메뉴 건너뛰기




Volumn 94, Issue 10, 2012, Pages 2097-2103

Modulation of the cardiovascular system by leptin

Author keywords

Cardiovascular; Heart failure; Leptin; Metabolic syndrome; Obesity

Indexed keywords

ATRIAL NATRIURETIC FACTOR; GLUCOSE; LEPTIN; LEPTIN RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; TAMOXIFEN;

EID: 84866135619     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.03.019     Document Type: Short Survey
Times cited : (18)

References (86)
  • 1
    • 33644850953 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: An update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
    • P. Poirier, T.D. Giles, G.A. Bray, Y. Hong, J.S. Stern, F.X. Pi-Sunyer, and R.H. Eckel Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism Circulation 113 2006 898 918
    • (2006) Circulation , vol.113 , pp. 898-918
    • Poirier, P.1    Giles, T.D.2    Bray, G.A.3    Hong, Y.4    Stern, J.S.5    Pi-Sunyer, F.X.6    Eckel, R.H.7
  • 2
    • 31744443753 scopus 로고    scopus 로고
    • Is visceral obesity the cause of the metabolic syndrome?
    • J.P. Despres Is visceral obesity the cause of the metabolic syndrome? Ann. Med. 38 2006 52 63
    • (2006) Ann. Med. , vol.38 , pp. 52-63
    • Despres, J.P.1
  • 4
    • 74949143243 scopus 로고    scopus 로고
    • Narrative review: The role of leptin in human physiology: Emerging clinical applications
    • T. Kelesidis, I. Kelesidis, S. Chou, and C.S. Mantzoros Narrative review: the role of leptin in human physiology: emerging clinical applications Ann. Intern. Med. 152 2010 93 100
    • (2010) Ann. Intern. Med. , vol.152 , pp. 93-100
    • Kelesidis, T.1    Kelesidis, I.2    Chou, S.3    Mantzoros, C.S.4
  • 5
    • 0036000280 scopus 로고    scopus 로고
    • Leptin signalling
    • DOI 10.1016/S0898-6568(02)00006-2, PII S0898656802000062
    • G. Sweeney Leptin signalling Cell. Signal. 14 2002 655 663 (Pubitemid 34518619)
    • (2002) Cellular Signalling , vol.14 , Issue.8 , pp. 655-663
    • Sweeney, G.1
  • 6
    • 58149499180 scopus 로고    scopus 로고
    • Leptin receptor signaling and the regulation of mammalian physiology
    • E.C. Villanueva, and M.G. Myers Jr. Leptin receptor signaling and the regulation of mammalian physiology Int. J. Obes. (Lond.) 32 Suppl. 7 2008 S8 12
    • (2008) Int. J. Obes. (Lond.) , vol.32 , Issue.SUPPL. 7 , pp. 8-12
    • Villanueva, E.C.1    Myers Jr., M.G.2
  • 7
    • 42049109696 scopus 로고    scopus 로고
    • Cardiac remodeling in obesity
    • DOI 10.1152/physrev.00017.2007
    • E.D. Abel, S.E. Litwin, and G. Sweeney Cardiac remodeling in obesity Physiol. Rev. 88 2008 389 419 (Pubitemid 351520084)
    • (2008) Physiological Reviews , vol.88 , Issue.2 , pp. 389-419
    • Abel, E.D.1    Litwin, S.E.2    Sweeney, G.3
  • 9
    • 76849089860 scopus 로고    scopus 로고
    • Cardiovascular effects of leptin
    • G. Sweeney Cardiovascular effects of leptin Nat. Rev. Cardiol. 7 2010 22 29
    • (2010) Nat. Rev. Cardiol. , vol.7 , pp. 22-29
    • Sweeney, G.1
  • 10
    • 82155180640 scopus 로고    scopus 로고
    • Leptin and cardiovascular diseases
