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Volumn 31, Issue 4, 2012, Pages 697-710

The use of nanoparticles for gene therapy in the nervous system

Author keywords

Blood brain barrier; dendrimers; gene transfer; nanoparticles; neurons; siRNA

Indexed keywords

CHITOSAN; CLATHRIN; COLLAGEN; DENDRIMER; DNA; LIPID; LIPOSOME; NANOMATERIAL; NANOPARTICLE; POLYAMIDOAMINE; POLYETHYLENEIMINE DERIVATIVE; RNA; SILICON DIOXIDE;

EID: 84866315959     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120661     Document Type: Review
Times cited : (52)

References (141)
  • 1
    • 78149346495 scopus 로고    scopus 로고
    • Nonviral vectors for the delivery of small interfering RNAs to the CNS
    • Posadas I, Guerra FJ, Ceña V (2010) Nonviral vectors for the delivery of small interfering RNAs to the CNS. Nanomedicine (Lond) 5, 1219-1236.
    • (2010) Nanomedicine (Lond) , vol.5 , pp. 1219-1236
    • Posadas, I.1    Guerra, F.J.2    Ceña, V.3
  • 4
    • 34548624517 scopus 로고    scopus 로고
    • Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment
    • Fernandez M, Segura MF, Sole C, Colino A, Comella JX, Ceña V (2007) Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment. J Neurochem 103, 190-203.
    • (2007) J Neurochem , vol.103 , pp. 190-203
    • Fernandez, M.1    Segura, M.F.2    Sole, C.3    Colino, A.4    Comella, J.X.5    Ceña, V.6
  • 5
    • 0029843596 scopus 로고    scopus 로고
    • Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector
    • Xiao X, Li J, Samulski RJ (1996) Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol 70, 8098-8108.
    • (1996) J Virol , vol.70 , pp. 8098-8108
    • Xiao, X.1    Li, J.2    Samulski, R.J.3
  • 6
    • 0033977047 scopus 로고    scopus 로고
    • Humoral immunity to adenoassociated virus type 2 vectors following administration to murine and nonhuman primate muscle
    • Chirmule N, Xiao W, Truneh A, Schnell MA, Hughes JV, Zoltick P, Wilson JM (2000) Humoral immunity to adenoassociated virus type 2 vectors following administration to murine and nonhuman primate muscle. J Virol 74, 2420-2425.
    • (2000) J Virol , vol.74 , pp. 2420-2425
    • Chirmule, N.1    Xiao, W.2    Truneh, A.3    Schnell, M.A.4    Hughes, J.V.5    Zoltick, P.6    Wilson, J.M.7
  • 7
    • 2442590862 scopus 로고    scopus 로고
    • Newdrugs for rheumatoid arthritis
    • Olsen NJ, SteinCM(2004) Newdrugs for rheumatoid arthritis. N Engl J Med 350, 2167-2179.
    • (2004) N Engl J Med , vol.350 , pp. 2167-2179
    • Olsen, N.J.1    Stein, C.M.2
  • 8
    • 0033954691 scopus 로고    scopus 로고
    • Researchers and regulators reflect on first gene therapy death
    • Hollon T (2000) Researchers and regulators reflect on first gene therapy death. Nat Med 6, 6-10.
    • (2000) Nat Med , vol.6 , pp. 6-10
    • Hollon, T.1
  • 9
    • 0034320366 scopus 로고    scopus 로고
    • A tumultuous year for gene therapy
    • Verma IM (2000) A tumultuous year for gene therapy. Mol Ther 2, 415-416.
    • (2000) Mol Ther , vol.2 , pp. 415-416
    • Verma, I.M.1
  • 10
    • 14144253164 scopus 로고    scopus 로고
    • Gene therapy put on hold as third child develops cancer
    • Check E (2005) Gene therapy put on hold as third child develops cancer. Nature 433, 561-564.
    • (2005) Nature , vol.433 , pp. 561-564
    • Check, E.1
  • 11
    • 72149113088 scopus 로고    scopus 로고
    • Liposomal gene delivery mediated by tissue-engineered scaffolds
    • Kulkarni M, Greiser U, O'Brien T, Pandit A (2010) Liposomal gene delivery mediated by tissue-engineered scaffolds. Trends Biotechnol 28, 28-36.
    • (2010) Trends Biotechnol , vol.28 , pp. 28-36
    • Kulkarni, M.1    Greiser, U.2    O'Brien, T.3    Pandit, A.4
  • 12
    • 36549034234 scopus 로고    scopus 로고
    • Polymers and nanoparticles: Intelligent tools for intracellular targeting?
    • Breunig M, Bauer S, Goepferich A (2008) Polymers and nanoparticles: Intelligent tools for intracellular targeting? Eur J Pharm Biopharm 68, 112-128.
    • (2008) Eur J Pharm Biopharm , vol.68 , pp. 112-128
    • Breunig, M.1    Bauer, S.2    Goepferich, A.3
  • 13
    • 60749111194 scopus 로고    scopus 로고
    • Recent development of nonviral gene delivery systems with virus-like structures and mechanisms
    • Itaka K, Kataoka K (2009) Recent development of nonviral gene delivery systems with virus-like structures and mechanisms. Eur J Pharm Biopharm 71, 475-483.
    • (2009) Eur J Pharm Biopharm , vol.71 , pp. 475-483
    • Itaka, K.1    Kataoka, K.2
  • 14
    • 67650690627 scopus 로고    scopus 로고
    • Dendrimers as carriers for delivery of chemotherapeutic agents
    • Medina SH, El-SayedME(2009) Dendrimers as carriers for delivery of chemotherapeutic agents. Chem Rev 109, 3141-3157.
    • (2009) Chem Rev , vol.109 , pp. 3141-3157
    • Medina, S.H.1    El-Sayed, M.E.2
  • 15
    • 79961168855 scopus 로고    scopus 로고
    • Barriers to non-viral vector-mediated gene delivery in the nervous system
    • P'erez-Martínez FC, Guerra J, Posadas I, Ceña V (2011) Barriers to non-viral vector-mediated gene delivery in the nervous system. Pharm Res 28, 1843-1858.
