The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity

Cell Cycle

Volumn 5, Issue 5, 2006, Pages 546-554

  Wohlbold, Lara ^a   Larochelle, Stéphane ^a   Liao, Jack C F ^a,b,d   Livshits, Geulah ^a,e   Singer, Juliet ^a   Shokat, Kevan M ^c   Fisher, Robert P ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ANIMAL MEDICAL CENTER   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Analog sensitive kinase; Apoptosis; CDK activating kinase (CAK); Cdk7; Cell cycle; Chemical genetics; Cyclin dependent kinase (CDK); PNQALRE CCRK; RNAi

Indexed keywords

CELL EXTRACT; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 7; CYCLIN DEPENDENT KINASE ACTIVATING KINASE; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P42; RECOMBINANT ENZYME; RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL FRACTIONATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IN VIVO STUDY; MALE; MAMMAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEPLETION; PROTEIN FAMILY; RNA INTERFERENCE;

ANIMALIA; EUKARYOTA; MAMMALIA; METAZOA; SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 33644785933     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.5.2541     Document Type: Article

References (51)

1. Morgan DO. Principles of CDK regulation. Nature 1995; 374:131-4.
2. Harper JW, Elledge SJ. The role of Cdk7 in CAK function, a retro-retrospective. Genes Dev 1998; 12:285-9.
3. Roy R, Adamczewski JP, Seroz T, Vermuelen W, Tassan JP, Schaeffer L, Nigg EA, Hoeijmakers JHJ, Egly JM. The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor. Cell 1994; 79:1093-101.
4. Serizawa H, Mäkelä TP, Conaway JW, Conaway RC, Weinberg RA, Young RA. Association of Cdk-activating kinase subunits with transcription factor TFIIH. Nature 1995; 374:280-2.
5. Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D. Cdk-activating kinase (CAK) complex is a component of human transcription factor IIH. Nature 1995; 374:283-7.
6. Larochelle S, Pandur J, Fisher RP, Salz HK, Suter B. Cdk7 is essential for mitosis and for in vivo Cdk-activating kinase activity. Genes Dev 1998; 12:370-81.
7. Wallenfang MR, Seydoux G. cdk-7 is required for mRNA transcription and cell cycle progression in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA 2002; 99:5527-32.
8. 2/M in the budding yeast cell cycle. Genetics 1997; 147:57-71.
9. Saiz JE, Fisher RP. A CDK-activating kinase network is required in cell cycle control and transcription in fission yeast. Curr Biol 2002; 12:1100-5.
10. Espinoza FH, Farrell A, Erdjument-Bromage H, Tempst P, Morgan DO. A cyclin-dependent kinase-activating kinase (CAK) in budding yeast unrelated to vertebrate CAK. Science 1996; 273:1714-7.
11. Kaldis P, Sutton A, Solomon MJ. The Cdk-activating kinase (CAK) from budding yeast. Cell 1996; 86:553-64.
12. Thuret JY, Valay JG, Faye G, Mann C. Civ1 (CAK in vivo), a novel Cdk-activating kinase. Cell 1996; 86:565-76.
13. Lee KM, Saiz JE, Barton WA, Fisher RP. Cdc2 activation in fission yeast depends on Mcs6 and Csk1, two partially redundant Cdk-activating kinases CAKs). Curr Biol 1999; 9:441-4.
14. Hermand D, Pihlak A, Westerling T, Damagnez V, Vandenhaute J, Cottarel G, Mäkelä TP. Fission yeast Csk1 is a CAK-activating kinase (CAKAK). EMBO J 1998; 17:7230-8.
15. Molz L, Beach D. Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. EMBO J 1993; 12:1723-32.
16. Hermand D, Westerling T, Pihlak A, Thuret JY, Vallenius T, Tiainen M, Vandenhaute J, Cottarel G, Mann C, Mäkelä TP. Specificity of Cdk activation in vivo by the two Caks Mcs6 and Csk1 in fission yeast. EMBO J 2001; 20:82-90.
17. Bimbo A, Jia Y, Poh SL, Karuturi RK, den Elzen N, Peng X, Zheng L, O'Connell M, Liu ET, Balasubramanian MK, Liu J. Systematic deletion analysis of fission yeast protein kinases. Eukaryot Cell 2005; 4:799-813.
18. Pei Y, Du H, Singer J, St Amour C, Granitto S, Shuman S, Fisher RP. Cyclin-dependent kinase 9 (Cdk9) of fission yeast is activated by the CDK-activating kinase Csk1, overlaps functionally with the TFIIH-associated kinase Mcs6, and associates with the mRNA cap methyltransferase Pcm1 in vivo. Mol Cell Biol 2006; 26:777-88.
19. Murray AW, Marks D. Can sequencing shed light on cell cycling? Nature 2001; 409:844-6.
20. Fisher RP. Secrets of a double agent: CDK7 in cell-cycle control and transcription. J Cell Sci 2005; 118:5171-80.
21. Matsuoka M, Kato J, Fisher RP, Morgan DO, Sherr CJ. Activation of cyclin-dependent kinase-4 (CDK4) by mouse MO15-associated kinase. Mol Cell Biol 1994; 14:7265-75.
