; 8: 983-994. (Pubitemid 350174643)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.12 , pp. 983-994
    • Ruthenburg, A.J.1    Li, H.2    Patel, D.J.3    David Allis, C.4
  • 16
    • 80052942443 scopus 로고    scopus 로고
    • Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
    • Tan M, Luo H, Lee S, et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell. 2011; 146: 1016-1028.
    • (2011) Cell. , vol.146 , pp. 1016-1028
    • Tan, M.1    Luo, H.2    Lee, S.3
  • 19
    • 34547890019 scopus 로고    scopus 로고
    • Functions of site-specific histone acetylation and deacetylation
    • Shahbazian MD, Grunstein M,. Functions of site-specific histone acetylation and deacetylation. Annu Rev Biochem. 2007; 76: 75-100.
    • (2007) Annu Rev Biochem. , vol.76 , pp. 75-100
    • Shahbazian, M.D.1    Grunstein, M.2
  • 20
    • 49349107518 scopus 로고    scopus 로고
    • Lysine acetylation: Codified crosstalk with other posttranslational modifications
    • Yang XJ, Seto E,. Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell. 2008; 31: 449-461.
    • (2008) Mol Cell. , vol.31 , pp. 449-461
    • Yang, X.J.1    Seto, E.2
  • 21
    • 78649855810 scopus 로고    scopus 로고
    • Small molecule modulators of histone acetylation and methylation: A disease perspective
    • Selvi BR, Mohankrishna DV, Ostwal YB, et al. Small molecule modulators of histone acetylation and methylation: a disease perspective. Biochim Biophys Acta. 2010; 1799: 810-828.
    • (2010) Biochim Biophys Acta. , vol.1799 , pp. 810-828
    • Selvi, B.R.1    Mohankrishna, D.V.2    Ostwal, Y.B.3
  • 23
    • 79959804516 scopus 로고    scopus 로고
    • Histone deacetylases as regulators of inflammation and immunity
    • Shakespear MR, Halili MA, Irvine KM, et al. Histone deacetylases as regulators of inflammation and immunity. Trends Immunol. 2011; 32: 335-343.
    • (2011) Trends Immunol. , vol.32 , pp. 335-343
    • Shakespear, M.R.1    Halili, M.A.2    Irvine, K.M.3
  • 24
    • 69949148388 scopus 로고    scopus 로고
    • Protein methyltransferases as a target class for drug discovery
    • Copeland RA, Solomon ME, Richon VM,. Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009; 8: 724-732.
    • (2009) Nat Rev Drug Discov. , vol.8 , pp. 724-732
    • Copeland, R.A.1    Solomon, M.E.2    Richon, V.M.3
  • 25
    • 23944509075 scopus 로고    scopus 로고
    • The SET-domain protein superfamily: Protein lysine methyltransferases
    • Dillon SC, Zhang X, Trievel RC, et al. The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol. 2005; 6: 227.
    • (2005) Genome Biol. , vol.6 , pp. 227
    • Dillon, S.C.1    Zhang, X.2    Trievel, R.C.3
  • 26
    • 78049286684 scopus 로고    scopus 로고
    • Histone demethylases in development and disease
    • Pedersen MT, Helin K,. Histone demethylases in development and disease. Trends Cell Biol. 2010; 20: 662-671.
    • (2010) Trends Cell Biol. , vol.20 , pp. 662-671
    • Pedersen, M.T.1    Helin, K.2
  • 27
    • 79959829510 scopus 로고    scopus 로고
    • Histone arginine methylation
    • Di Lorenzo A, Bedford MT,. Histone arginine methylation. FEBS Lett. 2011; 585: 2024-2031.
    • (2011) FEBS Lett. , vol.585 , pp. 2024-2031
    • Di Lorenzo, A.1    Bedford, M.T.2
  • 28
    • 79955505888 scopus 로고    scopus 로고
    • When signaling kinases meet histones and histone modifiers in the nucleus
    • Baek SH,. When signaling kinases meet histones and histone modifiers in the nucleus. Mol Cell. 2011; 42: 274-284.
    • (2011) Mol Cell. , vol.42 , pp. 274-284
    • Baek, S.H.1
  • 29
    • 77956919550 scopus 로고    scopus 로고
    • Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation
    • Gehani SS, Agrawal-Singh S, Dietrich N, et al. Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell. 2010; 39: 886-900.
    • (2010) Mol Cell. , vol.39 , pp. 886-900
    • Gehani, S.S.1    Agrawal-Singh, S.2    Dietrich, N.3
  • 30
    • 40849106789 scopus 로고    scopus 로고
    • Histone ubiquitination: Triggering gene activity
    • DOI 10.1016/j.molcel.2008.02.014, PII S1097276508001330
    • Weake VM, Workman JL,. Histone ubiquitination: triggering gene activity. Mol Cell. 2008; 29: 653-663. (Pubitemid 351400924)
    • (2008) Molecular Cell , vol.29 , Issue.6 , pp. 653-663
    • Weake, V.M.1    Workman, J.L.2
  • 31
    • 79959847254 scopus 로고    scopus 로고
    • The role of deubiquitinating enzymes in chromatin regulation
    • Atanassov BS, Koutelou E, Dent SY,. The role of deubiquitinating enzymes in chromatin regulation. FEBS Lett. 2011; 585: 2016-2023.