    • N. Hou, and J.D. Luo Leptin and cardiovascular diseases Clin. Exp. Pharmacol. Physiol. 38 12 2011 905 913
    • (2011) Clin. Exp. Pharmacol. Physiol. , vol.38 , Issue.12 , pp. 905-913
    • Hou, N.1    Luo, J.D.2
  • 11
    • 52949129178 scopus 로고    scopus 로고
    • Leptin resistance: A possible interface of inflammation and metabolism in obesity-related cardiovascular disease
    • S.S. Martin, A. Qasim, and M.P. Reilly Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease J. Am. Coll. Cardiol. 52 2008 1201 1210
    • (2008) J. Am. Coll. Cardiol. , vol.52 , pp. 1201-1210
    • Martin, S.S.1    Qasim, A.2    Reilly, M.P.3
  • 13
    • 51649124024 scopus 로고    scopus 로고
    • Leptin and cardiovascular disease: Response to therapeutic interventions
    • K.K. Koh, S.M. Park, and M.J. Quon Leptin and cardiovascular disease: response to therapeutic interventions Circulation 117 2008 3238 3249
    • (2008) Circulation , vol.117 , pp. 3238-3249
    • Koh, K.K.1    Park, S.M.2    Quon, M.J.3
  • 14
    • 80054968141 scopus 로고    scopus 로고
    • Obesity and risk of incident heart failure in older men with and without pre-existing coronary heart disease does leptin have a role?
    • S.G. Wannamethee, A.G. Shaper, P.H. Whincup, L. Lennon, and N. Sattar Obesity and risk of incident heart failure in older men with and without pre-existing coronary heart disease does leptin have a role? J. Am. Coll. Cardiol. 58 2011 1870 1877
    • (2011) J. Am. Coll. Cardiol. , vol.58 , pp. 1870-1877
    • Wannamethee, S.G.1    Shaper, A.G.2    Whincup, P.H.3    Lennon, L.4    Sattar, N.5
  • 15
    • 77953670617 scopus 로고    scopus 로고
    • Leptin signaling in the failing and mechanically unloaded human heart
    • K.R. McGaffin, C.S. Moravec, and C.F. McTiernan Leptin signaling in the failing and mechanically unloaded human heart Circ. Heart Fail. 2 2009 676 683
    • (2009) Circ. Heart Fail. , vol.2 , pp. 676-683
    • McGaffin, K.R.1    Moravec, C.S.2    McTiernan, C.F.3
  • 16
    • 79960700893 scopus 로고    scopus 로고
    • Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: The Heart and Soul Study
    • I.A. Ku, R. Farzaneh-Far, E. Vittinghoff, M.H. Zhang, B. Na, and M.A. Whooley Association of low leptin with cardiovascular events and mortality in patients with stable coronary artery disease: the Heart and Soul Study Atherosclerosis 217 2011 503 508
    • (2011) Atherosclerosis , vol.217 , pp. 503-508
    • Ku, I.A.1    Farzaneh-Far, R.2    Vittinghoff, E.3    Zhang, M.H.4    Na, B.5    Whooley, M.A.6
  • 18
  • 19
    • 77955701640 scopus 로고    scopus 로고
    • Interaction between age and obesity on cardiomyocyte contractile function: Role of leptin and stress signaling
    • J. Ren, F. Dong, G.J. Cai, P. Zhao, J.M. Nunn, L.E. Wold, and J. Pei Interaction between age and obesity on cardiomyocyte contractile function: role of leptin and stress signaling PLoS One 5 2010 e10085
    • (2010) PLoS One , vol.5 , pp. 10085
    • Ren, J.1    Dong, F.2    Cai, G.J.3    Zhao, P.4    Nunn, J.M.5    Wold, L.E.6    Pei, J.7
  • 22
    • 33745727431 scopus 로고    scopus 로고
    • Distinct effects of short- and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes
