메뉴 건너뛰기




Volumn 19, Issue 2, 2012, Pages 246-253

Mre11 regulates CtIP-dependent double-strand break repair by interaction with CDK2

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BINDING PROTEIN; BRCA1 PROTEIN; CYCLIN DEPENDENT KINASE 2; DOUBLE STRANDED DNA; MRE11 PROTEIN; NUCLEASE; PROTEIN CTIP; UNCLASSIFIED DRUG;

EID: 84856747932     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2212     Document Type: Article
Times cited : (93)

References (50)
  • 1
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson, S.P. & Bartek, J. The DNA-damage response in human biology and disease. Nature 461, 1071-1078 (2009).
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 4
    • 50649100744 scopus 로고    scopus 로고
    • Mechanism of eukaryotic homologous recombination
    • San Filippo, J., Sung, P. & Klein, H. Mechanism of eukaryotic homologous recombination. Annu. Rev. Biochem. 77, 229-257 (2008).
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 229-257
    • San Filippo, J.1    Sung, P.2    Klein, H.3
  • 5
    • 79951857925 scopus 로고    scopus 로고
    • DNA end resection-Unraveling the tail
    • Mimitou, E.P. & Symington, L.S. DNA end resection-Unraveling the tail. DNA Repair (Amst.) 10, 344-348 (2011).
    • (2011) DNA Repair (Amst.) , vol.10 , pp. 344-348
    • Mimitou, E.P.1    Symington, L.S.2
  • 6
    • 52949109260 scopus 로고    scopus 로고
    • Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
    • Buis, J. et al. Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 135, 85-96 (2008).
    • (2008) Cell , vol.135 , pp. 85-96
    • Buis, J.1
  • 7
    • 0033485758 scopus 로고    scopus 로고
    • Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
    • Yamaguchi-Iwai, Y. et al. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J. 18, 6619-6629 (1999).
    • (1999) EMBO J. , vol.18 , pp. 6619-6629
    • Yamaguchi-Iwai, Y.1
  • 8
    • 35648986560 scopus 로고    scopus 로고
    • Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination
    • DOI 10.1016/j.molcel.2007.10.016, PII S1097276507006983
    • Takeda, S., Nakamura, K., Taniguchi, Y. & Paull, T.T. Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination. Mol. Cell 28, 351-352 (2007). (Pubitemid 350030570)
    • (2007) Molecular Cell , vol.28 , Issue.3 , pp. 351-352
    • Takeda, S.1    Nakamura, K.2    Taniguchi, Y.3    Paull, T.T.4
  • 10
    • 78649445307 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks
    • Williams, G.J., Lees-Miller, S.P. & Tainer, J.A. Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks. DNA Repair (Amst.) 9, 1299-1306 (2010).
    • (2010) DNA Repair (Amst.) , vol.9 , pp. 1299-1306
    • Williams, G.J.1    Lees-Miller, S.P.2    Tainer, J.A.3
  • 11
    • 0035906860 scopus 로고    scopus 로고
    • Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
    • Hopfner, K.P. et al. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell 105, 473-485 (2001).
    • (2001) Cell , vol.105 , pp. 473-485
    • Hopfner, K.P.1
  • 12
    • 52949149420 scopus 로고    scopus 로고
    • Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair
    • Williams, R.S. et al. Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair. Cell 135, 97-109 (2008).
    • (2008) Cell , vol.135 , pp. 97-109
    • Williams, R.S.1
  • 14
    • 79951688343 scopus 로고    scopus 로고
    • BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
    • Nimonkar, A.V. et al. BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev. 25, 350-362 (2011).
    • (2011) Genes Dev. , vol.25 , pp. 350-362
    • Nimonkar, A.V.1
  • 15
    • 1842431822 scopus 로고    scopus 로고
    • Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
    • DOI 10.1126/science.1091496
    • Lee, J.H. & Paull, T.T. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304, 93-96 (2004). (Pubitemid 38451463)
    • (2004) Science , vol.304 , Issue.5667 , pp. 93-96
    • Lee, J.-H.1    Paull, T.T.2
  • 16
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • DOI 10.1126/science.1108297
    • Lee, J.H. & Paull, T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308, 551-554 (2005). (Pubitemid 40570585)
    • (2005) Science , vol.308 , Issue.5721 , pp. 551-554
    • Lee, J.-H.1    Paull, T.T.2
  • 17
    • 70349470626 scopus 로고    scopus 로고
    • A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage
    • Lloyd, J. et al. A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage. Cell 139, 100-111 (2009).
    • (2009) Cell , vol.139 , pp. 100-111
    • Lloyd, J.1
  • 18
    • 70349472553 scopus 로고    scopus 로고
    • Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair
    • Williams, R.S. et al. Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair. Cell 139, 87-99 (2009).
    • (2009) Cell , vol.139 , pp. 87-99
    • Williams, R.S.1
  • 19
    • 67349246802 scopus 로고    scopus 로고
    • CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
    • Yun, M.H. & Hiom, K. CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle. Nature 459, 460-463 (2009).
    • (2009) Nature , vol.459 , pp. 460-463
    • Yun, M.H.1    Hiom, K.2
  • 20
    • 43149118369 scopus 로고    scopus 로고
    • Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair
    • Chen, L., Nievera, C.J., Lee, A.Y. & Wu, X. Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair. J. Biol. Chem. 283, 7713-7720 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 7713-7720
    • Chen, L.1    Nievera, C.J.2    Lee, A.Y.3    Wu, X.4
  • 21
    • 72149103012 scopus 로고    scopus 로고
    • CtIP links DNA double-strand break sensing to resection
    • You, Z. et al. CtIP links DNA double-strand break sensing to resection. Mol. Cell 36, 954-969 (2009).
    • (2009) Mol. Cell , vol.36 , pp. 954-969
    • You, Z.1
  • 22
    • 66149114020 scopus 로고    scopus 로고
    • Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    • Huertas, P. & Jackson, S.P. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 284, 9558-9565 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 9558-9565
    • Huertas, P.1    Jackson, S.P.2
  • 24
    • 6344264992 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains
    • DOI 10.1128/MCB.24.21.9478-9486.2004
    • Yu, X. & Chen, J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol. Cell. Biol. 24, 9478-9486 (2004). (Pubitemid 39391684)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.21 , pp. 9478-9486
    • Yu, X.1    Chen, J.2
  • 25
    • 74049119311 scopus 로고    scopus 로고
    • Overall Cdk activity modulates the DNA damage response in mammalian cells
    • Cerqueira, A. et al. Overall Cdk activity modulates the DNA damage response in mammalian cells. J. Cell Biol. 187, 773-780 (2009).
    • (2009) J. Cell Biol. , vol.187 , pp. 773-780
    • Cerqueira, A.1
  • 26
    • 69249230769 scopus 로고    scopus 로고
    • Mammalian cell-cycle regulation: Several Cdks, numerous cyclins and diverse compensatory mechanisms
    • Satyanarayana, A. & Kaldis, P. Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 28, 2925-2939 (2009).
    • (2009) Oncogene , vol.28 , pp. 2925-2939
    • Satyanarayana, A.1    Kaldis, P.2
  • 27
    • 53349162987 scopus 로고    scopus 로고
    • CDK targets Sae2 to control DNA-end resection and homologous recombination
    • Huertas, P., Cortes-Ledesma, F., Sartori, A.A., Aguilera, A. & Jackson, S.P. CDK targets Sae2 to control DNA-end resection and homologous recombination. Nature 455, 689-692 (2008).
    • (2008) Nature , vol.455 , pp. 689-692
    • Huertas, P.1    Cortes-Ledesma, F.2    Sartori, A.A.3    Aguilera, A.4    Jackson, S.P.5
  • 29
    • 33748069123 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers
    • DOI 10.1158/0008-5472.CAN-05-3945
    • Deans, A.J. et al. Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers. Cancer Res. 66, 8219-8226 (2006). (Pubitemid 44299190)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 8219-8226
    • Deans, A.J.1    Khanna, K.K.2    McNees, C.J.3    Mercurio, C.4    Heierhorst, J.5    McArthur, G.A.6
  • 31
    • 0346156075 scopus 로고    scopus 로고
    • Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice
    • Theunissen, J.W. et al. Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice. Mol. Cell 12, 1511-1523 (2003).
    • (2003) Mol. Cell , vol.12 , pp. 1511-1523
    • Theunissen, J.W.1
  • 32
    • 33749678963 scopus 로고    scopus 로고
    • Ataxia-telangiectasia and related diseases
    • Frappart, P.O. & McKinnon, P.J. Ataxia-telangiectasia and related diseases. Neuromolecular Med. 8, 495-511 (2006).
    • (2006) Neuromolecular Med. , vol.8 , pp. 495-511
    • Frappart, P.O.1    McKinnon, P.J.2
  • 34
    • 58249101175 scopus 로고    scopus 로고
    • Rad50 is dispensable for the maintenance and viability of postmitotic tissues
    • Adelman, C.A., De, S. & Petrini, J.H. Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol. Cell. Biol. 29, 483-492 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 483-492
    • Adelman, C.A.1    De, S.2    Petrini, J.H.3
  • 35
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • DOI 10.1038/nature01368
    • Bakkenist, C.J. & Kastan, M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003). (Pubitemid 36168436)
