Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse

Journal of Pharmacology and Experimental Therapeutics

Volumn 292, Issue 3, 2000, Pages 1048-1052

  Lee, Hwa Jeong ^a   Engelhardt, Britta ^b   Lesley, Jayne ^c   Bickel, Ulrich ^d   Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^d TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; TRANSFERRIN RECEPTOR;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG HALF LIFE; DRUG PENETRATION; DRUG SELECTIVITY; DRUG TARGETING; DRUG UPTAKE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCYTOSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD-BRAIN BARRIER; BRAIN; DRUG DELIVERY SYSTEMS; MICE; MICE, INBRED BALB C; RATS; RECEPTORS, TRANSFERRIN; TISSUE DISTRIBUTION;

EID: 0002595302     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bickel U, Rang YS, Yoshikawa T and Pardridge WM (1994) In vivo demonstration of subcellular localization of anti-transferrin receptor monoclonal antibody-colloidal gold conjugate within brain capillary endothelium. J Histochem Cytochem 42: 1493-1497.
2. Bickel U, Yoshikawa T and Pardridge WM (1993) Delivery of peptides and proteins through the blood-brain barrier. Adv Drug Delivery Rev 10:205-245.
3. Broadwell RD, Baker-Cairns BJ, Friden PM, Oliver C and Villegas JC (1996) Transcytosis of protein through the mammalian cerebral epithelium and endothelium. Exp Neurol 142:47-65.
4. Descamps L, Dehouck MP, Torpier G and Cecchelli R (1996) Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells. Am J Physiol 270:H1149-H1158.
5. Dreier T, Lode HN, Xiang R, Dolman CS, Reisfeld RA and Kang AS (1998) Recombinant immunocytokines targeting the mouse transferrin receptor: Construction and biological activities. Bioconj Chem 9:482-489.
6. Fishman JB, Rubin JB, Handrahan JV, Connor JR and Fine RE (1987) Receptor-mediated transcytosis of transferrin across the blood-brain barrier. J Neurosci Res 18:299-304.
7. Gibaldi M and Perrier D (1982) Pharmacokinetics. Marcel Dekker, Inc., New York.
8. Jaenisch R (1988) Transgenic animals. Science (Wash DC) 240:1468-1474.
9. Jefferies WA, Brandon MR, Williams AF and Hunt V (1985) Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor. Immunology 54:333-341.
10. Kang Y-S, Bickel U and Pardridge WM (1994) Pharmacokinetics and saturable blood-brain barrier transport of biotin bound to a conjugate of avidin and a monoclonal antibody to the transferrin receptor. Drug Metab Dispos 22:99-105.
11. Kang YS and Pardridge WM (1994) Use of neutral-avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate. J Pharmacol Exp Ther 269:344-350.
12. Kissel K, Hamm S, Schulz M, Vecchi A, Garlanda C and Engelhardt B (1998) Immunohistochemical localization of the murine transferrin receptor (TfR) on blood-tissue barriers using a novel anti-TfR monoclonal antibody. Histochem Cell Biol 110:63-72.
13. Lesley J, Hyman R, Schulte R and Trotter J (1984) Expression of transferrin receptor on murine hematopoietic progenitors. Cell Immunol 83:14-25.
14. Lesley J, Schulte R and Woods J (1989) Modulation of transferrin receptor expression and function by anti-transferrin receptor antibodies and antibody fragments. Exp Cell Res 182:215-233.
15. Li JY, Sugimura K, Boado RJ, Lee HJ, Zhang C, Dubel S and Pardridge WM (1999) Genetically engineered brain drug delivery vectors - Cloning, expression, and in vivo application of an anti-transferrin receptor single chain antibody-streptavidin fusion gene and protein. Protein Eng 12:787-796.
16. Pardridge WM (1999) Vector-mediated drug delivery to the brain. Adv Drug Delivery Rev 36:299-321.
17. Pardridge WM, Buciak JL and Frieden PM (1991) Selective transport of antitransferrin receptor antibody through the blood-brain barrier in vivo. J Pharmacol Exp Ther 259:66-70.
18. Pardridge WM, Kang YS, Buciak JL and Yang J (1995) Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate. Pharm Res 12:807-816.
19. Rudolph JR, Regoeczi E and Southward S (1988) Quantification of rat heptocyte transferrin receptors with poly- and monoclonal antibodies and protein A. Histochemistry 88:187-192.
20. Shin SU, Wu D, Ramanathan R, Pardridge WM and Morrison SL (1997) Functional and pharmacokinetic properties of antibody-avidin fusion proteins. J Immunol 158:4797-4804.
21. Skarlatos S and Pardridge WM (1995) Targeting of an anti-CR3 (CD11b/CD18) monoclonal antibody to spleen but not brain, in vivo in mice. J Drug Targeting 3:9-14.
22. 125I]transferrin through the rat blood-brain barrier in vivo. Brain Res 683:164-171.
23. Stearne PA, Pietersz GA and Goding JW (1985) cDNA cloning of the murine transferrin receptor: Sequence of trans-membrane and adjacent regions. J Immunol 134:3474-3479.
24. Triguero D, Buciak J and Pardridge WM (1990) Capillary depletion method for quantification of blood-brain transport of circulating peptides and plasma proteins. J Neurochem 54:1882-1888.
25. Wu D and Pardridge WM (1999) Neuroprotection with non-invasive neurotrophin delivery to brain. Proc Natl Acad Sci USA 96:254-259.
26. Wu D, Yang J and Pardridge WM (1997) Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J Clin Invest 100:1804-1812.
27. Yoshikawa T and Pardridge WM (1992): Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor. J Pharmacol Exp Ther 263:897-903.