Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis

Molecular and Cellular Biology

Volumn 30, Issue 12, 2010, Pages 2874-2886

  Coward, William R ^a   Watts, Keira ^a   Feghali Bostwick, Carol A ^b   Jenkins, Gisli ^a   Pang, Linhua ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; G9A PROTEIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HETEROCHROMATIN PROTEIN 1; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HISTONE H3; HISTONE H4; HISTONE METHYLTRANSFERASE; MESSENGER RNA; SUV39H1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEACETYLATION; DNA METHYLATION; EPIGENETICS; FIBROSING ALVEOLITIS; GENE EXPRESSION; GENE REPRESSION; GENE TARGETING; GENETIC REGULATION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION;

ACETYLATION; CELL LINE; CHEMOKINE CXCL10; CHROMOSOMAL PROTEINS, NON-HISTONE; CYTOKINES; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; IDIOPATHIC PULMONARY FIBROSIS; METHYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 77953449840     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01527-09     Document Type: Article

References (49)

1. Allport, V. C., D. M. Slater, R. Newton, and P. R. Bennett. 2000. NF-κB and AP-1 are required for cyclooxygenase 2 gene expression in amnion epithelial cell line (WISH). Mol. Hum. Reprod. 6:561-565.
2. Antoniades, H. N., J. Neville-Golden, T. Galanopoulos, R. L. Kradin, A. J. Valente, and D. T. Graves. 1992. Expression of MCP-1 mRNA in human idiopathic pulmonary fibrosis. Proc. Natl. Acad. Sci. U. S. A. 89:5371-5375.
3. Bannister, A. J., P. Zegerman, J. F. Partridge, E. A. Miska, J. O. Thomas, R. C. Allshire, and T. Kouzarides. 2001. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410:120-124.
4. Bird, A. 2001. Molecular biology: methylation talk between histones and DNA. Science 294:2113-2115.
5. Buttmann, M., F. Berberich-Siebelt, E. Serfling, and P. Rieckmann. 2007. Interferon-β is a potent inducer of interferon regulatory factor-1/2-dependent IP-10/CXCL10 expression in primary human endothelial cells. J. Vasc. Res. 44:51-60.
6. Collard, H. R., J. H. Ryu, W. W. Douglas, M. I. Schwarz, D. Curran-Everett, T. E. King, Jr., and K. K. Brown. 2004. Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosis. Chest 125:2169-2174.
7. Coward, W. R., K. Watts, C. A. Feghali-Bostwick, A. Knox, and L. Pang. 2009. Defective histone acetylation is responsible for the diminished expression of cyclooxygenase 2 in idiopathic pulmonary fibrosis. Mol. Cell. Biol. 29:4325-4339.
8. de la Cruz, X., S. Lois, S. Sanchez-Molina, and M. A. Martinez-Balbas. 2005. Do protein motifs read the histone code? Bioessays 27:164-175.
9. Fuks, F., P. J. Hurd, R. Deplus, and T. Kouzarides. 2003. The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res. 31:2305-2312.
10. Fuks, F., W. A. Burgers, A. Brehm, L. Hughes-Davies, and T. Kouzarides. 2000. DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet. 24:88-91.
11. Keane, M. P. 2004. Angiogenesis and pulmonary fibrosis: feast or famine? Am. J. Respir. Crit. Care Med. 170:207-209.
12. Keane, M. P., D. A. Arenberg, J. P. R. Lynch, R. I. Whyte, M. D. Iannettoni, M. D. Burdick, C. A. Wilke, S. B. Morris, M. C. Glass, B. DiGiovine, S. L. Kunkel, and R. M. Strieter. 1997. The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis. J. Immunol. 159:1437-1443.
