Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-β1-induced fibrogenesis in skin fibroblasts

Experimental Cell Research

Volumn 278, Issue 2, 2002, Pages 184-197

  Rombouts, Krista ^a   Niki, Toshiro ^a   Greenwel, Patricia ^b   Vandermonde, Alain ^a   Wielant, Annemie ^a   Hellemans, Karine ^a   De Bleser, Pieter ^a   Yoshida, Minoru ^c   Schuppan, Detlef ^d   Rojkind, Marcos ^e   Geerts, Albert ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Anti Smad7; ECM; Histones; Skin fibroblasts; Smads; TGF 1; TGIF; Trichostatin A

Indexed keywords

COLLAGEN; HISTONE DEACETYLASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA1; TRICHOSTATIN A;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; COLLAGEN SYNTHESIS; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROGENESIS; GENETIC TRANSCRIPTION; HYPERTROPHIC SCAR; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT; REDUCTION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; STEADY STATE;

EID: 18544363755     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5577     Document Type: Article

References (65)

1. Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations
2. Modulation of fibrotic cytoskeletal features during pathological situations: The role of extracellular matrix and cytokines
3. Transforming growth factor beta in disease: The dark side of tissue repair
4. Transcriptional control by the TGF-beta/Smad signaling system
5. All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially
6. A histone deacetylase inhibitor, trichostatin A, suppresses transdifferentiation of cultured rat hepatic stellate cells
7. Effect of aldosterone on collagen steady state levels in primary and subcultured rat hepatic stellate cells
8. Influence of aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts
9. Collagen network of the myocardium: Function, structural remodeling and regulatory mechanisms
10. Cytokines and fibrogenesis
11. Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis
12. Histone acetylation and transcriptional regulatory mechanisms
13. The language of covalent histone modifications
14. The human histone deacetylase family
15. Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
16. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin
17. Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity
18. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening
19. Effects of Trichostatins on differentiation of murine erythroleukemia cells
20. Identification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial, Kupffer and fat-storing cells by Northern hybridization analysis
21. Purification of rat hepatic stellate cells by side scatter activated cell sorting
22. Different accessibilities in chromatin to histone acetylase
23. Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells
24. Serum concentration of the aminoterminal procollagen type III peptide in the rat reflects early formation of connective tissue in experimental liver cirrhosis
25. Construction of DNA sequences complementary to rat alpha 1 and alpha 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D
26. Characterization of excessive collagen production during development of pulmonary fibrosis induced by chronic silica inhalation in rats
27. Cell type specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Upregulation during in vitro activation and in hepatic tissue repair
28. Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism
29. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
30. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
31. IGF-II and IL-2 act synergistically to alter HDAC1 expression following treatments with trichostatin A
32. Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliverative effects
33. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1 beta-induced histone H4 acetylation on lysines 8 and 12
34. Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gen5p acetyltransferase
35. Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction
36. The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation
37. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
38. IGF-II enhances trichostatin A-induced TGFbeta1 and p21 (Waf1, Cip1, sdi1) expression in Hep3B cells
39. Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells
40. Dermal fibroblasts are one of the therapeutic targets for topical application of 1-alpha,25-dihydroxyvitamin D3: The possible involvement of transforming growth factor-beta induction
41. Regulation of type I collagen production by insulin and transforming growth factor beta in human lung fibroblasts
42. Ultraviolet A irradiation upregulates type VII collagen expression in dermal fibroblasts
43. Cytoskeleton regulates expression of genes for transforming growth factor beta 1 and extracellular matrix proteins in dermal fibroblasts
44. Turnover of glutathione S-transferase alpha mRNAs is accelerated by 12-O-tetradecanoyl phorbol-13-acetate in human hepatoma and colon carcinoma cell lines
45. Interrelationship of the pathways of mRNA decay and translation in eukaryotic cells
46. Interferon-gamma regulates collagen and fibronectin gene expression by transcriptional and post-transcriptional mechanisms
47. Regulation of connective tissue growth factor expression by prostaglandin E2
48. Identification of novel TGFbeta/Smad gene targets in dermal fibroblasts using a combined microarray/promoter transactivation approach
49. A transforming growth factor beta control element drives TGF-beta induced stimulation of smooth muscle alpha-actin gene expression in concert with twoCArG elements
50. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling
51. Identification of Smad7, a TGFbeta-inducible antagonist of TGFbeta signalling
52. Multiple modes of repression by the Smad transcriptional corepressor TGIF
53. A Smad transcriptional repressor
54. The Smad transcriptional corepressor TGIF recruits mSin3
55. MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells
56. Heterogeneous transforming growth factor (TGF)-beta unresponsiveness and loss of TGF-beta receptor type II expression caused by histone deacetylation in lung cancer cell lines
57. Regulation of Smad activity
58. Physical and functional interaction of SMADs and p300/CBP
59. Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling
60. SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor-beta signaling
61. An essential role of Mad homology Domain 1 in the association of Smad3 with histone deacetylase activity
62. The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling
63. TGIF2 interacts with histone deacetylase 1 and repress transcription
64. Transcriptional repression by blimp-1 (PRDI-BF1) involves recruitment of histone deacetylase
65. Transcriptional regulation of cyclooxygenase-1 by histone deacetylase inhibitors in normal human astrocyte cells