    • (2011) Pharm Res , vol.28 , pp. 1843-1858
    • Perez-Martínez, F.C.1    Guerra, J.2    Posadas, I.3    Ceña, V.4
  • 16
    • 77955466238 scopus 로고    scopus 로고
    • Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis
    • Yang H (2010) Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis. Pharm Res 27, 1759-1771.
    • (2010) Pharm Res , vol.27 , pp. 1759-1771
    • Yang, H.1
  • 17
    • 64049086772 scopus 로고    scopus 로고
    • Nanoparticles in cellular drug delivery
    • Faraji AH, Wipf P (2009) Nanoparticles in cellular drug delivery. Bioorg Med Chem 17, 2950-2962.
    • (2009) Bioorg Med Chem , vol.17 , pp. 2950-2962
    • Faraji, A.H.1    Wipf, P.2
  • 19
    • 0019523265 scopus 로고
    • Electrical resistance of a capillary endothelium
    • Crone C, Christensen O (1981) Electrical resistance of a capillary endothelium. J Gen Physiol 77, 349-371.
    • (1981) J Gen Physiol , vol.77 , pp. 349-371
    • Crone, C.1    Christensen, O.2
  • 20
    • 0032936851 scopus 로고    scopus 로고
    • The cell biology of the bloodbrain barrier
    • Rubin LL, Staddon JM (1999) The cell biology of the bloodbrain barrier. Annu Rev Neurosci 22, 11-28.
    • (1999) Annu Rev Neurosci , vol.22 , pp. 11-28
    • Rubin, L.L.1    Staddon, J.M.2
  • 21
    • 0345055299 scopus 로고    scopus 로고
    • Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2)
    • Kotze AF, Luessen HL, de Leeuw BJ, de Boer AG, Verhoef JC, Junginger HE (1998) Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2). J Control Release 51, 35-46.
    • (1998) J Control Release , vol.51 , pp. 35-46
    • Kotze, A.F.1    Luessen, H.L.2    De Leeuw, B.J.3    De Boer, A.G.4    Verhoef, J.C.5    Junginger, H.E.6
  • 23
    • 76749159851 scopus 로고    scopus 로고
    • Lactoferrin-modified nanoparticles could mediate efficient gene delivery to the brain in vivo
    • Huang R,KeW, Han L, LiuY, Shao K, Jiang C, PeiY(2010) Lactoferrin-modified nanoparticles could mediate efficient gene delivery to the brain in vivo. Brain Res Bull 81, 600-604.
    • (2010) Brain Res Bull , vol.81 , pp. 600-604
    • Huang, R.1    Ke, W.2    Han, L.3    Liu, Y.4    Shao, K.5    Jiang, C.6    Pei, Y.7
  • 24
    • 70350200866 scopus 로고    scopus 로고
    • Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycolmodified polyamidoamine dendrimer
    • Ke W, Shao K, Huang R, Han L, Liu Y, Li J, Kuang Y, Ye L, Lou J, Jiang C (2009) Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycolmodified polyamidoamine dendrimer. Biomaterials 30, 6976-6985.
    • (2009) Biomaterials , vol.30 , pp. 6976-6985
    • Ke, W.1    Shao, K.2    Huang, R.3    Han, L.4    Liu, Y.5    Li, J.6    Kuang, Y.7    Ye, L.8    Lou, J.9    Jiang, C.10
  • 25
    • 33947625559 scopus 로고    scopus 로고
    • Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer
    • Huang RQ, Qu YH, Ke WL, Zhu JH, Pei YY, Jiang C (2007) Efficient gene delivery targeted to the brain using a transferrin-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. FASEB J 21, 1117-1125.
    • (2007) FASEB J , vol.21 , pp. 1117-1125
    • Huang, R.Q.1    Qu, Y.H.2    Ke, W.L.3    Zhu, J.H.4    Pei, Y.Y.5    Jiang, C.6
  • 29
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • Kreuter J (2001) Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 47, 65-81.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 65-81
    • Kreuter, J.1
  • 30
    • 0002595302 scopus 로고    scopus 로고
    • Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse
    • Lee HJ, Engelhardt B, Lesley J, Bickel U, Pardridge WM (2000) Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse. J Pharmacol Exp Ther 292, 1048-1052.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 1048-1052
    • Lee, H.J.1    Engelhardt, B.2    Lesley, J.3    Bickel, U.4    Pardridge, W.M.5
  • 31
    • 39749200864 scopus 로고    scopus 로고
    • Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas: Enhanced efficacy and intratumoral transport capability
    • Dhanikula RS, Argaw A, Bouchard JF, Hildgen P (2008) Methotrexate loaded polyether-copolyester dendrimers for the treatment of gliomas: Enhanced efficacy and intratumoral transport capability. Mol Pharm 5, 105-116.
    • (2008) Mol Pharm , vol.5 , pp. 105-116
    • Dhanikula, R.S.1    Argaw, A.2    Bouchard, J.F.3    Hildgen, P.4
  • 32
    • 16244414899 scopus 로고    scopus 로고
    • Rabies virus receptors
    • Lafon M (2005) Rabies virus receptors. J Neurovirol 11, 82-87.
    • (2005) J Neurovirol , vol.11 , pp. 82-87
    • Lafon, M.1
  • 34
    • 33847396903 scopus 로고    scopus 로고
    • Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons
    • Suk JS, Suh J, Lai SK, Hanes J (2007) Quantifying the intracellular transport of viral and nonviral gene vectors in primary neurons. Exp Biol Med (Maywood) 232, 461-469.
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 461-469
    • Suk, J.S.1    Suh, J.2    Lai, S.K.3    Hanes, J.4
  • 35
    • 1642575957 scopus 로고    scopus 로고
    • Sizedependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis
    • Rejman J, Oberle V, Zuhorn IS, Hoekstra D (2004) Sizedependent internalization of particles via the pathways of clathrin-and caveolae-mediated endocytosis. Biochem J 377, 159-169.
