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Volumn 35, Issue 9, 2011, Pages 1183-1192

Combined amylin-leptin treatment lowers blood pressure and adiposity in lean and obese rats

Author keywords

energy balance; food intake; metabolism; respiratory quotient; telemetry

Indexed keywords

AMYLIN; LEPTIN;

EID: 80052748828     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2010.262     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 33751509016 scopus 로고    scopus 로고
    • Antiobesity effects of the β-cell hormone amylin in diet-induced obese rats: Effects on food intake, body weight, composition, energy expenditure, and gene expression
    • DOI 10.1210/en.2006-0393
    • Roth JD, Hughes H, Kendall E, Baron AD, Anderson CM. Antiobesity effects of the beta cell hormone amylin in dietinduced obese rats: effects on food intake, body weight, composition, energy expenditure, and gene expression. Endocrinology 2006; 147: 5855-5864. (Pubitemid 44833502)
    • (2006) Endocrinology , vol.147 , Issue.12 , pp. 5855-5864
    • Roth, J.D.1    Hughes, H.2    Kendall, E.3    Baron, A.D.4    Anderson, C.M.5
  • 3
    • 54349121294 scopus 로고    scopus 로고
    • Amylin-mediated restoration of leptin responsiveness in dietinduced obesity: Magnitude and mechanisms
    • Trevaskis JL, Coffey T, Cole R, Lei C, Wittmer C, Walsh B et al. Amylin-mediated restoration of leptin responsiveness in dietinduced obesity: magnitude and mechanisms. Endocrinology 2008; 149: 5679-5687.
    • (2008) Endocrinology , vol.149 , pp. 5679-5687
    • Trevaskis, J.L.1    Coffey, T.2    Cole, R.3    Lei, C.4    Wittmer, C.5    Walsh, B.6
  • 4
    • 74249091684 scopus 로고    scopus 로고
    • It takes two to tango: Combined amylin/leptin agonism as a potential approach to obesity drug development
    • Chan JLRJ, Weyer C. It takes two to tango: combined amylin/leptin agonism as a potential approach to obesity drug development. J Investig Med 2009; 57: 777-783.
    • (2009) J Investig Med , vol.57 , pp. 777-783
    • Jlrj, C.1    Weyer, C.2
  • 7
    • 77952893301 scopus 로고    scopus 로고
    • Obesity-induced hypertension: Role of sympathetic nervous system leptin and melanocortins
    • Hall JE, da Silva AA, do Carmo JM, Dubinion J, Hamza S, Munusamy S et al. Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem 2010; 285: 17271-17276.
    • (2010) J Biol Chem , vol.285 , pp. 17271-17276
    • Hall, J.E.1    Da Silva, A.A.2    Do Carmo, J.M.3    Dubinion, J.4    Hamza, S.5    Munusamy, S.6
  • 9
    • 70349323296 scopus 로고    scopus 로고
    • Cardiovascular side effects of antiobesity drugs: A yellow flag in the race to safe pharmacotherapy for obesity
    • Mark AL. Cardiovascular side effects of antiobesity drugs: a yellow flag in the race to safe pharmacotherapy for obesity. Circulation 2009; 120: 719-721.
    • (2009) Circulation , vol.120 , pp. 719-721
    • Mark, A.L.1
  • 10
    • 0037338694 scopus 로고    scopus 로고
    • Intracellular mechanisms involved in leptin regulation of sympathetic outflow
    • DOI 10.1161/01.HYP.0000048342.54392.40
    • Rahmouni K, Haynes WG, Morgan DA, Mark AL. Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension 2003; 41(3 Part 2): 763-767. (Pubitemid 36314588)
    • (2003) Hypertension , vol.41 , Issue.3 , pp. 763-767
    • Rahmouni, K.1    Haynes, W.G.2    Morgan, D.A.3    Mark, A.L.4
  • 11
    • 33847058514 scopus 로고    scopus 로고
    • Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin
    • Rahmouni K, Morgan DA. Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin. Hypertension 2007; 49: 647-652.
    • (2007) Hypertension , vol.49 , pp. 647-652
    • Rahmouni, K.1    Morgan, D.A.2
  • 12
    • 63049125732 scopus 로고    scopus 로고
    • Short-term physiological hyperleptinemia decreases arterial blood pressure
    • Knight WD, Seth R, Boron J, Overton JM. Short-term physiological hyperleptinemia decreases arterial blood pressure. Regul Pept 2009; 154(1-3): 60-68.
    • (2009) Regul Pept , vol.154 , Issue.1-3 , pp. 60-68
