Delivery of unmodified bioactive ribozymes by an RNA stabilizing polyethylenimine LMW PEI efficiently down regulates gene expression

Gene Therapy

Volumn 9, Issue 24, 2002, Pages 1700-1707

  Eigner, A ^a   Fischer, D ^a   Merdan, T ^a   Brus, C ^a   Kissel, T ^a   Czubayko, F ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Gene targeting; Gene therapy; PEI; Polyethylenimine; Ribozyme

Indexed keywords

GROWTH FACTOR; PLEIOTROPHIN; POLYETHYLENEIMINE; RIBOZYME; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANCER INHIBITION; CELL LINE; CELL TRANSPORT; COMPLEX FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFICACY; DRUG TISSUE LEVEL; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MELANOMA; METHODOLOGY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RNA CLEAVAGE; RNA DEGRADATION; RNA SEQUENCE; RNA STABILITY; SUBCUTANEOUS TISSUE TUMOR; TUMOR XENOGRAFT;

ANIMALS; CARRIER PROTEINS; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; GENE THERAPY; GENETIC ENGINEERING; INJECTIONS, INTRAPERITONEAL; MELANOMA; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MODELS, ANIMAL; POLYETHYLENEIMINE; RNA, CATALYTIC; SKIN NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

ANIMALIA; EUKARYOTA;

EID: 0036953454     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301839     Document Type: Review

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