    • (2011) FEBS Lett. , vol.585 , pp. 2016-2023
    • Atanassov, B.S.1    Koutelou, E.2    Dent, S.Y.3
  • 33
    • 0037019333 scopus 로고    scopus 로고
    • Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast
    • DOI 10.1038/nature00883
    • Sun ZW, Allis CD,. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature. 2002; 418: 104-108. (Pubitemid 34742580)
    • (2002) Nature , vol.418 , Issue.6893 , pp. 104-108
    • Sun, Z.-W.1    Allis, C.D.2
  • 34
    • 70349443224 scopus 로고    scopus 로고
    • Transcriptional control of the inflammatory response
    • Medzhitov R, Horng T,. Transcriptional control of the inflammatory response. Nat Rev Immunol. 2009; 9: 692-703.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 692-703
    • Medzhitov, R.1    Horng, T.2
  • 35
    • 69249203574 scopus 로고    scopus 로고
    • SUMO association with repressor complexes, emerging routes for transcriptional control
    • Garcia-Dominguez M, Reyes JC,. SUMO association with repressor complexes, emerging routes for transcriptional control. Biochim Biophys Acta. 2009; 1789: 451-459.
    • (2009) Biochim Biophys Acta. , vol.1789 , pp. 451-459
    • Garcia-Dominguez, M.1    Reyes, J.C.2
  • 36
    • 33645879818 scopus 로고    scopus 로고
    • Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications
    • Nathan D, Ingvarsdottir K, Sterner DE, et al. Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev. 2006; 20: 966-976.
    • (2006) Genes Dev. , vol.20 , pp. 966-976
    • Nathan, D.1    Ingvarsdottir, K.2    Sterner, D.E.3
  • 37
    • 26944461283 scopus 로고    scopus 로고
    • Chromatin remodeling through directional DNA translocation from an internal nucleosomal site
    • DOI 10.1038/nsmb973, PII NSMB973
    • Saha A, Wittmeyer J, Cairns BR,. Chromatin remodeling through directional DNA translocation from an internal nucleosomal site. Nat Struct Mol Biol. 2005; 12: 747-755. (Pubitemid 43102285)
    • (2005) Nature Structural and Molecular Biology , vol.12 , Issue.9 , pp. 747-755
    • Saha, A.1    Wittmeyer, J.2    Cairns, B.R.3
  • 38
    • 80052656113 scopus 로고    scopus 로고
    • Targeting chromatin remodelers: Signals and search mechanisms
    • Erdel F, Krug J, Langst G, et al. Targeting chromatin remodelers: signals and search mechanisms. Biochim Biophys Acta. 2011; 1809: 497-508.
    • (2011) Biochim Biophys Acta. , vol.1809 , pp. 497-508
    • Erdel, F.1    Krug, J.2    Langst, G.3
  • 39
    • 79960803077 scopus 로고    scopus 로고
    • Revealing histone variant induced changes via quantitative proteomics
    • Arnaudo AM, Molden RC, Garcia BA,. Revealing histone variant induced changes via quantitative proteomics. Crit Rev Biochem Mol Biol. 2011; 46: 284-294.
    • (2011) Crit Rev Biochem Mol Biol. , vol.46 , pp. 284-294
    • Arnaudo, A.M.1    Molden, R.C.2    Garcia, B.A.3
  • 40
    • 73349092441 scopus 로고    scopus 로고
    • Histones: Annotating chromatin
    • Campos EI, Reinberg D,. Histones: annotating chromatin. Annu Rev Genet. 2009; 43: 559-599.
    • (2009) Annu Rev Genet. , vol.43 , pp. 559-599
    • Campos, E.I.1    Reinberg, D.2
  • 41
    • 79959990071 scopus 로고    scopus 로고
    • Regulation of mammalian DNA methyltransferases: A route to new mechanisms
    • Denis H, Ndlovu MN, Fuks F,. Regulation of mammalian DNA methyltransferases: a route to new mechanisms. EMBO Rep. 2011; 12: 647-656.
    • (2011) EMBO Rep. , vol.12 , pp. 647-656
    • Denis, H.1    Ndlovu, M.N.2    Fuks, F.3
  • 42
    • 77958150580 scopus 로고    scopus 로고
    • Targeting DNA methylation for epigenetic therapy
    • Yang X, Lay F, Han H, et al. Targeting DNA methylation for epigenetic therapy. Trends Pharmacol Sci. 2010; 31: 536-546.
    • (2010) Trends Pharmacol Sci. , vol.31 , pp. 536-546
    • Yang, X.1    Lay, F.2    Han, H.3
  • 43
    • 29644436321 scopus 로고    scopus 로고
    • Molecular enzymology of mammalian DNA methyltransferases
    • DOI 10.1007/3-540-31390-7-7
    • Jeltsch A,. Molecular enzymology of mammalian DNA methyltransferases. Curr Top Microbiol Immunol. 2006; 301: 203-225. (Pubitemid 43022673)
    • (2006) Current Topics in Microbiology and Immunology , vol.301 , pp. 203-225
    • Jeltsch, A.1
  • 44
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner A, Mikkelsen TS, Gu H, et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature. 2008; 454: 766-770.