    • Knight, W.D.1    Seth, R.2    Boron, J.3    Overton, J.M.4
  • 13
    • 70349339509 scopus 로고    scopus 로고
    • Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function
    • Belin de Chantemele EJ, Muta K, Mintz J, Tremblay ML, Marrero MB, Fulton DJ et al. Protein tyrosine phosphatase 1B, a major regulator of leptin-mediated control of cardiovascular function. Circulation 2009; 120: 753-763.
    • (2009) Circulation , vol.120 , pp. 753-763
    • Belin De Chantemele, E.J.1    Muta, K.2    Mintz, J.3    Tremblay, M.L.4    Marrero, M.B.5    Fulton, D.J.6
  • 14
    • 0035100787 scopus 로고    scopus 로고
    • Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure
    • Correia MLG, Morgan DA, Sivitz WI, Mark AL, Haynes WG. Leptin acts in the central nervous system to produce dosedependent changes in arterial pressure. Hypertension 2001; 37: 936-942. (Pubitemid 32221617)
    • (2001) Hypertension , vol.37 , Issue.3 , pp. 936-942
    • Correia, M.L.G.1    Morgan, D.A.2    Sivitz, W.I.3    Mark, A.L.4    Haynes, W.G.5
  • 15
    • 0035096828 scopus 로고    scopus 로고
    • Central leptin infusion attenuates the cardiovascular and metabolic effects of fasting in rats
    • Overton JM, Williams TD, Chambers JB, Rashotte ME. Central leptin infusion attenuates the cardiovascular and metabolic effects of fasting in rats. Hypertension 2001; 37: 663-669. (Pubitemid 32199046)
    • (2001) Hypertension , vol.37 , Issue.2 , pp. 663-669
    • Overton, J.M.1    Williams, T.D.2    Chambers, J.B.3    Rashotte, M.E.4
  • 16
    • 33645223696 scopus 로고    scopus 로고
    • Cardiovascular effects
    • DOI 10.1016/S1054-3589(05)52014-3, PII S1054358905520143, Amylin: Physiology and Pharmacology
    • Young A. Cardiovascular effects. Adv Pharmacol 2005; 52: 239-250. (Pubitemid 43588533)
    • (2005) Advances in Pharmacology , vol.52 , pp. 239-250
    • Young, A.1
  • 17
    • 77956094570 scopus 로고    scopus 로고
    • Enhanced weight loss following coadministration of pramlintide with sibutramine or phentermine in a multicenter trial
    • Aronne LJ, Halseth AE, Burns CM, Miller S, Shen LZ. Enhanced weight loss following coadministration of pramlintide with sibutramine or phentermine in a multicenter trial. Obesity 2010; 18: 1739-1746.
    • (2010) Obesity , vol.18 , pp. 1739-1746
    • Aronne, L.J.1    Halseth, A.E.2    Burns, C.M.3    Miller, S.4    Shen, L.Z.5
  • 18
  • 19
    • 0028930961 scopus 로고
    • Daily cycles in body temperature, metabolic rate, and substrate utilization in pigeons: Influence of amount and timing of food consumption
    • Rashotte ME, Basco PS, Henderson RP. Daily cycles in body temperature, metabolic rate, and substrate utilization in pigeons: influence of amount and timing of food consumption. Physiol Behav 1995; 57: 731-746.
    • (1995) Physiol Behav , vol.57 , pp. 731-746
    • Rashotte, M.E.1    Basco, P.S.2    Henderson, R.P.3
  • 21
    • 11144283176 scopus 로고    scopus 로고
    • Dietary fat, lipogenesis and energy balance
    • DOI 10.1016/j.physbeh.2004.09.015, PII S0031938404004093, Dietary Fat and Energy Balace-Myths and Facts
    • Schutz Y. Dietary fat, lipogenesis and energy balance. Physiol Behav 2004; 83: 557-564. (Pubitemid 40038505)
    • (2004) Physiology and Behavior , vol.83 , Issue.4 , pp. 557-564
    • Schutz, Y.1
  • 22
    • 0035163545 scopus 로고    scopus 로고
    • The reconstruction of Kleiber's law at the organ-tissue level
    • Wang Z, O'Connor TP, Heshka S, Heymsfield SB. The reconstruction of Kleiber's law at the organ-tissue level. J Nutr 2001; 131: 2967-2970. (Pubitemid 33063132)
    • (2001) Journal of Nutrition , vol.131 , Issue.11 , pp. 2967-2970
    • Wang, Z.1    O'Connor, T.P.2    Heshka, S.3    Heymsfield, S.B.4
  • 23
    • 0034628503 scopus 로고    scopus 로고
    • Laying down the law
    • DOI 10.1038/35001159
    • Smil V. Laying down the law. Nature 2000; 403: 597. (Pubitemid 30103978)
    • (2000) Nature , vol.403 , Issue.6770 , pp. 597
    • Smil, V.1
  • 24
    • 0020593906 scopus 로고