    • (2004) Biochem J , vol.377 , pp. 159-169
    • Rejman, J.1    Oberle, V.2    Zuhorn, I.S.3    Hoekstra, D.4
  • 36
    • 33644764063 scopus 로고    scopus 로고
    • Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes
    • Lakadamyali M, Rust MJ, Zhuang X (2006) Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124, 997-1009.
    • (2006) Cell , vol.124 , pp. 997-1009
    • Lakadamyali, M.1    Rust, M.J.2    Zhuang, X.3
  • 40
    • 23944464631 scopus 로고    scopus 로고
    • Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives
    • Neu M, Fischer D, Kissel T (2005) Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives. J Gene Med 7, 992-1009.
    • (2005) J Gene Med , vol.7 , pp. 992-1009
    • Neu, M.1    Fischer, D.2    Kissel, T.3
  • 41
    • 28444435477 scopus 로고    scopus 로고
    • Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI
    • Kleemann E, Neu M, Jekel N, Fink L, Schmehl T, Gessler T, Seeger W, Kissel T (2005) Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J Control Release 109, 299-316.
    • (2005) J Control Release , vol.109 , pp. 299-316
    • Kleemann, E.1    Neu, M.2    Jekel, N.3    Fink, L.4    Schmehl, T.5    Gessler, T.6    Seeger, W.7    Kissel, T.8
  • 42
    • 33847671358 scopus 로고    scopus 로고
    • TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors
    • Sethuraman VA, Bae YH (2007) TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors. J Control Release 118, 216-224.
    • (2007) J Control Release , vol.118 , pp. 216-224
    • Sethuraman, V.A.1    Bae, Y.H.2
  • 43
    • 33748126226 scopus 로고    scopus 로고
    • Recent approaches to intracellular delivery of drugs and DNA and organelle targeting
    • Torchilin VP (2006) Recent approaches to intracellular delivery of drugs and DNA and organelle targeting. Annu Rev Biomed Eng 8, 343-375.
    • (2006) Annu Rev Biomed Eng , vol.8 , pp. 343-375
    • Torchilin, V.P.1
  • 45
    • 9244219656 scopus 로고    scopus 로고
    • Acetals as pHsensitive linkages for drug delivery
    • Gillies ER, Goodwin AP, Frechet JM (2004) Acetals as pHsensitive linkages for drug delivery. Bioconjug Chem 15, 1254-1263.
    • (2004) Bioconjug Chem , vol.15 , pp. 1254-1263
    • Gillies, E.R.1    Goodwin, A.P.2    Frechet, J.M.3
  • 46
    • 0027382982 scopus 로고
    • Inhibition of the Friend retrovirus by antisense oligonucleotides encapsulated in liposomes: Mechanism of action
    • Ropert C, Malvy C, Couvreur P (1993) Inhibition of the Friend retrovirus by antisense oligonucleotides encapsulated in liposomes: Mechanism of action. Pharm Res 10, 1427-1433.
    • (1993) Pharm Res , vol.10 , pp. 1427-1433
    • Ropert, C.1    Malvy, C.2    Couvreur, P.3
  • 47
    • 0037413362 scopus 로고    scopus 로고
    • Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery
    • Roy I,Mitra S, Maitra A, Mozumdar S (2003) Calcium phosphate nanoparticles as novel non-viral vectors for targeted gene delivery. Int J Pharm 250, 25-33.
    • (2003) Int J Pharm , vol.250 , pp. 25-33
    • Roy, I.1    Mitra, S.2    Maitra, A.3    Mozumdar, S.4
  • 48
    • 33745614305 scopus 로고    scopus 로고
    • Mesostructured germanium with cubic pore symmetry
    • Armatas GS, KanatzidisMG(2006) Mesostructured germanium with cubic pore symmetry. Nature 441, 1122-1125.
    • (2006) Nature , vol.441 , pp. 1122-1125
    • Armatas, G.S.1    Kanatzidis, M.G.2
  • 49
    • 0035810181 scopus 로고    scopus 로고
    • Varied pore organization in mesostructured semiconductors based on the [SnSe4](4-) anion
    • Trikalitis PN, Rangan KK, Bakas T, Kanatzidis MG (2001) Varied pore organization in mesostructured semiconductors based on the
    • (2001) Nature , vol.410 , pp. 671-675
    • Trikalitis, P.N.1    Rangan, K.K.2    Bakas, T.3    Kanatzidis, M.G.4
  • 50
    • 27144532929 scopus 로고    scopus 로고
    • A mesoporous germanium oxide with crystalline pore walls and its chiral derivative
    • Zou X, Conradsson T, Klingstedt M, Dadachov MS, O'Keeffe M (2005) A mesoporous germanium oxide with crystalline pore walls and its chiral derivative. Nature 437, 716-719.
    • (2005) Nature , vol.437 , pp. 716-719
    • Zou, X.1    Conradsson, T.2    Klingstedt, M.3    Dadachov, M.S.4    O'Keeffe, M.5
  • 51
    • 34447130258 scopus 로고    scopus 로고
    • Sol-Gel-derived TiO2-SiO2 implant coatings for direct tissue attachment. Part II: Evaluation of cell response
    • Areva S, Aaritalo V, Tuusa S, Jokinen M, Linden M, Peltola T (2007) Sol-Gel-derived TiO2-SiO2 implant coatings for direct tissue attachment. Part II: Evaluation of cell response. J Mater Sci Mater Med 18, 1633-1642.
    • (2007) J Mater Sci Mater Med , vol.18 , pp. 1633-1642
    • Areva, S.1    Aaritalo, V.2    Tuusa, S.3    Jokinen, M.4    Linden, M.5    Peltola, T.6
  • 52
    • 0037448920 scopus 로고    scopus 로고
    • A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules
    • LaiCY, Trewyn BG, JeftinijaDM,Jeftinija K, Xu S, Jeftinija S, Lin VS (2003) A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. J Am Chem Soc 125, 4451-4459.
    • (2003) J Am Chem Soc , vol.125 , pp. 4451-4459
    • Lai, C.Y.1    Trewyn, B.G.2    Jeftinija, D.M.3    Jeftinija, K.4    Xu, S.5    Jeftinija, S.6    Lin, V.S.7
  • 53
    • 34548183870 scopus 로고    scopus 로고
    • CdSe/CdS/SiO2 core/shell/shell nanoparticles
    • Zhu MQ, Han JJ, Li AD (2007) CdSe/CdS/SiO2 core/shell/shell nanoparticles. J Nanosci Nanotechnol 7, 432-439.