    • (2008) Nature. , vol.454 , pp. 766-770
    • Meissner, A.1    Mikkelsen, T.S.2    Gu, H.3
  • 45
    • 33847304609 scopus 로고    scopus 로고
    • Gene body-specific methylation on the active X chromosome
    • DOI 10.1126/science.1136352
    • Hellman A, Chess A,. Gene body-specific methylation on the active X chromosome. Science. 2007; 315: 1141-1143. (Pubitemid 46328027)
    • (2007) Science , vol.315 , Issue.5815 , pp. 1141-1143
    • Hellman, A.1    Chess, A.2
  • 46
    • 33845880624 scopus 로고    scopus 로고
    • Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription
    • DOI 10.1038/ng1929, PII NG1929
    • Zilberman D, Gehring M, Tran RK, et al. Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription. Nat Genet. 2007; 39: 61-69. (Pubitemid 46026502)
    • (2007) Nature Genetics , vol.39 , Issue.1 , pp. 61-69
    • Zilberman, D.1    Gehring, M.2    Tran, R.K.3    Ballinger, T.4    Henikoff, S.5
  • 47
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S, Heintz N,. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science. 2009; 324: 929-930.
    • (2009) Science. , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 48
    • 83855163995 scopus 로고    scopus 로고
    • Uncovering the role of 5-hydroxymethylcytosine in the epigenome
    • Branco MR, Ficz G, Reik W,. Uncovering the role of 5- hydroxymethylcytosine in the epigenome. Nat Rev Genet. 2012; 13: 7-13.
    • (2012) Nat Rev Genet. , vol.13 , pp. 7-13
    • Branco, M.R.1    Ficz, G.2    Reik, W.3
  • 49
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • Esteller M,. Non-coding RNAs in human disease. Nat Rev Genet. 2011; 12: 861-874.
    • (2011) Nat Rev Genet. , vol.12 , pp. 861-874
    • Esteller, M.1
  • 50
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • O'Connell RM, Rao DS, Chaudhuri AA, et al. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol. 2010; 10: 111-122.
    • (2010) Nat Rev Immunol. , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3
  • 51
    • 62049086288 scopus 로고    scopus 로고
    • PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing
    • Zhao Q, Rank G, Tan YT, et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 2009; 16: 304-311.
    • (2009) Nat Struct Mol Biol. , vol.16 , pp. 304-311
    • Zhao, Q.1    Rank, G.2    Tan, Y.T.3
  • 52
    • 57149107350 scopus 로고    scopus 로고
    • Gene-specific control of the TLR-induced inflammatory response
    • Foster SL, Medzhitov R,. Gene-specific control of the TLR-induced inflammatory response. Clin Immunol. 2009; 130: 7-15.
    • (2009) Clin Immunol. , vol.130 , pp. 7-15
    • Foster, S.L.1    Medzhitov, R.2
  • 53
    • 77949971595 scopus 로고    scopus 로고
    • Selective transcription in response to an inflammatory stimulus
    • Smale ST,. Selective transcription in response to an inflammatory stimulus. Cell. 2010; 140: 833-844.
    • (2010) Cell. , vol.140 , pp. 833-844
    • Smale, S.T.1
  • 54
    • 84857052421 scopus 로고    scopus 로고
    • Transcriptional regulation in the innate immune system
    • Smale ST,. Transcriptional regulation in the innate immune system. Curr Opin Immunol. 2011; 24: 1-7.
    • (2011) Curr Opin Immunol. , vol.24 , pp. 1-7
    • Smale, S.T.1
  • 55
    • 70249104647 scopus 로고    scopus 로고
    • Defining mechanisms that regulate RNA polymerase II transcription in vivo
    • Fuda NJ, Ardehali MB, Lis JT,. Defining mechanisms that regulate RNA polymerase II transcription in vivo. Nature. 2009; 461: 186-192.
    • (2009) Nature. , vol.461 , pp. 186-192
    • Fuda, N.J.1    Ardehali, M.B.2    Lis, J.T.3
  • 56
    • 70449641057 scopus 로고    scopus 로고
    • Progression through the RNA polymerase II CTD cycle
    • Buratowski S,. Progression through the RNA polymerase II CTD cycle. Mol Cell. 2009; 36: 541-546.
    • (2009) Mol Cell. , vol.36 , pp. 541-546
    • Buratowski, S.1
  • 57
    • 0033681250 scopus 로고    scopus 로고
    • Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter
    • Agalioti T, Lomvardas S, Parekh B, et al. Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell. 2000; 103: 667-678.