    • The 3/4 mass exponent for energy metabolism is not a statistical artifact
    • DOI 10.1016/0034-5687(83)90002-6
    • Feldman HA, McMahon TA. The 3/4 mass exponent for energy metabolism is not a statistical artifact. Respir Physiol 1983; 52: 149-163. (Pubitemid 13055195)
    • (1983) Respiration Physiology , vol.52 , Issue.2 , pp. 149-163
    • Feldman, H.A.1    McMahon, T.A.2
  • 26
    • 77950965179 scopus 로고    scopus 로고
    • Multi-hormonal weight loss combinations in diet-induced obese rats: Therapeutic potential of cholecystokinin?
    • Trevaskis JL, Turek VF, Griffin PS, Wittmer C, Parkes DG, Roth JD. Multi-hormonal weight loss combinations in diet-induced obese rats: therapeutic potential of cholecystokinin? Physiol Behav 2010; 100: 187-195.
    • (2010) Physiol Behav , vol.100 , pp. 187-195
    • Trevaskis, J.L.1    Turek, V.F.2    Griffin, P.S.3    Wittmer, C.4    Parkes, D.G.5    Roth, J.D.6
  • 28
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1995; 1: 1311-1314.
    • (1995) Nat Med , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3    Lollmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 31
    • 33745224149 scopus 로고    scopus 로고
    • The effects of high fat diets on the blood-brain barrier transport of leptin: Failure or adaptation?
    • Banks WA, Farr SA, Morley JE. The effects of high fat diets on the blood-brain barrier transport of leptin: failure or adaptation? Physiol Behav 2006; 88: 244-248.
    • (2006) Physiol Behav , vol.88 , pp. 244-248
    • Banks, W.A.1    Farr, S.A.2    Morley, J.E.3
  • 33
    • 0035800015 scopus 로고    scopus 로고
    • Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats
    • DOI 10.1016/S0306-4522(01)00142-7, PII S0306452201001427
    • Scarpace PJ, Matheny M, Tumer N. Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats. Neuroscience 2001; 104: 1111-1117. (Pubitemid 32701970)
    • (2001) Neuroscience , vol.104 , Issue.4 , pp. 1111-1117
    • Scarpace, P.J.1    Matheny, M.2    Tumer, N.3
  • 35
    • 0344089206 scopus 로고    scopus 로고
    • Differential effects of amylin and salmon calcitonin on neuropeptide gene expression in the lateral hypothalamic area and the arcuate nucleus of the rat
    • DOI 10.1016/S0304-3940(03)00190-3
    • Barth SW, Riediger T, Lutz TA, Rechkemmer G. Differential effects of amylin and salmon calcitonin on neuropeptide gene expression in the lateral hypothalamic area and the arcuate nucleus of the rat. Neurosci Lett 2003; 341: 131-134. (Pubitemid 36398486)
    • (2003) Neuroscience Letters , vol.341 , Issue.2 , pp. 131-134
    • Barth, S.W.1    Riediger, T.2    Lutz, T.A.3    Rechkemmer, G.4
  • 36
    • 15444362716 scopus 로고    scopus 로고
    • Pancreatic amylin as a centrally acting satiating hormone
    • Lutz TA. Pancreatic amylin as a centrally acting satiating hormone. Curr Drug Targets 2005; 6: 181-189. (Pubitemid 40394313)
    • (2005) Current Drug Targets , vol.6 , Issue.2 , pp. 181-189
    • Lutz, T.A.1
  • 37
    • 0037258685 scopus 로고    scopus 로고
    • 1 receptors in the ventromedial hypothalamus mediate the anorectic action of the pancreatic hormone amylin
    • DOI 10.1016/S0196-9781(02)00288-7, PII S0196978102002887
    • Mollet A, Meier S, Riediger T, Lutz TA. Histamine H1 receptors in the ventromedial hypothalamus mediate the anorectic action of the pancreatic hormone amylin. Peptides 2003; 24: 155-158. (Pubitemid 36165186)
    • (2003) Peptides , vol.24 , Issue.1 , pp. 155-158
    • Mollet, A.1    Meier, S.2    Riediger, T.3    Lutz, T.A.4
  • 38
    • 0033569730 scopus 로고    scopus 로고
    • The role of SOCS-3 in leptin signaling and leptin resistance
    • Bjorbaek C, El-Haschimi K, Frantz JD, Flier JS. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 1999; 274: 30059-30065.
    • (1999) J Biol Chem , vol.274 , pp. 30059-30065
    • Bjorbaek, C.1    El-Haschimi, K.2    Frantz, J.D.3    Flier, J.S.4
  • 40
    • 0036854518 scopus 로고    scopus 로고