    • R. Palanivel, M. Eguchi, I. Shuralyova, I. Coe, and G. Sweeney Distinct effects of short- and long-term leptin treatment on glucose and fatty acid uptake and metabolism in HL-1 cardiomyocytes Metabolism 55 2006 1067 1075
    • (2006) Metabolism , vol.55 , pp. 1067-1075
    • Palanivel, R.1    Eguchi, M.2    Shuralyova, I.3    Coe, I.4    Sweeney, G.5
  • 24
    • 74949084316 scopus 로고    scopus 로고
    • Membrane fatty acid transporters as regulators of lipid metabolism: Implications for metabolic disease
    • J.F. Glatz, J.J. Luiken, and A. Bonen Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease Physiol. Rev. 90 2010 367 417
    • (2010) Physiol. Rev. , vol.90 , pp. 367-417
    • Glatz, J.F.1    Luiken, J.J.2    Bonen, A.3
  • 25
    • 0037119410 scopus 로고    scopus 로고
    • Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis
    • DOI 10.1074/jbc.M203813200
    • L.L. Atkinson, M.A. Fischer, and G.D. Lopaschuk Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis J. Biol. Chem. 277 2002 29424 29430 (Pubitemid 41079226)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.33 , pp. 29424-29430
    • Atkinson, L.L.1    Fischer, M.A.2    Lopaschuk, G.D.3
  • 27
    • 78951481202 scopus 로고    scopus 로고
    • Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat diet
    • W. Keung, V.J. Cadete, A. Palaniyappan, A. Jablonski, M. Fischer, and G.D. Lopaschuk Intracerebroventricular leptin administration differentially alters cardiac energy metabolism in mice fed a low-fat and high-fat diet J. Cardiovasc. Pharmacol. 57 2011 103 113
    • (2011) J. Cardiovasc. Pharmacol. , vol.57 , pp. 103-113
    • Keung, W.1    Cadete, V.J.2    Palaniyappan, A.3    Jablonski, A.4    Fischer, M.5    Lopaschuk, G.D.6
  • 28
    • 79951877179 scopus 로고    scopus 로고
    • Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms
    • X. Li, X. Wu, R. Camacho, G.J. Schwartz, and D. LeRoith Intracerebroventricular leptin infusion improves glucose homeostasis in lean type 2 diabetic MKR mice via hepatic vagal and non-vagal mechanisms PLoS One 6 2011 e17058
    • (2011) PLoS One , vol.6 , pp. 17058
    • Li, X.1    Wu, X.2    Camacho, R.3    Schwartz, G.J.4    Leroith, D.5
  • 30
    • 52949108394 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure
    • T. Oka, and I. Komuro Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure Circ. J. 72 Suppl. A 2008 A13 A16
    • (2008) Circ. J. , vol.72 , Issue.SUPPL. A
    • Oka, T.1    Komuro, I.2
  • 31
    • 42049096195 scopus 로고    scopus 로고
    • Pathways involved in the transition from hypertension to hypertrophy to heart failure. Treatment strategies
    • J.W. Wright, S. Mizutani, and J.W. Harding Pathways involved in the transition from hypertension to hypertrophy to heart failure. Treatment strategies Heart Fail. Rev. 13 2008 367 375
    • (2008) Heart Fail. Rev. , vol.13 , pp. 367-375
    • Wright, J.W.1    Mizutani, S.2    Harding, J.W.3
  • 32
    • 79955161098 scopus 로고    scopus 로고
    • The athlete's heart vs. The failing heart: Can signaling explain the two distinct outcomes?