    • (2007) J Nanosci Nanotechnol , vol.7 , pp. 432-439
    • Zhu, M.Q.1    Han, J.J.2    Li, A.D.3
  • 54
    • 9644254309 scopus 로고    scopus 로고
    • Epithelial internalization of superparamagnetic nanoparticles and response to external magnetic field
    • Dormer K, Seeney C, Lewelling K, Lian G, Gibson D, Johnson M (2005) Epithelial internalization of superparamagnetic nanoparticles and response to external magnetic field. Biomaterials 26, 2061-2072.
    • (2005) Biomaterials , vol.26 , pp. 2061-2072
    • Dormer, K.1    Seeney, C.2    Lewelling, K.3    Lian, G.4    Gibson, D.5    Johnson, M.6
  • 56
    • 46749123819 scopus 로고    scopus 로고
    • Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
    • Slowing II, Vivero-Escoto JL, Wu CW, Lin VS (2008) Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev 60, 1278-1288.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1278-1288
    • Slowing, I.I.1    Vivero-Escoto, J.L.2    Wu, C.W.3    Lin, V.S.4
  • 57
    • 66949127647 scopus 로고    scopus 로고
    • Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI)
    • Jeffery ND, McBain SC, Dobson J, Chari DM (2009) Uptake of systemically administered magnetic nanoparticles (MNPs) in areas of experimental spinal cord injury (SCI). J Tissue Eng Regen Med 3, 153-157.
    • (2009) J Tissue Eng Regen Med , vol.3 , pp. 153-157
    • Jeffery, N.D.1    McBain, S.C.2    Dobson, J.3    Chari, D.M.4
  • 59
    • 76849112146 scopus 로고    scopus 로고
    • Nanotechnology applications for improved delivery of antiretroviral drugs to the brain
    • Wong HL, Chattopadhyay N, Wu XY, Bendayan R (2010) Nanotechnology applications for improved delivery of antiretroviral drugs to the brain. Adv Drug Deliver Rev 62, 503-517.
    • (2010) Adv Drug Deliver Rev , vol.62 , pp. 503-517
    • Wong, H.L.1    Chattopadhyay, N.2    Wu, X.Y.3    Bendayan, R.4
  • 60
    • 61349123258 scopus 로고    scopus 로고
    • Nucleic acid delivery with chitosan and its derivatives
    • Lai WF, Lin MC (2009) Nucleic acid delivery with chitosan and its derivatives. J Control Release 134, 158-168.
    • (2009) J Control Release , vol.134 , pp. 158-168
    • Lai, W.F.1    Lin, M.C.2
  • 64
    • 0000893449 scopus 로고
    • Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA
    • Behr JP, Demeneix B, Loeffler JP, P'erez-Mutul J (1989) Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc Natl Acad Sci U S A 86, 6982-6986.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 6982-6986
    • Behr, J.P.1    Demeneix, B.2    Loeffler, J.P.3    P'erez-Mutul, J.4
  • 67
    • 0029444559 scopus 로고
    • Surrogate cells or trojan horses. The discovery of liposomes
    • Bangham AD (1995) Surrogate cells or Trojan horses. The discovery of liposomes. Bioessays 17, 1081-1088.
    • (1995) Bioessays , vol.17 , pp. 1081-1088
    • Bangham, A.D.1
  • 68
    • 12344262085 scopus 로고    scopus 로고
    • Drug transport to brain with targeted liposomes
    • Schnyder A, Huwyler J (2005) Drug transport to brain with targeted liposomes. NeuroRx 2, 99-107.
    • (2005) NeuroRx , vol.2 , pp. 99-107
    • Schnyder, A.1    Huwyler, J.2
  • 69
    • 38949192863 scopus 로고    scopus 로고
    • Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers
    • Torchilin VP (2008) Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers. Adv Drug Deliv Rev 60, 548-558.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 548-558
    • Torchilin, V.P.1
  • 72
    • 0025272049 scopus 로고
    • Lipofection of cDNAs in the embryonic vertebrate central nervous system
    • Holt CE, Garlick N, Cornel E (1990) Lipofection of cDNAs in the embryonic vertebrate central nervous system. Neuron 4, 203-214.
    • (1990) Neuron , vol.4 , pp. 203-214
    • Holt, C.E.1    Garlick, N.2    Cornel, E.3
  • 73
    • 0032078127 scopus 로고    scopus 로고
    • Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex
    • Imaoka T, Date I, Ohmoto T, Nagatsu T (1998) Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex. Hum Gene Ther 9, 1093-1102.
    • (1998) Hum Gene Ther , vol.9 , pp. 1093-1102
    • Imaoka, T.1    Date, I.2    Ohmoto, T.3    Nagatsu, T.4
  • 74
    • 1842636306 scopus 로고    scopus 로고
    • Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter
    • Zhang Y, Schlachetzki F, Zhang YF, Boado RJ, Pardridge WM (2004) Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter. Hum Gene Ther 15, 339-350.
    • (2004) Hum Gene Ther , vol.15 , pp. 339-350
    • Zhang, Y.1    Schlachetzki, F.2    Zhang, Y.F.3    Boado, R.J.4    Pardridge, W.M.5
  • 76
    • 23944465946 scopus 로고    scopus 로고
    • Tf-lipoplex-mediated NGF gene transfer to the CNS: Neuronal protection and recovery in an excitotoxic model of brain injury
    • da CruzMT, Cardoso AL, de Almeida LP, Simoes S, de Lima MC (2005) Tf-lipoplex-mediated NGF gene transfer to the CNS: Neuronal protection and recovery in an excitotoxic model of brain injury. Gene Ther 12, 1242-1252.