    • (2000) Cell. , vol.103 , pp. 667-678
    • Agalioti, T.1    Lomvardas, S.2    Parekh, B.3
  • 58
    • 0037178777 scopus 로고    scopus 로고
    • Modifying gene expression programs by altering core promoter chromatin architecture
    • DOI 10.1016/S0092-8674(02)00822-X
    • Lomvardas S, Thanos D,. Modifying gene expression programs by altering core promoter chromatin architecture. Cell. 2002; 110: 261-271. (Pubitemid 34876553)
    • (2002) Cell , vol.110 , Issue.2 , pp. 261-271
    • Lomvardas, S.1    Thanos, D.2
  • 59
    • 33750314677 scopus 로고    scopus 로고
    • Regulation of cytokine transcription in the context of chromatin
    • DOI 10.1007/s00005-006-0037-8
    • Nikolajczyk B,. Regulation of cytokine transcription in the context of chromatin. Arch Immunol Ther Exp (Warsz). 2006; 54: 299-305. (Pubitemid 44627667)
    • (2006) Archivum Immunologiae et Therapiae Experimentalis , vol.54 , Issue.5 , pp. 299-305
    • Nikolajczyk, B.1
  • 60
    • 0035908126 scopus 로고    scopus 로고
    • Two waves of nuclear factor κB recruitment to target promoters
    • DOI 10.1084/jem.193.12.1351
    • Saccani S, Pantano S, Natoli G,. Two waves of nuclear factor kappaB recruitment to target promoters. J Exp Med. 2001; 193: 1351-1359. (Pubitemid 32565964)
    • (2001) Journal of Experimental Medicine , vol.193 , Issue.12 , pp. 1351-1359
    • Saccani, S.1    Pantano, S.2    Natoli, G.3
  • 61
    • 0036712454 scopus 로고    scopus 로고
    • Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes
    • DOI 10.1101/gad.232502
    • Saccani S, Natoli G,. Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev. 2002; 16: 2219-2224. (Pubitemid 35013084)
    • (2002) Genes and Development , vol.16 , Issue.17 , pp. 2219-2224
    • Saccani, S.1    Natoli, G.2
  • 62
    • 0036143654 scopus 로고    scopus 로고
    • P38-dependent marking of inflammatory genes for increased NF-κB recruitment
    • DOI 10.1038/ni748
    • Saccani S, Pantano S, Natoli G,. p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol. 2002; 3: 69-75. (Pubitemid 34065620)
    • (2002) Nature Immunology , vol.3 , Issue.1 , pp. 69-75
    • Saccani, S.1    Pantano, S.2    Natoli, G.3
  • 63
    • 67649669255 scopus 로고    scopus 로고
    • A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling
    • Ramirez-Carrozzi VR, Braas D, Bhatt DM, et al. A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodeling. Cell. 2009; 138: 114-128.
    • (2009) Cell. , vol.138 , pp. 114-128
    • Ramirez-Carrozzi, V.R.1    Braas, D.2    Bhatt, D.M.3
  • 64
    • 67649648237 scopus 로고    scopus 로고
    • Control of inducible gene expression by signal-dependent transcriptional elongation
    • Hargreaves DC, Horng T, Medzhitov R,. Control of inducible gene expression by signal-dependent transcriptional elongation. Cell. 2009; 138: 129-145.
    • (2009) Cell. , vol.138 , pp. 129-145
    • Hargreaves, D.C.1    Horng, T.2    Medzhitov, R.3
  • 65
    • 2342423022 scopus 로고    scopus 로고
    • In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions
    • DOI 10.1074/jbc.M311786200
    • Miao F, Gonzalo IG, Lanting L, et al. In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions. J Biol Chem. 2004; 279: 18091-18097. (Pubitemid 38560579)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.17 , pp. 18091-18097
    • Miao, F.1    Gonzalo, I.G.2    Lanting, L.3    Natarajan, R.4
  • 67
    • 63049122784 scopus 로고    scopus 로고
    • Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways
    • Ghisletti S, Huang W, Jepsen K, et al. Cooperative NCoR/SMRT interactions establish a corepressor-based strategy for integration of inflammatory and anti-inflammatory signaling pathways. Genes Dev. 2009; 23: 681-693.
    • (2009) Genes Dev. , vol.23 , pp. 681-693
    • Ghisletti, S.1    Huang, W.2    Jepsen, K.3
  • 68
    • 70350754328 scopus 로고    scopus 로고
    • Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
    • De Santa F, Narang V, Yap ZH, et al. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J. 2009; 28: 3341-3352.
    • (2009) EMBO J , vol.28 , pp. 3341-3352
    • De Santa, F.1    Narang, V.2    Yap, Z.H.3
  • 69
    • 0035955640 scopus 로고    scopus 로고
    • Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells
    • Hodge DR, Xiao W, Clausen PA, et al. Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. J Biol Chem. 2001; 276: 39508-39511.
    • (2001) J Biol Chem. , vol.276 , pp. 39508-39511
    • Hodge, D.R.1    Xiao, W.2    Clausen, P.A.3
  • 70
    • 70349559403 scopus 로고    scopus 로고
    • Endotoxin tolerance: New mechanisms, molecules and clinical significance
    • Biswas SK, Lopez-Collazo E,. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 2009; 30: 475-487.
    • (2009) Trends Immunol. , vol.30 , pp. 475-487
    • Biswas, S.K.1    Lopez-Collazo, E.2
  • 72
    • 21244481640 scopus 로고    scopus 로고
    • Endotoxin tolerance disrupts chromatin remodeling and NF-κB transactivation at the IL-1β promoter
    • Chan C, Li L, McCall CE, et al. Endotoxin tolerance disrupts chromatin remodeling and NF-kappaB transactivation at the IL-1beta promoter. J Immunol. 2005; 175: 461-468. (Pubitemid 40884350)
    • (2005) Journal of Immunology , vol.175 , Issue.1 , pp. 461-468
    • Chan, C.1    Li, L.2    McCall, C.E.3    Yoza, B.K.4
  • 73
    • 70350463559 scopus 로고    scopus 로고
    • The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance
    • Chen X, El Gazzar M, Yoza BK, et al. The NF-kappaB factor RelB and histone H3 lysine methyltransferase G9a directly interact to generate epigenetic silencing in endotoxin tolerance. J Biol Chem. 2009; 284: 27857-27865.