    • K.L. Weeks, and J.R. McMullen The athlete's heart vs. the failing heart: can signaling explain the two distinct outcomes? Physiology (Bethesda) 26 2011 97 105
    • (2011) Physiology (Bethesda) , vol.26 , pp. 97-105
    • Weeks, K.L.1    McMullen, J.R.2
  • 33
    • 69949142200 scopus 로고    scopus 로고
    • Distinguishing hypertrophic cardiomyopathy from athlete's heart physiological remodelling: Clinical significance, diagnostic strategies and implications for preparticipation screening
    • B.J. Maron Distinguishing hypertrophic cardiomyopathy from athlete's heart physiological remodelling: clinical significance, diagnostic strategies and implications for preparticipation screening Br. J. Sports Med. 43 2009 649 656
    • (2009) Br. J. Sports Med. , vol.43 , pp. 649-656
    • Maron, B.J.1
  • 34
    • 31344444358 scopus 로고    scopus 로고
    • Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes
    • DOI 10.1016/j.cardiores.2005.11.022, PII S0008636305005353
    • S. Madani, S. De Girolamo, D.M. Munoz, R.K. Li, and G. Sweeney Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes Cardiovasc. Res. 69 2006 716 725 (Pubitemid 43139734)
    • (2006) Cardiovascular Research , vol.69 , Issue.3 , pp. 716-725
    • Madani, S.1    De Girolamo, S.2    Munoz, D.M.3    Li, R.-K.4    Sweeney, G.5
  • 35
    • 33746093293 scopus 로고    scopus 로고
    • An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1
    • DOI 10.1016/j.yjmcc.2006.05.001, PII S0022282806005645
    • V. Rajapurohitam, S. Javadov, D.M. Purdham, L.A. Kirshenbaum, and M. Karmazyn An autocrine role for leptin in mediating the cardiomyocyte hypertrophic effects of angiotensin II and endothelin-1 J. Mol. Cell Cardiol. 41 2006 265 274 (Pubitemid 44080214)
    • (2006) Journal of Molecular and Cellular Cardiology , vol.41 , Issue.2 , pp. 265-274
    • Rajapurohitam, V.1    Javadov, S.2    Purdham, D.M.3    Kirshenbaum, L.A.4    Karmazyn, M.5
  • 36
    • 0041857804 scopus 로고    scopus 로고
    • The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes
    • DOI 10.1161/01.RES.0000089255.37804.72
    • V. Rajapurohitam, X.T. Gan, L.A. Kirshenbaum, and M. Karmazyn The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes Circ. Res. 93 2003 277 279 (Pubitemid 37048239)
    • (2003) Circulation Research , vol.93 , Issue.4 , pp. 277-279
    • Rajapurohitam, V.1    Gan, X.T.2    Kirshenbaum, L.A.3    Karmazyn, M.4
  • 37
    • 4444303576 scopus 로고    scopus 로고
    • Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes
    • DOI 10.1161/01.CIR.0000140766.52771.6D
    • F.P. Xu, M.S. Chen, Y.Z. Wang, Q. Yi, S.B. Lin, A.F. Chen, and J.D. Luo Leptin induces hypertrophy via endothelin-1-reactive oxygen species pathway in cultured neonatal rat cardiomyocytes Circulation 110 2004 1269 1275 (Pubitemid 39202344)
    • (2004) Circulation , vol.110 , Issue.10 , pp. 1269-1275
    • Xu, F.-P.1    Chen, M.-S.2    Wang, Y.-Z.3    Yi, Q.4    Lin, S.-B.5    Chen, A.F.6    Luo, J.-D.7
  • 38
    • 78049259608 scopus 로고    scopus 로고
    • Leptin induces hypertrophy through activating the peroxisome proliferator-activated receptor alpha pathway in cultured neonatal rat cardiomyocytes
    • N. Hou, M.S. Luo, S.M. Liu, H.N. Zhang, Q. Xiao, P. Sun, G.S. Zhang, J.D. Luo, and M.S. Chen Leptin induces hypertrophy through activating the peroxisome proliferator-activated receptor alpha pathway in cultured neonatal rat cardiomyocytes Clin. Exp. Pharmacol. Physiol. 37 2011 1087 1095
    • (2011) Clin. Exp. Pharmacol. Physiol. , vol.37 , pp. 1087-1095