13. Keane, M. P., J. A. Belperio, D. A. Arenberg, M. D. Burdick, Z. J. Xu, Y. Y. Xue, and R. M. Strieter. 1999a. IFN-γ-inducible protein-10 attenuates bleomycin-induced pulmonary fibrosis via inhibition of angiogenesis. J. Immunol. 163:5686-5692.
14. Keane, M. P., J. A. Belperio, T. A. Moore, B. B. Moore, D. A. Arenberg, R. E. Smith, M. D. Burdick, S. L. Kunkel, and R. M. Strieter. 1999b. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis. J. Immunol. 162:5511-5518.
15. Khorasanizadeh, S. 2004. The nucleosome: from genomic organization to genomic regulation. Cell 116:259-272.
16. Kouzarides, T. 2002. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev. 12:198-209.
17. Kubicek, S., R. J. O'Sullivan, E. M. August, E. R. Hickey, Q. Zhang, M. L. Teodoro, S. Rea, K. Mechtler, J. A. Kowalski, C. A. Homon, T. A. Kelly, and T. Jenuwein. 2007. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol. Cell 25:473-481.
18. Lachner, M., D. O'Carroll, S. Rea, K. Mechtler, and T. Jenuwein. 2001. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature 410:116-120.
19. Lachner, M., and T. Jenuwein. 2002. The many faces of histone lysine methylation. Curr. Opin. Cell Biol. 14:286-298.
20. Loyola, A., H. Tagami, T. Bonaldi, D. Roche, J. P. Quivy, A. Imhof, Y. Nakatani, S. Y. Dent, and G. Almouzni. 2009. The HP1α-CAF1-SetDB1- containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Rep. 10:769-775.
21. Lynch, J. P., III, E. White, and K. Flaherty. 2001. Corticosteroids in idiopathic pulmonary fibrosis. Curr. Opin. Pulm. Med. 7:298-308.
22. Maison, C., and G. Almouzni. 2004. HP1 and the dynamics of heterochromatin maintenance. Nat. Rev. Mol. Cell Biol. 5:296-304.
23. Majumder, S., L. Z. Zhou, P. Chaturvedi, G. Babcock, S. Aras, and R. M. Ransohoff. 1998. p48/STAT-1α-containing complexes play a predominant role in induction of IFN-γ-inducible protein, 10 kDa (IP-10) by IFN-γ alone or in synergy with TNF-α. J. Immunol. 161:4736-4744. (Pubitemid 28492049)
24. Marks, P. A., and R. Breslow. 2007. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat. Biotechnol. 25:84-90.
25. Moss, T. J., and L. L. Wallrath. 2007. Connections between epigenetic gene silencing and human disease. Mutat. Res. 618:163-174.
26. Nakayama, J., J. C. Rice, B. D. Strahl, C. D. Allis, and S. I. Grewal. 2001. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292:110-113.
27. Nie, M., A. J. Knox, and L. Pang. 2005. β2-Adrenoceptor agonists, like glucocorticoids, repress eotaxin gene transcription by selective inhibition of histone H4 acetylation. J. Immunol. 175:478-486. (Pubitemid 40884352)
28. Ohmori, Y., and T. A. Hamilton. 1993. Cooperative interaction between interferon stimulus response element and κB sequence motifs controls IFN-γ and lipopolysaccharide-stimulated transcription from the murine IP-10 promoter. J. Biol. Chem. 268:6677-6688.
29. Ohmori, Y., and T. A. Hamilton. 1995. The interferon-stimulated response element and a κB site mediate synergistic induction of murine IP-10 gene transcription by IFN-γ and TNF-α. J. Immunol. 154:5235-5244.
30. Peters, A. H., S. Kubicek, K. Mechtler, R. J. O'Sullivan, A. A. Derijck, L. Perez-Burgos, A. Kohlmaier, S. Opravil, M. Tachibana, Y. Shinkai, J. H. Martens, and T. Jenuwein. 2003. Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol. Cell 12:1577-1589.
31. Pilewski, J. M., L. Liu, A. C. Henry, A. V. Knauer, and C. A. Feghali-Bostwick. 2005. Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Am. J. Pathol. 166:399-407.