    • (2009) J Biol Chem. , vol.284 , pp. 27857-27865
    • Chen, X.1    El Gazzar, M.2    Yoza, B.K.3
  • 75
    • 74049154783 scopus 로고    scopus 로고
    • Dynamic and selective nucleosome repositioning during endotoxin tolerance
    • El Gazzar M, Liu T, Yoza BK, et al. Dynamic and selective nucleosome repositioning during endotoxin tolerance. J Biol Chem. 2010; 285: 1259-1271.
    • (2010) J Biol Chem. , vol.285 , pp. 1259-1271
    • El Gazzar, M.1    Liu, T.2    Yoza, B.K.3
  • 76
    • 63049092806 scopus 로고    scopus 로고
    • Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance
    • El Gazzar M, Yoza BK, Chen X, et al. Chromatin-specific remodeling by HMGB1 and linker histone H1 silences proinflammatory genes during endotoxin tolerance. Mol Cell Biol. 2009; 29: 1959-1971.
    • (2009) Mol Cell Biol. , vol.29 , pp. 1959-1971
    • El Gazzar, M.1    Yoza, B.K.2    Chen, X.3
  • 77
    • 34250823515 scopus 로고    scopus 로고
    • Gene-specific control of inflammation by TLR-induced chromatin modifications
    • DOI 10.1038/nature05836, PII NATURE05836
    • Foster SL, Hargreaves DC, Medzhitov R,. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature. 2007; 447: 972-978. (Pubitemid 46975746)
    • (2007) Nature , vol.447 , Issue.7147 , pp. 972-978
    • Foster, S.L.1    Hargreaves, D.C.2    Medzhitov, R.3
  • 78
    • 58849092225 scopus 로고    scopus 로고
    • Epigenetic control of T-helper-cell differentiation
    • Wilson CB, Rowell E, Sekimata M,. Epigenetic control of T-helper-cell differentiation. Nat Rev Immunol. 2009; 9: 91-105.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 91-105
    • Wilson, C.B.1    Rowell, E.2    Sekimata, M.3
  • 79
    • 68349121366 scopus 로고    scopus 로고
    • At the crossroads of T helper lineage commitment-Epigenetics points the way
    • Janson PC, Winerdal ME, Winqvist O,. At the crossroads of T helper lineage commitment-Epigenetics points the way. Biochim Biophys Acta. 2009; 1790: 906-919.
    • (2009) Biochim Biophys Acta. , vol.1790 , pp. 906-919
    • Janson, P.C.1    Winerdal, M.E.2    Winqvist, O.3
  • 80
    • 34147138648 scopus 로고    scopus 로고
    • Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
    • DOI 10.1074/jbc.C600322200
    • Akimzhanov AM, Yang XO, Dong C,. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem. 2007; 282: 5969-5972. (Pubitemid 47100812)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.9 , pp. 5969-5972
    • Akimzhanov, A.M.1    Yang, X.O.2    Dong, C.3
  • 81
    • 70449717294 scopus 로고    scopus 로고
    • Epigenetic mechanisms of regulation of Foxp3 expression
    • Lal G, Bromberg JS,. Epigenetic mechanisms of regulation of Foxp3 expression. Blood. 2009; 114: 3727-3735.
    • (2009) Blood. , vol.114 , pp. 3727-3735
    • Lal, G.1    Bromberg, J.S.2
  • 82
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
    • Lal G, Zhang N, van der Touw W, et al. Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J Immunol. 2009; 182: 259-273.
    • (2009) J Immunol. , vol.182 , pp. 259-273
    • Lal, G.1    Zhang, N.2    Van Der Touw, W.3
  • 83
    • 33749051214 scopus 로고    scopus 로고
    • Keeping up NF-κB appearances: Epigenetic control of immunity or inflammation-triggered epigenetics
    • DOI 10.1016/j.bcp.2006.07.012, PII S0006295206004291
    • Vanden Berghe W, Ndlovu MN, Hoya-Arias R, et al. Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics. Biochem Pharmacol. 2006; 72: 1114-1131. (Pubitemid 44465844)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.9 SPEC. ISSUE , pp. 1114-1131
    • Vanden Berghe, W.1    Ndlovu, '.N.2    Hoya-Arias, R.3    Dijsselbloem, N.4    Gerlo, S.5    Haegeman, G.6
  • 84
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • DOI 10.1038/nature05919, PII NATURE05919
    • Feinberg AP,. Phenotypic plasticity and the epigenetics of human disease. Nature. 2007; 447: 433-440. (Pubitemid 46816750)
    • (2007) Nature , vol.447 , Issue.7143 , pp. 433-440
    • Feinberg, A.P.1
  • 85
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
    • Jones PA, Baylin SB,. The epigenomics of cancer. Cell. 2007; 128: 683-692. (Pubitemid 46273572)
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 86
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009; 41: 178-186.
    • (2009) Nat Genet. , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3
  • 87
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A, et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet. 2005; 37: 391-400.