    • Hou, N.1    Luo, M.S.2    Liu, S.M.3    Zhang, H.N.4    Xiao, Q.5    Sun, P.6    Zhang, G.S.7    Luo, J.D.8    Chen, M.S.9
  • 39
    • 79959211157 scopus 로고    scopus 로고
    • MTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy
    • A. Zeidan, J.C. Hunter, S. Javadov, and M. Karmazyn mTOR mediates RhoA-dependent leptin-induced cardiomyocyte hypertrophy Mol. Cell Biochem. 352 2011 99 108
    • (2011) Mol. Cell Biochem. , vol.352 , pp. 99-108
    • Zeidan, A.1    Hunter, J.C.2    Javadov, S.3    Karmazyn, M.4
  • 41
    • 0042018759 scopus 로고    scopus 로고
    • Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice
    • DOI 10.1161/01.CIR.0000083716.82622.FD
    • L.A. Barouch, D.E. Berkowitz, R.W. Harrison, C.P. O'Donnell, and J.M. Hare Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice Circulation 108 2003 754 759 (Pubitemid 36999263)
    • (2003) Circulation , vol.108 , Issue.6 , pp. 754-759
    • Barouch, L.A.1    Berkowitz, D.E.2    Harrison, R.W.3    O'Donnell, C.P.4    Hare, J.M.5
  • 42
    • 68049126126 scopus 로고    scopus 로고
    • Enhanced hypertrophy in ob/ob mice due to an impairment in expression of atrial natriuretic peptide
    • E. Mascareno, D. Beckles, M. Dhar-Mascareno, and M.A. Siddiqui Enhanced hypertrophy in ob/ob mice due to an impairment in expression of atrial natriuretic peptide Vascul. Pharmacol. 51 2009 198 204
    • (2009) Vascul. Pharmacol. , vol.51 , pp. 198-204
    • Mascareno, E.1    Beckles, D.2    Dhar-Mascareno, M.3    Siddiqui, M.A.4
  • 44
    • 70350662888 scopus 로고    scopus 로고
    • Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease
    • P. Majumdar, S. Chen, B. George, S. Sen, M. Karmazyn, and S. Chakrabarti Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease Diabetes Metab. Res. Rev. 25 2009 452 463
    • (2009) Diabetes Metab. Res. Rev. , vol.25 , pp. 452-463
    • Majumdar, P.1    Chen, S.2    George, B.3    Sen, S.4    Karmazyn, M.5    Chakrabarti, S.6
  • 45
    • 77952501955 scopus 로고    scopus 로고
    • Mechanisms of cardiac fibrosis in inflammatory heart disease
    • G. Kania, P. Blyszczuk, and U. Eriksson Mechanisms of cardiac fibrosis in inflammatory heart disease Trends Cardiovasc. Med. 19 2009 247 252
    • (2009) Trends Cardiovasc. Med. , vol.19 , pp. 247-252
    • Kania, G.1    Blyszczuk, P.2    Eriksson, U.3
  • 46
    • 78751507979 scopus 로고    scopus 로고
    • Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart
    • E.E. Creemers, and Y.M. Pinto Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart Cardiovasc. Res. 89 2011 265 272
    • (2011) Cardiovasc. Res. , vol.89 , pp. 265-272
    • Creemers, E.E.1    Pinto, Y.M.2
  • 47
    • 58649114508 scopus 로고    scopus 로고
    • Implications of myocardial matrix remodeling by adipokines in obesity-related heart failure
    • K. Schram, and G. Sweeney Implications of myocardial matrix remodeling by adipokines in obesity-related heart failure Trends Cardiovasc. Med. 18 2008 199 205
    • (2008) Trends Cardiovasc. Med. , vol.18 , pp. 199-205
    • Schram, K.1    Sweeney, G.2
  • 48
    • 80455155124 scopus 로고    scopus 로고
    • Leptin's regulation of obesity-induced cardiac extracellular matrix remodeling
    • S. Zibadi, F. Cordova, E.H. Slack, R.R. Watson, and D.F. Larson Leptin's regulation of obesity-induced cardiac extracellular matrix remodeling Cardiovasc. Toxicol. 11 2011 325 333
    • (2011) Cardiovasc. Toxicol. , vol.11 , pp. 325-333
    • Zibadi, S.1    Cordova, F.2    Slack, E.H.3    Watson, R.R.4    Larson, D.F.5