    • (2005) Gene Ther , vol.12 , pp. 1242-1252
    • Da Cruz, M.T.1    Cardoso, A.L.2    De Almeida, L.P.3    Simoes, S.4    De Lima, M.C.5
  • 77
    • 0036518450 scopus 로고    scopus 로고
    • Receptor-mediated delivery of an antisense gene to human brain cancer cells
    • Zhang Y, Jeong LH, Boado RJ, Pardridge WM (2002) Receptor-mediated delivery of an antisense gene to human brain cancer cells. J Gene Med 4, 183-194.
    • (2002) J Gene Med , vol.4 , pp. 183-194
    • Zhang, Y.1    Jeong, L.H.2    Boado, R.J.3    Pardridge, W.M.4
  • 78
    • 2542561420 scopus 로고    scopus 로고
    • Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer
    • Zhang Y, Zhang YF, Bryant J, Charles A, Boado RJ, Pardridge WM (2004) Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer. Clin Cancer Res 10, 3667-3677.
    • (2004) Clin Cancer Res , vol.10 , pp. 3667-3677
    • Zhang, Y.1    Zhang, Y.F.2    Bryant, J.3    Charles, A.4    Boado, R.J.5    Pardridge, W.M.6
  • 79
    • 12344269275 scopus 로고    scopus 로고
    • RNA interference and nonviral targeted gene therapy of experimental brain cancer
    • Boado RJ (2005) RNA interference and nonviral targeted gene therapy of experimental brain cancer. NeuroRx 2, 139-150.
    • (2005) NeuroRx , vol.2 , pp. 139-150
    • Boado, R.J.1
  • 80
    • 1942453805 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for parenteral drug delivery
    • Wissing SA, Kayser O, Muller RH (2004) Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 56, 1257-1272.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 1257-1272
    • Wissing, S.A.1    Kayser, O.2    Muller, R.H.3
  • 81
    • 21744460519 scopus 로고    scopus 로고
    • Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice
    • Harivardhan Reddy L, Sharma RK, Chuttani K, Mishra AK, Murthy RS (2005) Influence of administration route on tumor uptake and biodistribution of etoposide loaded solid lipid nanoparticles in Dalton's lymphoma tumor bearing mice. J Control Release 105, 185-198.
    • (2005) J Control Release , vol.105 , pp. 185-198
    • Harivardhan Reddy, L.1    Sharma, R.K.2    Chuttani, K.3    Mishra, A.K.4    Murthy, R.S.5
  • 82
    • 24944496710 scopus 로고    scopus 로고
    • Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration
    • Manjunath K, Venkateswarlu V (2005) Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration. J Control Release 107, 215-228.
    • (2005) J Control Release , vol.107 , pp. 215-228
    • Manjunath, K.1    Venkateswarlu, V.2
  • 83
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • MehnertW, Mader K (2001) Solid lipid nanoparticles: Production, characterization and applications. Adv Drug Deliv Rev 47, 165-196.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 165-196
    • Mehnert, W.1    Mader, K.2
  • 84
    • 0026505698 scopus 로고
    • Influence of the surface properties of low contact angle surfactants on the body distribution of 14C-poly(methyl methacrylate) nanoparticles
    • Troster SD, Kreuter J (1992) Influence of the surface properties of low contact angle surfactants on the body distribution of 14C-poly(methyl methacrylate) nanoparticles. J Microencapsul 9, 19-28.
    • (1992) J Microencapsul , vol.9 , pp. 19-28
    • Troster, S.D.1    Kreuter, J.2
  • 85
    • 0035912928 scopus 로고    scopus 로고
    • Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages
    • Scholer N, Olbrich C, Tabatt K, Muller RH, Hahn H, Liesenfeld O (2001) Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages. Int J Pharm 221, 57-67.
    • (2001) Int J Pharm , vol.221 , pp. 57-67
    • Scholer, N.1    Olbrich, C.2    Tabatt, K.3    Muller, R.H.4    Hahn, H.5    Liesenfeld, O.6
  • 86
    • 0038407930 scopus 로고    scopus 로고
    • Vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide
    • Peira E, Marzola P, Podio V, Aime S, Sbarbati A, GascoMR (2003) In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide. J Drug Target 11, 19-24.
    • (2003) J Drug Target , vol.11 , pp. 19-24
    • Peira, E.1    Marzola, P.2    Podio, V.3    Aime, S.4    Sbarbati, A.5    Gasco, M.R.6
  • 88
    • 0029799791 scopus 로고    scopus 로고
    • A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethylenimine
    • Abdallah B, Hassan A, Benoist C, Goula D, Behr JP, Demeneix BA (1996) A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethylenimine. Hum Gene Ther 7, 1947-1954.
    • (1996) Hum Gene Ther , vol.7 , pp. 1947-1954
    • Abdallah, B.1    Hassan, A.2    Benoist, C.3    Goula, D.4    Behr, J.P.5    Demeneix, B.A.6
  • 89
    • 0034887157 scopus 로고    scopus 로고
    • Interaction of poly(butylcyanoacrylate) nanoparticles with the blood-brain barrier in vivo and in vitro
    • Alyaudtin RN, Reichel A, Lobenberg R, Ramge P, Kreuter J, Begley DJ (2001) Interaction of poly(butylcyanoacrylate) nanoparticles with the blood-brain barrier in vivo and in vitro. J Drug Target 9, 209-221.
    • (2001) J Drug Target , vol.9 , pp. 209-221
    • Alyaudtin, R.N.1    Reichel, A.2    Lobenberg, R.3    Ramge, P.4    Kreuter, J.5    Begley, D.J.6
  • 90
    • 33344460518 scopus 로고    scopus 로고
    • Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles
    • Gao K, JiangX(2006) Influence of particle size on transport of methotrexate across blood brain barrier by polysorbate 80-coated polybutylcyanoacrylate nanoparticles. Int J Pharm 310, 213-219.
    • (2006) Int J Pharm , vol.310 , pp. 213-219
    • Gao, K.1    Jiang, X.2
  • 91
    • 11144268181 scopus 로고    scopus 로고
    • Controlled ring-opening polymerization of lactide and glycolide
    • Dechy-Cabaret O, Martin-Vaca B, BourissouD(2004) Controlled ring-opening polymerization of lactide and glycolide. Chem Rev 104, 6147-6176.