    • (2005) Nat Genet. , vol.37 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3
  • 88
    • 65649142216 scopus 로고    scopus 로고
    • Global levels of histone modifications predict prognosis in different cancers
    • Seligson DB, Horvath S, McBrian MA, et al. Global levels of histone modifications predict prognosis in different cancers. Am J Pathol. 2009; 174: 1619-1628.
    • (2009) Am J Pathol. , vol.174 , pp. 1619-1628
    • Seligson, D.B.1    Horvath, S.2    McBrian, M.A.3
  • 89
    • 55949136562 scopus 로고    scopus 로고
    • Roles of the EZH2 histone methyltransferase in cancer epigenetics
    • Simon JA, Lange CA,. Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 2008; 647: 21-29.
    • (2008) Mutat Res. , vol.647 , pp. 21-29
    • Simon, J.A.1    Lange, C.A.2
  • 90
    • 79955513100 scopus 로고    scopus 로고
    • Aberrations of EZH2 in cancer
    • Chase A, Cross NC,. Aberrations of EZH2 in cancer. Clin Cancer Res. 2011; 17: 2613-2618.
    • (2011) Clin Cancer Res. , vol.17 , pp. 2613-2618
    • Chase, A.1    Cross, N.C.2
  • 91
    • 75749093015 scopus 로고    scopus 로고
    • Deregulation of H3K27 methylation in cancer
    • Martinez-Garcia E, Licht JD,. Deregulation of H3K27 methylation in cancer. Nat Genet. 2010; 42: 100-101.
    • (2010) Nat Genet. , vol.42 , pp. 100-101
    • Martinez-Garcia, E.1    Licht, J.D.2
  • 94
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • DOI 10.1038/sj.onc.1204639
    • Ayton PM, Cleary ML,. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene. 2001; 20: 5695-5707. (Pubitemid 32928107)
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.M.1    Cleary, M.L.2
  • 95
    • 0033566770 scopus 로고    scopus 로고
    • Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia
    • Grand F, Kulkarni S, Chase A, et al. Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia. Cancer Res. 1999; 59: 3870-3874. (Pubitemid 29393542)
    • (1999) Cancer Research , vol.59 , Issue.16 , pp. 3870-3874
    • Grand, F.1    Kulkarni, S.2    Chase, A.3    Goldman, J.M.4    Gordon, M.5    Cross, N.C.P.6
  • 96
    • 0034697973 scopus 로고    scopus 로고
    • BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
    • Bochar DA, Wang L, Beniya H, et al. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell. 2000; 102: 257-265.
    • (2000) Cell. , vol.102 , pp. 257-265
    • Bochar, D.A.1    Wang, L.2    Beniya, H.3
  • 97
    • 0034326257 scopus 로고    scopus 로고
    • BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines
    • Wong AK, Shanahan F, Chen Y, et al. BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines. Cancer Res. 2000; 60: 6171-6177.
    • (2000) Cancer Res. , vol.60 , pp. 6171-6177
    • Wong, A.K.1    Shanahan, F.2    Chen, Y.3
  • 98
    • 38349191617 scopus 로고    scopus 로고
    • CpG island hypermethylation of tumor suppressor microRNAs in human cancer
    • Lujambio A, Esteller M,. CpG island hypermethylation of tumor suppressor microRNAs in human cancer. Cell Cycle. 2007; 6: 1455-1459.
    • (2007) Cell Cycle. , vol.6 , pp. 1455-1459
    • Lujambio, A.1    Esteller, M.2
  • 100
    • 0141537154 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation
    • Kang GH, Lee HJ, Hwang KS, et al. Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol. 2003; 163: 1551-1556. (Pubitemid 37175101)
    • (2003) American Journal of Pathology , vol.163 , Issue.4 , pp. 1551-1556
    • Kang, G.H.1    Lee, H.J.2    Hwang, K.S.3    Lee, S.4    Kim, J.-H.5    Kim, J.-S.6
  • 102
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson B, Scheinbart L, Strahler J, et al. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum. 1990; 33: 1665-1673.
    • (1990) Arthritis Rheum. , vol.33 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3
  • 103
    • 79958260145 scopus 로고    scopus 로고
    • A new epigenetic challenge: Systemic lupus erythematosus
    • Javierre BM, Richardson B,. A new epigenetic challenge: systemic lupus erythematosus. Adv Exp Med Biol. 2011; 711: 117-136.
    • (2011) Adv Exp Med Biol. , vol.711 , pp. 117-136
    • Javierre, B.M.1    Richardson, B.2
  • 107
    • 33744813317 scopus 로고    scopus 로고
    • CpG island methylation in precursors of gastrointestinal malignancies
    • DOI 10.2174/156652406777435417
    • Chan AO, Rashid A,. CpG island methylation in precursors of gastrointestinal malignancies. Curr Mol Med. 2006; 6: 401-408. (Pubitemid 43834253)
    • (2006) Current Molecular Medicine , vol.6 , Issue.4 , pp. 401-408
    • Chan, A.O.O.1    Rashid, A.2
  • 108
    • 67349285075 scopus 로고    scopus 로고
    • Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC)
    • Tahara T, Shibata T, Nakamura M, et al. Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC). Clin Exp Med. 2009; 9: 125-130.