  • 49
    • 42749090245 scopus 로고    scopus 로고
    • Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts
    • K. Schram, M.M. Wong, R. Palanivel, E.K. No, I.M. Dixon, and G. Sweeney Increased expression and cell surface localization of MT1-MMP plays a role in stimulation of MMP-2 activity by leptin in neonatal rat cardiac myofibroblasts J. Mol. Cell Cardiol. 44 2008 874 881
    • (2008) J. Mol. Cell Cardiol. , vol.44 , pp. 874-881
    • Schram, K.1    Wong, M.M.2    Palanivel, R.3    No, E.K.4    Dixon, I.M.5    Sweeney, G.6
  • 50
    • 79955459948 scopus 로고    scopus 로고
    • Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration
    • K. Schram, R. Ganguly, E.K. No, X. Fang, F.S. Thong, and G. Sweeney Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration Endocrinology 152 2011 2037 2047
    • (2011) Endocrinology , vol.152 , pp. 2037-2047
    • Schram, K.1    Ganguly, R.2    No, E.K.3    Fang, X.4    Thong, F.S.5    Sweeney, G.6
  • 51
    • 0035973147 scopus 로고    scopus 로고
    • Potential role of leptin in angiogenesis: Leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro
    • H.Y. Park, H.M. Kwon, H.J. Lim, B.K. Hong, J.Y. Lee, B.E. Park, Y. Jang, S.Y. Cho, and H.S. Kim Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro Exp. Mol. Med. 33 2001 95 102 (Pubitemid 32655888)
    • (2001) Experimental and Molecular Medicine , vol.33 , Issue.2 , pp. 95-102
    • Park, H.-Y.1    Kwon, H.M.2    Lim, H.J.3    Hong, B.K.4    Lee, J.Y.5    Park, B.E.6    Jang, Y.7    Cho, S.Y.8    Kim, H.-S.9
  • 53
    • 58949084971 scopus 로고    scopus 로고
    • Cardiomyocyte apoptosis in animal models of obesity
    • P.S. Trivedi, and L.A. Barouch Cardiomyocyte apoptosis in animal models of obesity Curr. Hypertens. Rep. 10 2008 454 460
    • (2008) Curr. Hypertens. Rep. , vol.10 , pp. 454-460
    • Trivedi, P.S.1    Barouch, L.A.2
  • 56
    • 70149093942 scopus 로고    scopus 로고
    • Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells
    • E.J. Shin, K. Schram, X.L. Zheng, and G. Sweeney Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells J. Cell Physiol. 221 2009 490 497
    • (2009) J. Cell Physiol. , vol.221 , pp. 490-497
    • Shin, E.J.1    Schram, K.2    Zheng, X.L.3    Sweeney, G.4
  • 59
    • 20044377423 scopus 로고    scopus 로고
    • Hyperleptinemia: Protecting the heart from lipid overload
    • DOI 10.1161/01.HYP.0000165683.09053.02
    • R.H. Unger Hyperleptinemia: protecting the heart from lipid overload Hypertension 45 2005 1031 1034 (Pubitemid 40770299)
    • (2005) Hypertension , vol.45 , Issue.6 , pp. 1031-1034
    • Unger, R.H.1
  • 60
  • 61
  • 63
  • 65
    • 33646360219 scopus 로고    scopus 로고
    • Role of leptin in blood pressure regulation and arterial hypertension
    • DOI 10.1097/01.hjh.0000222743.06584.66, PII 0000487220060500000001
    • J. Beltowski Role of leptin in blood pressure regulation and arterial hypertension J. Hypertens. 24 2006 789 801 (Pubitemid 43670444)
    • (2006) Journal of Hypertension , vol.24 , Issue.5 , pp. 789-801
    • Beltowski, J.1
  • 67
    • 77952497025 scopus 로고    scopus 로고
    • Leptin-induced sympathetic nerve activation: Signaling mechanisms and cardiovascular consequences in obesity
    • K. Rahmouni Leptin-induced sympathetic nerve activation: signaling mechanisms and cardiovascular consequences in obesity Curr. Hypertens. Rev. 6 2010 104 209
    • (2010) Curr. Hypertens. Rev. , vol.6 , pp. 104-209
    • Rahmouni, K.1
  • 68
    • 80052748828 scopus 로고    scopus 로고