    • (2004) Chem Rev , vol.104 , pp. 6147-6176
    • Dechy-Cabaret, O.1    Martin-Vaca, B.2    Bourissou, D.3
  • 93
    • 0030757526 scopus 로고    scopus 로고
    • Nanoscopic structure of DNA condensed for gene delivery
    • Dunlap DD, Maggi A, Soria MR, Monaco L (1997) Nanoscopic structure of DNA condensed for gene delivery. Nucleic Acids Res 25, 3095-3101.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3095-3101
    • Dunlap, D.D.1    Maggi, A.2    Soria, M.R.3    Monaco, L.4
  • 94
    • 8844239128 scopus 로고    scopus 로고
    • Towards multifunctional synthetic vectors
    • Demeneix B, Hassani Z, Behr JP (2004) Towards multifunctional synthetic vectors. Curr Gene Ther 4, 445-455.
    • (2004) Curr Gene Ther , vol.4 , pp. 445-455
    • Demeneix, B.1    Hassani, Z.2    Behr, J.P.3
  • 95
    • 0032811354 scopus 로고    scopus 로고
    • Poly(ethylenimine) and its role in gene delivery
    • GodbeyWT,Wu KK, Mikos AG (1999) Poly(ethylenimine) and its role in gene delivery. J Control Release 60, 149-160.
    • (1999) J Control Release , vol.60 , pp. 149-160
    • Godbey, W.T.1    Wu, K.K.2    Mikos, A.G.3
  • 96
    • 0030817274 scopus 로고    scopus 로고
    • Polyethyleneimine is an effective permeabilizer of gramnegative bacteria
    • Helander IM, Alakomi HL, Latva-Kala K, Koski P (1997) Polyethyleneimine is an effective permeabilizer of gramnegative bacteria. Microbiology 143, 3193-3199.
    • (1997) Microbiology , vol.143 , pp. 3193-3199
    • Helander, I.M.1    Alakomi, H.L.2    Latva-Kala, K.3    Koski, P.4
  • 98
    • 0032938324 scopus 로고    scopus 로고
    • PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
    • Ogris M, Brunner S, Schuller S, Kircheis R, Wagner E (1999) PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery. Gene Ther 6, 595-605.
    • (1999) Gene Ther , vol.6 , pp. 595-605
    • Ogris, M.1    Brunner, S.2    Schuller, S.3    Kircheis, R.4    Wagner, E.5
  • 99
    • 34548083701 scopus 로고    scopus 로고
    • Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine
    • Park IK, Lasiene J, Chou SH, Horner PJ, Pun SH (2007) Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine). J Gene Med 9, 691-702.
    • (2007) J Gene Med , vol.9 , pp. 691-702
    • Park, I.K.1    Lasiene, J.2    Chou, S.H.3    Horner, P.J.4    Pun, S.H.5
  • 100
    • 38849095313 scopus 로고    scopus 로고
    • Clostridium neurotoxin fragments as potential targeting moieties for liposomal gene delivery to the CNS
    • Andreu A, Fairweather N, Miller AD (2008) Clostridium neurotoxin fragments as potential targeting moieties for liposomal gene delivery to the CNS. Chembiochem 9, 219-231.
    • (2008) Chembiochem , vol.9 , pp. 219-231
    • Andreu, A.1    Fairweather, N.2    Miller, A.D.3
  • 101
    • 42049114012 scopus 로고    scopus 로고
    • Nonviral approaches for neuronal delivery of nucleic acids
    • Bergen JM, Park IK, Horner PJ, Pun SH (2008) Nonviral approaches for neuronal delivery of nucleic acids. Pharm Res 25, 983-998.
    • (2008) Pharm Res , vol.25 , pp. 983-998
    • Bergen, J.M.1    Park, I.K.2    Horner, P.J.3    Pun, S.H.4
  • 103
    • 0031954707 scopus 로고    scopus 로고
    • Pegylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate-hexadecyl cyanoacrylate amphiphilic copolymer
    • Peracchia MT, Vauthier C, Desmaele D, Gulik A, Dedieu JC, Demoy M, D'Angelo J, Couvreur P (1998) Pegylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate-hexadecyl cyanoacrylate amphiphilic copolymer. Pharm Res 15, 550-556.
    • (1998) Pharm Res , vol.15 , pp. 550-556
    • Peracchia, M.T.1    Vauthier, C.2    Desmaele, D.3    Gulik, A.4    Dedieu, J.C.5    Demoy, M.6    D'Angelo, J.7    Couvreur, P.8
  • 104
    • 0036460265 scopus 로고    scopus 로고
    • Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat
    • Calvo P, Gouritin B, Villarroya H, Eclancher F, Giannavola C, Klein C, Andreux JP, Couvreur P (2002) Quantification and localization of PEGylated polycyanoacrylate nanoparticles in brain and spinal cord during experimental allergic encephalomyelitis in the rat. Eur J Neurosci 15, 1317-1326.
    • (2002) Eur J Neurosci , vol.15 , pp. 1317-1326
    • Calvo, P.1    Gouritin, B.2    Villarroya, H.3    Eclancher, F.4    Giannavola, C.5    Klein, C.6    Andreux, J.P.7    Couvreur, P.8
  • 105
    • 0345280812 scopus 로고    scopus 로고
    • Influence of the surfactant concentration on the body distribution of nanoparticles
    • Araujo L, Lobenberg R, Kreuter J (1999) Influence of the surfactant concentration on the body distribution of nanoparticles. J Drug Target 6, 373-385.
    • (1999) J Drug Target , vol.6 , pp. 373-385
    • Araujo, L.1    Lobenberg, R.2    Kreuter, J.3
  • 107
    • 0033537836 scopus 로고    scopus 로고
    • Nucleotide exchange in genomic DNA of rat hepatocytes usingRNA/DNAoligonucleotides. Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor
    • Bandyopadhyay P, Ma X, Linehan-Stieers C, Kren BT, Steer CJ (1999) Nucleotide exchange in genomic DNA of rat hepatocytes usingRNA/ DNAoligonucleotides. Targeted delivery of liposomes and polyethyleneimine to the asialoglycoprotein receptor. J Biol Chem 274, 10163-10172.