    • (2003) Nature , vol.421 , Issue.6922 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 39
    • 0037665145 scopus 로고    scopus 로고
    • Roscovitine and other purines as kinase inhibitors. from starfish oocytes to clinical trials
    • Meijer, L. & Raymond, E. Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials. Acc. Chem. Res. 36, 417-425 (2003).
    • (2003) Acc. Chem. Res. , vol.36 , pp. 417-425
    • Meijer, L.1    Raymond, E.2
  • 41
    • 0033569684 scopus 로고    scopus 로고
    • XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
    • DOI 10.1101/gad.13.20.2633
    • Pierce, A.J., Johnson, R.D., Thompson, L.H. & Jasin, M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev. 13, 2633-2638 (1999). (Pubitemid 29508550)
    • (1999) Genes and Development , vol.13 , Issue.20 , pp. 2633-2638
    • Pierce, A.J.1    Johnson, R.D.2    Thompson, L.H.3    Jasin, M.4
  • 42
    • 0034749425 scopus 로고    scopus 로고
    • DNA damage-dependent nuclear dynamics of the Mre11 complex
    • Mirzoeva, O.K. & Petrini, J.H. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell. Biol. 21, 281-288 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 281-288
    • Mirzoeva, O.K.1    Petrini, J.H.2
  • 43
    • 4544281398 scopus 로고    scopus 로고
    • Choreography of the DNA damage response: Spatiotemporal relationships among checkpoint and repair proteins
    • DOI 10.1016/j.cell.2004.08.015, PII S0092867404007974
    • Lisby, M., Barlow, J.H., Burgess, R.C. & Rothstein, R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118, 699-713 (2004). (Pubitemid 39221730)
    • (2004) Cell , vol.118 , Issue.6 , pp. 699-713
    • Lisby, M.1    Barlow, J.H.2    Burgess, R.C.3    Rothstein, R.4
  • 44
    • 77953287126 scopus 로고    scopus 로고
    • MRN and the race to the break
    • Rupnik, A., Lowndes, N.F. & Grenon, M. MRN and the race to the break. Chromosoma 119, 115-135 (2010).
    • (2010) Chromosoma , vol.119 , pp. 115-135
    • Rupnik, A.1    Lowndes, N.F.2    Grenon, M.3
  • 45
    • 29144450333 scopus 로고    scopus 로고
    • S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor
    • DOI 10.1101/gad.1373705
    • Morales, M. et al. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev. 19, 3043-3054 (2005). (Pubitemid 41798119)
    • (2005) Genes and Development , vol.19 , Issue.24 , pp. 3043-3054
    • Morales, M.1    Theunissen, J.-W.F.2    Bender Kim, C.F.3    Kitagawa, R.4    Kastan, M.B.5    Petrini, J.H.J.6
  • 46
    • 0033759543 scopus 로고    scopus 로고
    • Mre11 and Rad50 from Pyrococcus furiosus: Cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine
    • Hopfner, K.P. et al. Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine. J. Bacteriol. 182, 6036-6041 (2000).
    • (2000) J. Bacteriol. , vol.182 , pp. 6036-6041
    • Hopfner, K.P.1
  • 47
    • 0035724134 scopus 로고    scopus 로고
    • Recombinational repair of chromosomal DNA double-strand breaks generated by a restriction endonuclease
    • DOI 10.1046/j.1365-2958.2001.02553.x
    • Cromie, G.A. & Leach, D.R. Recombinational repair of chromosomal DNA double-strand breaks generated by a restriction endonuclease. Mol. Microbiol. 41, 873-883 (2001). (Pubitemid 34208996)
    • (2001) Molecular Microbiology , vol.41 , Issue.4 , pp. 873-883
    • Cromie, G.A.1    Leach, D.R.F.2
  • 48
    • 68249135624 scopus 로고    scopus 로고
    • Multiple functions of MRN in end-joining pathways during isotype class switching
    • Dinkelmann, M. et al. Multiple functions of MRN in end-joining pathways during isotype class switching. Nat. Struct. Mol. Biol. 16, 808-813 (2009).
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 808-813
    • Dinkelmann, M.1
  • 49
    • 48249121979 scopus 로고    scopus 로고
    • Complementary functions of ATM and H2AX in development and suppression of genomic instability
    • Zha, S., Sekiguchi, J., Brush, J.W., Bassing, C.H. & Alt, F.W. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc. Natl. Acad. Sci. USA 105, 9302-9306 (2008).
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9302-9306
    • Zha, S.1    Sekiguchi, J.2    Brush, J.W.3    Bassing, C.H.4    Alt, F.W.5
  • 50
    • 63449084054 scopus 로고    scopus 로고
    • MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
    • Helmink, B.A. et al. MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks. J. Exp. Med. 206, 669-679 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 669-679
    • Helmink, B.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.