    • Combined amylin-leptin treatment lowers blood pressure and adiposity in lean and obese rats
    • R. Seth, W.D. Knight, and J.M. Overton Combined amylin-leptin treatment lowers blood pressure and adiposity in lean and obese rats Int. J. Obes. (Lond.) 35 2011 1183 1192
    • (2011) Int. J. Obes. (Lond.) , vol.35 , pp. 1183-1192
    • Seth, R.1    Knight, W.D.2    Overton, J.M.3
  • 72
    • 84872490186 scopus 로고    scopus 로고
    • Leptin and the regulation of endothelial function in physiological and pathological conditions
    • J. Beltowski Leptin and the regulation of endothelial function in physiological and pathological conditions Clin. Exp. Pharmacol. Physiol. 2011
    • (2011) Clin. Exp. Pharmacol. Physiol.
    • Beltowski, J.1
  • 73
    • 33748970803 scopus 로고    scopus 로고
    • Leptin and atherosclerosis
    • DOI 10.1016/j.atherosclerosis.2006.03.003, PII S0021915006001286
    • J. Beltowski Leptin and atherosclerosis Atherosclerosis 189 2006 47 60 (Pubitemid 44441296)
    • (2006) Atherosclerosis , vol.189 , Issue.1 , pp. 47-60
    • Beltowski, J.1
  • 74
    • 37449000326 scopus 로고    scopus 로고
    • Leptin and adipocytokines: Bridging the gap between immunity and atherosclerosis
    • G. Matarese, C. Mantzoros, and A. La Cava Leptin and adipocytokines: bridging the gap between immunity and atherosclerosis Curr. Pharm. Des. 13 2007 3676 3680
    • (2007) Curr. Pharm. Des. , vol.13 , pp. 3676-3680
    • Matarese, G.1    Mantzoros, C.2    La Cava, A.3
  • 75
    • 33847625379 scopus 로고    scopus 로고
    • Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance
    • DOI 10.1161/01.ATV.0000252068.89775.ee, PII 0004360520070100000012
    • P.F. Bodary, Y. Shen, M. Ohman, K.L. Bahrou, F.B. Vargas, S.S. Cudney, K.J. Wickenheiser, M.G. Myers Jr., and D.T. Eitzman Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance Arterioscler. Thromb. Vasc. Biol. 27 2007 70 76 (Pubitemid 46360382)
    • (2007) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.27 , Issue.1 , pp. 70-76
    • Bodary, P.F.1    Shen, Y.2    Ohman, M.3    Bahrou, K.L.4    Vargas, F.B.5    Cudney, S.S.6    Wickenheiser, K.J.7    Myers Jr., M.G.8    Eitzman, D.T.9
  • 76
    • 78650836336 scopus 로고    scopus 로고
    • Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemia
    • W. Luo, P.F. Bodary, Y. Shen, K.J. Wickenheiser, M.K. Ohman, C. Guo, K.L. Bahrou, M.G. Myers Jr., and D.T. Eitzman Leptin receptor-induced STAT3-independent signaling pathways are protective against atherosclerosis in a murine model of obesity and hyperlipidemia Atherosclerosis 214 2011 81 85
    • (2011) Atherosclerosis , vol.214 , pp. 81-85
    • Luo, W.1    Bodary, P.F.2    Shen, Y.3    Wickenheiser, K.J.4    Ohman, M.K.5    Guo, C.6    Bahrou, K.L.7    Myers Jr., M.G.8    Eitzman, D.T.9
  • 77
    • 21044457290 scopus 로고    scopus 로고
    • Lessons from the leptin paradox in cardiac regulation - Too much versus too little
    • DOI 10.1113/jphysiol.2005.086678
    • J. Ren Lessons from the leptin paradox in cardiac regulation-too much versus too little J. Physiol. 565 2005 347 (Pubitemid 40872466)
    • (2005) Journal of Physiology , vol.565 , Issue.2 , pp. 347
    • Ren, J.1
  • 78
    • 84866122177 scopus 로고    scopus 로고
    • Sympathetic nervous system in obesity-related hypertension: Mechanisms and clinical implications
    • G.Z. Kalil, and W.G. Haynes Sympathetic nervous system in obesity-related hypertension: mechanisms and clinical implications Hypertens. Res. 2011
    • (2011) Hypertens. Res.
