Significant behavioral recovery in Parkinson's disease model by direct intracerebral gene transfer using continuous injection of a plasmid DNA-liposome complex

Human Gene Therapy

Volumn 9, Issue 7, 1998, Pages 1093-1102

  Imaoka, Takashi ^a   Date, Isao ^a   Ohmoto, Takashi ^a   Nagatsu, Toshiharu ^b  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOMORPHINE; AROMATIC LEVO AMINO ACID DECARBOXYLASE; LIPOSOME; OXIDOPAMINE; PLASMID DNA; PLASMID VECTOR; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CIRCLING BEHAVIOR; CONTROLLED STUDY; DISEASE MODEL; DNA TRANSFECTION; FEMALE; GENE TRANSFER; GLIA CELL; NONHUMAN; PAPILLOMA VIRUS; PARKINSON DISEASE; RAT;

ANIMALIA; BOVINAE; BOVINE PAPILLOMA VIRUS; PAPILLOMAVIRUS;

EID: 0032078127     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.7-1093     Document Type: Article

References (11)

1. ALEXANDER, G.M., SCHWARTZMAN, R.J., GROTHUSEN, J.R., BRAINARD, L., and GORDON, S.W. (1993). Changes in brain dopamine receptors in MPTP parkinsonian monkeys following L-dopa treatment. Brain Res. 625, 276-282.
2. BENCSICS, C., WACHTEL, S.R., MILSTIEN, S., HATAKEYAMA, K., BECKER, J.B., and KANG, U.J. (1996). Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts. J. Neurosci. 16, 4449-4456.
3. CAO, L., ZHENG, Z.C., ZHAO, Y.C., JIANG, Z.H., LIU, Z.G., CHEN, S.D., ZHOU, C.F., and LIU, X.Y. (1995). Gene therapy of Parkinson disease model rat by direct injection of plasmid DNA-lipofectin complex. Hum. Gene Ther. 6, 1497-1501.
4. CITRON, B.A., MILSTIEN, S., GUTIERREZ, J.C., LEVINE, R.A., YANAK, B.L., and KAUFMAN, S. (1990). Isolation and expression of rat liver sepiapterin reductase cDNA. Proc. Natl. Acad. Sci. U.S.A. 87, 6436-6440.
5. DURING, M.J., NAEGELE, J.R., O'MALLEY, K.L., and GELLER, A.I. (1994). Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266, 1399-1403.
6. FISHER, L.J., JINNAH, H.A., KALE, L.C., HIGGINS, G.A., and GAGE, F.H. (1991). Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce L-dopa. Neuron 6, 371-380.
7. GALEA, E., FEINSTEIN, D.L., and REIS, D.J. (1992). Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. Proc. Natl. Acad. Sci. U.S.A. 89, 10945-10949.
8. HATAKEYAMA, K., INOUE, Y., HARADA, T., and KAGAMIYAMA, H. (1991). Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. J. Biol. Chem. 266, 765-769.
9. HEFTI, F., MELAMED, E., AND WURTMAN, R.J. (1981). The site of dopamine formation in rat striatum after L-dopa administration. J. Pharmacol. Exp. Ther. 217, 189-197.
10. HIRAYAMA, K., LENTZ, S.I., and KAPATOS, G. (1993). Tetrahydrobiopterin cofactor biosynthesis: GTP cyclohydrolase I mRNA expression in rat brain and superior cervical ganglia. J. Neurochem. 61, 1006-1014.
11. WOLFF, J.A., FISHER, L.J., XU, L., JINNAH, H.A., LANGLAIS, P.J., IUVONE, P.M., O'MALLEY, K.L., ROSENBERG, M.B., SHIMOHAMA, S., FRIEDMANN, T., and GAGE, F.H. (1989). Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. U.S.A. 86, 9011-9014.