    • (1999) J Biol Chem , vol.274 , pp. 10163-10172
    • Bandyopadhyay, P.1    Ma, X.2    Linehan-Stieers, C.3    Kren, B.T.4    Steer, C.J.5
  • 108
    • 0036082871 scopus 로고    scopus 로고
    • Polyethylenimine-mediated suicide gene transfer induces a therapeutic effect for hepatocellular carcinoma in vivo by using an epstein-barr virus-based plasmid vector
    • IwaiM,HaradaY,Tanaka S, Muramatsu A, MoriT, Kashima K, Imanishi J, Mazda O (2002) Polyethylenimine-mediated suicide gene transfer induces a therapeutic effect for hepatocellular carcinoma in vivo by using an Epstein-Barr virus-based plasmid vector. Biochem Biophys Res Commun 291, 48-54.
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 48-54
    • Iwai, M.1    Harada, Y.2    Tanaka, S.3    Muramatsu, A.4    Mori, T.5    Kashima, K.6    Imanishi, J.7    Mazda, O.8
  • 109
    • 0036953454 scopus 로고    scopus 로고
    • Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression
    • Aigner A, Fischer D, Merdan T, Brus C, Kissel T, Czubayko F (2002) Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression. Gene Ther 9, 1700-1707.
    • (2002) Gene Ther , vol.9 , pp. 1700-1707
    • Aigner, A.1    Fischer, D.2    Merdan, T.3    Brus, C.4    Kissel, T.5    Czubayko, F.6
  • 111
    • 0031860769 scopus 로고    scopus 로고
    • Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system
    • Goula D, Remy JS, Erbacher P, Wasowicz M, Levi G, Abdallah B, Demeneix BA (1998) Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther 5, 712-717.
    • (1998) Gene Ther , vol.5 , pp. 712-717
    • Goula, D.1    Remy, J.S.2    Erbacher, P.3    Wasowicz, M.4    Levi, G.5    Abdallah, B.6    Demeneix, B.A.7
  • 112
    • 0041808905 scopus 로고    scopus 로고
    • Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord
    • Shi L, Tang GP, Gao SJ, Ma YX, Liu BH, Li Y, Zeng JM, Ng YK, Leong KW, Wang S (2003) Repeated intrathecal administration of plasmid DNA complexed with polyethylene glycol-grafted polyethylenimine led to prolonged transgene expression in the spinal cord. Gene Ther 10, 1179-1188.
    • (2003) Gene Ther , vol.10 , pp. 1179-1188
    • Shi, L.1    Tang, G.P.2    Gao, S.J.3    Ma, Y.X.4    Liu, B.H.5    Li, Y.6    Zeng, J.M.7    Ng, Y.K.8    Leong, K.W.9    Wang, S.10
  • 113
    • 33745265648 scopus 로고    scopus 로고
    • Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system
    • Tang GP, Guo HY, Alexis F, Wang X, Zeng S, Lim TM, Ding J, Yang YY, Wang S (2006) Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system. J Gene Med 8, 736-744.
    • (2006) J Gene Med , vol.8 , pp. 736-744
    • Tang, G.P.1    Guo, H.Y.2    Alexis, F.3    Wang, X.4    Zeng, S.5    Lim, T.M.6    Ding, J.7    Yang, Y.Y.8    Wang, S.9
  • 115
    • 0034990933 scopus 로고    scopus 로고
    • Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes
    • Wang S, Ma N, Gao SJ, Yu H, Leong KW (2001) Transgene expression in the brain stem effected by intramuscular injection of polyethylenimine/DNA complexes. Mol Ther 3, 658-664.
    • (2001) Mol Ther , vol.3 , pp. 658-664
    • Wang, S.1    Ma, N.2    Gao, S.J.3    Yu, H.4    Leong, K.W.5
  • 117
    • 0030293017 scopus 로고    scopus 로고
    • Vitro gene delivery by degraded polyamidoamine dendrimers
    • Tang MX, Redemann CT, Szoka FC Jr (1996) In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 7, 703-714.
    • (1996) Bioconjug Chem , vol.7 , pp. 703-714
    • Tang, M.X.1    Redemann, C.T.2    Szoka Jr., F.C.3
  • 118
    • 33646563152 scopus 로고    scopus 로고
    • Amine terminated G-6 PAMAM dendrimer and its interaction with DNA probed by Hoechst 33258
    • Choi YS, Cho TS, Kim JM, HanSW, Kim SK (2006) Amine terminated G-6 PAMAM dendrimer and its interaction with DNA probed by Hoechst 33258. Biophys Chem 121, 142-149.
    • (2006) Biophys Chem , vol.121 , pp. 142-149
    • Choi, Y.S.1    Cho, T.S.2    Kim, J.M.3    Han, S.W.4    Kim, S.K.5
  • 119
    • 40849140969 scopus 로고    scopus 로고
    • Rapid action of estrogens on intracellular calcium oscillations in primate luteinizing hormone-releasing hormone-1 neurons
    • Abe H, Keen KL, Terasawa E (2008) Rapid action of estrogens on intracellular calcium oscillations in primate luteinizing hormone-releasing hormone-1 neurons. Endocrinology 149, 1155-1162.
    • (2008) Endocrinology , vol.149 , pp. 1155-1162
    • Abe, H.1    Keen, K.L.2    Terasawa, E.3
  • 120
    • 84855767201 scopus 로고    scopus 로고
    • Sensitive electrochemical immunosensor for alpha-synuclein based on dual signal amplification using PAMAM dendrimer-encapsulated Au and enhanced gold nanoparticle labels
    • An Y, Jiang X, Bi W, Chen H, Jin L, Zhang S, Wang C, Zhang W (2012) Sensitive electrochemical immunosensor for alpha-synuclein based on dual signal amplification using PAMAM dendrimer-encapsulated Au and enhanced gold nanoparticle labels. Biosens Bioelectron 32, 224-230.