    • Nutritional regulation of hypothalamic leptin receptor gene expression is defective in diet-induced obesity
    • Sahu A, Nguyen L, O'Doherty RM. Nutritional regulation of hypothalamic leptin receptor gene expression is defective in dietinduced obesity. J Neuroendocrinol 2002; 14: 887-893. (Pubitemid 35378706)
    • (2002) Journal of Neuroendocrinology , vol.14 , Issue.11 , pp. 887-893
    • Sahu, A.1    Nguyen, L.2    O'Doherty, R.M.3
  • 42
    • 0035094738 scopus 로고    scopus 로고
    • Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin
    • Kuo JJ, Jones OB, Hall JE. Inhibition of NO synthesis enhances chronic cardiovascular and renal actions of leptin. Hypertension 2001; 37(2 Part 2): 670-676. (Pubitemid 32199047)
    • (2001) Hypertension , vol.37 , Issue.2 , pp. 670-676
    • Kuo, J.J.1    Jones, O.B.2    Hall, J.E.3
  • 43
    • 33745986945 scopus 로고    scopus 로고
    • Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin
    • DOI 10.1161/01.HYP.0000227966.36744.d9, PII 0000426820060700000014
    • Tallam LS, da Silva AA, Hall JE. Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension 2006; 48: 58-64. (Pubitemid 44297525)
    • (2006) Hypertension , vol.48 , Issue.1 , pp. 58-64
    • Tallam, L.S.1    Da Silva, A.A.2    Hall, J.E.3
  • 44
    • 33947246530 scopus 로고    scopus 로고
    • Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptin
    • DOI 10.1016/j.regpep.2006.12.007, PII S0167011506002618
    • Beltowski J,Wojcicka G, Jamroz-Wisniewska A, Borkowska E. Role of PI3K and PKB/Akt in acute natriuretic and NO-mimetic effects of leptin. Regul Pept 2007; 140: 168-177. (Pubitemid 46418916)
    • (2007) Regulatory Peptides , vol.140 , Issue.3 , pp. 168-177
    • Beltowski, J.1    Wojcicka, G.2    Jamroz-Wisniewska, A.3    Borkowska, E.4
  • 45
    • 33845914627 scopus 로고    scopus 로고
    • The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism
    • DOI 10.1210/en.2006-0940
    • Rodriguez A, Fortuno A, Gomez-Ambrosi J, Zalba G, Diez J, Fruhbeck G. The inhibitory effect of leptin on angiotensin IIinduced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism. Endocrinology 2007; 148: 324-331. (Pubitemid 46021465)
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 324-331
    • Rodriguez, A.1    Fortuno, A.2    Gomez-Ambrosi, J.3    Zalba, G.4    Diez, J.5    Fruhbeck, G.6
  • 46
    • 0036179086 scopus 로고    scopus 로고
    • Chronic cardiovascular and renal actions of leptin: Role of adrenergic activity
    • DOI 10.1161/hy0202.104398
    • Carlyle M, Jones OB, Kuo JJ, Hall JE. Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension 2002; 39(2 Part 2): 496-501. (Pubitemid 34165172)
    • (2002) Hypertension , vol.39 , Issue.2 , pp. 496-501
    • Carlyle, M.1    Jones, O.B.2    Kuo, J.J.3    Hall, J.E.4
  • 47
    • 2542465882 scopus 로고    scopus 로고
    • Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin
    • DOI 10.1161/01.HYP.0000128421.23499.b9
    • da Silva AA, Kuo JJ, Hall JE. Role of hypothalamic melanocortin 3/4-receptors in mediating chronic cardiovascular, renal, and metabolic actions of leptin. Hypertension 2004; 43: 1312-1317. (Pubitemid 38691755)
    • (2004) Hypertension , vol.43 , Issue.6 , pp. 1312-1317
    • Da Silva, A.A.1    Kuo, J.J.2    Hall, J.E.3
  • 48
    • 33748995672 scopus 로고    scopus 로고
    • Leptin and vascular function: Friend or foe?
    • DOI 10.1093/eurheartj/ehl246
    • Wolk R, Somers VK. Leptin and vascular function: friend or foe? Eur Heart J 2006; 27: 2263-2265. (Pubitemid 44453564)
    • (2006) European Heart Journal , vol.27 , Issue.19 , pp. 2263-2265
    • Wolk, R.1    Somers, V.K.2
  • 50
    • 0024555948 scopus 로고
    • Regional hemodynamic effects of calcitonin gene-related peptide
    • Gardiner SM, Compton AM, Bennett T. Regional hemodynamic effects of calcitonin gene-related peptide. Am J Physiol 1989; 256 (2 Part 2): R332-R338.
    • (1989) Am J Physiol , vol.256 , Issue.2 PART 2
    • Gardiner, S.M.1    Compton, A.M.2    Bennett, T.3


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