Cdk-mediated phosphorylation of Chk1 is required for efficient activation and full checkpoint proficiency in response to DNA damage

Oncogene

Volumn 31, Issue 9, 2012, Pages 1086-1094

  Xu, N ^a,b   Libertini, S ^a   Black, E J ^a   Lao, Y ^a   Hegarat, N ^c   Walker, M ^a   Gillespie, D A ^a,d  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b TSINGHUA UNIVERSITY   (China)

^c UNIVERSITY OF SUSSEX   (United Kingdom)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Cdk; cell cycle; checkpoint; Chk1; DNA damage; RPA

Indexed keywords

CHECKPOINT KINASE 1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 2; MUTANT PROTEIN; REPLICATION FACTOR A; ROSCOVITINE; SINGLE STRANDED DNA;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; IMMUNOCYTOCHEMISTRY; IRRADIATION; LYMPHOMA CELL; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING;

CDC2 PROTEIN KINASE; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; DNA DAMAGE; ENZYME ACTIVATION; HUMANS; MODELS, BIOLOGICAL; PHOSPHORYLATION; PROTEIN KINASES;

EID: 84857785627     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.310     Document Type: Article

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