    • (2009) Clin Exp Med. , vol.9 , pp. 125-130
    • Tahara, T.1    Shibata, T.2    Nakamura, M.3
  • 109
    • 67649451991 scopus 로고    scopus 로고
    • Effect of MDR1 gene promoter methylation in patients with ulcerative colitis
    • Tahara T, Shibata T, Nakamura M, et al. Effect of MDR1 gene promoter methylation in patients with ulcerative colitis. Int J Mol Med. 2009; 23: 521-527.
    • (2009) Int J Mol Med. , vol.23 , pp. 521-527
    • Tahara, T.1    Shibata, T.2    Nakamura, M.3
  • 110
    • 79958119436 scopus 로고    scopus 로고
    • Identification of disease-associated DNA methylation in intestinal tissues from patients with inflammatory bowel disease
    • Lin Z, Hegarty JP, Cappel JA, et al. Identification of disease-associated DNA methylation in intestinal tissues from patients with inflammatory bowel disease. Clin Genet. 2011; 80: 59-67.
    • (2011) Clin Genet. , vol.80 , pp. 59-67
    • Lin, Z.1    Hegarty, J.P.2    Cappel, J.A.3
  • 111
    • 84866345336 scopus 로고    scopus 로고
    • Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway
    • [Epub ahead of print]
    • Nimmo ER, Prendergast JG, Aldhous MC, et al. Genome-wide methylation profiling in Crohn's disease identifies altered epigenetic regulation of key host defense mechanisms including the Th17 pathway. Inflamm Bowel Dis. 2011 [Epub ahead of print].
    • (2011) Inflamm Bowel Dis.
    • Nimmo, E.R.1    Prendergast, J.G.2    Aldhous, M.C.3
  • 112
    • 55249119513 scopus 로고    scopus 로고
    • MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha
    • e24
    • Wu F, Zikusoka M, Trindade A, et al. MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology. 2008; 135: 1624-1635 e24.
    • (2008) Gastroenterology. , vol.135 , pp. 1624-1635
    • Wu, F.1    Zikusoka, M.2    Trindade, A.3
  • 113
  • 115
    • 16544381769 scopus 로고    scopus 로고
    • Phenylbutyrate decreases type I collagen production in human lung fibroblasts
    • Rishikof DC, Ricupero DA, Liu H, et al. Phenylbutyrate decreases type I collagen production in human lung fibroblasts. J Cell Biochem. 2004; 91: 740-748.
    • (2004) J Cell Biochem. , vol.91 , pp. 740-748
    • Rishikof, D.C.1    Ricupero, D.A.2    Liu, H.3
  • 117
    • 69249114634 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid: A potential epigenetic therapeutic agent for lung fibrosis?
    • Wang Z, Chen C, Finger SN, et al. Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis? Eur Respir J. 2009; 34: 145-155.
    • (2009) Eur Respir J. , vol.34 , pp. 145-155
    • Wang, Z.1    Chen, C.2    Finger, S.N.3
  • 118
    • 75449084922 scopus 로고    scopus 로고
    • Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo
    • Mannaerts I, Nuytten NR, Rogiers V, et al. Chronic administration of valproic acid inhibits activation of mouse hepatic stellate cells in vitro and in vivo. Hepatology. 2010; 51: 603-614.
    • (2010) Hepatology. , vol.51 , pp. 603-614
    • Mannaerts, I.1    Nuytten, N.R.2    Rogiers, V.3
  • 119
    • 77949794821 scopus 로고    scopus 로고
    • Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats
    • Iyer A, Fenning A, Lim J, et al. Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats. Br J Pharmacol. 2010; 159: 1408-1417.
    • (2010) Br J Pharmacol. , vol.159 , pp. 1408-1417
    • Iyer, A.1    Fenning, A.2    Lim, J.3
  • 120
    • 77952116121 scopus 로고    scopus 로고
    • Methylation determines fibroblast activation and fibrogenesis in the kidney
    • Bechtel W, McGoohan S, Zeisberg EM, et al. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nat Med. 2010; 16: 544-550.
    • (2010) Nat Med. , vol.16 , pp. 544-550
    • Bechtel, W.1    McGoohan, S.2    Zeisberg, E.M.3
  • 121
    • 55249123438 scopus 로고    scopus 로고
    • Thy-1 promoter hypermethylation: A novel epigenetic pathogenic mechanism in pulmonary fibrosis
    • Sanders YY, Pardo A, Selman M, et al. Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2008; 39: 610-618.
    • (2008) Am J Respir Cell Mol Biol. , vol.39 , pp. 610-618
    • Sanders, Y.Y.1    Pardo, A.2    Selman, M.3
  • 122
    • 77953449840 scopus 로고    scopus 로고
    • Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis
    • Coward WR, Watts K, Feghali-Bostwick CA, et al. Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis. Mol Cell Biol. 2010; 30: 2874-2886.
    • (2010) Mol Cell Biol. , vol.30 , pp. 2874-2886
    • Coward, W.R.1    Watts, K.2    Feghali-Bostwick, C.A.3
  • 123
    • 75149141045 scopus 로고    scopus 로고
    • MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis
    • 14 e1-4
    • Mann J, Chu DC, Maxwell A, et al. MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology. 2010; 138: 705-714, 14 e1-4.
    • (2010) Gastroenterology. , vol.138 , pp. 705-714
    • Mann, J.1    Chu, D.C.2    Maxwell, A.3
  • 124
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
    • McDonald OG, Wu H, Timp W, et al. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol. 2011; 18: 867-874.
