Chemical Genetics Reveals a Specific Requirement for Cdk2 Activity in the DNA Damage Response and Identifies Nbs1 as a Cdk2 Substrate in Human Cells

PLoS Genetics

Volumn 8, Issue 8, 2012, Pages

  Wohlbold, Lara ^a   Merrick, Karl A ^a,b   De, Saurav ^c   Amat, Ramon ^a   Kim, Jun Hyun ^c   Larochelle, Stéphane ^a   Allen, Jasmina J ^d   Zhang, Chao ^d   Shokat, Kevan M ^d   Petrini, John H J ^c   Fisher, Robert P ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 N BENZYLADENINE; ADENOSINE TRIPHOSPHATE; APHIDICOLIN; CHECKPOINT KINASE 2; CYCLIN A; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE 9; MAGNESIUM ION; MRE11 PROTEIN; NIBRIN; PURVALANOL A; REPLICATION FACTOR A; ROSCOVITINE; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; MRE11A PROTEIN, HUMAN; NBN PROTEIN, HUMAN; NUCLEAR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAD50 PROTEIN, HUMAN;

AMINO ACID SUBSTITUTION; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL KILLING; CELL PROLIFERATION; CELL PROTECTION; CELL STRAIN HCT116; CELL SURVIVAL; CHEMICAL GENETICS; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA REPAIR; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MOLECULAR DYNAMICS; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RNA INTERFERENCE; CELL CYCLE; METABOLISM; PHOSPHORYLATION; RADIATION EXPOSURE;

MAMMALIA;

CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE 2; DNA DAMAGE; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; NUCLEAR PROTEINS; PHOSPHORYLATION; RADIATION, IONIZING;

EID: 84866170589     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002935     Document Type: Article

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