    • Kalil, G.Z.1    Haynes, W.G.2
  • 79
    • 80051474126 scopus 로고    scopus 로고
    • Impact of leptin-mediated sympatho-activation on cardiovascular function in obese mice
    • E.J. Belin de Chantemele, J.D. Mintz, W.E. Rainey, and D.W. Stepp Impact of leptin-mediated sympatho-activation on cardiovascular function in obese mice Hypertension 58 2011 271 279
    • (2011) Hypertension , vol.58 , pp. 271-279
    • Belin De Chantemele, E.J.1    Mintz, J.D.2    Rainey, W.E.3    Stepp, D.W.4
  • 80
    • 79952767300 scopus 로고    scopus 로고
    • Chronic blood pressure and appetite responses to central leptin infusion in rats fed a high fat diet
    • J.H. Dubinion, A.A. da Silva, and J.E. Hall Chronic blood pressure and appetite responses to central leptin infusion in rats fed a high fat diet J. Hypertens. 29 2011 758 762
    • (2011) J. Hypertens. , vol.29 , pp. 758-762
    • Dubinion, J.H.1    Da Silva, A.A.2    Hall, J.E.3
  • 82
    • 77950507182 scopus 로고    scopus 로고
    • Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits
    • L.J. Prior, N. Eikelis, J.A. Armitage, P.J. Davern, S.L. Burke, J.P. Montani, B. Barzel, and G.A. Head Exposure to a high-fat diet alters leptin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits Hypertension 55 2010 862 868
    • (2010) Hypertension , vol.55 , pp. 862-868
    • Prior, L.J.1    Eikelis, N.2    Armitage, J.A.3    Davern, P.J.4    Burke, S.L.5    Montani, J.P.6    Barzel, B.7    Head, G.A.8
  • 83
    • 33750153292 scopus 로고    scopus 로고
    • Attenuation of leptin and insulin signaling by SOCS proteins
    • DOI 10.1016/j.tem.2006.09.007, PII S1043276006001779
    • J.K. Howard, and J.S. Flier Attenuation of leptin and insulin signaling by SOCS proteins Trends Endocrinol. Metab. 17 2006 365 371 (Pubitemid 44596259)
    • (2006) Trends in Endocrinology and Metabolism , vol.17 , Issue.9 , pp. 365-371
    • Howard, J.K.1    Flier, J.S.2
  • 86
    • 80051968584 scopus 로고    scopus 로고
    • In search of new therapeutic targets and strategies for heart failure: Recent advances in basic science
    • A.M. Shah, and D.L. Mann In search of new therapeutic targets and strategies for heart failure: recent advances in basic science Lancet 378 2011 704 712
    • (2011) Lancet , vol.378 , pp. 704-712
    • Shah, A.M.1    Mann, D.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.