    • (2011) Nat Struct Mol Biol. , vol.18 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Timp, W.3
  • 125
    • 51949111451 scopus 로고    scopus 로고
    • Chemical probes for histone-modifying enzymes
    • Cole PA,. Chemical probes for histone-modifying enzymes. Nat Chem Biol. 2008; 4: 590-597.
    • (2008) Nat Chem Biol. , vol.4 , pp. 590-597
    • Cole, P.A.1
  • 126
    • 84867047505 scopus 로고    scopus 로고
    • Epigenetic cancer therapy: Rationales, targets and drugs
    • [Epub ahead of print].
    • Rius M, Lyko F,. Epigenetic cancer therapy: rationales, targets and drugs. Oncogene. 2011 [Epub ahead of print].
    • (2011) Oncogene.
    • Rius, M.1    Lyko, F.2
  • 127
    • 0346873023 scopus 로고    scopus 로고
    • A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis
    • Chung YL, Lee MY, Wang AJ, et al. A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. Mol Ther. 2003; 8: 707-717.
    • (2003) Mol Ther. , vol.8 , pp. 707-717
    • Chung, Y.L.1    Lee, M.Y.2    Wang, A.J.3
  • 128
    • 33645775726 scopus 로고    scopus 로고
    • Histone hyperacetylation is associated with amelioration of experimental colitis in mice
    • Glauben R, Batra A, Fedke I, et al. Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J Immunol. 2006; 176: 5015-5022.
    • (2006) J Immunol. , vol.176 , pp. 5015-5022
    • Glauben, R.1    Batra, A.2    Fedke, I.3
  • 129
    • 34047210698 scopus 로고    scopus 로고
    • Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents
    • Lin HS, Hu CY, Chan HY, et al. Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br J Pharmacol. 2007; 150: 862-872.
    • (2007) Br J Pharmacol. , vol.150 , pp. 862-872
    • Lin, H.S.1    Hu, C.Y.2    Chan, H.Y.3
  • 130
    • 44549083450 scopus 로고    scopus 로고
    • Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model
    • Nasu Y, Nishida K, Miyazawa S, et al. Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model. Osteoarthritis Cartilage. 2008; 16: 723-732.
    • (2008) Osteoarthritis Cartilage. , vol.16 , pp. 723-732
    • Nasu, Y.1    Nishida, K.2    Miyazawa, S.3
  • 132
    • 65449142457 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in inflammatory disease
    • Halili MA, Andrews MR, Sweet MJ, et al. Histone deacetylase inhibitors in inflammatory disease. Curr Top Med Chem. 2009; 9: 309-319.
    • (2009) Curr Top Med Chem. , vol.9 , pp. 309-319
    • Halili, M.A.1    Andrews, M.R.2    Sweet, M.J.3
  • 133
    • 77950355734 scopus 로고    scopus 로고
    • Anti-inflammatory agents: Present and future
    • Dinarello CA,. Anti-inflammatory agents: present and future. Cell. 2010; 140: 935-950.
    • (2010) Cell. , vol.140 , pp. 935-950
    • Dinarello, C.A.1
  • 134
    • 0029930039 scopus 로고    scopus 로고
    • Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat
    • Butzner JD, Parmar R, Bell CJ, et al. Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat. Gut. 1996; 38: 568-573. (Pubitemid 26111377)
    • (1996) Gut , vol.38 , Issue.4 , pp. 568-573
    • Butzner, J.D.1    Parmar, R.2    Bell, C.J.3    Dalal, V.4
  • 135
    • 78650376689 scopus 로고    scopus 로고
    • Topical agents for idiopathic distal colitis and proctitis
    • Lawrance IC,. Topical agents for idiopathic distal colitis and proctitis. J Gastroenterol Hepatol. 2011; 26: 36-43.
    • (2011) J Gastroenterol Hepatol. , vol.26 , pp. 36-43
    • Lawrance, I.C.1
  • 136
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM,. Cellular differentiation, cytidine analogs and DNA methylation. Cell. 1980; 20: 85-93. (Pubitemid 10117303)
    • (1980) Cell , vol.20 , Issue.1 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 137
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with RB, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • DOI 10.1038/77124
    • Robertson KD, Ait-Si-Ali S, Yokochi T, et al. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet. 2000; 25: 338-342. (Pubitemid 30437325)
    • (2000) Nature Genetics , vol.25 , Issue.3 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 138
    • 0035873225 scopus 로고    scopus 로고
    • Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription
    • DOI 10.1093/emboj/20.10.2536
    • Fuks F, Burgers WA, Godin N, et al. Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription. EMBO J. 2001; 20: 2536-2544. (Pubitemid 32452872)
    • (2001) EMBO Journal , vol.20 , Issue.10 , pp. 2536-2544
    • Fuks, F.1    Burgers, W.A.2    Godin, N.3    Kasai, M.4    Kouzarides, T.5
  • 139
    • 59449087016 scopus 로고    scopus 로고
    • Histone modifying enzymes: Structures, mechanisms, and specificities
    • Marmorstein R, Trievel RC,. Histone modifying enzymes: structures, mechanisms, and specificities. Biochim Biophys Acta. 2009; 1789: 58-68.
    • (2009) Biochim Biophys Acta. , vol.1789 , pp. 58-68
    • Marmorstein, R.1    Trievel, R.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.