Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages

International Journal of Pharmaceutics

Volumn 221, Issue 1-2, 2001, Pages 57-67

  Scholer N ^a   Olbrich, C ^a   Tabatt, K ^a   Muller R H ^a   Hahn, H ^a   Liesenfeld, O ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Cytokines; Cytotoxicity; Peritoneal macrophages; Size; Solid lipid nanoparticles; Surface modification; Surfactant

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CETYLPYRIDINIUM SALT; CHOLIC ACID; DODECYL SULFATE SODIUM; DYNASAN 114; INTERLEUKIN 12; INTERLEUKIN 6; NANOPARTICLE; PHOSPHATIDYLCHOLINE; POLOXAMER; POLOXAMINE 908; POLYSORBATE 80; SOLID LIPID NANOPARTICLE; SOLUTOL HS 15; SURFACTANT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG COATING; DRUG FORMULATION; FEMALE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPERNATANT;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CHEMISTRY, PHARMACEUTICAL; CYTOKINES; FEMALE; LIPIDS; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; NITRIC OXIDE; PARTICLE SIZE; SURFACE-ACTIVE AGENTS;

EID: 0035912928     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00660-3     Document Type: Article

References (37)

1. Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butylcyanoacrylate) nanoparticles
2. Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles
3. Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: An in situ brain perfusion study
4. The acute phase response
5. Flow cytometric analysis of macrophage response to ceramic and polyethylene particles: Effect of size, concentration and composition
6. The role of plasma proteins in brain targeting: Species dependent protein adsorption pattern on brain-specific lipid drug conjugate (LDC) nanoparticles
7. Polyethylene particles of a 'critical size' are necessary for the induction of cytokines by macrophages in vitro
8. Preparation, characterization and cytotoxicity of methylmethacrytale copolymer nanoparticles with a permanent positive surface charge
9. The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a blockpolymer - Poloxamine 908
10. Surface characteristics and the interaction of colloidal particles with mouse peritoneal macrophages
11. Alkylcyanoacrylate drug carriers: II. Cytotoxicity of cyanoacrylate nanoparticles with different alkyl chain length
12. Cell culture for the assessment of toxicity and uptake of polymeric particulate drug carriers
13. Comparison of cytotoxicity between polyester nanoparticles and solid lipid nanoparticles
14. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay
15. Solid lipid nanoparticles: Phagocytic uptake, in vitro cytotoxicity and in vitro biodegration, 2nd Communication
16. Solid lipid nanoparticles (SLN) - An alternative colloidal carrier system for controlled drug delivery
17. Solid lipid nanoparticles (SLN) as potential carrier for human use: Interaction with human granulocytes
18. Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant
19. Interaction of differentiated HL60 cells with poloxamer and poloxamine surface modified model drug carrier
20. Nitro-L-arginine interferes with the cadmium reduction of nitrate/griess reaction method of measuring nitric oxide production
21. Enzymatic degradation of SLN - Effect of surfactant and surfactant mixtures
22. Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity
23. Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action
24. In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. I. Effect of analytical parameters, particle size and particle concentration
25. Phagocytic uptake of polymeric particles in vitro-effect of surface hydrophobicity and fluorescence labeling
26. In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. II. Effect of surface modification by coating of particles with poloxamer on the phagocytic uptake
27. In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. III. Uptake of differently sized surface-modified particles, and its correlation to particle properties and in vivo distribution
28. In vitro uptake of polystyrene latex particles and parenteral fat emulsions by human granulocytes
29. In vitro phagocytosis assay of nano- and microparticles by chemiluminscence. IV. Effect of surface modification by coating with poloxamine and Antarox CO on the phagocytic uptake
30. Effect of solid lipid nanoparticles (SLN) on cytokine production and the viability of murine peritoneal macrophages
31. Preserved solid lipid nanoparticles (SLN) at low concentrations do cause neither direct nor indirect cytotoxic effects in peritoneal macrophages
32. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis
33. The mononuclear phagocyte system. A new classification of macrophages and their precursor cells
34. Interaction of phagocytes with other blood cells and with pathogenic and nonpathogenic microbes