22. Fesquet D, Morin N, Doree M, Devault A. Is cdk7/cyclin H/MAT1 the genuine cdk activating kinase in cycling xenopus egg extracts? Oncogene 1997; 15:1303-7.
23. Larochelle S, Batliner J, Gamble MJ, Barboza NM, Kraybill BC, Blethrow JD, Shokat KM, Fisher RP. Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol 2006; 13:55-62.
24. Nagahara H, Ezhevsky SA, Vocero-Akbani AM, Kaldis P, Solomon MJ, Dowdy SF. Transforming growth factor beta targeted inactivation of cyclin E: Cyclin-dependent kinase 2 (Cdk2) complexes by inhibition of Cdk2 activating kinase activity. Proc Natl Acad Sci USA 1999; 96:14961-6.
25. Kaldis P, Solomon MJ. Analysis of CAK activities from human cells. Eur J Biochem 2000; 267:4213-21.
26. Kato J, Matsuoka M, Polyak K, Massague J, Sherr CJ. Cyclic AMP-induced G, phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase-4 activation. Cell 1994; 79:487-96.
27. Lents NH, Keenan SM, Bellone C, Baldassare JJ. Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2. J Biol Chem 2002; 277:47469-75.
28. Ukomadu C, Dutta A. Inhibition of cdk2 activating phosphorylation by mevastatin. J Biol Chem 2003; 278:4840-6.
29. Harper JW, Elledge SJ, Keyomarski K, Dynlacht B, Tsai LH, Zhang P, Dobrowolski S, Bai C, Connell-Crowley L, Swindell E, Fox MP, Wei N. Inhibition of cyclin-dependent kinases by p21. Mol Biol Cell 1995; 6:387-400.
30. Fisher RP, Morgan DO. A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase. Cell 1994; 78:713-24.
31. Aprelikova O, Xiong Y, Liu ET. Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. J Biol Chem 1995; 270:18195-7.
32. Rosales J, Han B, Lee KY. Cdk7 functions as a cdk5 activating kinase in brain. Cell Physiol Biochem 2003; 13:285-96.
33. Kaldis P, Russo AA, Chou HS, Pavletich NP, Solomon MJ. Human and yeast cdk-activating kinases (CAKs) display distinct substrate specificities. Mol Biol Cell 1998; 9:2545-60.
34. Tsakraklides V, Solomon MJ. Comparison of Cak1p-like cyclin-dependent kinase-activating kinases. J Biol Chem 2002; 277:33482-9.
35. Liu Y, Wu C, Galaktionov K. p42, a novel cyclin-dependent kinase-activating kinase in mammalian cells. J Biol Chem 2004; 279:4507-14.
36. MacKeigan JP, Murphy LO, Blenis J. Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 2005; 7:591-600.
37. Fisher RP, Jin P, Chamberlin HM, Morgan DO. Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase. Cell 1995; 83:47-57.
38. Kunkel TA. Rapid and efficient site-directed mutagenesis without phenotypic selection. Proc Natl Acad Sci USA 1985; 82:488-92.
39. O'Reilly DR, Miller LK, Luckow VA. Baculovirus Expression Vectors: A Laboratory Manual. New York: W.H.Freeman and Co., 1993.
40. Rosenblatt J, De Bondt H, Jancarik J, Morgan DO, Kim SH. Purification and crystallization of human cyclin-dependent kinase 2. J Mol Biol 1993; 230:1317-9.
41. Fisher RP. Reconstitution of mammalian CDK-activating kinase. Methods Enzymol 1997; 283:256-70.
42. Garrett S, Barton WA, Knights R, Jin P, Morgan DO, Fisher RP. Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T-loop. Mol Cell Biol 2001; 21:88-99.
43. Kaldis P. The cdk-activating kinase (CAK): From yeast to mammals. Cell Mol Life Sci 1999; 55:284-96.
44. Liu J, Kipreos ET. Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): Differential conservation of CAKs in yeast and metazoa. Mol Biol Evol 2000; 17:1061-74.
45. Hanks SK, Quinn AM. Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members. Meth Enz 1991; 200:38-62.
46. Edwards MC, Wong C, Elledge SJ. Human cyclin K, a novel RNA polymerase II-associated cyclin possessing both carboxy-terminal domain kinase and cdk-activating kinase activity. Mol Cell Biol 1998; 18:4291-300.
47. Kraybill BC, Elkin LL, Blethrow JD, Morgan DO, Shokat KM. Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc 2002; 124:12118-28.
48. Specht KM, Shokat KM. The emerging power of chemical genetics. Curr Opin Cell Biol 2002; 14:155-9.
49. Cismowski MJ, Laff GM, Solomon MJ, Reed SI. KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. Mol Cell Biol 1995; 15:2983-92.
50. Caligiuri M, Becker F, Murthi K, Kaplan F, Dedier S, Kaufmann C, Machl A, Zybarth G, Richard J, Bockovich N, Kluge A, Kley N. A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem Biol 2005; 12:1103-15.
51. Morgan DO. Cyclin-dependent kinases: Engines, clocks and microprocessors. Annu Rev Cell Dev Biol 1997; 13:261-91.