    • (2012) Biosens Bioelectron , vol.32 , pp. 224-230
    • An, Y.1    Jiang, X.2    Bi, W.3    Chen, H.4    Jin, L.5    Zhang, S.6    Wang, C.7    Zhang, W.8
  • 121
    • 63949086284 scopus 로고    scopus 로고
    • Highly efficient transfection of rat cortical neurons using carbosilane dendrimers unveils a neuroprotective role for HIF-1alpha in early chemical hypoxia-mediated neurotoxicity
    • Posadas I, L'opez-Hernández B, Clemente MI, Jim'enez JL, Ortega P, de la MJ, G'omez R, Muñoz-Fernández MA, Ceña V(2009) Highly efficient transfection of rat cortical neurons using carbosilane dendrimers unveils a neuroprotective role for HIF-1alpha in early chemical hypoxia-mediated neurotoxicity. Pharm Res 26, 1181-1191.
    • (2009) Pharm Res , vol.26 , pp. 1181-1191
    • Posadas, I.1    L'opez-Hernández, B.2    Clemente, M.I.3    Jim'enez, J.L.4    Ortega, P.5    De La, M.J.6    G'Omez, R.7    Muñoz-Fernández, M.A.8    Ceña, V.9
  • 122
    • 33746415181 scopus 로고    scopus 로고
    • Enhanced transfection of primary cortical cultures using arginine-grafted pamamdendrimer, pamam-arg
    • Kim JB, Choi JS, Nam K, Lee M, Park JS, Lee JK (2006) Enhanced transfection of primary cortical cultures using arginine-grafted PAMAMdendrimer, PAMAM-Arg. J Control Release 114, 110-117.
    • (2006) J Control Release , vol.114 , pp. 110-117
    • Kim, J.B.1    Choi, J.S.2    Nam, K.3    Lee, M.4    Park, J.S.5    Lee, J.K.6
  • 123
    • 67349155532 scopus 로고    scopus 로고
    • Comparison between arginine conjugated PAMAM dendrimers with structural diversity for gene delivery systems
    • Kim TI, Bai CZ, Nam K, Park JS (2009) Comparison between arginine conjugated PAMAM dendrimers with structural diversity for gene delivery systems. J Control Release 136, 132-139.
    • (2009) J Control Release , vol.136 , pp. 132-139
    • Kim, T.I.1    Bai, C.Z.2    Nam, K.3    Park, J.S.4
  • 125
    • 84855932980 scopus 로고    scopus 로고
    • Cofilin activation mediates Bax translocation to mitochondria during excitotoxic neuronal death
    • Posadas I, P'erez-Martínez FC, Guerra J, Sánchez-Verd'u P, Ceña V (2012) Cofilin activation mediates Bax translocation to mitochondria during excitotoxic neuronal death. J Neurochem 120, 515-527.
    • (2012) J Neurochem , vol.120 , pp. 515-527
    • Posadas, I.1    P'erez-Martínez, F.C.2    Guerra, J.3    Sánchez-Verd'u, P.4    Ceña, V.5
  • 127
  • 129
    • 35548959221 scopus 로고    scopus 로고
    • The use of lactoferrin as a ligand for targeting the polyamidoaminebased gene delivery system to the brain
    • Huang R, Ke W, Liu Y, Jiang C, Pei Y (2008) The use of lactoferrin as a ligand for targeting the polyamidoaminebased gene delivery system to the brain. Biomaterials 29, 238-246.
    • (2008) Biomaterials , vol.29 , pp. 238-246
    • Huang, R.1    Ke, W.2    Liu, Y.3    Jiang, C.4    Pei, Y.5
  • 130
    • 77349107167 scopus 로고    scopus 로고
    • Neuroprotection by biodegradable PAMAMester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain
    • Kim ID, Lim CM, Kim JB, Nam HY, Nam K, Kim SW, Park JS, Lee JK (2010) Neuroprotection by biodegradable PAMAMester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain. J Control Release 142, 422-430.
    • (2010) J Control Release , vol.142 , pp. 422-430
    • Kim, I.D.1    Lim, C.M.2    Kim, J.B.3    Nam, H.Y.4    Nam, K.5    Kim, S.W.6    Park, J.S.7    Lee, J.K.8
  • 131
    • 70849084320 scopus 로고    scopus 로고
    • Design and adaptation of miniaturized electrochemical devices integrating carbon nanotube-based sensors to commercial CE equipment
    • Arribas AS, Moreno M, Bermejo E, Angeles Lorenzo M, Zapardiel A, Chicharro M (2009) Design and adaptation of miniaturized electrochemical devices integrating carbon nanotube-based sensors to commercial CE equipment. Electrophoresis 30, 3480-3488.
    • (2009) Electrophoresis , vol.30 , pp. 3480-3488
    • Arribas, A.S.1    Moreno, M.2    Bermejo, E.3    Angeles Lorenzo, M.4    Zapardiel, A.5    Chicharro, M.6
  • 133
    • 1642540193 scopus 로고    scopus 로고
    • Translocation of bioactive peptides across cell membranes by carbon nanotubes
    • Pantarotto D, Briand JP, Prato M, Bianco A (2004) Translocation of bioactive peptides across cell membranes by carbon nanotubes. Chem Commun (Camb), 16-17.
    • (2004) Chem Commun (Camb) , pp. 16-17
    • Pantarotto, D.1    Briand, J.P.2    Prato, M.3    Bianco, A.4
  • 134
    • 70350662339 scopus 로고    scopus 로고
    • Promises, facts and challenges for carbon nanotubes in imaging and therapeutics
    • Kostarelos K, Bianco A, PratoM(2009) Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat Nanotechnol 4, 627-633.
    • (2009) Nat Nanotechnol , vol.4 , pp. 627-633
    • Kostarelos, K.1    Pratom, B.A.2
  • 138
    • 3342901882 scopus 로고    scopus 로고
    • An introduction to the shortterm toxicology of respirable industrial fibres
    • Donaldson K, Tran CL (2004) An introduction to the shortterm toxicology of respirable industrial fibres. Mutat Res 553, 5-9.
    • (2004) Mutat Res , vol.553 , pp. 5-9
    • Donaldson, K.1    Tran, C.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.