32. Polverini, P. J. 2002. Angiogenesis in health and disease: insights into basic mechanisms and therapeutic opportunities. J. Dent. Educ. 66:962-975.
33. Rea, S., F. Eisenhaber, D. O'Carroll, B. D. Strahl, Z. W. Sun, M. Schmid, S. Opravil, K. Mechtler, C. P. Ponting, C. D. Allis, and T. Jenuwein. 2000. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406:593-599.
34. Rice, J. C., S. D. Briggs, B. Ueberheide, C. M. Barber, J. Shabanowitz, D. F. Hunt, Y. Shinkai, and C. D. Allis. 2003. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol. Cell 12:1591-1598.
35. Schultz, D. C., K. Ayyanathan, D. Negorev, G. G. Maul, and F. J. Rauscher III. 2002. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev. 16:919-932.
36. Sims, R. J., III, K. Nishioka, and D. Reinberg. 2003. Histone lysine methylation: a signature for chromatin function. Trends Genet. 19:629-639.
37. Smallwood, A., P.-O. Estève, S. Pradhan, and M. Carey. 2007. Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev. 21:1169-1178.
38. Spurrell, J. C., S. Wiehler, R. S. Zaheer, S. P. Sanders, and D. Proud. 2005. Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection. Am. J. Physiol. Lung Cell. Mol. Physiol. 289:L85-L95.
39. Strieter, R. M. 2005. Pathogenesis and natural history of usual interstitial pneumonia: the whole story or the last chapter of a long novel. Chest 128:526S-532S.
40. Strieter, R. M., S. L. Kunkel, D. A. Arenberg, M. D. Burdick, and P. I. Polverini. 1995. Interferon γ-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis. Biochem. Biophys. Res. Commun. 210:51-57.
41. Tachibana, M., K. Sugimoto, T. Fukushima, and Y. Shinkai. 2001. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J. Biol. Chem. 276:25309-25317.
42. Watts, K. L., and M. A. Spiteri. 2004. Connective tissue growth factor expression and induction by transforming growth factor-β is abrogated by simvastatin via a Rho signaling mechanism. Am. J. Physiol. Lung Cell. Mol. Physiol. 287:L1323-L1332.
43. Westendorf, J. J. 2006. Transcriptional co-repressors of Runx2. J. Cell. Biochem. 98:54-64.
44. Wu, L. P., X. Wang, L. Li, Y. Zhao, S. Lu, Y. Yu, W. Zhou, X. Liu, J. Yang, Z. Zheng, H. Zhang, J. Feng, Y. Yang, H. Wang, and W. G. Zhu. 2008. Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter. Mol. Cell. Biol. 28:3219-3235.
45. Yang, L., L. Xia, D. Y. Wu, H. Wang, H. A. Chansky, W. H. Schubach, D. D. Hickstein, and Y. Zhang. 2002. Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene 21:148-152.
46. Yeruva, S., G. Ramadori, and D. Raddatz. 2008. NF-κB-dependent synergistic regulation of CXCL10 gene expression by IL-1β and IFN-γ in human intestinal epithelial cell lines. Int. J. Colorectal Dis. 23:305-317.
47. You, A., J. K. Tong, C. M. Grozinger, and S. L. Schreiber. 2001. CoREST is an integral component of the CoREST-human histone deacetylase complex. Proc. Natl. Acad. Sci. U. S. A. 98:1454-1458.
48. Zaheer, R. S., R. Koetzler, N. S. Holden, S. Wiehler, and D. Proud. 2009. Selective transcriptional down-regulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathway. J. Immunol. 182:4854-4864.
49. Zhou, Q., P. Atadja, and N. E. Davidson. 2007. Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor α (ER) gene expression without loss of DNA hypermethylation. Cancer Biol. Ther. 6:64-69.